{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:23:23Z","timestamp":1765610603056,"version":"build-2065373602"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,19]]},"DOI":"10.7759\/cureus.94916","type":"journal-article","created":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:56:43Z","timestamp":1760878603000},"source":"Crossref","is-referenced-by-count":1,"title":["Utility of Serial Repetitive Nerve Stimulation in Differentiating Pharmacological From Immunological Exacerbation of Myasthenia Gravis: A Case Report"],"prefix":"10.7759","author":[{"given":"Akira","family":"Hanazono","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yui","family":"Sanpei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14996","article-title":"The risk of worsening of myasthenia by cardiovascular medication as reflected by reporting frequency","volume":"28","author":"Trillenberg P","year":"2021","unstructured":"Trillenberg P, Katalinic A, Thern J, Graf T. The risk of worsening of myasthenia by cardiovascular medication as reflected by reporting frequency. Eur J Neurol. 2021, 28:2965-70. 10.1111\/ene.14996","journal-title":"Eur J Neurol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10071537","article-title":"Drugs that induce or cause deterioration of myasthenia gravis: an update","volume":"10","author":"Sheikh S","year":"2021","unstructured":"Sheikh S, Alvi U, Soliven B, Rezania K. Drugs that induce or cause deterioration of myasthenia gravis: an update. J Clin Med. 2021, 10:7. 10.3390\/jcm10071537","journal-title":"J Clin Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26689","article-title":"Factors associated with acute exacerbations of myasthenia gravis","volume":"60","author":"Gummi RR","year":"2019","unstructured":"Gummi RR, Kukulka NA, Deroche CB, Govindarajan R. Factors associated with acute exacerbations of myasthenia gravis. Muscle Nerve. 2019, 60:693-9. 10.1002\/mus.26689","journal-title":"Muscle Nerve"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00156","article-title":"Pathomechanisms and clinical implications of myasthenic syndromes exacerbated and induced by medical treatments","volume":"13","author":"Krenn M","year":"2020","unstructured":"Krenn M, Grisold A, Wohlfarth P, Rath J, Cetin H, Koneczny I, Zimprich F. Pathomechanisms and clinical implications of myasthenic syndromes exacerbated and induced by medical treatments. Front Mol Neurosci. 2020, 13:156. 10.3389\/fnmol.2020.00156","journal-title":"Front Mol Neurosci"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(01)00606-4","article-title":"A case of severe respiratory depression due to cibenzoline overdosage induced by a transient renal dysfunction","volume":"82","author":"Inada K","year":"2002","unstructured":"Inada K, Sekita G, Sawaki D, Otani Y, Fukushima K, Takeuchi H, Aoyagi T. A case of severe respiratory depression due to cibenzoline overdosage induced by a transient renal dysfunction. Int J Cardiol. 2002, 82:177-8. 10.1016\/S0167-5273(01)00606-4","journal-title":"Int J Cardiol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-4598(199803)21:3<416::aid-mus23>3.0.co;2-i","article-title":"Myasthenialike syndrome due to adverse effects of cibenzoline in a patient with chronic renal failure","volume":"21","author":"Wakutani Y","year":"1998","unstructured":"Wakutani Y, Matsushima E, Son A, Shimizu Y, Goto Y, Ishida H. Myasthenialike syndrome due to adverse effects of cibenzoline in a patient with chronic renal failure. Muscle Nerve. 1998, 21:416-7. 10.1002\/(sici)1097-4598(199803)21:3&lt;416::aid-mus23&gt;3.0.co;2-i","journal-title":"Muscle Nerve"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.6.582","article-title":"Neuromuscular blockade with acute respiratory failure in a patient receiving cibenzoline","volume":"52","author":"Similowski T","year":"1997","unstructured":"Similowski T, Straus C, Attali V, et al.. Neuromuscular blockade with acute respiratory failure in a patient receiving cibenzoline. Thorax. 1997, 52:582-4. 10.1136\/thx.52.6.582","journal-title":"Thorax"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.35.512","article-title":"Myasthenia-like syndrome induced by overdosage of cibenzoline","volume":"35","author":"Kasuga A","year":"1996","unstructured":"Kasuga A, Maruyama H, Sato T, Nogawa S, Mitamura H, Saruta T. Myasthenia-like syndrome induced by overdosage of cibenzoline. Intern Med. 1996, 35:512-4. 10.2169\/internalmedicine.35.512","journal-title":"Intern Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/BF02479912","article-title":"Cibenzoline-induced respiratory muscular paralysis in a hemodialysis patient","volume":"1","author":"Tsuruya K","year":"1997","unstructured":"Tsuruya K, Harada A, Kubo S, Mitsuiki K, Takeda K. Cibenzoline-induced respiratory muscular paralysis in a hemodialysis patient. Clin Exp Nephrol. 1997, 1:131-5. 10.1007\/BF02479912","journal-title":"Clin Exp Nephrol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.cn-001070","article-title":"A case of myasthenia-like symptoms induced by cibenzoline overdosage","volume":"58","author":"Nakagawa Y","year":"2018","unstructured":"Nakagawa Y, Ishizaki M, Kozono A, Hanada K, Higashi T, Ueyama H. A case of myasthenia-like symptoms induced by cibenzoline overdosage. Rinsho Shinkeigaku. 2018, 58:41-4. 