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J Neurol Neurosurg Psychiatry. 1999, 66:137-47. 10.1136\/jnnp.66.2.137","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1110","article-title":"Dehydroepiandrosterone administration counteracts oxidative imbalance and advanced glycation end product formation in type 2 diabetic patients","volume":"30","author":"Brignardello E","year":"2007","unstructured":"Brignardello E, Runzo C, Aragno M, Catalano MG, Cassader M, Perin PC, Boccuzzi G. Dehydroepiandrosterone administration counteracts oxidative imbalance and advanced glycation end product formation in type 2 diabetic patients. Diabetes Care. 2007, 30:2922-7. 10.2337\/dc07-1110","journal-title":"Diabetes Care"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-0023-4","article-title":"Cognitive decline and dementia in diabetes\u2014systematic overview of prospective observational studies","volume":"48","author":"Cukierman T","year":"2005","unstructured":"Cukierman T, Gerstein HC, Williamson JD. Cognitive decline and dementia in diabetes\u2014systematic overview of prospective observational studies. Diabetologia. 2005, 48:2460-9. 10.1007\/s00125-005-0023-4","journal-title":"Diabetologia"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.106","article-title":"Stress and disorders of the stress system","volume":"5","author":"Chrousos GP","year":"2009","unstructured":"Chrousos GP. Stress and disorders of the stress system. Nat Rev Endocrinol. 2009, 5:374-81. 10.1038\/nrendo.2009.106","journal-title":"Nat Rev Endocrinol"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1683","article-title":"Stress and the brain: from adaptation to disease","volume":"6","author":"de Kloet ER","year":"2005","unstructured":"de Kloet ER, Jo\u00ebls M, Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci. 2005, 6:463-75. 10.1038\/nrn1683","journal-title":"Nat Rev Neurosci"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1324-0","article-title":"Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration: therapeutic potential?","volume":"15","author":"Powrie YS","year":"2018","unstructured":"Powrie YS, Smith C. Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration: therapeutic potential?. J Neuroinflammation. 2018, 15:289. 10.1186\/s12974-018-1324-0","journal-title":"J Neuroinflammation"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/s0278-2626(02)00519-5","article-title":"Cortisol and dehydroepiandosterone sulfate plasma levels and their relationship to aging, cognitive function, and dementia","volume":"50","author":"De Bruin V M","year":"2002","unstructured":"De Bruin V M, Vieira MC, Rocha M N, Viana G S. Cortisol and dehydroepiandosterone sulfate plasma levels and their relationship to aging, cognitive function, and dementia. Brain Cogn. 2002, 50:316-23. 10.1016\/s0278-2626(02)00519-5","journal-title":"Brain Cogn"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.892754","article-title":"Cerebrospinal fluid cortisol and dehydroepiandrosterone sulfate, Alzheimer's disease pathology, and cognitive decline","volume":"14","author":"Ouanes S","year":"2022","unstructured":"Ouanes S, Clark C, Richiardi J, et al.. Cerebrospinal fluid cortisol and dehydroepiandrosterone sulfate, Alzheimer's disease pathology, and cognitive decline. Front Aging Neurosci. 2022, 14:892754. 10.3389\/fnagi.2022.892754","journal-title":"Front Aging Neurosci"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1080\/03602530600569877","article-title":"The biological actions of dehydroepiandrosterone involves multiple receptors","volume":"38","author":"Webb SJ","year":"2006","unstructured":"Webb SJ, Geoghegan TE, Prough RA, Michael Miller KK. The biological actions of dehydroepiandrosterone involves multiple receptors. Drug Metab Rev. 2006, 38:89-116. 10.1080\/03602530600569877","journal-title":"Drug Metab Rev"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161278698","article-title":"Dehydroepiandrosterone sulfate and longevity: new clues for an old friend","volume":"98","author":"Yen SS","year":"2001","unstructured":"Yen SS. Dehydroepiandrosterone sulfate and longevity: new clues for an old friend. Proc Natl Acad Sci U S A. 2001, 98:8167-9. 10.1073\/pnas.161278698","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref62","article-title":"Adrenarche","author":"Loomba-Albrecht LA","year":"2019","unstructured":"Loomba-Albrecht LA, Styne DM. Adrenarche. Encyclopedia of Endocrine Diseases (Second Edition). 2019."},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2019.108507","article-title":"Pharmacological activities of dehydroepiandrosterone: a review","volume":"153","author":"Sahu P","year":"2020","unstructured":"Sahu P, Gidwani B, Dhongade HJ. Pharmacological activities of dehydroepiandrosterone: a review. 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