{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:34:13Z","timestamp":1793446453676,"version":"4.5.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,28]]},"DOI":"10.7759\/cureus.93439","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T03:15:26Z","timestamp":1759115726000},"source":"Crossref","is-referenced-by-count":1,"title":["Characteristics of Secondary Malignancy Among Children With Primary Immunodeficiency Disorders in Saudi Arabia"],"prefix":"10.7759","author":[{"given":"Ali","family":"Alnakhli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Almanjomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Alrasheedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza A","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahla","family":"Mobarak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-018-0290-5","article-title":"Primary immunodeficiency","volume":"14","author":"McCusker C","year":"2018","unstructured":"McCusker C, Upton J, Warrington R. Primary immunodeficiency. Allergy Asthma Clin Immunol. 2018, 14:61. 10.1186\/s13223-018-0290-5","journal-title":"Allergy Asthma Clin Immunol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-022-01352-z","article-title":"The 2022 update of IUIS phenotypical classification for human inborn errors of immunity","volume":"42","author":"Bousfiha A","year":"2022","unstructured":"Bousfiha A, Moundir A, Tangye SG, et al.. The 2022 update of IUIS phenotypical classification for human inborn errors of immunity. J Clin Immunol. 2022, 42:1508-20. 10.1007\/s10875-022-01352-z","journal-title":"J Clin Immunol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-017-0465-8","article-title":"The 2017 IUIS phenotypic classification for primary immunodeficiencies","volume":"38","author":"Bousfiha A","year":"2018","unstructured":"Bousfiha A, Jeddane L, Picard C, et al.. The 2017 IUIS phenotypic classification for primary immunodeficiencies. J Clin Immunol. 2018, 38:129-43. 10.1007\/s10875-017-0465-8","journal-title":"J Clin Immunol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00678","article-title":"Primary immunodeficiency diseases in highly consanguineous populations from Middle East and North Africa: epidemiology, diagnosis, and care","volume":"8","author":"Al-Mousa H","year":"2017","unstructured":"Al-Mousa H, Al-Saud B. Primary immunodeficiency diseases in highly consanguineous populations from Middle East and North Africa: epidemiology, diagnosis, and care. Front Immunol. 2017, 8:678. 10.3389\/fimmu.2017.00678","journal-title":"Front Immunol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.86","article-title":"Primary immunodeficiency diseases","volume":"111","author":"Bonilla FA","year":"2003","unstructured":"Bonilla FA, Geha RS. Primary immunodeficiency diseases. J Allergy Clin Immunol. 2003, 111:S571-81. 10.1067\/mai.2003.86","journal-title":"J Allergy Clin Immunol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4971","article-title":"Neoantigens in cancer immunotherapy","volume":"348","author":"Schumacher TN","year":"2015","unstructured":"Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science. 2015, 348:69-74. 10.1126\/science.aaa4971","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.05.024","article-title":"Cancer in primary immunodeficiency diseases: cancer incidence in the United States Immune Deficiency Network Registry","volume":"141","author":"Mayor PC","year":"2018","unstructured":"Mayor PC, Eng KH, Singel KL, et al.. Cancer in primary immunodeficiency diseases: cancer incidence in the United States Immune Deficiency Network Registry. J Allergy Clin Immunol. 2018, 141:1028-35. 10.1016\/j.jaci.2017.05.024","journal-title":"J Allergy Clin Immunol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.06.009","article-title":"Intrinsic and extrinsic causes of malignancies in patients with primary immunodeficiency disorders","volume":"141","author":"Hauck F","year":"2018","unstructured":"Hauck F, Voss R, Urban C, Seidel MG. Intrinsic and extrinsic causes of malignancies in patients with primary immunodeficiency disorders. J Allergy Clin Immunol. 2018, 141:59-68.e4. 10.1016\/j.jaci.2017.06.009","journal-title":"J Allergy Clin Immunol"},{"key":"ref9","doi-asserted-by":"crossref","DOI":"10.2174\/1573396315666190917154058","article-title":"Primary immunodeficiency and cancer in children; a review of the literature","volume":"15","author":"Kebudi R","year":"2019","unstructured":"Kebudi R, Kiykim A, Sahin MK. Primary immunodeficiency and cancer in children; a review of the literature. Curr Pediatr Rev. 2019, 15:245-50.","journal-title":"Curr Pediatr Rev"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03619-2","article-title":"Primary immunodeficiencies and their associated risk of malignancies in children: an overview","volume":"179","author":"Renzi S","year":"2020","unstructured":"Renzi S, Langenberg-Ververgaert KP, Waespe N, et al.. Primary immunodeficiencies and their associated risk of malignancies in children: an overview. Eur J Pediatr. 2020, 179:689-97. 