{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:23:46Z","timestamp":1790832226001,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,20]]},"DOI":"10.7759\/cureus.94979","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:20:36Z","timestamp":1760966436000},"source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness of Indocyanine Green Fluorescence Angiography in Preventing Anastomotic Leakage: A Systematic Review and Meta-Analysis of Randomised Controlled Trials"],"prefix":"10.7759","author":[{"given":"Nirmani","family":"Widanage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zain","family":"Ahmed Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasun","family":"Gunathilaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1010122","article-title":"Meta analysis of indocyanine green fluorescence in patients undergoing laparoscopic colorectal cancer surgery","volume":"12","author":"Deng J","year":"2022","unstructured":"Deng J, Hu W, Li Y, Xiong K, Yue T, Lai X, Xiao T. Meta analysis of indocyanine green fluorescence in patients undergoing laparoscopic colorectal cancer surgery. Front Oncol. 2022, 12:1010122. 10.3389\/fonc.2022.1010122","journal-title":"Front Oncol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005647","article-title":"Long-term oncological outcomes after colorectal anastomotic leakage: a retrospective Dutch population-based study","volume":"276","author":"Arron MN","year":"2022","unstructured":"Arron MN, Greijdanus NG, Bastiaans S, et al.. Long-term oncological outcomes after colorectal anastomotic leakage: a retrospective Dutch population-based study. Ann Surg. 2022, 276:882-9. 10.1097\/SLA.0000000000005647","journal-title":"Ann Surg"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.21037\/ales-24-43","article-title":"Indocyanine green uses in colorectal surgery \u2014 a narrative review","volume":"10","author":"Fok KY","year":"2025","unstructured":"Fok KY, Harris C, Clark DA. Indocyanine green uses in colorectal surgery \u2014 a narrative review. Ann Laparosc Endosc Surg. 2025, 10:24-43. 10.21037\/ales-24-43","journal-title":"Ann Laparosc Endosc Surg"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.815753","article-title":"Effect of indocyanine green fluorescence angiography on anastomotic leakage in patients undergoing colorectal surgery: a meta-analysis of randomized controlled trials and propensity-score-matched studies","volume":"9","author":"Tang G","year":"2022","unstructured":"Tang G, Du D, Tao J, Wei Z. Effect of indocyanine green fluorescence angiography on anastomotic leakage in patients undergoing colorectal surgery: a meta-analysis of randomized controlled trials and propensity-score-matched studies. Front Surg. 2022, 9:815753. 10.3389\/fsurg.2022.815753","journal-title":"Front Surg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Rayyan - AI-powered systematic review tool. (2025). Accessed. 03.10.2025: https:\/\/www.rayyan.ai.","DOI":"10.5339\/jist.2025.15"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne JA","year":"2019","unstructured":"Sterne JA, Savovi\u0107 J, Page MJ, et al.. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019, 366:l4898. 10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"ref8","unstructured":"Review Manager (RevMan) [Computer program]. (2020). Accessed. 01.10.2025: https:\/\/training.cochrane.org\/online-learning\/core-software-cochrane-reviews\/revman.."},{"key":"ref9","unstructured":"GRADE Working Group. GRADE (Grading of Recommendations, Assessment, Development and Evaluation). (2025). Accessed. 05\/09\/2025: https:\/\/www.gradeworkinggroup.org\/."},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.5114\/wiitm.2023.129545","article-title":"Fluorescent ICG angiography in laparoscopic rectal resection - a randomized controlled trial. Preliminary report","volume":"18","author":"Gach T","year":"2023","unstructured":"Gach T, Bogacki P, Orzeszko Z, et al.. Fluorescent ICG angiography in laparoscopic rectal resection - a randomized controlled trial. Preliminary report. Wideochir Inne Tech Maloinwazyjne. 2023, 18:410-7. 10.5114\/wiitm.2023.129545","journal-title":"Wideochir Inne Tech Maloinwazyjne"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15037","article-title":"A study investigating the perfusion of colorectal anastomoses using fluorescence angiography: results of the FLAG randomized trial","volume":"22","author":"Alekseev M","year":"2020","unstructured":"Alekseev M, Rybakov E, Shelygin Y, Chernyshov S, Zarodnyuk I. A study investigating the perfusion of colorectal anastomoses using fluorescence angiography: results of the FLAG randomized trial. Colorectal Dis. 2020, 22:1147-53. 