{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T21:40:07Z","timestamp":1756762807515,"version":"3.44.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"DOI":"10.7759\/cureus.91434","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T21:12:59Z","timestamp":1756761179000},"source":"Crossref","is-referenced-by-count":0,"title":["Multisystem Phenotypic Spectrum in Pediatric Heterotaxy Syndrome: A Case Series"],"prefix":"10.7759","author":[{"given":"Trisha G","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle E","family":"Thurmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy R","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.118.007490","article-title":"Classifying heterotaxy syndrome: time for a new approach","volume":"11","author":"Sanders SP","year":"2018","unstructured":"Sanders SP, Geva T. Classifying heterotaxy syndrome: time for a new approach. Circ Cardiovasc Imaging. 2018, 11:e007490. 10.1161\/CIRCIMAGING.118.007490","journal-title":"Circ Cardiovasc Imaging"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-015-1925-x","article-title":"Cardiac and non-cardiac abnormalities in heterotaxy syndrome","volume":"82","author":"Mishra S","year":"2015","unstructured":"Mishra S. Cardiac and non-cardiac abnormalities in heterotaxy syndrome. Indian J Pediatr. 2015, 82:1135-1146. 10.1007\/s12098-015-1925-x","journal-title":"Indian J Pediatr"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-44087-8_42","article-title":"Human genetics of defects of situs","author":"Perrot A","year":"2024","unstructured":"Perrot A, Rickert-Sperling S. Human genetics of defects of situs. In: Congenital Heart Diseases: The Broken Heart. Advances in Experimental Medicine and Biology. Rickert-Sperling S, Kelly RG, Haas N (ed): Springer, Cham; 2024. 1441:705-717. 10.1007\/978-3-031-44087-8_42"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-7311-3_15","article-title":"ZIC3 in heterotaxy","author":"Bellchambers HM","year":"2018","unstructured":"Bellchambers HM, Ware SM. ZIC3 in heterotaxy. In: Zic family. Advances in Experimental Medicine and Biology. Aruga J (ed): Springer, Singapore; 2018. 1046:301-327. 10.1007\/978-981-10-7311-3_15"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s12055-020-00935-y","article-title":"The heterotaxy syndrome: associated congenital heart defects and management","volume":"37","author":"Agarwal R","year":"2021","unstructured":"Agarwal R, Varghese R, Jesudian V, Moses J. The heterotaxy syndrome: associated congenital heart defects and management. Indian J Thorac Cardiovasc Surg. 2021, 37:67-81. 10.1007\/s12055-020-00935-y","journal-title":"Indian J Thorac Cardiovasc Surg"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2011.41.5.227","article-title":"Heterotaxy syndrome","volume":"41","author":"Kim SJ","year":"2011","unstructured":"Kim SJ. Heterotaxy syndrome. Korean Circ J. 2011, 41:227-232. 10.4070\/kcj.2011.41.5.227","journal-title":"Korean Circ J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-44087-8_9","article-title":"Establishment of cardiac laterality","author":"Gabriel GC","year":"2024","unstructured":"Gabriel GC, Wu YL, Lo CW. Establishment of cardiac laterality. In: Congenital Heart Diseases: The Broken Heart. Advances in Experimental Medicine and Biology. Rickert-Sperling S, Kelly RG, Haas N (ed): Springer, Cham; 2024. 1441:167-183. 10.1007\/978-3-031-44087-8_9"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006917","article-title":"Disharmonious patterns of heterotaxy and isomerism: how often are the classic patterns breached?","volume":"11","author":"Yim D","year":"2018","unstructured":"Yim D, Nagata H, Lam CZ, Grosse-Wortmann L, Seed M, Jaeggi E, Yoo SJ. Disharmonious patterns of heterotaxy and isomerism: how often are the classic patterns breached?. Circ Cardiovasc Imaging. 2018, 11:e006917. 10.1161\/CIRCIMAGING.117.006917","journal-title":"Circ Cardiovasc Imaging"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951107001138","article-title":"The nomenclature, definition and classification of cardiac structures in the setting of heterotaxy","volume":"17","author":"Jacobs JP","year":"2007","unstructured":"Jacobs JP, Anderson RH, Weinberg PM, et al.. The nomenclature, definition and classification of cardiac structures in the setting of heterotaxy. Cardiol Young. 