10.1007\/s00431-020-03619-2","journal-title":"Eur J Pediatr"},{"key":"ref11","article-title":"Primary immunodeficiency diseases and malignancy in Japan","volume":"77","author":"Hayakawa H","year":"1986","unstructured":"Hayakawa H, Kobayashi N, Yata J. Primary immunodeficiency diseases and malignancy in Japan. Jpn J Cancer Res. 1986, 77:74-9.","journal-title":"Jpn J Cancer Res"},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-3476(95)70491-4","article-title":"Cancer in children with primary or secondary immunodeficiencies","volume":"126","author":"Mueller BU","year":"1995","unstructured":"Mueller BU, Pizzo PA. Cancer in children with primary or secondary immunodeficiencies. J Pediatr. 1995, 126:1-10.","journal-title":"J Pediatr"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21903","article-title":"Malignancies in the setting of primary immunodeficiency: implications for hematologists\/oncologists","volume":"86","author":"Shapiro RS","year":"2011","unstructured":"Shapiro RS. Malignancies in the setting of primary immunodeficiency: implications for hematologists\/oncologists. Am J Hematol. 2011, 86:48-55. 10.1002\/ajh.21903","journal-title":"Am J Hematol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00232","article-title":"Primary immunodeficiencies and oncological risk: the experience of the Children's Hospital of Brescia","volume":"7","author":"Maffeis M","year":"2019","unstructured":"Maffeis M, Notarangelo LD, Schumacher RF, Soncini E, Soresina A, Lanfranchi A, Porta F. Primary immunodeficiencies and oncological risk: the experience of the Children's Hospital of Brescia. Front Pediatr. 2019, 7:232. 10.3389\/fped.2019.00232","journal-title":"Front Pediatr"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00777","article-title":"A systematic review on predisposition to lymphoid (B and T cell) neoplasias in patients with primary immunodeficiencies and immune dysregulatory disorders (inborn errors of immunity)","volume":"10","author":"Riaz IB","year":"2019","unstructured":"Riaz IB, Faridi W, Patnaik MM, Abraham RS. A systematic review on predisposition to lymphoid (B and T cell) neoplasias in patients with primary immunodeficiencies and immune dysregulatory disorders (inborn errors of immunity). Front Immunol. 2019, 10:777. 10.3389\/fimmu.2019.00777","journal-title":"Front Immunol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-015-0197-6","article-title":"Primary immunodeficiency diseases in Saudi Arabia: a tertiary care hospital experience over a period of three years (2010-2013)","volume":"35","author":"Al-Saud B","year":"2015","unstructured":"Al-Saud B, Al-Mousa H, Al Gazlan S, et al.. Primary immunodeficiency diseases in Saudi Arabia: a tertiary care hospital experience over a period of three years (2010-2013). J Clin Immunol. 2015, 35:651-60. 10.1007\/s10875-015-0197-6","journal-title":"J Clin Immunol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.11406\/rinketsu.59.2459","article-title":"Primary immunodeficiencies and hematological malignancies [Article in Japanese]","volume":"59","author":"Kanegane H","year":"2018","unstructured":"Kanegane H, Hoshino A, Takagi M. Primary immunodeficiencies and hematological malignancies [Article in Japanese]. Rinsho Ketsueki. 2018, 59:2459-67. 10.11406\/rinketsu.59.2459","journal-title":"Rinsho Ketsueki"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-2596488\/v1","article-title":"Sepsis and shock septic among patients with hematological malignancies: factors associated with mortality [PREPRINT]","author":"e Silva LL","year":"2023","unstructured":"e Silva LL, Ferreira DB, Goto JM, Becker OM, Tuma P, Medeiros EA. Sepsis and shock septic among patients with hematological malignancies: factors associated with mortality [PREPRINT]. Research Square. 2023, 10.21203\/rs.3.rs-2596488\/v1","journal-title":"Research Square"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000908668.01114.3e","article-title":"Mortality trend from sepsis in pediatric oncology patients 2016-2019","volume":"51","author":"Feroz S","year":"2023","unstructured":"Feroz S, Prout A. Mortality trend from sepsis in pediatric oncology patients 2016-2019. Crit Care Med. 2023, 51:357. 10.1097\/01.ccm.0000908668.01114.3e","journal-title":"Crit Care Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1676658","article-title":"Severe sepsis-associated morbidity and mortality among critically ill children with cancer","volume":"8","author":"Aljabari S","year":"2019","unstructured":"Aljabari S, Balch A, Larsen GY, Fluchel M, Workman JK. Severe sepsis-associated morbidity and mortality among critically ill children with cancer. J Pediatr Intensive Care. 2019, 8:122-9. 10.1055\/s-0038-1676658","journal-title":"J Pediatr Intensive Care"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/407264-characteristics-of-secondary-malignancy-among-children-with-primary-immunodeficiency-disorders-in-saudi-arabia","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T03:15:28Z","timestamp":1759115728000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/407264-characteristics-of-secondary-malignancy-among-children-with-primary-immunodeficiency-disorders-in-saudi-arabia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,28]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.93439","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,28]]}}}