{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:12:24Z","timestamp":1760001144187,"version":"build-2065373602"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,9]]},"DOI":"10.7759\/cureus.94173","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:46:04Z","timestamp":1759999564000},"source":"Crossref","is-referenced-by-count":0,"title":["Liver Maximum Capacity (LiMAx) Test Is a Promising Tool to Predict Fibrosis and Cirrhosis in Chronic Liver Disease: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Anushri","family":"Joshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eashan","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61838-9","article-title":"Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis","volume":"384","author":"Williams R","year":"2014","unstructured":"Williams R, Aspinall R, Bellis M, et al.. Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis. Lancet. 2014, 384:1953-97. 10.1016\/S0140-6736(14)61838-9","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310633","article-title":"Chronic liver disease: latest research in pathogenesis, detection and treatment","volume":"24","author":"De Siervi S","year":"2023","unstructured":"De Siervi S, Cannito S, Turato C. Chronic liver disease: latest research in pathogenesis, detection and treatment. Int J Mol Sci. 2023, 24:10633. 10.3390\/ijms241310633","journal-title":"Int J Mol Sci"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-019-00345-1","article-title":"Nonalcoholic fatty liver disease and obesity treatment","volume":"8","author":"Brunner KT","year":"2019","unstructured":"Brunner KT, Henneberg CJ, Wilechansky RM, Long MT. Nonalcoholic fatty liver disease and obesity treatment. Curr Obes Rep. 2019, 8:220-8. 10.1007\/s13679-019-00345-1","journal-title":"Curr Obes Rep"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i23.3682","article-title":"Non invasive fibrosis biomarkers reduce but not substitute the need for liver biopsy","volume":"12","author":"Sebastiani G","year":"2006","unstructured":"Sebastiani G, Alberti A. Non invasive fibrosis biomarkers reduce but not substitute the need for liver biopsy. World J Gastroenterol. 2006, 12:3682-94. 10.3748\/wjg.v12.i23.3682","journal-title":"World J Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i17.2069","article-title":"Prediction of liver cirrhosis, using diagnostic imaging tools","volume":"7","author":"Yeom SK","year":"2015","unstructured":"Yeom SK, Lee CH, Cha SH, Park CM. Prediction of liver cirrhosis, using diagnostic imaging tools. World J Hepatol. 2015, 7:2069-79. 10.4254\/wjh.v7.i17.2069","journal-title":"World J Hepatol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000480385","article-title":"Current modalities for the assessment of future remnant liver function","volume":"33","author":"Rassam F","year":"2017","unstructured":"Rassam F, Olthof PB, Bennink RJ, van Gulik TM. Current modalities for the assessment of future remnant liver function. Visc Med. 2017, 33:442-8. 10.1159\/000480385","journal-title":"Visc Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002877","article-title":"Child-Pugh versus MELD score for the assessment of prognosis in liver cirrhosis: a systematic review and meta-analysis of observational studies","volume":"95","author":"Peng Y","year":"2016","unstructured":"Peng Y, Qi X, Guo X. Child-Pugh versus MELD score for the assessment of prognosis in liver cirrhosis: a systematic review and meta-analysis of observational studies. Medicine (Baltimore). 2016, 95:e2877. 10.1097\/MD.0000000000002877","journal-title":"Medicine (Baltimore)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2012.11.002","article-title":"Model for end-stage liver disease","volume":"3","author":"Singal AK","year":"2013","unstructured":"Singal AK, Kamath PS. Model for end-stage liver disease. J Clin Exp Hepatol. 2013, 3:50-60. 10.1016\/j.jceh.2012.11.002","journal-title":"J Clin Exp Hepatol"},{"key":"ref9","unstructured":"Humedics. About LiMAx. https.\/\/www.humedics.eu\/en\/about-limax.html."},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12424","article-title":"Reductions in post-hepatectomy liver failure and related mortality after implementation of the LiMAx algorithm in preoperative work-up: a single-centre analysis of 1170 hepatectomies of one or more segments","volume":"17","author":"Jara M","year":"2015","unstructured":"Jara M, Reese T, Malinowski M, et al.. Reductions in post-hepatectomy liver failure and related mortality after implementation of the LiMAx algorithm in preoperative work-up: a single-centre analysis of 1170 hepatectomies of one or more segments. HPB (Oxford). 