{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T15:41:20Z","timestamp":1760802080346,"version":"build-2065373602"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,18]]},"DOI":"10.7759\/cureus.94868","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T15:01:56Z","timestamp":1760799716000},"source":"Crossref","is-referenced-by-count":0,"title":["Delayed Appendectomy Versus Early Intervention: A Systematic Review of Outcomes in Complicated Appendicitis"],"prefix":"10.7759","author":[{"given":"Nazim F","family":"Hamed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turki Dakhil","family":"Alofi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Yasir","family":"Alamori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Fahad","family":"Alkhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr3690","article-title":"To use or not to use opioid analgesia for acute abdominal pain before definitive surgical diagnosis? A systematic review and network meta-analysis","volume":"11","author":"Gavriilidis P","year":"2019","unstructured":"Gavriilidis P, de'Angelis N, Tobias A. To use or not to use opioid analgesia for acute abdominal pain before definitive surgical diagnosis? A systematic review and network meta-analysis. J Clin Med Res. 2019, 11:121-6. 10.14740\/jocmr3690","journal-title":"J Clin Med Res"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000544304.30954.40","article-title":"Complicated appendicitis and considerations for interval appendectomy","volume":"31","author":"Perez KS","year":"2018","unstructured":"Perez KS, Allen SR. Complicated appendicitis and considerations for interval appendectomy. JAAPA. 2018, 31:35-41. 10.1097\/01.JAA.0000544304.30954.40","journal-title":"JAAPA"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.8562","article-title":"Acute appendicitis review: Background, epidemiology, diagnosis, and treatment","volume":"12","author":"Krzyzak M","year":"2020","unstructured":"Krzyzak M, Mulrooney SM. Acute appendicitis review: Background, epidemiology, diagnosis, and treatment. Cureus. 2020, 12:e8562. 10.7759\/cureus.8562","journal-title":"Cureus"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5152\/UCD.2015.3031","article-title":"Risk factors for the development of complicated appendicitis in adults","volume":"32","author":"Naderan M","year":"2016","unstructured":"Naderan M, Babaki AE, Shoar S, Mahmoodzadeh H, Nasiri S, Khorgami Z. Risk factors for the development of complicated appendicitis in adults. Ulus Cerrahi Derg. 2016, 32:37-42. 10.5152\/UCD.2015.3031","journal-title":"Ulus Cerrahi Derg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5505\/tjtes.2018.80103","article-title":"Complicated appendicitis: Risk factors and outcomes of laparoscopic appendectomy - Polish laparoscopic appendectomy results from a multicenter, large-cohort study","volume":"25","author":"Pedziwiatr M","year":"2019","unstructured":"Pedziwiatr M, Lasek A, Wysocki M, et al.. Complicated appendicitis: Risk factors and outcomes of laparoscopic appendectomy - Polish laparoscopic appendectomy results from a multicenter, large-cohort study. Ulus Travma Acil Cerrahi Derg. 2019, 25:129-36. 10.5505\/tjtes.2018.80103","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-014-1271-x","article-title":"High admission C-reactive protein level and longer in-hospital delay to surgery are associated with increased risk of complicated appendicitis","volume":"400","author":"Sammalkorpi HE","year":"2015","unstructured":"Sammalkorpi HE, Lepp\u00e4niemi A, Mentula P. High admission C-reactive protein level and longer in-hospital delay to surgery are associated with increased risk of complicated appendicitis. Langenbecks Arch Surg. 2015, 400:221-8. 10.1007\/s00423-014-1271-x","journal-title":"Langenbecks Arch Surg"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0b013e3181a4cda2","article-title":"Risk factors of postoperative infections in adults with complicated appendicitis","volume":"19","author":"Ming PC","year":"2009","unstructured":"Ming PC, Yan TY, Tat LH. Risk factors of postoperative infections in adults with complicated appendicitis. Surg Laparosc Endosc Percutan Tech. 2009, 19:244-8. 10.1097\/SLE.0b013e3181a4cda2","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2018.02.001","article-title":"Postoperative opioid prescribing: Getting it RIGHTT","volume":"215","author":"Yorkgitis BK","year":"2018","unstructured":"Yorkgitis BK, Brat GA. Postoperative opioid prescribing: Getting it RIGHTT. Am J Surg. 2018, 215:707-11. 10.1016\/j.amjsurg.2018.02.001","journal-title":"Am J Surg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2020.09.026","article-title":"Increasing incidence of complicated appendicitis during COVID-19 pandemic","volume":"221","author":"Orthopoulos G","year":"2021","unstructured":"Orthopoulos G, Santone E, Izzo F, Tirabassi M, P\u00e9rez-Caraballo AM, Corriveau N, Jabbour N. Increasing incidence of complicated appendicitis during COVID-19 pandemic. Am J Surg. 2021, 221:1056-60. 10.1016\/j.amjsurg.2020.09.026","journal-title":"Am J Surg"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2017.10.032","article-title":"Outcomes of complicated appendicitis: Is conservative management as smooth as it seems?","volume":"215","author":"Young KA","year":"2018","unstructured":"Young KA, Neuhaus NM, Fluck M, et al.. Outcomes of complicated appendicitis: Is conservative management as smooth as it seems?. Am J Surg. 2018, 215:586-92. 10.1016\/j.amjsurg.2017.10.032","journal-title":"Am J Surg"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1101-z","article-title":"In-hospital delay increases the risk of perforation in adults with appendicitis","volume":"35","author":"Busch M","year":"2011","unstructured":"Busch M, Gutzwiller FS, Aellig S, Kuettel R, Metzger U, Zingg U. In-hospital delay increases the risk of perforation in adults with appendicitis. World J Surg. 2011, 35:1626-33. 