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Pain. 2017, 158:669-81. 10.1097\/j.pain.0000000000000814","journal-title":"Pain"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3233\/BMR-160667","article-title":"The effectiveness of transcutaneous electrical nerve stimulation in the management of patients with complex regional pain syndrome: a randomized, double-blinded, placebo-controlled prospective study","volume":"29","author":"Bilgili A","year":"2016","unstructured":"Bilgili A, \u00c7ak\u0131r T, Do\u011fan \u015eK, Er\u00e7al\u0131k T, Filiz MB, Toraman F. The effectiveness of transcutaneous electrical nerve stimulation in the management of patients with complex regional pain syndrome: a randomized, double-blinded, placebo-controlled prospective study. J Back Musculoskelet Rehabil. 2016, 29:661-71. 10.3233\/BMR-160667","journal-title":"J Back Musculoskelet Rehabil"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.5606\/tftrd.2022.9074","article-title":"Effectiveness of pulsed electromagnetic field therapy in the management of complex regional pain syndrome type 1: a randomized-controlled trial","volume":"68","author":"C\u00f6merto\u011flu \u0130","year":"2022","unstructured":"C\u00f6merto\u011flu \u0130, G\u00fcne\u015f S, Elhan AH, \u00dcst\u00fcner E, Kutlay \u015e, K\u00fc\u00e7\u00fckdeveci AA. Effectiveness of pulsed electromagnetic field therapy in the management of complex regional pain syndrome type 1: a randomized-controlled trial. Turk J Phys Med Rehabil. 2022, 68:107-16. 10.5606\/tftrd.2022.9074","journal-title":"Turk J Phys Med Rehabil"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.03.002","article-title":"The effectiveness of fluidotherapy in poststroke complex regional pain syndrome: a randomized controlled study","volume":"28","author":"Sezgin Ozcan D","year":"2019","unstructured":"Sezgin Ozcan D, Tatli HU, Polat CS, Oken O, Koseoglu BF. The effectiveness of fluidotherapy in poststroke complex regional pain syndrome: a randomized controlled study. J Stroke Cerebrovasc Dis. 2019, 28:1578-85. 10.1016\/j.jstrokecerebrovasdis.2019.03.002","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1766","article-title":"Visual illusions modulate body perception disturbance and pain in complex regional pain syndrome: a randomized trial","volume":"25","author":"Lewis JS","year":"2021","unstructured":"Lewis JS, Newport R, Taylor G, Smith M, McCabe CS. Visual illusions modulate body perception disturbance and pain in complex regional pain syndrome: a randomized trial. Eur J Pain. 2021, 25:1551-63. 10.1002\/ejp.1766","journal-title":"Eur J Pain"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181790355","article-title":"Do occlusal splints have an effect on complex regional pain syndrome? A randomized, controlled proof-of-concept trial","volume":"24","author":"Fischer MJ","year":"2008","unstructured":"Fischer MJ, Reiners A, Kohnen R, Bernateck M, Gutenbrunner C, Fink M, Svensson P. Do occlusal splints have an effect on complex regional pain syndrome? A randomized, controlled proof-of-concept trial. Clin J Pain. 2008, 24:776-83. 10.1097\/AJP.0b013e3181790355","journal-title":"Clin J Pain"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac060","article-title":"Pharmacological treatment in adult patients with CRPS-I: a systematic review and meta-analysis of randomized controlled trials","volume":"61","author":"Fassio A","year":"2022","unstructured":"Fassio A, Mantovani A, Gatti D, et al.. Pharmacological treatment in adult patients with CRPS-I: a systematic review and meta-analysis of randomized controlled trials. Rheumatology (Oxford). 2022, 61:3534-46. 10.1093\/rheumatology\/keac060","journal-title":"Rheumatology (Oxford)"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000001089","article-title":"The effectiveness of rehabilitation interventions on pain and disability for complex regional pain syndrome: a systematic review and meta-analysis","volume":"39","author":"Shafiee E","year":"2023","unstructured":"Shafiee E, MacDermid J, Packham T, Walton D, Grewal R, Farzad M. The effectiveness of rehabilitation interventions on pain and disability for complex regional pain syndrome: a systematic review and meta-analysis. Clin J Pain. 2023, 39:91-105. 10.1097\/AJP.0000000000001089","journal-title":"Clin J Pain"},{"key":"ref58","unstructured":"Treatment - complex regional pain syndrome. (2022). Accessed. July 8, 2025: https:\/\/www.nhs.uk\/conditions\/complex-regional-pain-syndrome\/treatment\/."}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/389109-the-analgesic-efficacy-of-therapies-used-for-complex-regional-pain-syndrome-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T07:04:53Z","timestamp":1757142293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/389109-the-analgesic-efficacy-of-therapies-used-for-complex-regional-pain-syndrome-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,6]]},"references-count":58,"URL":"https:\/\/doi.org\/10.7759\/cureus.91697","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,6]]}}}