{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:42:34Z","timestamp":1780638154997,"version":"3.54.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,6]]},"DOI":"10.7759\/cureus.93913","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T08:19:41Z","timestamp":1759738781000},"source":"Crossref","is-referenced-by-count":1,"title":["Investigating the Dosimetric Impact of Acuros XB in Lung Cases Before Clinical Implementation"],"prefix":"10.7759","author":[{"given":"Marina","family":"Chalkia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Patatoukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tsimpoukelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Kollaros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Eleni","family":"Zachou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrosyni","family":"Kypraiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Kouloulias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalliopi","family":"Platoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-8-149","article-title":"Dosimetric accuracy and clinical quality of Acuros XB and AAA dose calculation algorithm for stereotactic and conventional lung volumetric modulated arc therapy plans","volume":"8","author":"Kroon PS","year":"2013","unstructured":"Kroon PS, Hol S, Essers M. Dosimetric accuracy and clinical quality of Acuros XB and AAA dose calculation algorithm for stereotactic and conventional lung volumetric modulated arc therapy plans. Radiat Oncol. 2013, 8:149. 10.1186\/1748-717X-8-149","journal-title":"Radiat Oncol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.10.078","article-title":"Critical appraisal of Acuros XB and Anisotropic Analytic Algorithm dose calculation in advanced non-small-cell lung cancer treatments","volume":"83","author":"Fogliata A","year":"2012","unstructured":"Fogliata A, Nicolini G, Clivio A, Vanetti E, Cozzi L. Critical appraisal of Acuros XB and Anisotropic Analytic Algorithm dose calculation in advanced non-small-cell lung cancer treatments. Int J Radiat Oncol Biol Phys. 2012, 83:1587-95. 10.1016\/j.ijrobp.2011.10.078","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.12426","article-title":"Dosimetric comparison of pencil beam and Monte Carlo algorithms in conformal lung radiotherapy","volume":"19","author":"Elcim Y","year":"2018","unstructured":"Elcim Y, Dirican B, Yavas O. Dosimetric comparison of pencil beam and Monte Carlo algorithms in conformal lung radiotherapy. J Appl Clin Med Phys. 2018, 19:616-24. 10.1002\/acm2.12426","journal-title":"J Appl Clin Med Phys"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.3635","article-title":"Cancer and radiation therapy: current advances and future directions","volume":"9","author":"Baskar R","year":"2012","unstructured":"Baskar R, Lee KA, Yeo R, Yeoh KW. Cancer and radiation therapy: current advances and future directions. Int J Med Sci. 2012, 9:193-9. 10.7150\/ijms.3635","journal-title":"Int J Med Sci"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-022-00355-7","article-title":"The key to immunotherapy: how to choose better therapeutic biomarkers for patients with non-small cell lung cancer","volume":"10","author":"Pan Y","year":"2022","unstructured":"Pan Y, Fu Y, Zeng Y, et al.. The key to immunotherapy: how to choose better therapeutic biomarkers for patients with non-small cell lung cancer. Biomark Res. 2022, 10:9. 10.1186\/s40364-022-00355-7","journal-title":"Biomark Res"},{"key":"ref6","article-title":"Monte Carlo Treatment Planning: An Introduction. Report 16 of the Netherlands Commission on Radiation Dosimetry (NCS)","author":"Reynaert N","year":"2006","unstructured":"Reynaert N, van der Marck S, Schaart D, et al.. Monte Carlo Treatment Planning: An Introduction. Report 16 of the Netherlands Commission on Radiation Dosimetry (NCS). Netherlands Commission on Radiation Dosimetry, Delft, the Netherlands; 2006."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1118\/1.2358333","article-title":"Testing of the analytical anisotropic algorithm for photon dose calculation","volume":"33","author":"Van Esch A","year":"2006","unstructured":"Van Esch A, Tillikainen L, Pyykkonen J, et al.. Testing of the analytical anisotropic algorithm for photon dose calculation. Med Phys. 2006, 33:4130-48. 10.1118\/1.2358333","journal-title":"Med Phys"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1259\/bjro.20210041","article-title":"The effect on tumour control probability of using AXB algorithm in replacement of AAA for SBRT of hepatocellular carcinoma located at lung-liver boundary region","volume":"3","author":"Cheung ML","year":"2021","unstructured":"Cheung ML, Kan MW, Yeung VT, Poon DM, Kam MK, Lee LK, Chan AT. The effect on tumour control probability of using AXB algorithm in replacement of AAA for SBRT of hepatocellular carcinoma located at lung-liver boundary region. BJR Open. 2021, 3:20210041. 