{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:59:35Z","timestamp":1787032775818,"version":"build-2736575974"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,20]]},"DOI":"10.7759\/cureus.935","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T07:13:54Z","timestamp":1708672434000},"source":"Crossref","is-referenced-by-count":2,"title":["Stereotactic Body Radiotherapy for Inoperable Liver Tumors: Results of a Single Institutional Experience"],"prefix":"10.7759","author":[{"given":"Hussam","family":"Hijazi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre","family":"Campeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Roberge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Donath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Real","family":"Lapointe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Vandenbroucke-Menu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Taussky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Boudam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Bujold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guila","family":"Delouya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1007\/s10434-999-0651-x","article-title":"Nonoperative management of primary colorectal cancer in patients with stage IV disease","volume":"6","author":"Scoggins CR","year":"1999","unstructured":"Scoggins CR, Meszoely IM, Blanke CD, Beauchamp RD, Leach SD. Nonoperative management of primary colorectal cancer in patients with stage IV disease. Ann Surg Oncol. 1999, 6:651\u20137.","journal-title":"Ann Surg Oncol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92529-1","article-title":"Factors influencing the natural history of colorectal liver metastases","volume":"343","author":"Stangl R","year":"1994","unstructured":"Stangl R, Altendorf-Hofmann A, Charnley RM, Scheele J. Factors influencing the natural history of colorectal liver metastases. Lancet. 1994, 343:1405\u201310. 10.1016\/S0140-6736(94)92529-1","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20097","article-title":"The role and limitation of living donor liver transplantation for hepatocellular carcinoma","volume":"10","author":"Lo CM","year":"2004","unstructured":"Lo CM, Fan ST, Liu CL, Chan SC, Wong J. The role and limitation of living donor liver transplantation for hepatocellular carcinoma. Liver Transpl. 2004, 10:440\u20137. 10.1002\/lt.20097","journal-title":"Liver Transpl"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.0600","article-title":"Phase I study of individualized stereotactic body radiotherapy of liver metastases","volume":"27","author":"Lee MT","year":"2009","unstructured":"Lee MT, Kim JJ, Dinniwell R, Brierley J, Lockwood G, Wong R, Cummings B, Ringash J, Tse RV, Knox JJ, Dawson LA. Phase I study of individualized stereotactic body radiotherapy of liver metastases. J Clin Oncol. 2009, 27:1585\u201391. 10.1200\/JCO.2008.20.0600","journal-title":"J Clin Oncol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2241011262","article-title":"Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials","volume":"224","author":"Camma C","year":"2002","unstructured":"Camma C, Schepis F, Orlando A, Albanese M, Shahied L, Trevisani F, Andreone P, Craxi A, Cottone M. Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials. Radiology. 2002, 224:47\u201354. 10.1148\/radiol.2241011262","journal-title":"Radiology"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.1659","article-title":"Sequential phase I and II trials of stereotactic body radiotherapy for locally advanced hepatocellular carcinoma","volume":"31","author":"Bujold A","year":"2013","unstructured":"Bujold A, Massey CA, Kim JJ, Brierley J, Cho C, Wong RK, Dinniwell RE, Kassam Z, Ringash J, Cummings B, Sykes J, Sherman M, Knox JJ, Dawson LA. Sequential phase I and II trials of stereotactic body radiotherapy for locally advanced hepatocellular carcinoma. J Clin Oncol. 2013, 31:1631\u20139. 10.1200\/JCO.2012.44.1659","journal-title":"J Clin Oncol"},{"key":"ref7","unstructured":"NCCN Guidelines Version 1.2016 Hepatocellular Carcinoma. (2016). Accessed. June 19, 2016: http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/hepatobiliary.pdf."