10.5692\/clinicalneurol.cn-001070","journal-title":"Rinsho Shinkeigaku"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1985.tb02825.x","article-title":"Pharmacokinetics of cibenzoline in patients with renal impairment","volume":"25","author":"Canal M","year":"1985","unstructured":"Canal M, Flouvat B, Aubert P, Guedon J, Prinseau J, Baglin A. Pharmacokinetics of cibenzoline in patients with renal impairment. J Clin Pharmacol. 1985, 25:197-203. 10.1002\/j.1552-4604.1985.tb02825.x","journal-title":"J Clin Pharmacol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2015.05.014","article-title":"Impact of chronic use of cibenzoline on left ventricular pressure gradient and left ventricular remodeling in patients with hypertrophic obstructive cardiomyopathy","volume":"67","author":"Hamada M","year":"2016","unstructured":"Hamada M, Ikeda S, Ohshima K, Nakamura M, Kubota N, Ogimoto A, Shigematsu Y. Impact of chronic use of cibenzoline on left ventricular pressure gradient and left ventricular remodeling in patients with hypertrophic obstructive cardiomyopathy. J Cardiol. 2016, 67:279-86. 10.1016\/j.jjcc.2015.05.014","journal-title":"J Cardiol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/1409983","article-title":"Association between initial corticosteroid regimen and treatment response time in acetylcholine receptor antibody-positive myasthenia gravis","volume":"1","author":"Kim J","year":"2024","unstructured":"Kim J, Park HJ, Kim SW, Shin HY. Association between initial corticosteroid regimen and treatment response time in acetylcholine receptor antibody-positive myasthenia gravis. Acta Neurol Scand. 2024, 1:3. 10.1155\/2024\/1409983","journal-title":"Acta Neurol Scand"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30154-5","article-title":"The diagnostic and prognostic utility of repetitive nerve stimulation in patients with myasthenia gravis","volume":"13","author":"Tomschik M","year":"2023","unstructured":"Tomschik M, Renaud E, J\u00e4ger F, et al.. The diagnostic and prognostic utility of repetitive nerve stimulation in patients with myasthenia gravis. Sci Rep. 2023, 13:2985. 10.1038\/s41598-023-30154-5","journal-title":"Sci Rep"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004379","article-title":"2023 American Society of Anesthesiologists practice guidelines for monitoring and antagonism of neuromuscular blockade: a report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade","volume":"138","author":"Thilen SR","year":"2023","unstructured":"Thilen SR, Weigel WA, Todd MM, et al.. 2023 American Society of Anesthesiologists practice guidelines for monitoring and antagonism of neuromuscular blockade: a report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade. Anesthesiology. 2023, 138:13-41. 10.1097\/ALN.0000000000004379","journal-title":"Anesthesiology"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11925-6","article-title":"Myasthenia gravis treatment in the elderly presents with a significant iatrogenic risk: a multicentric retrospective study","volume":"270","author":"Chanson JB","year":"2023","unstructured":"Chanson JB, Bouhour F, Aub\u00e9-Nathier AC, et al.. Myasthenia gravis treatment in the elderly presents with a significant iatrogenic risk: a multicentric retrospective study. J Neurol. 2023, 270:5819-26. 10.1007\/s00415-023-11925-6","journal-title":"J Neurol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.02007.x","article-title":"Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications","volume":"57","author":"Mangoni AA","year":"2004","unstructured":"Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol. 2004, 57:6-14. 10.1046\/j.1365-2125.2003.02007.x","journal-title":"Br J Clin Pharmacol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140504","article-title":"Prognosis of ocular myasthenia","volume":"14","author":"Bever CT Jr","year":"1983","unstructured":"Bever CT Jr, Aquino AV, Penn AS, Lovelace RE, Rowland LP. Prognosis of ocular myasthenia. Ann Neurol. 1983, 14:516-9. 10.1002\/ana.410140504","journal-title":"Ann Neurol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21555","article-title":"Ocular myasthenia gravis in a senior population: diagnosis, therapy, and prognosis","volume":"41","author":"Allen JA","year":"2010","unstructured":"Allen JA, Scala S, Jones HR. Ocular myasthenia gravis in a senior population: diagnosis, therapy, and prognosis. Muscle Nerve. 2010, 41:379-84. 10.1002\/mus.21555","journal-title":"Muscle Nerve"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.8.1105","article-title":"Evidence of underdiagnosis of myasthenia gravis in older people","volume":"74","author":"Vincent A","year":"2003","unstructured":"Vincent A, Clover L, Buckley C, Grimley Evans J, Rothwell PM. Evidence of underdiagnosis of myasthenia gravis in older people. J Neurol Neurosurg Psychiatry. 2003, 74:1105-8. 10.1136\/jnnp.74.8.1105","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/425652-utility-of-serial-repetitive-nerve-stimulation-in-differentiating-pharmacological-from-immunological-exacerbation-of-myasthenia-gravis-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:56:44Z","timestamp":1760878604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/425652-utility-of-serial-repetitive-nerve-stimulation-in-differentiating-pharmacological-from-immunological-exacerbation-of-myasthenia-gravis-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,19]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.94916","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,19]]}}}