10.1111\/codi.15037","journal-title":"Colorectal Dis"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000002007","article-title":"Perfusion assessment in left-sided\/low anterior resection (PILLAR  III): a randomized, controlled, parallel, multicenter study assessing perfusion outcomes with PINPOINT near-infrared fluorescence imaging in low anterior resection","volume":"64","author":"Jafari MD","year":"2021","unstructured":"Jafari MD, Pigazzi A, McLemore EC, et al.. Perfusion assessment in left-sided\/low anterior resection (PILLAR  III): a randomized, controlled, parallel, multicenter study assessing perfusion outcomes with PINPOINT near-infrared fluorescence imaging in low anterior resection. Dis Colon Rectum. 2021, 64:995-1002. 10.1097\/DCR.0000000000002007","journal-title":"Dis Colon Rectum"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-019-06730-0","article-title":"Intraoperative angiography with indocyanine green to assess anastomosis perfusion in patients undergoing laparoscopic colorectal resection: results of a multicenter randomized controlled trial","volume":"34","author":"De Nardi P","year":"2020","unstructured":"De Nardi P, Elmore U, Maggi G, et al.. Intraoperative angiography with indocyanine green to assess anastomosis perfusion in patients undergoing laparoscopic colorectal resection: results of a multicenter randomized controlled trial. Surg Endosc. 2020, 34:53-60. 10.1007\/s00464-019-06730-0","journal-title":"Surg Endosc"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005907","article-title":"Blood perfusion assessment by Indocyanine green fluorescence imaging for minimally invasive rectal cancer surgery (EssentiAL trial): a randomized clinical trial","volume":"278","author":"Watanabe J","year":"2023","unstructured":"Watanabe J, Takemasa I, Kotake M, et al.. Blood perfusion assessment by Indocyanine green fluorescence imaging for minimally invasive rectal cancer surgery (EssentiAL trial): a randomized clinical trial. Ann Surg. 2023, 278:e688-94. 10.1097\/SLA.0000000000005907","journal-title":"Ann Surg"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(24)00198-5","article-title":"Indocyanine green near-infrared fluorescence bowel perfusion assessment to prevent anastomotic leakage in minimally invasive colorectal surgery (AVOID): a multicentre, randomised, controlled, phase 3 trial","volume":"9","author":"Faber RA","year":"2024","unstructured":"Faber RA, Meijer RP, Droogh DH, et al.. Indocyanine green near-infrared fluorescence bowel perfusion assessment to prevent anastomotic leakage in minimally invasive colorectal surgery (AVOID): a multicentre, randomised, controlled, phase 3 trial. Lancet Gastroenterol Hepatol. 2024, 9:924-34. 10.1016\/S2468-1253(24)00198-5","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2025.0006","article-title":"Indocyanine green fluorescence imaging in prevention of colorectal anastomotic leakage: a randomized clinical trial","volume":"160","author":"Rinne JK","year":"2025","unstructured":"Rinne JK, Huhta H, Pinta T, et al.. Indocyanine green fluorescence imaging in prevention of colorectal anastomotic leakage: a randomized clinical trial. JAMA Surg. 2025, 160:486-93. 10.1001\/jamasurg.2025.0006","journal-title":"JAMA Surg"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s13304-025-02389-6","article-title":"Pushing the boundaries of indocyanine green fluorescence angiography in colorectal surgery","author":"Peltrini R","year":"2025","unstructured":"Peltrini R, Ferrara F, Pilone V. Pushing the boundaries of indocyanine green fluorescence angiography in colorectal surgery. Updates Surg. 2025, 10.1007\/s13304-025-02389-6","journal-title":"Updates Surg"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/codi.17284","article-title":"Local excision for organ preservation in low rectal cancer: video technique and case report applying GRECCAR 2 and GRECCAR 12 trial principles-a video vignette","volume":"27","author":"S\u00e1nchez-Rodr\u00edguez M","year":"2025","unstructured":"S\u00e1nchez-Rodr\u00edguez M, Koo CH, Assenat V, Fran\u00e7ois MO, Tejedor P, Denost Q. Local excision for organ preservation in low rectal cancer: video technique and case report applying GRECCAR 2 and GRECCAR 12 trial principles-a video vignette. Colorectal Dis. 2025, 27:e17284. 