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.4675","article-title":"Emergence of stereotactic body radiation therapy and its impact on current and future clinical practice","volume":"32","author":"Timmerman RD","year":"2014","unstructured":"Timmerman RD, Herman J, Cho LC. Emergence of stereotactic body radiation therapy and its impact on current and future clinical practice. J Clin Oncol. 2014, 32:2847\u201354. 10.1200\/JCO.2014.55.4675","journal-title":"J Clin Oncol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/02841860600904854","article-title":"Phase II study on stereotactic body radiotherapy of colorectal metastases","volume":"45","author":"Hoyer M","year":"2006","unstructured":"Hoyer M, Roed H, Traberg Hansen A, Ohlhuis L, Petersen J, Nellemann H, Kiil Berthelsen A, Grau C, Aage Engelholm S, Von der Maase H. Phase II study on stereotactic body radiotherapy of colorectal metastases. Acta Oncol. 2006, 45:823\u201330. 10.1080\/02841860600904854","journal-title":"Acta Oncol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.08.012","article-title":"Univariate analysis of factors correlated with tumor control probability of three-dimensional conformal hypofractionated high-dose radiotherapy for small pulmonary or hepatic tumors","volume":"58","author":"Wada H","year":"2004","unstructured":"Wada H, Takai Y, Nemoto K, Yamada S. Univariate analysis of factors correlated with tumor control probability of three-dimensional conformal hypofractionated high-dose radiotherapy for small pulmonary or hepatic tumors. Int J Radiat Oncol Biol Phys. 2004, 58:1114\u201320. 10.1016\/j.ijrobp.2003.08.012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1186\/1748-717X-9-112","article-title":"Local effect of stereotactic body radiotherapy for primary and metastatic liver tumors in 130 Japanese patients","volume":"9","author":"Yamashita H","year":"2014","unstructured":"Yamashita H, Onishi H, Matsumoto Y, Murakami N, Matsuo Y, Nomiya T, Nakagawa K,\r\nJapanese Radiological Society multi-institutional, Sbrt study group. Local effect of stereotactic body radiotherapy for primary and metastatic liver tumors in 130 Japanese patients. Radiat Oncol. 2014, 9:112.","journal-title":"Radiat Oncol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rru130","article-title":"Survival outcomes after stereotactic body radiotherapy for 79 Japanese patients with hepatocellular carcinoma","volume":"56","author":"Yamashita H","year":"2015","unstructured":"Yamashita H, Onishi H, Murakami N, Matsumoto Y, Matsuo Y, Nomiya T, Nakagawa K,\r\nJapanese Radiological Society multi-institutional, Sbrt study group. Survival outcomes after stereotactic body radiotherapy for 79 Japanese patients with hepatocellular carcinoma. J Radiat Res. 2015, 56:561\u20137. 10.1093\/jrr\/rru130","journal-title":"J Radiat Res"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2015.01.032","article-title":"Stereotactic body radiotherapy for liver metastases","volume":"27","author":"Aitken KL","year":"2015","unstructured":"Aitken KL, Hawkins MA. Stereotactic body radiotherapy for liver metastases. Clin Oncol (R Coll Radiol), 2015. 2015, 27:307\u201315. 10.1016\/j.clon.2015.01.032","journal-title":"Clin Oncol (R Coll Radiol), 2015"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.862595","article-title":"Risk-adapted strategy partial liver irradiation for the treatment of large volume metastatic liver disease","volume":"53","author":"Aitken KL","year":"2014","unstructured":"Aitken KL, Tait DM, Nutting CM, Khabra K, Hawkins MA. Risk-adapted strategy partial liver irradiation for the treatment of large volume metastatic liver disease. Acta Oncol. 2014, 53:702\u20136. 10.3109\/0284186X.2013.862595","journal-title":"Acta Oncol"},{"key":"ref15","doi-asserted-by":"crossref","DOI":"10.1007\/s00432-014-1833-x","article-title":"Final results of a phase II trial for stereotactic body radiation therapy for patients with inoperable liver metastases from colorectal cancer","volume":"141","author":"Scorsetti M","year":"2015","unstructured":"Scorsetti M, Comito T, Tozzi A, Navarria P, Fogliata A, Clerici E, Mancosu P, Reggiori G, Rimassa L, Torzilli G, Tomatis S, Santoro A, Cozzi L. Final results of a phase II trial for stereotactic body radiation therapy for patients with inoperable liver metastases from colorectal cancer. J Cancer Res Clin Oncol. 