10.1259\/bjro.20210041","journal-title":"BJR Open"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/51\/6\/004","article-title":"Dosimetric validation of the anisotropic analytical algorithm for photon dose calculation: fundamental characterization in water","volume":"51","author":"Fogliata A","year":"2006","unstructured":"Fogliata A, Nicolini G, Vanetti E, Clivio A, Cozzi L. Dosimetric validation of the anisotropic analytical algorithm for photon dose calculation: fundamental characterization in water. Phys Med Biol. 2006, 51:1421-38. 10.1088\/0031-9155\/51\/6\/004","journal-title":"Phys Med Biol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/56\/6\/022","article-title":"Dosimetric validation of the Acuros XB Advanced Dose Calculation algorithm: fundamental characterization in water","volume":"56","author":"Fogliata A","year":"2011","unstructured":"Fogliata A, Nicolini G, Clivio A, Vanetti E, Mancosu P, Cozzi L. Dosimetric validation of the Acuros XB Advanced Dose Calculation algorithm: fundamental characterization in water. Phys Med Biol. 2011, 56:1879-904. 10.1088\/0031-9155\/56\/6\/022","journal-title":"Phys Med Biol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/55\/3\/002","article-title":"Validation of a new grid-based Boltzmann equation solver for dose calculation in radiotherapy with photon beams","volume":"55","author":"Vassiliev ON","year":"2010","unstructured":"Vassiliev ON, Wareing TA, McGhee J, Failla G, Salehpour MR, Mourtada F. Validation of a new grid-based Boltzmann equation solver for dose calculation in radiotherapy with photon beams. Phys Med Biol. 2010, 55:581-98. 10.1088\/0031-9155\/55\/3\/002","journal-title":"Phys Med Biol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.5603\/RPOR.a2021.0050","article-title":"A comparative analysis of Acuros XB and the analytical anisotropic algorithm for volumetric modulation arc therapy","volume":"26","author":"Srivastava RP","year":"2021","unstructured":"Srivastava RP, Basta K, De Gersem W, De Wagter C. A comparative analysis of Acuros XB and the analytical anisotropic algorithm for volumetric modulation arc therapy. Rep Pract Oncol Radiother. 2021, 26:481-8. 10.5603\/RPOR.a2021.0050","journal-title":"Rep Pract Oncol Radiother"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-015-0357-0","article-title":"Dose calculation of Acuros XB and Anisotropic Analytical Algorithm in lung stereotactic body radiotherapy treatment with flattening filter free beams and the potential role of calculation grid size","volume":"10","author":"Huang B","year":"2015","unstructured":"Huang B, Wu L, Lin P, Chen C. Dose calculation of Acuros XB and Anisotropic Analytical Algorithm in lung stereotactic body radiotherapy treatment with flattening filter free beams and the potential role of calculation grid size. Radiat Oncol. 2015, 10:53. 10.1186\/s13014-015-0357-0","journal-title":"Radiat Oncol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.meddos.2009.01.003","article-title":"Factors influencing conformity index in radiotherapy for non-small cell lung cancer","volume":"35","author":"Brennan SM","year":"2010","unstructured":"Brennan SM, Thirion P, Buckney S, Shea CO, Armstrong J. Factors influencing conformity index in radiotherapy for non-small cell lung cancer. Med Dosim. 2010, 35:38-42. 10.1016\/j.meddos.2009.01.003","journal-title":"Med Dosim"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/jicru_os32.1.52","article-title":"ICRU Report 62: Prescribing, Recording and Reporting Photon Beam Therapy (Supplement to ICRU Report 50)","volume":"32","author":"Landberg T","year":"1999","unstructured":"Landberg T, Chavaudra J, Dobbs J, et al.. ICRU Report 62: Prescribing, Recording and Reporting Photon Beam Therapy (Supplement to ICRU Report 50). J ICRU. 1999, 32:10.1093\/jicru_os32.1.52","journal-title":"J ICRU"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71207-0","article-title":"Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study","volume":"16","author":"Bradley JD","year":"2015","unstructured":"Bradley JD, Paulus R, Komaki R, et al.. Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. Lancet Oncol. 2015, 16:187-99. 10.1016\/S1470-2045(14)71207-0","journal-title":"Lancet Oncol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4103\/0971-6203.103606","article-title":"Homogeneity Index: an objective tool for assessment of conformal radiation treatments","volume":"37","author":"Kataria T","year":"2012","unstructured":"Kataria T, Sharma K, Subramani V, Karrthick KP, Bisht SS. Homogeneity Index: an objective tool for assessment of conformal radiation treatments. J Med Phys. 2012, 37:207-13. 