{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:48:57Z","timestamp":1761184137220,"version":"build-2065373602"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,22]]},"DOI":"10.7759\/cureus.95184","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T21:07:46Z","timestamp":1761167266000},"source":"Crossref","is-referenced-by-count":0,"title":["Optimizing Venous Thromboembolism Prophylaxis in Achilles Tendon Rupture: A Systematic Review of Current Evidence and Protocol Recommendations"],"prefix":"10.7759","author":[{"given":"Mohamed","family":"Hashem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Elbeshbeshy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Khalafallah\u00a0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousif A","family":"Othman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Al-Saqili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed A","family":"Ghobashy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Anatomy, Bony Pelvis and Lower Limb: Achilles Tendon","author":"Wong M","year":"2025","unstructured":"Wong M, Jardaly AH, Kiel J. Anatomy, Bony Pelvis and Lower Limb: Achilles Tendon. StatPearls [Internet], StatPearls Publishing, Treasure Island, FL; 2025."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-015-3544-5","article-title":"Increasing incidence of acute Achilles tendon rupture and a noticeable decline in surgical treatment from 1994 to 2013. A nationwide registry study of 33,160 patients","volume":"24","author":"Ganestam A","year":"2016","unstructured":"Ganestam A, Kallemose T, Troelsen A, Barfod KW. Increasing incidence of acute Achilles tendon rupture and a noticeable decline in surgical treatment from 1994 to 2013. A nationwide registry study of 33,160 patients. Knee Surg Sports Traumatol Arthrosc. 2016, 24:3730-7. 10.1007\/s00167-015-3544-5","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109\/17453679608994688","article-title":"Incidence of Achilles tendon rupture","volume":"67","author":"Leppilahti J","year":"1996","unstructured":"Leppilahti J, Puranen J, Orava S. Incidence of Achilles tendon rupture. Acta Orthop Scand. 1996, 67:277-9. 10.3109\/17453679608994688","journal-title":"Acta Orthop Scand"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2017.10.036","article-title":"A prospective cohort study of symptomatic venous thromboembolic events in foot and ankle trauma: the need for stratification in thromboprophylaxis?","volume":"57","author":"Blanco JA","year":"2018","unstructured":"Blanco JA, Slater G, Mangwani J. A prospective cohort study of symptomatic venous thromboembolic events in foot and ankle trauma: the need for stratification in thromboprophylaxis?. J Foot Ankle Surg. 2018, 57:484-8. 10.1053\/j.jfas.2017.10.036","journal-title":"J Foot Ankle Surg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12395","article-title":"Comparison of fondaparinux with low molecular weight heparin for venous thromboembolism prevention in patients requiring rigid or semi-rigid immobilization for isolated non-surgical below-knee injury","volume":"11","author":"Samama CM","year":"2013","unstructured":"Samama CM, Lecoules N, Kierzek G, et al.. Comparison of fondaparinux with low molecular weight heparin for venous thromboembolism prevention in patients requiring rigid or semi-rigid immobilization for isolated non-surgical below-knee injury. J Thromb Haemost. 2013, 11:1833-43. 10.1111\/jth.12395","journal-title":"J Thromb Haemost"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7547\/17-012","article-title":"Incidence of venous thromboembolism after Achilles tendon surgery in patients receiving thromboprophlaxis","volume":"110","author":"\u00c7olak \u0130","year":"2020","unstructured":"\u00c7olak \u0130, G\u00fclabi D, Eceviz E, \u00c7evik BH, Bulut G, Bekler HI. Incidence of venous thromboembolism after Achilles tendon surgery in patients receiving thromboprophlaxis. J Am Podiatr Med Assoc. 2020, 110:Article3. 10.7547\/17-012","journal-title":"J Am Podiatr Med Assoc"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/24730114231178791","article-title":"Thromboembolic events during weightbearing vs nonweightbearing accelerated rehabilitation protocols for complete Achilles tendon ruptures","volume":"8","author":"Lee C","year":"2023","unstructured":"Lee C, Haarer F, Titheradge R, Iliopoulos E. Thromboembolic events during weightbearing vs nonweightbearing accelerated rehabilitation protocols for complete Achilles tendon ruptures. Foot Ankle Orthop. 2023, 8:24730114231178791. 10.1177\/24730114231178791","journal-title":"Foot Ankle Orthop"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2013.11.002","article-title":"The impact of risk assessment on the implementation of venous thromboembolism prophylaxis in foot and ankle surgery","volume":"20","author":"Saragas NP","year":"2014","unstructured":"Saragas NP, Ferrao PN, Saragas E, Jacobson BF. The impact of risk assessment on the implementation of venous thromboembolism prophylaxis in foot and ankle surgery. Foot Ankle Surg. 2014, 20:85-9. 10.1016\/j.fas.2013.11.002","journal-title":"Foot Ankle Surg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7196\/samj.6706","article-title":"Venous thromboembolism: prophylactic and therapeutic practice guideline","volume":"103","author":"Jacobson BF","year":"2013","unstructured":"Jacobson BF, Louw S, B\u00fcller H, et al.. Venous thromboembolism: prophylactic and therapeutic practice guideline. S Afr Med J. 2013, 103:261-7. 10.7196\/samj.6706","journal-title":"S Afr Med J"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-011-2166-6","article-title":"Incidence of deep vein thrombosis and pulmonary embolism after Achilles tendon rupture","volume":"470","author":"Patel A","year":"2012","unstructured":"Patel A, Ogawa B, Charlton T, Thordarson D. Incidence of deep vein thrombosis and pulmonary embolism after Achilles tendon rupture. Clin Orthop Relat Res. 2012, 470:270-4. 