2007, 17:1-28. 10.1017\/S1047951107001138","journal-title":"Cardiol Young"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17546","article-title":"Outcome of prenatally diagnosed fetal heterotaxy: systematic review and meta-analysis","volume":"51","author":"Buca DI","year":"2018","unstructured":"Buca DI, Khalil A, Rizzo G, et al.. Outcome of prenatally diagnosed fetal heterotaxy: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2018, 51:323-330. 10.1002\/uog.17546","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.16742","article-title":"National outcomes of the Fontan operation with endocardial cushion defect","volume":"37","author":"Sainathan S","year":"2022","unstructured":"Sainathan S, Said SM, Agala CB, Mullinari L, Sharma M. National outcomes of the Fontan operation with endocardial cushion defect. J Card Surg. 2022, 37:3151-3158. 10.1111\/jocs.16742","journal-title":"J Card Surg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.05.042","article-title":"Perinatal and infant outcomes of prenatal diagnosis of heterotaxy syndrome (asplenia and polysplenia)","volume":"114","author":"Escobar-Diaz MC","year":"2014","unstructured":"Escobar-Diaz MC, Friedman K, Salem Y, et al.. Perinatal and infant outcomes of prenatal diagnosis of heterotaxy syndrome (asplenia and polysplenia). Am J Cardiol. 2014, 114:612-617. 10.1016\/j.amjcard.2014.05.042","journal-title":"Am J Cardiol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2012.07.001","article-title":"Anomalous pulmonary venous connections","volume":"33","author":"Katre R","year":"2012","unstructured":"Katre R, Burns SK, Murillo H, Lane MJ, Restrepo CS. Anomalous pulmonary venous connections. Semin Ultrasound CT MR. 2012, 33:485-499. 10.1053\/j.sult.2012.07.001","journal-title":"Semin Ultrasound CT MR"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-229413","article-title":"Dextrocardia with pulmonary hypoplasia: an unusual cause of unilateral lung white-out","volume":"12","author":"Biswas S","year":"2019","unstructured":"Biswas S, Ray A. Dextrocardia with pulmonary hypoplasia: an unusual cause of unilateral lung white-out. BMJ Case Rep. 2019, 12:e229413. 10.1136\/bcr-2019-229413","journal-title":"BMJ Case Rep"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13375","article-title":"Atrioventricular canal defect and genetic syndromes: the unifying role of sonic hedgehog","volume":"95","author":"Digilio MC","year":"2019","unstructured":"Digilio MC, Pugnaloni F, De Luca A, et al.. Atrioventricular canal defect and genetic syndromes: the unifying role of sonic hedgehog. Clin Genet. 2019, 95:268-276. 10.1111\/cge.13375","journal-title":"Clin Genet"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096-8628(19990604)84:4<373::aid-ajmg13>3.0.co;2-8","article-title":"Heterotaxy-neural tube defect and holoprosencephaly occurring independently in two sib fetuses","volume":"84","author":"Bonneau D","year":"1999","unstructured":"Bonneau D, Mar\u00e9chaud M, Odent S, Piegay I, Godard A, Amati P. Heterotaxy-neural tube defect and holoprosencephaly occurring independently in two sib fetuses. Am J Med Genet. 1999, 84:373-376. 10.1002\/(sici)1096-8628(19990604)84:4&lt;373::aid-ajmg13&gt;3.0.co;2-8","journal-title":"Am J Med Genet"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-022-02515-2","article-title":"A multi-disciplinary, comprehensive approach to management of children with heterotaxy","volume":"17","author":"Saba TG","year":"2022","unstructured":"Saba TG, Geddes GC, Ware SM, et al.. A multi-disciplinary, comprehensive approach to management of children with heterotaxy. Orphanet J Rare Dis. 2022, 17:351. 10.1186\/s13023-022-02515-2","journal-title":"Orphanet J Rare Dis"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/402866-multisystem-phenotypic-spectrum-in-pediatric-heterotaxy-syndrome-a-case-series","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T21:13:00Z","timestamp":1756761180000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/402866-multisystem-phenotypic-spectrum-in-pediatric-heterotaxy-syndrome-a-case-series"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":17,"URL":"https:\/\/doi.org\/10.7759\/cureus.91434","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,1]]}}}