10.4103\/0971-6203.103606","journal-title":"J Med Phys"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.03.010","article-title":"Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas: II--clinical results","volume":"60","author":"Lauve A","year":"2004","unstructured":"Lauve A, Morris M, Schmidt-Ullrich R, et al.. Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas: II--clinical results. Int J Radiat Oncol Biol Phys. 2004, 60:374-87. 10.1016\/j.ijrobp.2004.03.010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/jicru_os13.1.iii","article-title":"Preface Reports of the International Commission on Radiation Units and Measurements","volume":"13","author":"Wyckoff HO","year":"1976","unstructured":"Wyckoff HO. Preface Reports of the International Commission on Radiation Units and Measurements. J ICRU. 1976, 13:iii-v. 10.1093\/jicru_os13.1.iii","journal-title":"J ICRU"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1118\/1.4802216","article-title":"Dosimetric impact of Acuros XB deterministic radiation transport algorithm for heterogeneous dose calculation in lung cancer","volume":"40","author":"Han T","year":"2013","unstructured":"Han T, Followill D, Mikell J, et al.. Dosimetric impact of Acuros XB deterministic radiation transport algorithm for heterogeneous dose calculation in lung cancer. Med Phys. 2013, 40:051710. 10.1118\/1.4802216","journal-title":"Med Phys"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1118\/1.3567146","article-title":"Dosimetric validation of Acuros XB with Monte Carlo methods for photon dose calculations","volume":"38","author":"Bush K","year":"2011","unstructured":"Bush K, Gagne IM, Zavgorodni S, Ansbacher W, Beckham W. Dosimetric validation of Acuros XB with Monte Carlo methods for photon dose calculations. Med Phys. 2011, 38:2208-21. 10.1118\/1.3567146","journal-title":"Med Phys"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2020.11.030","article-title":"The influence of Acuros XB on dose volume histogram metrics and tumour control probability modelling in locally advanced non-small cell lung cancer","volume":"81","author":"Fleming C","year":"2021","unstructured":"Fleming C, O'Keeffe S, McDermott R, Dunne M, McClean B, Le\u00f3n Vintr\u00f3 L. The influence of Acuros XB on dose volume histogram metrics and tumour control probability modelling in locally advanced non-small cell lung cancer. Phys Med. 2021, 81:295-301. 10.1016\/j.ejmp.2020.11.030","journal-title":"Phys Med"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.14051","article-title":"Dosimetric comparison and evaluation of two computational algorithms in VMAT treatment plans","volume":"24","author":"Tsimpoukelli M","year":"2023","unstructured":"Tsimpoukelli M, Patatoukas G, Chalkia M, et al.. Dosimetric comparison and evaluation of two computational algorithms in VMAT treatment plans. J Appl Clin Med Phys. 2023, 24:e14051. 10.1002\/acm2.14051","journal-title":"J Appl Clin Med Phys"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.08.059","article-title":"Cone-beam computed tomographic image guidance for lung cancer radiation therapy","volume":"73","author":"Bissonnette JP","year":"2009","unstructured":"Bissonnette JP, Purdie TG, Higgins JA, Li W, Bezjak A. Cone-beam computed tomographic image guidance for lung cancer radiation therapy. Int J Radiat Oncol Biol Phys. 2009, 73:927-34. 10.1016\/j.ijrobp.2008.08.059","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.02.023","article-title":"ESTRO ACROP guidelines for target volume definition in the treatment of locally advanced non-small cell lung cancer","volume":"127","author":"Nestle U","year":"2018","unstructured":"Nestle U, De Ruysscher D, Ricardi U, et al.. ESTRO ACROP guidelines for target volume definition in the treatment of locally advanced non-small cell lung cancer. Radiother Oncol. 2018, 127:1-5. 10.1016\/j.radonc.2018.02.023","journal-title":"Radiother Oncol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/388092-investigating-the-dosimetric-impact-of-acuros-xb-in-lung-cases-before-clinical-implementation","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T08:19:42Z","timestamp":1759738782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/388092-investigating-the-dosimetric-impact-of-acuros-xb-in-lung-cases-before-clinical-implementation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.93913","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,6]]}}}