10.1007\/s00268-011-1101-z","journal-title":"World J Surg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3614-8","article-title":"72\u00a0h is the time critical point to operate in acute appendicitis","volume":"22","author":"Elniel M","year":"2018","unstructured":"Elniel M, Grainger J, Nevins EJ, Misra N, Skaife P. 72\u00a0h is the time critical point to operate in acute appendicitis. J Gastrointest Surg. 2018, 22:310-5. 10.1007\/s11605-017-3614-8","journal-title":"J Gastrointest Surg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne JA","year":"2016","unstructured":"Sterne JA, Hern\u00e1n MA, Reeves BC, et al.. ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016, 355:i4919. 10.1136\/bmj.i4919","journal-title":"BMJ"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher D","year":"2015","unstructured":"Moher D, Shamseer L, Clarke M, et al.. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015, 4:1. 10.1186\/2046-4053-4-1","journal-title":"Syst Rev"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.09.012","article-title":"Early versus late surgical management of complicated appendicitis in children: A statewide database analysis with one-year follow-up","volume":"53","author":"Saluja S","year":"2018","unstructured":"Saluja S, Sun T, Mao J, et al.. Early versus late surgical management of complicated appendicitis in children: A statewide database analysis with one-year follow-up. J Pediatr Surg. 2018, 53:1339-44. 10.1016\/j.jpedsurg.2017.09.012","journal-title":"J Pediatr Surg"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2019.97.2.103","article-title":"Early versus late surgical management for complicated appendicitis in adults: A multicenter propensity score matching study","volume":"97","author":"Kim JY","year":"2019","unstructured":"Kim JY, Kim JW, Park JH, Kim BC, Yoon SN. Early versus late surgical management for complicated appendicitis in adults: A multicenter propensity score matching study. Ann Surg Treat Res. 2019, 97:103-11. 10.4174\/astr.2019.97.2.103","journal-title":"Ann Surg Treat Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2018.04.010","article-title":"Early operative management of complicated appendicitis is associated with improved surgical outcomes in adults","volume":"216","author":"Symer MM","year":"2018","unstructured":"Symer MM, Abelson JS, Sedrakyan A, Yeo HL. Early operative management of complicated appendicitis is associated with improved surgical outcomes in adults. Am J Surg. 2018, 216:431-7. 10.1016\/j.amjsurg.2018.04.010","journal-title":"Am J Surg"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31811f3f9f","article-title":"Nonsurgical treatment of appendiceal abscess or phlegmon: A systematic review and meta-analysis","volume":"246","author":"Andersson RE","year":"2007","unstructured":"Andersson RE, Petzold MG. Nonsurgical treatment of appendiceal abscess or phlegmon: A systematic review and meta-analysis. Ann Surg. 2007, 246:741-8. 10.1097\/SLA.0b013e31811f3f9f","journal-title":"Ann Surg"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.11.013","article-title":"A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon)","volume":"147","author":"Simillis C","year":"2010","unstructured":"Simillis C, Symeonides P, Shorthouse AJ, Tekkis PP. A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon). Surgery. 2010, 147:818-29. 10.1016\/j.surg.2009.11.013","journal-title":"Surgery"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000064216","article-title":"The need for interval appendectomy after resolution of an appendiceal mass questioned","volume":"19","author":"Willemsen PJ","year":"2002","unstructured":"Willemsen PJ, Hoorntje LE, Eddes EH, Ploeg RJ. The need for interval appendectomy after resolution of an appendiceal mass questioned. Dig Surg. 2002, 19:216-20; discussion 221. 10.1159\/000064216","journal-title":"Dig Surg"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-014-2460-1","article-title":"How to treat an appendiceal inflammatory mass: Operatively or nonoperatively?","volume":"18","author":"Deelder JD","year":"2014","unstructured":"Deelder JD, Richir MC, Schoorl T, Schreurs WH. How to treat an appendiceal inflammatory mass: Operatively or nonoperatively?. J Gastrointest Surg. 2014, 18:641-5. 10.1007\/s11605-014-2460-1","journal-title":"J Gastrointest Surg"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011670.pub2","article-title":"Early versus delayed appendicectomy for appendiceal phlegmon or abscess","volume":"6","author":"Cheng Y","year":"2017","unstructured":"Cheng Y, Xiong X, Lu J, Wu S, Zhou R, Cheng N. Early versus delayed appendicectomy for appendiceal phlegmon or abscess. Cochrane Database Syst Rev. 2017, 6:CD011670. 10.1002\/14651858.CD011670.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-024-00549-4","article-title":"The impact of timing on outcomes in appendicectomy: A systematic review and network meta-analysis","volume":"19","author":"Calpin GG","year":"2024","unstructured":"Calpin GG, Hembrecht S, Giblin K, Hehir C, Dowling GP, Hill AD. The impact of timing on outcomes in appendicectomy: A systematic review and network meta-analysis. World J Emerg Surg. 2024, 19:24. 10.1186\/s13017-024-00549-4","journal-title":"World J Emerg Surg"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/409007-delayed-appendectomy-versus-early-intervention-a-systematic-review-of-outcomes-in-complicated-appendicitis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T15:01:57Z","timestamp":1760799717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/409007-delayed-appendectomy-versus-early-intervention-a-systematic-review-of-outcomes-in-complicated-appendicitis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,18]]},"references-count":23,"URL":"https:\/\/doi.org\/10.7759\/cureus.94868","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,18]]}}}