{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T13:47:25Z","timestamp":1758289645614,"version":"3.44.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,18]]},"DOI":"10.7759\/cureus.92609","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T10:22:46Z","timestamp":1758190966000},"source":"Crossref","is-referenced-by-count":0,"title":["Acute Myeloid Leukemia With RUNX1::RUNX1T1 Fusion Transformed From JAK2V617F-Mutated Polycythemia Vera: A Case Report"],"prefix":"10.7759","author":[{"given":"Hidenori","family":"Tsukiji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiko","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadafumi","family":"Iino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goichi","family":"Yoshimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27002","article-title":"Polycythemia vera: 2024 update on diagnosis, risk-stratification, and management","volume":"98","author":"Tefferi A","year":"2023","unstructured":"Tefferi A, Barbui T. Polycythemia vera: 2024 update on diagnosis, risk-stratification, and management. Am J Hematol. 2023, 98:1465-87. 10.1002\/ajh.27002","journal-title":"Am J Hematol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2014.1.287","article-title":"The evolving genomic landscape of myeloproliferative neoplasms","volume":"2014","author":"Nangalia J","year":"2014","unstructured":"Nangalia J, Green TR. The evolving genomic landscape of myeloproliferative neoplasms. Hematology Am Soc Hematol Educ Program. 2014, 2014:287-96. 10.1182\/asheducation-2014.1.287","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S242479","article-title":"Genetic characterization and risk stratification of acute myeloid leukemia","volume":"12","author":"Pourrajab F","year":"2020","unstructured":"Pourrajab F, Zare-Khormizi MR, Hashemi AS, Hekmatimoghaddam S. Genetic characterization and risk stratification of acute myeloid leukemia. Cancer Manag Res. 2020, 12:2231-53. 10.2147\/CMAR.S242479","journal-title":"Cancer Manag Res"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-024-04691-0","article-title":"Transformation into acute myeloid leukemia with t(8;21)(q22;q22.1); RUNX1::RUNX1T1 from JAK2-mutated essential thrombocythemia: a case report","volume":"18","author":"Asou C","year":"2024","unstructured":"Asou C, Sakamoto T, Suzuki K, et al.. Transformation into acute myeloid leukemia with t(8;21)(q22;q22.1); RUNX1::RUNX1T1 from JAK2-mutated essential thrombocythemia: a case report. J Med Case Rep. 2024, 18:372. 10.1186\/s13256-024-04691-0","journal-title":"J Med Case Rep"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0037-1963(01)90136-2","article-title":"Evaluation of diagnostic criteria in polycythemia vera","volume":"38","author":"Pearson TC","year":"2001","unstructured":"Pearson TC. Evaluation of diagnostic criteria in polycythemia vera. Semin Hematol. 2001, 38:21-4. 10.1016\/s0037-1963(01)90136-2","journal-title":"Semin Hematol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13938","article-title":"Simultaneous detection of JAK2, CALR, and MPL mutations and quantitation of JAK2 V617F allele burden in myeloproliferative neoplasms using the quenching probe-Tm method in i-densy IS-5320","volume":"44","author":"Arai K","year":"2022","unstructured":"Arai K, Sakaguchi M, Yui S, et al.. Simultaneous detection of JAK2, CALR, and MPL mutations and quantitation of JAK2 V617F allele burden in myeloproliferative neoplasms using the quenching probe-Tm method in i-densy IS-5320. Int J Lab Hematol. 2022, 44:1102-10. 10.1111\/ijlh.13938","journal-title":"Int J Lab Hematol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.glmedi.2024.100118","article-title":"An autopsy presentation of spontaneous splenic rupture in chronic myeloid leukemia: a rare case report","volume":"3","author":"Kanani J","year":"2024","unstructured":"Kanani J, Sheikh MI. An autopsy presentation of spontaneous splenic rupture in chronic myeloid leukemia: a rare case report. J Med Surg Public Health. 2024, 3:100118. 10.1016\/j.glmedi.2024.100118","journal-title":"J Med Surg Public Health"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.95","article-title":"Blast transformation and fibrotic progression in polycythemia vera and essential thrombocythemia: a literature review of incidence and risk factors","volume":"5","author":"Cerquozzi S","year":"2015","unstructured":"Cerquozzi S, Tefferi A. Blast transformation and fibrotic progression in polycythemia vera and essential thrombocythemia: a literature review of incidence and risk factors. Blood Cancer J. 2015, 5:e366. 10.1038\/bcj.2015.95","journal-title":"Blood Cancer J"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.163","article-title":"Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study","volume":"27","author":"Tefferi A","year":"2013","unstructured":"Tefferi A, Rumi E, Finazzi G, et al.. Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study. Leukemia. 2013, 27:1874-81. 10.1038\/leu.2013.163","journal-title":"Leukemia"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002271","article-title":"Leukemic evolution of polycythemia vera and essential thrombocythemia: genomic profiles predict time to transformation","volume":"4","author":"Luque Paz D","year":"2020","unstructured":"Luque Paz D, Jouanneau-Courville R, Riou J, et al.. Leukemic evolution of polycythemia vera and essential thrombocythemia: genomic profiles predict time to transformation. Blood Adv. 2020, 4:4887-97. 