2015, 17:651-8. 10.1111\/hpb.12424","journal-title":"HPB (Oxford)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06535-5","article-title":"Volume-function analysis (LiMAx Test) in patients with HCC and cirrhosis undergoing TACE - a feasibility study","volume":"66","author":"Reichert MC","year":"2021","unstructured":"Reichert MC, Massmann A, Schulz A, Buecker A, Glanemann M, Lammert F, Malinowski M. Volume-function analysis (LiMAx Test) in patients with HCC and cirrhosis undergoing TACE - a feasibility study. Dig Dis Sci. 2021, 66:2452-60. 10.1007\/s10620-020-06535-5","journal-title":"Dig Dis Sci"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2019.10.778","article-title":"Preoperative evaluation of liver function in patients with hepatocellular carcinoma using the LiMAx Test","volume":"21","author":"Anger F","year":"2019","unstructured":"Anger F, Sperl D, Singh G, et al.. Preoperative evaluation of liver function in patients with hepatocellular carcinoma using the LiMAx Test. HPB. 2019, 21:S808. 10.1016\/j.hpb.2019.10.778","journal-title":"HPB"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2018.11.012","article-title":"The predictive value of future liver remnant function after liver resection for HCC in noncirrhotic and cirrhotic patients","volume":"21","author":"Bl\u00fcthner E","year":"2019","unstructured":"Bl\u00fcthner E, Jara M, Shrestha R, Faber W, Pratschke J, Stockmann M, Malinowski M. The predictive value of future liver remnant function after liver resection for HCC in noncirrhotic and cirrhotic patients. HPB (Oxford). 2019, 21:912-22. 10.1016\/j.hpb.2018.11.012","journal-title":"HPB (Oxford)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2009.00151.x","article-title":"The LiMAx test: a new liver function test for predicting postoperative outcome in liver surgery","volume":"12","author":"Stockmann M","year":"2010","unstructured":"Stockmann M, Lock JF, Malinowski M, Niehues SM, Seehofer D, Neuhaus P. The LiMAx test: a new liver function test for predicting postoperative outcome in liver surgery. HPB (Oxford). 2010, 12:139-46. 10.1111\/j.1477-2574.2009.00151.x","journal-title":"HPB (Oxford)"},{"key":"ref15","unstructured":"Excellence NIfHaC. LiMAx system for assessing the functional capacity of the liver. NICE. (2019). https.\/\/www.nice.org.uk\/advice\/mib168\/chapter\/Summary."},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting PF","year":"2011","unstructured":"Whiting PF, Rutjes AW, Westwood ME, et al.. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 2011, 155:529-36. 10.7326\/0003-4819-155-8-201110180-00009","journal-title":"Ann Intern Med"},{"key":"ref17","unstructured":"Review Manager (RevMan). 5The Cochrane Collaboration. (2020). https.\/\/www.cochrane.org\/authors\/handbooks-and-manuals\/style-manual\/references\/reference-types\/software#revman."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747","article-title":"The meaning and use of the area under a receiver operating characteristic (ROC) curve","volume":"143","author":"Hanley JA","year":"1982","unstructured":"Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982, 143:29-36. 10.1148\/radiology.143.1.7063747","journal-title":"Radiology"},{"key":"ref19","article-title":"Effect sizes based on correlations","unstructured":"Effect sizes based on correlations. Introduction to Meta-analysis. Borenstein M, Hedges LV, Higgins JPT, Rothstein HR (ed). John Wiley & Sons, Chichester, UK; 41-3."},{"key":"ref20","article-title":"Chapter 10: Analysing data and undertaking meta-analyses","author":"Deeks J","unstructured":"Deeks J, Higgins J, Altman D, et al.. Chapter 10: Analysing data and undertaking meta-analyses. Cochrane Handbook for Systematic Reviews of Interventions. 41-3."},{"key":"ref21","unstructured":"Corporation M. (Microsoft Excel. Microsoft Corporation). https.\/\/www.microsoft.com\/en-gb\/microsoft-365\/excel."},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5360-5","article-title":"Prospective assessment of liver function by an enzymatic liver function test to estimate short-term survival in patients with liver cirrhosis","volume":"64","author":"Jara M","year":"2019","unstructured":"Jara M, Dziodzio T, Malinowski M, et al.. Prospective assessment of liver function by an enzymatic liver function test to estimate short-term survival in patients with liver cirrhosis. Dig Dis Sci. 2019, 64:576-84. 