{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:39:21Z","timestamp":1785807561316,"version":"3.56.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,16]]},"DOI":"10.7759\/cureus.92496","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T05:08:02Z","timestamp":1758085682000},"source":"Crossref","is-referenced-by-count":4,"title":["Transcranial Magnetic Stimulation in Obsessive-Compulsive Disorder and Adolescent Depression: A Systematic Review of Efficacy, Safety, and Predictors of Treatment Response"],"prefix":"10.7759","author":[{"given":"Naga Venkata Satish","family":"Babu Bodapati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.09.022","article-title":"The psychosocial and educational burden of obsessive-compulsive disorder in youth","volume":"367","author":"Abramovitch A","year":"2024","unstructured":"Abramovitch A, Duncan B, Schuyler M, Geller DA. The psychosocial and educational burden of obsessive-compulsive disorder in youth. J Affect Disord. 2024, 367:678-85. 10.1016\/j.jad.2024.09.022","journal-title":"J Affect Disord"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.703701","article-title":"Comorbidities in obsessive-compulsive disorder across the lifespan: a systematic review and meta-analysis","volume":"12","author":"Sharma E","year":"2021","unstructured":"Sharma E, Sharma LP, Balachander S, et al.. Comorbidities in obsessive-compulsive disorder across the lifespan: a systematic review and meta-analysis. Front Psychiatry. 2021, 12:703701. 10.3389\/fpsyt.2021.703701","journal-title":"Front Psychiatry"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/9781118381953.ch63","article-title":"Depressive disorders in childhood and adolescence","author":"Brent D","year":"2015","unstructured":"Brent D, Maalouf F. Depressive disorders in childhood and adolescence. Rutter's Child and Adolescent Psychiatry. Thapar A, Pine DS, Leckman JF, Scott S, Snowling MJ, Taylor E (ed): John Wiley & Sons, Ltd., Hoboken (NJ); 2015. 874-92. 10.1002\/9781118381953.ch63"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s41983-024-00824-w","article-title":"A narrative review of non-invasive brain stimulation techniques in neuropsychiatric disorders: current applications and future directions","volume":"60","author":"Aderinto N","year":"2024","unstructured":"Aderinto N, Olatunji G, Muili A, et al.. A narrative review of non-invasive brain stimulation techniques in neuropsychiatric disorders: current applications and future directions. Egypt J Neurol Psychiatry Neurosurg. 2024, 60:50. 10.1186\/s41983-024-00824-w","journal-title":"Egypt J Neurol Psychiatry Neurosurg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2019-0741","article-title":"Precision non-implantable neuromodulation therapies: a perspective for the depressed brain","volume":"42","author":"Borrione L","year":"2020","unstructured":"Borrione L, Bellini H, Razza LB, et al.. Precision non-implantable neuromodulation therapies: a perspective for the depressed brain. Braz J Psychiatry. 2020, 42:403-19. 10.1590\/1516-4446-2019-0741","journal-title":"Braz J Psychiatry"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13071029","article-title":"Regulatory clearance and approval of therapeutic protocols of transcranial magnetic stimulation for psychiatric disorders","volume":"13","author":"Cotovio G","year":"2023","unstructured":"Cotovio G, Ventura F, Rodrigues da Silva D, Pereira P, Oliveira-Maia AJ. Regulatory clearance and approval of therapeutic protocols of transcranial magnetic stimulation for psychiatric disorders. Brain Sci. 2023, 13:10.3390\/brainsci13071029","journal-title":"Brain Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.642847","article-title":"Repetitive transcranial magnetic stimulation for adolescent major depressive disorder: a focus on neurodevelopment","volume":"12","author":"Oberman LM","year":"2021","unstructured":"Oberman LM, Hynd M, Nielson DM, Towbin KE, Lisanby SH, Stringaris A. Repetitive transcranial magnetic stimulation for adolescent major depressive disorder: a focus on neurodevelopment. Front Psychiatry. 2021, 12:642847. 10.3389\/fpsyt.2021.642847","journal-title":"Front Psychiatry"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomized trials","author":"Sterne JA","year":"2019","unstructured":"Sterne JA, Savovi\u0107 J, Page MJ, et al.. RoB 2: a revised tool for assessing risk of bias in randomized trials. BMJ. 2019, 366. 10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne JA","year":"2016","unstructured":"Sterne JA, Hern\u00e1n MA, Reeves BC, et al.. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016, 355:i4919. 10.1136\/bmj.i4919","journal-title":"BMJ"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2021.113784","article-title":"Efficacy of intensive orbitofrontal continuous theta burst stimulation (iOFcTBS) in obsessive compulsive disorder: a randomized placebo controlled study","volume":"298","author":"Dutta P","year":"2021","unstructured":"Dutta P, Dhyani M, Garg S, Tikka SK, Khattri S, Mehta S, Mishra J. Efficacy of intensive orbitofrontal continuous theta burst stimulation (iOFcTBS) in obsessive compulsive disorder: a randomized placebo controlled study. Psychiatry Res. 2021, 298:113784. 10.1016\/j.psychres.2021.113784","journal-title":"Psychiatry Res"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2021.105809","article-title":"Improvements in error-monitoring and symptoms following low-frequency rTMS of dorsal anterior cingulate cortex in obsessive compulsive disorder; a randomized, sham-controlled study","volume":"154","author":"Meek BP","year":"2021","unstructured":"Meek BP, Fotros A, Aoun MA, Modirrousta M. Improvements in error-monitoring and symptoms following low-frequency rTMS of dorsal anterior cingulate cortex in obsessive compulsive disorder; a randomized, sham-controlled study. Brain Cogn. 2021, 154:105809. 10.1016\/j.bandc.2021.105809","journal-title":"Brain Cogn"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S318069","article-title":"Continuous theta-burst stimulation over the right orbitofrontal cortex in treatment-resistant obsessive-compulsive disorder treatment: a randomized sham-controlled trial","volume":"14","author":"Liu W","year":"2021","unstructured":"Liu W, Shao H, Liao J, Yang D, Ma M, Yang J. Continuous theta-burst stimulation over the right orbitofrontal cortex in treatment-resistant obsessive-compulsive disorder treatment: a randomized sham-controlled trial. Int J Gen Med. 2021, 14:3109-18. 10.2147\/IJGM.S318069","journal-title":"Int J Gen Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852922000980","article-title":"Adjunctive neuronavigated accelerated continuous theta-burst stimulation in obsessive-compulsive disorder: a randomized sham-controlled study","volume":"28","author":"Mukherjee A","year":"2023","unstructured":"Mukherjee A, Kumre PK, Goyal N, Khanra S. Adjunctive neuronavigated accelerated continuous theta-burst stimulation in obsessive-compulsive disorder: a randomized sham-controlled study. CNS Spectr. 2023, 28:495-504. 10.1017\/S1092852922000980","journal-title":"CNS Spectr"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2024.02.005","article-title":"Efficacy of accelerated deep transcranial magnetic stimulation wi\u0307th double cone coi\u0307l in obsessive-compulsive disorder: a double-blind, placebo-controlled study","volume":"171","author":"Ozer U","year":"2024","unstructured":"Ozer U, Yucens B, Tumkaya S. Efficacy of accelerated deep transcranial magnetic stimulation wi\u0307th double cone coi\u0307l in obsessive-compulsive disorder: a double-blind, placebo-controlled study. J Psychiatr Res. 2024, 171:325-31. 10.1016\/j.jpsychires.2024.02.005","journal-title":"J Psychiatr Res"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/2741287","article-title":"A controlled clinical study of accelerated high-dose theta burst stimulation in patients with obsessive-compulsive disorder","volume":"2023","author":"Jiang J","year":"2023","unstructured":"Jiang J, Wan K, Liu Y, et al.. A controlled clinical study of accelerated high-dose theta burst stimulation in patients with obsessive-compulsive disorder. Neural Plast. 2023, 2023:2741287. 10.1155\/2023\/2741287","journal-title":"Neural Plast"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.03.061","article-title":"Deep transcranial magnetic stimulation for adolescents with treatment-resistant depression: a preliminary dose-finding study exploring safety and clinical effectiveness","volume":"354","author":"Thai M","year":"2024","unstructured":"Thai M, Nair AU, Klimes-Dougan B, et al.. Deep transcranial magnetic stimulation for adolescents with treatment-resistant depression: a preliminary dose-finding study exploring safety and clinical effectiveness. J Affect Disord. 2024, 354:589-600. 10.1016\/j.jad.2024.03.061","journal-title":"J Affect Disord"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.12.057","article-title":"Deep transcranial magnetic stimulation for adolescents with treatment-resistant depression: behavioral and neural correlates of clinical improvement","volume":"372","author":"Nair AU","year":"2025","unstructured":"Nair AU, Klimes-Dougan B, Silamongkol T, et al.. Deep transcranial magnetic stimulation for adolescents with treatment-resistant depression: behavioral and neural correlates of clinical improvement. J Affect Disord. 