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Diagnostics (Basel). 2019, 9:186. 10.3390\/diagnostics9040186","journal-title":"Diagnostics (Basel)"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17228533","article-title":"Is irritable bowel syndrome considered in clinical trials on physical therapy applied to patients with temporo-mandibular disorders? A scoping review","volume":"17","author":"Rodrigues-de-Souza DP","year":"2020","unstructured":"Rodrigues-de-Souza DP, Paz-Vega J, Fern\u00e1ndez-de-Las-Pe\u00f1as C, Cleland JA, Alburquerque-Send\u00edn F. Is irritable bowel syndrome considered in clinical trials on physical therapy applied to patients with temporo-mandibular disorders? A scoping review. 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