10.1182\/bloodadvances.2020002271","journal-title":"Blood Adv"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000030064","article-title":"Transformation from polycythemia vera to acute promyelocytic leukemia: case report and literature review","volume":"101","author":"Li WW","year":"2022","unstructured":"Li WW, Sui XF, Fan S, Xu H, Wang CL, Wang FY, Mo XD. Transformation from polycythemia vera to acute promyelocytic leukemia: case report and literature review. Medicine (Baltimore). 2022, 101:e30064. 10.1097\/MD.0000000000030064","journal-title":"Medicine (Baltimore)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00488.x","article-title":"Transition of polycythemia vera to chronic myeloid leukaemia","volume":"75","author":"Saviola A","year":"2005","unstructured":"Saviola A, Fiorani C, Ferrara L, et al.. Transition of polycythemia vera to chronic myeloid leukaemia. Eur J Haematol. 2005, 75:264-6. 10.1111\/j.1600-0609.2005.00488.x","journal-title":"Eur J Haematol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(93)90181-k","article-title":"t(8;21) prior to acute leukemia","volume":"70","author":"Berger R","year":"1993","unstructured":"Berger R, Hillion J, Janvier D, Chen Z, Bussel A. t(8;21) prior to acute leukemia. Cancer Genet Cytogenet. 1993, 70:125-6. 10.1016\/0165-4608(93)90181-k","journal-title":"Cancer Genet Cytogenet"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3426","article-title":"Acute leukemia in polycythemia vera: an analysis of 1638 patients enrolled in a prospective observational study","volume":"105","author":"Finazzi G","year":"2005","unstructured":"Finazzi G, Caruso V, Marchioli R, et al.. Acute leukemia in polycythemia vera: an analysis of 1638 patients enrolled in a prospective observational study. Blood. 2005, 105:2664-70. 10.1182\/blood-2004-09-3426","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008259","article-title":"Second malignancies among older patients with classical myeloproliferative neoplasms treated with hydroxyurea","volume":"7","author":"Wang R","year":"2023","unstructured":"Wang R, Shallis RM, Stempel JM, et al.. Second malignancies among older patients with classical myeloproliferative neoplasms treated with hydroxyurea. Blood Adv. 2023, 7:734-43. 10.1182\/bloodadvances.2022008259","journal-title":"Blood Adv"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-08-236596","article-title":"Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm","volume":"115","author":"Beer PA","year":"2010","unstructured":"Beer PA, Delhommeau F, LeCou\u00e9dic JP, et al.. Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm. Blood. 2010, 115:2891-900. 10.1182\/blood-2009-08-236596","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-062125","article-title":"Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation","volume":"110","author":"Theocharides A","year":"2007","unstructured":"Theocharides A, Boissinot M, Girodon F, et al.. Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation. Blood. 2007, 110:375-9. 10.1182\/blood-2006-12-062125","journal-title":"Blood"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400618","article-title":"Morphological subtyping of acute myeloid leukemia with maturation (AML-M2): homogeneous pink-colored cytoplasm of mature neutrophils is most characteristic of AML-M2 with t(8;21)","volume":"11","author":"Nakamura H","year":"1997","unstructured":"Nakamura H, Kuriyama K, Sadamori N, et al.. Morphological subtyping of acute myeloid leukemia with maturation (AML-M2): homogeneous pink-colored cytoplasm of mature neutrophils is most characteristic of AML-M2 with t(8;21). Leukemia. 1997, 11:651-5. 10.1038\/sj.leu.2400618","journal-title":"Leukemia"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1309\/C3G2-CXA0-HE9J-TKDR","article-title":"Therapy-related acute myeloid leukemia\/myelodysplasia with balanced 21q22 translocations","volume":"117","author":"Arber DA","year":"2002","unstructured":"Arber DA, Slovak ML, Popplewell L, Bedell V, Ikle D, Rowley JD. Therapy-related acute myeloid leukemia\/myelodysplasia with balanced 21q22 translocations. Am J Clin Pathol. 2002, 117:306-13. 10.1309\/C3G2-CXA0-HE9J-TKDR","journal-title":"Am J Clin Pathol"},{"key":"ref20","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V80.2.470.470","article-title":"Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality: frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34","volume":"80","author":"Kita K","year":"1992","unstructured":"Kita K, Nakase K, Miwa H, et al.. Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality: frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34. Blood. 1992, 80:470-7.","journal-title":"Blood"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3211-7","article-title":"Bone marrow findings in blast phase of polycythemia vera","volume":"97","author":"Hidalgo L\u00f3pez JE","year":"2018","unstructured":"Hidalgo L\u00f3pez JE, Carballo-Zarate A, Verstovsek S, et al.. Bone marrow findings in blast phase of polycythemia vera. Ann Hematol. 2018, 97:425-34. 10.1007\/s00277-017-3211-7","journal-title":"Ann Hematol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/406760-acute-myeloid-leukemia-with-runx1runx1t1-fusion-transformed-from-jak2v617f-mutated-polycythemia-vera-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T10:22:47Z","timestamp":1758190967000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/406760-acute-myeloid-leukemia-with-runx1runx1t1-fusion-transformed-from-jak2v617f-mutated-polycythemia-vera-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":21,"URL":"https:\/\/doi.org\/10.7759\/cureus.92609","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2025,9,18]]}}}