10.1007\/s10620-018-5360-5","journal-title":"Dig Dis Sci"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01407-8","article-title":"Validation of a new prognostic model to predict short and medium-term survival in patients with liver cirrhosis","volume":"20","author":"Dziodzio T","year":"2020","unstructured":"Dziodzio T, \u00d6llinger R, Sch\u00f6ning W, et al.. Validation of a new prognostic model to predict short and medium-term survival in patients with liver cirrhosis. BMC Gastroenterol. 2020, 20:265. 10.1186\/s12876-020-01407-8","journal-title":"BMC Gastroenterol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49746-1","article-title":"Enzymatic liver function measured by LiMAx - a reliable diagnostic and prognostic tool in chronic liver disease","volume":"9","author":"Buechter M","year":"2019","unstructured":"Buechter M, Kersting S, Gerken G, Kahraman A. Enzymatic liver function measured by LiMAx - a reliable diagnostic and prognostic tool in chronic liver disease. Sci Rep. 2019, 9:13577. 10.1038\/s41598-019-49746-1","journal-title":"Sci Rep"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000493573","article-title":"Liver maximum capacity: a novel test to accurately diagnose different stages of liver fibrosis","volume":"100","author":"Buechter M","year":"2019","unstructured":"Buechter M, Thimm J, Baba HA, Bertram S, Willuweit K, Gerken G, Kahraman A. Liver maximum capacity: a novel test to accurately diagnose different stages of liver fibrosis. Digestion. 2019, 100:45-54. 10.1159\/000493573","journal-title":"Digestion"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01400-1","article-title":"Evaluation of NAFLD and fibrosis in obese patients - a comparison of histological and clinical scoring systems","volume":"20","author":"Schmitz SM","year":"2020","unstructured":"Schmitz SM, Kroh A, Ulmer TF, et al.. Evaluation of NAFLD and fibrosis in obese patients - a comparison of histological and clinical scoring systems. BMC Gastroenterol. 2020, 20:254. 10.1186\/s12876-020-01400-1","journal-title":"BMC Gastroenterol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3250-z","article-title":"Enzymatic liver function capacity correlates with disease severity of patients with liver cirrhosis: a study with the LiMAx test","volume":"59","author":"Malinowski M","year":"2014","unstructured":"Malinowski M, Jara M, L\u00fcttgert K, Orr J, Lock JF, Schott E, Stockmann M. Enzymatic liver function capacity correlates with disease severity of patients with liver cirrhosis: a study with the LiMAx test. Dig Dis Sci. 2014, 59:2983-91. 10.1007\/s10620-014-3250-z","journal-title":"Dig Dis Sci"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4307462","article-title":"Noninvasive evaluation of liver function in morbidly obese patients","volume":"2019","author":"Alizai PH","year":"2019","unstructured":"Alizai PH, Lurje I, Kroh A, et al.. Noninvasive evaluation of liver function in morbidly obese patients. Gastroenterol Res Pract. 2019, 2019:4307462. 10.1155\/2019\/4307462","journal-title":"Gastroenterol Res Pract"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01374-X","article-title":"Liver cirrhosis","volume":"398","author":"Gin\u00e8s P","year":"2021","unstructured":"Gin\u00e8s P, Krag A, Abraldes JG, Sol\u00e0 E, Fabrellas N, Kamath PS. Liver cirrhosis. Lancet. 2021, 398:1359-76. 10.1016\/S0140-6736(21)01374-X","journal-title":"Lancet"},{"key":"ref30","article-title":"Starting a review","author":"Higgins J","year":"2022","unstructured":"Higgins J, Thomas J, Chandler J, Cumpston M, Li T. Starting a review. Cochrane Handbook for Systematic Reviews of Interventions Cochrane Training. 2022. 41-3."}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/405160-liver-maximum-capacity-limax-test-is-a-promising-tool-to-predict-fibrosis-and-cirrhosis-in-chronic-liver-disease-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:46:09Z","timestamp":1759999569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/405160-liver-maximum-capacity-limax-test-is-a-promising-tool-to-predict-fibrosis-and-cirrhosis-in-chronic-liver-disease-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.94173","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,9]]}}}