{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:07:58Z","timestamp":1759104478109,"version":"3.44.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,28]]},"DOI":"10.7759\/cureus.93419","type":"journal-article","created":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T18:13:27Z","timestamp":1759083207000},"source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Utility of Antibodies to Extractable Nuclear Antigens in the Absence of Positive Antinuclear Antibodies"],"prefix":"10.7759","author":[{"given":"Jason","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassel B","family":"Dargham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Luggen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000771","article-title":"New lupus criteria: a critical view","volume":"33","author":"Aringer M","year":"2021","unstructured":"Aringer M, Johnson SR. New lupus criteria: a critical view. Curr Opin Rheumatol. 2021, 33:205-10. 10.1097\/BOR.0000000000000771","journal-title":"Curr Opin Rheumatol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203320908939","article-title":"Application of the 2019 European League Against Rheumatism\/American College of Rheumatology systemic lupus erythematosus classification criteria in clinical practice: a single center experience","volume":"29","author":"Rubio J","year":"2020","unstructured":"Rubio J, Krishfield S, Kyttaris VC. Application of the 2019 European League Against Rheumatism\/American College of Rheumatology systemic lupus erythematosus classification criteria in clinical practice: a single center experience. Lupus. 2020, 29:421-5. 10.1177\/0961203320908939","journal-title":"Lupus"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2017-0905\/html","article-title":"Screening for connective tissue disease-associated antibodies by automated immunoassay","volume":"56","author":"Willems P","year":"2018","unstructured":"Willems P, De Langhe E, Claessens J, et al.. Screening for connective tissue disease-associated antibodies by automated immunoassay. Clin Chem Lab Med. 2018, 56:909-18. 10.1515\/cclm-2017-0905\/html","journal-title":"Clin Chem Lab Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00541\/full","article-title":"Autoantibodies associated with connective tissue diseases: what meaning for clinicians?","volume":"26","author":"Didier K","year":"2018","unstructured":"Didier K, Bolko L, Giusti D, Toquet S, Robbins A, Antonicelli F. Autoantibodies associated with connective tissue diseases: what meaning for clinicians?. Front Immunol. 2018, 26:541. 10.3389\/fimmu.2018.00541\/full","journal-title":"Front Immunol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21930","article-title":"Choosing wisely: the American College of Rheumatology's top 5 list of things physicians and patients should question","volume":"65","author":"Yazdany J","year":"2013","unstructured":"Yazdany J, Schmajuk G, Robbins M, et al.. Choosing wisely: the American College of Rheumatology's top 5 list of things physicians and patients should question. Arthritis Care Res (Hoboken). 2013, 65:329-39. 10.1002\/acr.21930","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24990","article-title":"Frequency and clinical utility of antibodies to extractable nuclear antigen in the setting of a negative antinuclear antibody test","volume":"75","author":"Yeo AL","year":"2023","unstructured":"Yeo AL, Ojaimi S, Le S, Leech M, Morand E. Frequency and clinical utility of antibodies to extractable nuclear antigen in the setting of a negative antinuclear antibody test. Arthritis Care Res (Hoboken). 2023, 75:1595-601. 10.1002\/acr.24990","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2024.1937","article-title":"The relative timing, outcomes, and economic impact of anti-nuclear antibody (ANA) and extractable nuclear antigen (ENA) laboratory ordering","volume":"22","author":"Ethington E","year":"2024","unstructured":"Ethington E, Melrose E, Stratman EJ. The relative timing, outcomes, and economic impact of anti-nuclear antibody (ANA) and extractable nuclear antigen (ENA) laboratory ordering. Clin Med Res. 2024, 22:123-6. 10.3121\/cmr.2024.1937","journal-title":"Clin Med Res"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2174\/1874312901409010082","article-title":"Applying choosing wisely: antinuclear antibody (ANA) and sub-serology testing in a safety net hospital system","volume":"9","author":"Davis LA","year":"2015","unstructured":"Davis LA, Goldstein B, Tran V, et al.. Applying choosing wisely: antinuclear antibody (ANA) and sub-serology testing in a safety net hospital system. Open Rheumatol J. 2015, 9:82-7. 10.2174\/1874312901409010082","journal-title":"Open Rheumatol J"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4065\/70.2.183","article-title":"Cascade testing for autoantibodies in connective tissue diseases","volume":"70","author":"Homburger HA","year":"1995","unstructured":"Homburger HA. Cascade testing for autoantibodies in connective tissue diseases. Mayo Clin Proc. 1995, 70:183-4. 10.4065\/70.2.183","journal-title":"Mayo Clin Proc"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.5.413","article-title":"Is it useful to test for antibodies to extractable nuclear antigens in the presence of a negative antinuclear antibody on Hep-2 cells?","volume":"54","author":"Thomson KF","year":"2001","unstructured":"Thomson KF, Murphy A, Goodfield MJ, Misbah SA. Is it useful to test for antibodies to extractable nuclear antigens in the presence of a negative antinuclear antibody on Hep-2 cells?. J Clin Pathol. 2001, 54:413. 10.1136\/jcp.54.5.413","journal-title":"J Clin Pathol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00927","article-title":"Automated processing and evaluation of anti-nuclear antibody indirect immunofluorescence testing","volume":"9","author":"Ricchiuti V","year":"2018","unstructured":"Ricchiuti V, Adams J, Hardy DJ, Katayev A, Fleming JK. Automated processing and evaluation of anti-nuclear antibody indirect immunofluorescence testing. Front Immunol. 2018, 9:927. 10.3389\/fimmu.2018.00927","journal-title":"Front Immunol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1313.120","article-title":"Evaluation of the BioPlex 2200 ANA screen: analysis of 510 healthy subjects: incidence of natural\/predictive autoantibodies","volume":"1050","author":"Shovman O","year":"2005","unstructured":"Shovman O, Gilburd B, Barzilai O, et al.. Evaluation of the BioPlex 2200 ANA screen: analysis of 510 healthy subjects: incidence of natural\/predictive autoantibodies. Ann N Y Acad Sci. 2005, 1050:380-8. 10.1196\/annals.1313.120","journal-title":"Ann N Y Acad Sci"},{"key":"ref13","article-title":"Defining unclassifiable connective tissue diseases: Incomplete, undifferentiated, or both?","volume":"32","author":"Doria A","year":"2005","unstructured":"Doria A, Mosca M, Gambari PF, et al.. Defining unclassifiable connective tissue diseases: Incomplete, undifferentiated, or both?. J Rheumatol. 2005, 32:213-21.","journal-title":"J Rheumatol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/384785-diagnostic-utility-of-antibodies-to-extractable-nuclear-antigens-in-the-absence-of-positive-antinuclear-antibodies","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T18:13:27Z","timestamp":1759083207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/384785-diagnostic-utility-of-antibodies-to-extractable-nuclear-antigens-in-the-absence-of-positive-antinuclear-antibodies"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,28]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.93419","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,28]]}}}