10.1007\/s11999-011-2166-6","journal-title":"Clin Orthop Relat Res"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2013.03.001","article-title":"Incidence of symptomatic deep venous thrombosis after Achilles tendon rupture","volume":"52","author":"Makhdom AM","year":"2013","unstructured":"Makhdom AM, Cota A, Saran N, Chaytor R. Incidence of symptomatic deep venous thrombosis after Achilles tendon rupture. J Foot Ankle Surg. 2013, 52:584-7. 10.1053\/j.jfas.2013.03.001","journal-title":"J Foot Ankle Surg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/1076029614545212","article-title":"Sustained release of tissue factor following thrombosis of lower limb trauma","volume":"20","author":"Walenga JM","year":"2014","unstructured":"Walenga JM, Kaiser PC, Prechel MM, et al.. Sustained release of tissue factor following thrombosis of lower limb trauma. Clin Appl Thromb Hemost. 2014, 20:678-86. 10.1177\/1076029614545212","journal-title":"Clin Appl Thromb Hemost"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/01.bot.0000250741.65003.14","article-title":"Prolonged thromboprophylaxis with dalteparin after surgical treatment of achilles tendon rupture: a randomized, placebo-controlled study","volume":"21","author":"Lapidus LJ","year":"2007","unstructured":"Lapidus LJ, Rosfors S, Ponzer S, Levander C, Elvin A, L\u00e4rfars G, de Bri E. Prolonged thromboprophylaxis with dalteparin after surgical treatment of achilles tendon rupture: a randomized, placebo-controlled study. J Orthop Trauma. 2007, 21:52-7. 10.1097\/01.bot.0000250741.65003.14","journal-title":"J Orthop Trauma"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-009-0727-y","article-title":"High incidence of deep venous thrombosis after Achilles tendon rupture: a prospective study","volume":"17","author":"Nilsson-Helander K","year":"2009","unstructured":"Nilsson-Helander K, Thurin A, Karlsson J, Eriksson BI. High incidence of deep venous thrombosis after Achilles tendon rupture: a prospective study. Knee Surg Sports Traumatol Arthrosc. 2009, 17:1234-8. 10.1007\/s00167-009-0727-y","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref16","unstructured":"EndNote. (2013). Accessed. 2025: https:\/\/endnote.com."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne JA","year":"2019","unstructured":"Sterne JA, Savovi\u0107 J, Page MJ, et al.. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019, 366:l4898. 10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang A","year":"2010","unstructured":"Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010, 25:603-5. 10.1007\/s10654-010-9491-z","journal-title":"Eur J Epidemiol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1693410","article-title":"Individualized thromboprophylaxis in patients with lower-leg cast immobilization - a validation and subgroup analysis in the POT-CAST trial","volume":"119","author":"Nemeth B","year":"2019","unstructured":"Nemeth B, van Adrichem R, Nelissen R, le Cessie S, Cannegieter SC. Individualized thromboprophylaxis in patients with lower-leg cast immobilization - a validation and subgroup analysis in the POT-CAST trial. Thromb Haemost. 2019, 119:1508-16. 10.1055\/s-0039-1693410","journal-title":"Thromb Haemost"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.2017.v107i4.10843","article-title":"The benefit of pharmacological venous thromboprophylaxis in foot and ankle surgery","volume":"107","author":"Saragas NP","year":"2017","unstructured":"Saragas NP, Ferrao PN, Jacobson BF, Saragas E, Strydom A. The benefit of pharmacological venous thromboprophylaxis in foot and ankle surgery. S Afr Med J. 2017, 107:327-30. 10.7196\/SAMJ.2017.v107i4.10843","journal-title":"S Afr Med J"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100270","article-title":"Clinical risk assessment model to predict venous thromboembolism risk after immobilization for lower-limb trauma","volume":"20","author":"Nemeth B","year":"2020","unstructured":"Nemeth B, Douillet D, le Cessie S, Penaloza A, Moumneh T, Roy PM, Cannegieter S. Clinical risk assessment model to predict venous thromboembolism risk after immobilization for lower-limb trauma. EClinicalMedicine. 2020, 20:100270. 10.1016\/j.eclinm.2020.100270","journal-title":"EClinicalMedicine"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02369-3","article-title":"Targeted prophylactic anticoagulation based on the TRiP(cast) score in patients with lower limb immobilisation: a multicentre, stepped wedge, randomised implementation trial","volume":"403","author":"Douillet D","year":"2024","unstructured":"Douillet D, Penaloza A, Viglino D, et al.. Targeted prophylactic anticoagulation based on the TRiP(cast) score in patients with lower limb immobilisation: a multicentre, stepped wedge, randomised implementation trial. Lancet. 2024, 403:1051-60. 10.1016\/S0140-6736(23)02369-3","journal-title":"Lancet"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-015-3976-y","article-title":"Meta-analysis and suggested guidelines for prevention of venous thromboembolism (VTE) in foot and ankle surgery","volume":"24","author":"Calder JD","year":"2016","unstructured":"Calder JD, Freeman R, Domeij-Arverud E, van Dijk CN, Ackermann PW. Meta-analysis and suggested guidelines for prevention of venous thromboembolism (VTE) in foot and ankle surgery. Knee Surg Sports Traumatol Arthrosc. 2016, 24:1409-20. 10.1007\/s00167-015-3976-y","journal-title":"Knee Surg Sports Traumatol Arthrosc"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/405258-optimizing-venous-thromboembolism-prophylaxis-in-achilles-tendon-rupture-a-systematic-review-of-current-evidence-and-protocol-recommendations","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T21:07:47Z","timestamp":1761167267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/405258-optimizing-venous-thromboembolism-prophylaxis-in-achilles-tendon-rupture-a-systematic-review-of-current-evidence-and-protocol-recommendations"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":23,"URL":"https:\/\/doi.org\/10.7759\/cureus.95184","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,22]]}}}