{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:53:57Z","timestamp":1782939237140,"version":"3.54.5"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,17]]},"DOI":"10.7759\/cureus.94826","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T01:50:25Z","timestamp":1760752225000},"source":"Crossref","is-referenced-by-count":1,"title":["Can Fractional Flow Reserve-Computed Tomography (FFR-CT) Overestimate the Severity of Coronary Stenoses in the Presence of High Calcium Burden?"],"prefix":"10.7759","author":[{"given":"Carly A","family":"Robinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Tso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lemuel","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmadreza","family":"Ghasemiesfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.11.005","article-title":"The global burden of cardiovascular diseases and risk: a compass for future health","volume":"80","author":"Vaduganathan M","year":"2022","unstructured":"Vaduganathan M, Mensah GA, Turco JV, Fuster V, Roth GA. The global burden of cardiovascular diseases and risk: a compass for future health. J Am Coll Cardiol. 2022, 80:2361-71. 10.1016\/j.jacc.2022.11.005","journal-title":"J Am Coll Cardiol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90282-t","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston A","year":"1990","unstructured":"Agatston A, Janowitz W, Hildner F, et al.. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990, 15:827-32. 10.1016\/0735-1097(90)90282-t","journal-title":"J Am Coll Cardiol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.043","article-title":"Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps)","volume":"63","author":"N\u00f8rgaard BL","year":"2014","unstructured":"N\u00f8rgaard BL, Leipsic J, Gaur S, et al.. Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). J Am Coll Cardiol. 2014, 63:1145-55. 10.1016\/j.jacc.2013.11.043","journal-title":"J Am Coll Cardiol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.07.013","article-title":"Impact of coronary artery calcium characteristics on accuracy of CT angiography","volume":"7","author":"Kruk M","year":"2014","unstructured":"Kruk M, Noll D, Achenbach S, et al.. Impact of coronary artery calcium characteristics on accuracy of CT angiography. JACC Cardiovasc Imaging. 2014, 7:49-58. 10.1016\/j.jcmg.2013.07.013","journal-title":"JACC Cardiovasc Imaging"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.12.031","article-title":"Diagnostic and prognostic value of absence of coronary artery calcification","volume":"2","author":"Sarwar A","year":"2009","unstructured":"Sarwar A, Shaw LJ, Shapiro MD, et al.. Diagnostic and prognostic value of absence of coronary artery calcification. JACC Cardiovasc Imaging. 2009, 2:675-88. 10.1016\/j.jcmg.2008.12.031","journal-title":"JACC Cardiovasc Imaging"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/14017430902785501","article-title":"Diagnostic value of cardiac 64-slice computed tomography: importance of coronary calcium","volume":"43","author":"Diederichsen AC","year":"2009","unstructured":"Diederichsen AC, Petersen H, Jensen LO, et al.. Diagnostic value of cardiac 64-slice computed tomography: importance of coronary calcium. Scand Cardiovasc J. 2009, 43:337-44. 10.1080\/14017430902785501","journal-title":"Scand Cardiovasc J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.06.027","article-title":"Influence of coronary calcium on diagnostic performance of machine learning CT-FFR: results from MACHINE registry","volume":"13","author":"Tesche C","year":"2020","unstructured":"Tesche C, Otani K, De Cecco CN, et al.. Influence of coronary calcium on diagnostic performance of machine learning CT-FFR: results from MACHINE registry. JACC Cardiovasc Imaging. 2020, 13:760-70. 10.1016\/j.jcmg.2019.06.027","journal-title":"JACC Cardiovasc Imaging"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjem.2018.04.004","article-title":"The HEART score: a guide to its application in the emergency department","volume":"18","author":"Brady W","year":"2018","unstructured":"Brady W, de Souza K. The HEART score: a guide to its application in the emergency department. Turk J Emerg Med. 2018, 18:47-51. 10.1016\/j.tjem.2018.04.004","journal-title":"Turk J Emerg Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.096","article-title":"Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation","volume":"55","author":"Tonino PA","year":"2010","unstructured":"Tonino PA, Fearon WF, De Bruyne B, et al.. Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation. J Am Coll Cardiol. 2010, 55:2816-21. 10.1016\/j.jacc.2009.11.096","journal-title":"J Am Coll Cardiol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.001","article-title":"ACCF\/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF\/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography) developed in collaboration with the Society of Atherosclerosis Imaging and Prevention and the Society of Cardiovascular Computed Tomography","volume":"49","author":"Greenland P","year":"2007","unstructured":"Greenland P, Bonow RO, Brundage BH, et al.. ACCF\/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF\/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography) developed in collaboration with the Society of Atherosclerosis Imaging and Prevention and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiol. 2007, 49:378-402. 10.1016\/j.jacc.2006.10.001","journal-title":"J Am Coll Cardiol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-019-01335-7","article-title":"Prognostic value of the coronary artery calcium score in suspected coronary artery disease: a\u00a0study of 644 symptomatic patients","volume":"28","author":"Rijlaarsdam-Hermsen D","year":"2020","unstructured":"Rijlaarsdam-Hermsen D, Lo-Kioeng-Shioe MS, Kuijpers D, van Domburg RT, Deckers JW, van Dijkman PR. Prognostic value of the coronary artery calcium score in suspected coronary artery disease: a\u00a0study of 644 symptomatic patients. Neth Heart J. 2020, 28:44-50. 10.1007\/s12471-019-01335-7","journal-title":"Neth Heart J"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-011-9902-6","article-title":"Influence of coronary calcification on the diagnostic accuracy of 64-slice computed tomography coronary angiography: a systematic review and meta-analysis","volume":"28","author":"Abdulla J","year":"2012","unstructured":"Abdulla J, Pedersen KS, Budoff M, Kofoed KF. Influence of coronary calcification on the diagnostic accuracy of 64-slice computed tomography coronary angiography: a systematic review and meta-analysis. Int J Cardiovasc Imaging. 2012, 28:943-53. 10.1007\/s10554-011-9902-6","journal-title":"Int J Cardiovasc Imaging"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.06.003","article-title":"Influence of coronary calcification on the diagnostic performance of CT angiography derived FFR in coronary artery disease: a substudy of the NXT trial","volume":"8","author":"N\u00f8rgaard BL","year":"2015","unstructured":"N\u00f8rgaard BL, Gaur S, Leipsic J, et al.. Influence of coronary calcification on the diagnostic performance of CT angiography derived FFR in coronary artery disease: a substudy of the NXT trial. JACC Cardiovasc Imaging. 2015, 8:1045-55. 10.1016\/j.jcmg.2015.06.003","journal-title":"JACC Cardiovasc Imaging"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1148\/rg.210097","article-title":"CT fractional flow reserve: a practical guide to application, interpretation, and problem solving","volume":"42","author":"Rajiah P","year":"2022","unstructured":"Rajiah P, Cummings KW, Williamson E, Young PM. CT fractional flow reserve: a practical guide to application, interpretation, and problem solving. Radiographics. 2022, 42:340-58. 10.1148\/rg.210097","journal-title":"Radiographics"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/302970-can-fractional-flow-reserve-computed-tomography-ffr-ct-overestimate-the-severity-of-coronary-stenoses-in-the-presence-of-high-calcium-burden","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T01:50:25Z","timestamp":1760752225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/302970-can-fractional-flow-reserve-computed-tomography-ffr-ct-overestimate-the-severity-of-coronary-stenoses-in-the-presence-of-high-calcium-burden"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":14,"URL":"https:\/\/doi.org\/10.7759\/cureus.94826","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,17]]}}}