{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:20:29Z","timestamp":1792686029616,"version":"4.5.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,28]]},"DOI":"10.7759\/cureus.93434","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T01:31:29Z","timestamp":1759109489000},"source":"Crossref","is-referenced-by-count":3,"title":["From Therapy to Toxicity: A Rare Case of Acute Piperacillin\/Tazobactam-Associated Drug-Induced Liver Injury"],"prefix":"10.7759","author":[{"given":"Priya Kumari","family":"Maheshwari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Maddox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Fahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr159","article-title":"Hepatic safety of antibiotics used in primary care","volume":"66","author":"Andrade RJ","year":"2011","unstructured":"Andrade RJ, Tulkens PM. Hepatic safety of antibiotics used in primary care. J Antimicrob Chemother. 2011, 66:1431-46. 10.1093\/jac\/dkr159","journal-title":"J Antimicrob Chemother"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2020.12.3.430","article-title":"Evaluation of drug-induced liver injury developed during hospitalization using electronic health record (EHR)-based algorithm","volume":"12","author":"Kang Y","year":"2020","unstructured":"Kang Y, Kim SH, Park SY, et al.. Evaluation of drug-induced liver injury developed during hospitalization using electronic health record (EHR)-based algorithm. Allergy Asthma Immunol Res. 2020, 12:430-42. 10.4168\/aair.2020.12.3.430","journal-title":"Allergy Asthma Immunol Res"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/17562848231163410","article-title":"Drug-induced liver injury: a comprehensive review","volume":"16","author":"Hosack T","year":"2023","unstructured":"Hosack T, Damry D, Biswas S. Drug-induced liver injury: a comprehensive review. Therap Adv Gastroenterol. 2023, 16:10.1177\/17562848231163410","journal-title":"Therap Adv Gastroenterol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-025-01541-w","article-title":"The frequency of drug-induced liver injury due to antibiotics among hospitalised patients","volume":"48","author":"Bj\u00f6rnsson RA","year":"2025","unstructured":"Bj\u00f6rnsson RA, Sigurdsson SS, Arnarson DT, Logason E, Bj\u00f6rnsson ES. The frequency of drug-induced liver injury due to antibiotics among hospitalised patients. Drug Saf. 2025, 48:795-804. 10.1007\/s40264-025-01541-w","journal-title":"Drug Saf"},{"key":"ref5","article-title":"Piperacillin-tazobactam","author":"Hoofnagle JH","year":"2020","unstructured":"Hoofnagle JH. Piperacillin-tazobactam. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD; 2020."},{"key":"ref6","unstructured":"American Board of Internal Medicine. Laboratory test reference ranges. (2025). Accessed. September 12, 2025: https:\/\/www.abim.org\/media\/e2wdwdqu\/laboratory-reference-ranges.pdf."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-12-200212170-00007","article-title":"Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States","volume":"137","author":"Ostapowicz G","year":"2002","unstructured":"Ostapowicz G, Fontana RJ, Schi\u00f8dt FV, et al.. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002, 137:947-54. 10.7326\/0003-4819-137-12-200212170-00007","journal-title":"Ann Intern Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v6.i4.160","article-title":"Drug-induced autoimmune liver disease: a diagnostic dilemma of an increasingly reported disease","volume":"6","author":"Castiella A","year":"2014","unstructured":"Castiella A, Zapata E, Lucena MI, Andrade RJ. Drug-induced autoimmune liver disease: a diagnostic dilemma of an increasingly reported disease. World J Hepatol. 2014, 6:160-8. 10.4254\/wjh.v6.i4.160","journal-title":"World J Hepatol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10071530","article-title":"Thrombocytopenia and hemostatic changes in acute and chronic liver disease: pathophysiology, clinical and laboratory features, and management","volume":"10","author":"Scharf RE","year":"2021","unstructured":"Scharf RE. Thrombocytopenia and hemostatic changes in acute and chronic liver disease: pathophysiology, clinical and laboratory features, and management. J Clin Med. 2021, 10:1530. 10.3390\/jcm10071530","journal-title":"J Clin Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.37349\/edd.2023.00034","article-title":"Deciphering the liver enigma: distinguishing drug-induced liver injury and metabolic dysfunction-associated steatotic liver disease\u2014a comprehensive narrative review","volume":"2","author":"Garc\u00eda-Cort\u00e9s M","year":"2023","unstructured":"Garc\u00eda-Cort\u00e9s M, Toro-Ortiz JP, Garc\u00eda-Garc\u00eda A. Deciphering the liver enigma: distinguishing drug-induced liver injury and metabolic dysfunction-associated steatotic liver disease\u2014a comprehensive narrative review. Explor Dig Dis. 2023, 2:318-36. 10.37349\/edd.2023.00034","journal-title":"Explor Dig Dis"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/404420-from-therapy-to-toxicity-a-rare-case-of-acute-piperacillintazobactam-associated-drug-induced-liver-injury","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T01:31:32Z","timestamp":1759109492000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/404420-from-therapy-to-toxicity-a-rare-case-of-acute-piperacillintazobactam-associated-drug-induced-liver-injury"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,28]]},"references-count":10,"URL":"https:\/\/doi.org\/10.7759\/cureus.93434","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,28]]}}}