2025, 372:665-75. 10.1016\/j.jad.2024.12.057","journal-title":"J Affect Disord"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2024.1397706","article-title":"Effect analysis of repeated transcranial magnetic stimulation combined with fluoxetine in the treatment of first-episode adolescent depression","volume":"15","author":"Jiao L","year":"2024","unstructured":"Jiao L, Chen T, Huang Y, Huang X. Effect analysis of repeated transcranial magnetic stimulation combined with fluoxetine in the treatment of first-episode adolescent depression. Front Psychiatry. 2024, 15:1397706. 10.3389\/fpsyt.2024.1397706","journal-title":"Front Psychiatry"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.01.048","article-title":"Repetitive transcranial magnetic stimulation for obsessive-compulsive disorder: a systematic review and pairwise\/network meta-analysis","volume":"302","author":"Fitzsimmons SM","year":"2022","unstructured":"Fitzsimmons SM, van der Werf YD, van Campen AD, et al.. Repetitive transcranial magnetic stimulation for obsessive-compulsive disorder: a systematic review and pairwise\/network meta-analysis. J Affect Disord. 2022, 302:302-12. 10.1016\/j.jad.2022.01.048","journal-title":"J Affect Disord"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-022-01453-8","article-title":"Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation","volume":"48","author":"Jannati A","year":"2023","unstructured":"Jannati A, Oberman LM, Rotenberg A, Pascual-Leone A. Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation. Neuropsychopharmacology. 2023, 48:191-208. 10.1038\/s41386-022-01453-8","journal-title":"Neuropsychopharmacology"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.05.048","article-title":"Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features","volume":"61","author":"Siegle GJ","year":"2007","unstructured":"Siegle GJ, Thompson W, Carter CS, Steinhauer SR, Thase ME. Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features. Biol Psychiatry. 2007, 61:198-209. 10.1016\/j.biopsych.2006.05.048","journal-title":"Biol Psychiatry"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.10.003","article-title":"Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: expert guidelines","volume":"132","author":"Rossi S","year":"2021","unstructured":"Rossi S, Antal A, Bestmann S, et al.. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: expert guidelines. Clin Neurophysiol. 2021, 132:269-306. 10.1016\/j.clinph.2020.10.003","journal-title":"Clin Neurophysiol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-022-01942-7","article-title":"Systematic review: electroconvulsive therapy for treatment-resistant mood disorders in children and adolescents","volume":"32","author":"Castaneda-Ramirez S","year":"2023","unstructured":"Castaneda-Ramirez S, Becker TD, Bruges-Boude A, Kellner C, Rice TR. Systematic review: electroconvulsive therapy for treatment-resistant mood disorders in children and adolescents. Eur Child Adolesc Psychiatry. 2023, 32:1529-60. 10.1007\/s00787-022-01942-7","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/da.22424","article-title":"Neurobiological predictors of response to dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation in depression: a systematic review","volume":"32","author":"Silverstein WK","year":"2015","unstructured":"Silverstein WK, Noda Y, Barr MS, et al.. Neurobiological predictors of response to dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation in depression: a systematic review. Depress Anxiety. 2015, 32:871-91. 10.1002\/da.22424","journal-title":"Depress Anxiety"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/413140-transcranial-magnetic-stimulation-in-obsessive-compulsive-disorder-and-adolescent-depression-a-systematic-review-of-efficacy-safety-and-predictors-of-treatment-response","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T05:08:03Z","timestamp":1758085683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/413140-transcranial-magnetic-stimulation-in-obsessive-compulsive-disorder-and-adolescent-depression-a-systematic-review-of-efficacy-safety-and-predictors-of-treatment-response"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,16]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.92496","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,16]]}}}