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J Microbiol Immunol Infect. 2016, 49:359-62. 10.1016\/j.jmii.2014.06.007","journal-title":"J Microbiol Immunol Infect"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013618","article-title":"Removal of intrauterine device as part of the treatment for women with pelvic inflammatory disease","volume":"2020","author":"Viveros-Carre\u00f1o DA","year":"2020","unstructured":"Viveros-Carre\u00f1o DA, Grillo-Ardila CF, Amaya-Guio J. Removal of intrauterine device as part of the treatment for women with pelvic inflammatory disease. Cochrane Database Syst Rev. 2020, 2020:CD013618. 10.1002\/14651858.CD013618","journal-title":"Cochrane Database Syst Rev"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.18502\/ijph.v50i8.6840","article-title":"Assessing the trend of infertility rate in 198 countries and territories in last decades","volume":"50","author":"Borumandnia N","year":"2021","unstructured":"Borumandnia N, Majd HA, Khadembashi N, Alaii H. Assessing the trend of infertility rate in 198 countries and territories in last decades. Iran J Public Health. 2021, 50:1735-7. 10.18502\/ijph.v50i8.6840","journal-title":"Iran J Public Health"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-009-1042-z","article-title":"Correlation of mycoplasma with unexplained infertility","volume":"280","author":"Gupta A","year":"2009","unstructured":"Gupta A, Gupta A, Gupta S, Mittal A, Chandra P, Gill AK. Correlation of mycoplasma with unexplained infertility. Arch Gynecol Obstet. 2009, 280:981-5. 10.1007\/s00404-009-1042-z","journal-title":"Arch Gynecol Obstet"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.1.51-55.2006","article-title":"Association between preterm birth and vaginal colonization by mycoplasmas in early pregnancy","volume":"44","author":"Kataoka S","year":"2006","unstructured":"Kataoka S, Yamada T, Chou K, et al.. 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Korean J Pediatr. 2010, 53:989-93. 10.3345\/kjp.2010.53.12.989","journal-title":"Korean J Pediatr"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.77","article-title":"The association between respiratory tract Ureaplasma urealyticum colonization and severe retinopathy of prematurity in preterm infants \u22641250\u2009g","volume":"26","author":"Ozdem\u0131r R","year":"2012","unstructured":"Ozdem\u0131r R, Sar\u0131 FN, Tunay ZO, et al.. The association between respiratory tract Ureaplasma urealyticum colonization and severe retinopathy of prematurity in preterm infants \u22641250\u2009g. 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