2015, 141:543\u201353.","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.05.188","article-title":"Local control following stereotactic body radiotherapy for liver tumors: a preliminary report of the AAPM Working Group","volume":"90","author":"Ohri N","year":"2014","unstructured":"Ohri N, Jackson A, Mendez Romero A, Miften M, Ten Haken RK, Dawson LA, Grimm J, Yorke ED, Tome WA. Local control following stereotactic body radiotherapy for liver tumors: a preliminary report of the AAPM Working Group. Int J Radiat Oncol Biol Phys. 2014, 90:52. 10.1016\/j.ijrobp.2014.05.188","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.08.020","article-title":"Dose-escalation study of single-fraction stereotactic body radiotherapy for liver malignancies","volume":"78","author":"Goodman KA","year":"2010","unstructured":"Goodman KA, Wiegner EA, Maturen KE, Zhang Z, Mo Q, Yang G, Gibbs IC, Fisher GA, \r\nKoong AC. Dose-escalation study of single-fraction stereotactic body radiotherapy for liver malignancies. Int J Radiat Oncol Biol Phys. 2010, 78:486\u201393. 10.1016\/j.ijrobp.2009.08.020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2078-6891.2014.039","article-title":"Stereotactic body radiation therapy for liver metastases","volume":"5","author":"Scorsetti M","year":"2014","unstructured":"Scorsetti M, Clerici E, Comito T. Stereotactic body radiation therapy for liver metastases. J Gastrointest Oncol. 2014, 5:190\u20137. 10.3978\/j.issn.2078-6891.2014.039","journal-title":"J Gastrointest Oncol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyi236","article-title":"Fractionated stereotactic radiotherapy in patients with primary hepatocellular carcinoma","volume":"36","author":"Choi BO","year":"2006","unstructured":"Choi BO, Jang HS, Kang KM, Lee SW, Kang YN, Chai GY, Choi IB. Fractionated stereotactic radiotherapy in patients with primary hepatocellular carcinoma. Jpn J Clin Oncol. 2006, 36:154\u20138. 10.1093\/jjco\/hyi236","journal-title":"Jpn J Clin Oncol"},{"key":"ref20","doi-asserted-by":"crossref","DOI":"10.1177\/153303461000900506","article-title":"Stereotactic radiotherapy of hepatocellular carcinoma: preliminary results","volume":"9","author":"Louis C","year":"2010","unstructured":"Louis C, Dewas S, Mirabel X, Lacornerie T, Adenis A, Bonodeau F, Lartigau E. Stereotactic radiotherapy of hepatocellular carcinoma: preliminary results. Technol Cancer Res Treat. 2010, 9:479\u201387.","journal-title":"Technol Cancer Res Treat"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063864","article-title":"Effectiveness of stereotactic body radiotherapy for hepatocellular carcinoma with portal vein and\/or inferior vena cava tumor thrombosis","volume":"8","author":"Xi M","year":"2013","unstructured":"Xi M, Zhang L, Zhao L, Li QQ, Guo SP, Feng ZZ, Deng XW, Huang XY, Liu MZ. Effectiveness of stereotactic body radiotherapy for hepatocellular carcinoma with portal vein and\/or inferior vena cava tumor thrombosis. PLoS One. 2013, 8:63864. 10.1371\/journal.pone.0063864","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.11.058","article-title":"Stereotactic body radiation therapy in recurrent hepatocellular carcinoma","volume":"84","author":"Huang WY","year":"2012","unstructured":"Huang WY, Jen YM, Lee MS, Chang LP, Chen CM, Ko KH, Lin KT, Lin JC, Chao HL, Lin CS, Su YF, Fan CY, Chang YW. Stereotactic body radiation therapy in recurrent hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 2012, 84:355\u201361. 10.1016\/j.ijrobp.2011.11.058","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.3529","article-title":"Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma","volume":"26","author":"Tse RV","year":"2008","unstructured":"Tse RV, Hawkins M, Lockwood G, Kim JJ, Cummings B, Knox J, Sherman M, Dawson LA. Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. J Clin Oncol. 2008, 26:657\u201364. 10.1200\/JCO.2007.14.3529","journal-title":"J Clin Oncol"},{"key":"ref24","doi-asserted-by":"crossref","DOI":"10.4254\/wjh.v7.i9.1184","article-title":"Intermediate hepatocellular carcinoma: how to choose the best treatment modality?","volume":"7","author":"Di Costanzo GG","year":"2015","unstructured":"Di Costanzo GG, Tortora R. Intermediate hepatocellular carcinoma: how to choose the best treatment modality?. World J Hepatol. 2015, 7:1184\u201391.","journal-title":"World J Hepatol"},{"key":"ref25","doi-asserted-by":"crossref","DOI":"10.1007\/s12032-015-0532-z","article-title":"Long-term outcomes and prognostic analysis of radiofrequency ablation for small hepatocellular carcinoma: 10-year follow-up in Chinese patients","volume":"32","author":"Zhang L","year":"2015","unstructured":"Zhang L, Ge NL, Chen Y, Xie XY, Yin X, Gan YH, Zhang BH, Zhang JB, Chen RX, Wang YH, Ye SL, Ren ZG. Long-term outcomes and prognostic analysis of radiofrequency ablation for small hepatocellular carcinoma: 10-year follow-up in Chinese patients. Med Oncol. 2015, 32:77.","journal-title":"Med Oncol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.9936","article-title":"Radiofrequency ablation with or without transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma: a prospective randomized trial","volume":"31","author":"Peng ZW","year":"2013","unstructured":"Peng ZW, Zhang YJ, Chen MS, Xu L, Liang HH, Lin XJ, Guo RP, Zhang YQ, Lau WY. Radiofrequency ablation with or without transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma: a prospective randomized trial. J Clin Oncol. 2013, 31:426\u201332. 10.1200\/JCO.2012.42.9936","journal-title":"J Clin Oncol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12331","article-title":"Adjuvant stereotactic body radiotherapy following transarterial chemoembolization in patients with non-resectable hepatocellular carcinoma tumours of >\/= 3 cm","volume":"17","author":"Jacob R","year":"2015","unstructured":"Jacob R, Turley F, Redden DT, Saddekni S, Aal AK, Keene K, Yang E, Zarzour J, Bolus D, Smith JK, Gray S, White J, Eckhoff DE, DuBay DA. Adjuvant stereotactic body radiotherapy following transarterial chemoembolization in patients with non-resectable hepatocellular carcinoma tumours of >\/= 3 cm. HPB Oxford. 2015, 17:140\u20139. 10.1111\/hpb.12331","journal-title":"HPB Oxford"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23439","article-title":"Long-term outcomes of stereotactic body radiation therapy in the treatment of hepatocellular cancer as a bridge to transplantation","volume":"18","author":"O'Connor JK","year":"2012","unstructured":"O'Connor JK, Trotter J, Davis GL, Dempster J, Klintmalm GB, Goldstein RM. Long-term outcomes of stereotactic body radiation therapy in the treatment of hepatocellular cancer as a bridge to transplantation. Liver Transpl. 2012, 18:949\u201354. 10.1002\/lt.23439","journal-title":"Liver Transpl"},{"key":"ref29","article-title":"Stereotactic radiotherapy of the liver: a bridge to transplantation stereotactic radiotherapy of the liver: a bridge to transplantation","volume":"8","author":"Al Hamad  AA","year":"2009","unstructured":"Al Hamad  AA, Hassanain M, Michel RP, Metrakos P, Roberge D. Stereotactic radiotherapy of the liver: a bridge to transplantation stereotactic radiotherapy of the liver: a bridge to transplantation. Technol Cancer Res Treat. 2009, 8:401\u20135.","journal-title":"Technol Cancer Res Treat"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/4547-stereotactic-body-radiotherapy-for-inoperable-liver-tumors-results-of-a-single-institutional-experience","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T07:14:03Z","timestamp":1708672443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/4547-stereotactic-body-radiotherapy-for-inoperable-liver-tumors-results-of-a-single-institutional-experience"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,20]]},"references-count":29,"URL":"https:\/\/doi.org\/10.7759\/cureus.935","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12,20]]}}}