10.1111\/codi.17284","journal-title":"Colorectal Dis"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-025-11582-y","article-title":"Impact of indocyanine green fluorescence angiography on surgeon action and anastomotic leak in colorectal resections. A systematic review and meta-analysis","volume":"39","author":"Mc Entee PD","year":"2025","unstructured":"Mc Entee PD, Singaravelu A, Boland PA, Moynihan A, Creavin B, Cahill RA. Impact of indocyanine green fluorescence angiography on surgeon action and anastomotic leak in colorectal resections. A systematic review and meta-analysis. Surg Endosc. 2025, 39:1473-89. 10.1007\/s00464-025-11582-y","journal-title":"Surg Endosc"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-025-11547-1","article-title":"The impact of indocyanine green fluorescence angiography (ICG-FA) on anastomotic leak rates and postoperative outcomes in colorectal anastomoses: a systematic review","volume":"39","author":"Hussain K","year":"2025","unstructured":"Hussain K, Balamurugan G, Ravindra C, Kodali R, Hansalia DS, Rengan V. The impact of indocyanine green fluorescence angiography (ICG-FA) on anastomotic leak rates and postoperative outcomes in colorectal anastomoses: a systematic review. Surg Endosc. 2025, 39:749-65. 10.1007\/s00464-025-11547-1","journal-title":"Surg Endosc"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1134723","article-title":"Indocyanine green angiography for lower incidence of anastomotic leakage after transanal total mesorectal excision: a propensity score-matched cohort study","volume":"13","author":"Chen H","year":"2023","unstructured":"Chen H, Ye L, Huang C, Shi Y, Lin F, Ye H, Huang Y. Indocyanine green angiography for lower incidence of anastomotic leakage after transanal total mesorectal excision: a propensity score-matched cohort study. Front Oncol. 2023, 13:1134723. 10.3389\/fonc.2023.1134723","journal-title":"Front Oncol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.886478","article-title":"The role of indocyanine near-infrared fluorescence in colorectal surgery","volume":"9","author":"Maione F","year":"2022","unstructured":"Maione F, Manigrasso M, Chini A, et al.. The role of indocyanine near-infrared fluorescence in colorectal surgery. Front Surg. 2022, 9:886478. 10.3389\/fsurg.2022.886478","journal-title":"Front Surg"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-020-00745-4","article-title":"Indocyanine green fluorescence imaging to assess bowel perfusion during totally laparoscopic surgery for colon cancer","volume":"20","author":"Su H","year":"2020","unstructured":"Su H, Wu H, Bao M, et al.. Indocyanine green fluorescence imaging to assess bowel perfusion during totally laparoscopic surgery for colon cancer. BMC Surg. 2020, 20:102. 10.1186\/s12893-020-00745-4","journal-title":"BMC Surg"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3267217","article-title":"Assessment of anastomotic perfusion in left-sided robotic assisted colorectal resection by Indocyanine green fluorescence angiography","volume":"2019","author":"Shapera E","year":"2019","unstructured":"Shapera E, Hsiung RW. Assessment of anastomotic perfusion in left-sided robotic assisted colorectal resection by Indocyanine green fluorescence angiography. Minim Invasive Surg. 2019, 2019:3267217. 10.1155\/2019\/3267217","journal-title":"Minim Invasive Surg"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i34.5017","article-title":"Reducing anastomotic leak in colorectal surgery: the old dogmas and the new challenges","volume":"25","author":"Meyer J","year":"2019","unstructured":"Meyer J, Naiken S, Christou N, Liot E, Toso C, Buchs NC, Ris F. Reducing anastomotic leak in colorectal surgery: the old dogmas and the new challenges. World J Gastroenterol. 2019, 25:5017-25. 10.3748\/wjg.v25.i34.5017","journal-title":"World J Gastroenterol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt GH","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Sch\u00fcnemann HJ. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008, 336:924-6. 10.1136\/bmj.39489.470347.AD","journal-title":"BMJ"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/422041-effectiveness-of-indocyanine-green-fluorescence-angiography-in-preventing-anastomotic-leakage-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:20:38Z","timestamp":1760966438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/422041-effectiveness-of-indocyanine-green-fluorescence-angiography-in-preventing-anastomotic-leakage-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.94979","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,20]]}}}