{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:26:11Z","timestamp":1761197171829,"version":"build-2065373602"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,22]]},"DOI":"10.7759\/cureus.95199","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:14:32Z","timestamp":1761196472000},"source":"Crossref","is-referenced-by-count":0,"title":["Association Between Postoperative Complications and Real-Time Oxidative Stress Measurements Using Electron Spin Resonance: An Observational Study"],"prefix":"10.7759","author":[{"given":"Shigekiyo","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Kuribayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takenori","family":"Makino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Kai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004455","article-title":"Perioperative oxidative stress: the unseen enemy","volume":"129","author":"Stevens JL","year":"2019","unstructured":"Stevens JL, Feelisch M, Martin DS. Perioperative oxidative stress: the unseen enemy. Anesth Analg. 2019, 129:1749-60. 10.1213\/ANE.0000000000004455","journal-title":"Anesth Analg"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2021.1891808","article-title":"Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome","volume":"26","author":"Toro-P\u00e9rez J","year":"2021","unstructured":"Toro-P\u00e9rez J, Rodrigo R. Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome. Redox Rep. 2021, 26:35-44. 10.1080\/13510002.2021.1891808","journal-title":"Redox Rep"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/RES.0000000000000110","article-title":"Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the American Heart Association","volume":"119","author":"Griendling KK","year":"2016","unstructured":"Griendling KK, Touyz RM, Zweier JL, et al.. Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the American Heart Association. Circ Res. 2016, 119:e39-75. 10.1161\/RES.0000000000000110","journal-title":"Circ Res"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.16.6377","article-title":"Ascorbate is an outstanding antioxidant in human blood plasma","volume":"86","author":"Frei B","year":"1989","unstructured":"Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA. 1989, 86:6377-81. 10.1073\/pnas.86.16.6377","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181bb80d4","article-title":"The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study","volume":"68","author":"Matsumoto S","year":"2010","unstructured":"Matsumoto S, Shingu C, Koga H, et al.. The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study. J Trauma. 2010, 68:796-801. 10.1097\/TA.0b013e3181bb80d4","journal-title":"J Trauma"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000179621.33268.83","article-title":"Determinants of long-term survival after major surgery and the adverse effect of postoperative complications","volume":"242","author":"Khuri SF","year":"2005","unstructured":"Khuri SF, Henderson WG, DePalma RG, Mosca C, Healey NA, Kumbhani DJ. Determinants of long-term survival after major surgery and the adverse effect of postoperative complications. Ann Surg. 2005, 242:326-41. 10.1097\/01.sla.0000179621.33268.83","journal-title":"Ann Surg"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.02.068","article-title":"Comparison of risk-adjusted 30-day postoperative mortality and morbidity in Department of Veterans Affairs hospitals and selected university medical centers: general surgical operations in men","volume":"204","author":"Henderson WG","year":"2007","unstructured":"Henderson WG, Khuri SF, Mosca C, Fink AS, Hutter MM, Neumayer LA. Comparison of risk-adjusted 30-day postoperative mortality and morbidity in Department of Veterans Affairs hospitals and selected university medical centers: general surgical operations in men. J Am Coll Surg. 2007, 204:1103-14. 10.1016\/j.jamcollsurg.2007.02.068","journal-title":"J Am Coll Surg"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.11.011","article-title":"An Apgar score for surgery","volume":"204","author":"Gawande AA","year":"2007","unstructured":"Gawande AA, Kwaan MR, Regenbogen SE, Lipsitz SA, Zinner MJ. An Apgar score for surgery. J Am Coll Surg. 2007, 204:201-8. 10.1016\/j.jamcollsurg.2006.11.011","journal-title":"J Am Coll Surg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185685","article-title":"Inflammatory response and oxidative stress during liver resection","volume":"12","author":"Schwarz C","year":"2017","unstructured":"Schwarz C, Fitschek F, Bar-Or D, et al.. Inflammatory response and oxidative stress during liver resection. PLoS One. 2017, 12:e0185685. 10.1371\/journal.pone.0185685","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1404200410","article-title":"Preoperative hydroperoxide concentrations are associated with a risk of postoperative complications after cardiac surgery","volume":"42","author":"Suehiro K","year":"2014","unstructured":"Suehiro K, Tanaka K, Matsuura T, et al.. Preoperative hydroperoxide concentrations are associated with a risk of postoperative complications after cardiac surgery. Anaesth Intensive Care. 2014, 42:487-94. 10.1177\/0310057X1404200410","journal-title":"Anaesth Intensive Care"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.98106s51229","article-title":"Lipid peroxidation products and antioxidants in human disease","volume":"106","author":"Romero FJ","year":"1998","unstructured":"Romero FJ, Bosch-Morell F, Romero MJ, Jare\u00f1o EJ, Romero B, Mar\u00edn N, Rom\u00e1 J. Lipid peroxidation products and antioxidants in human disease. Environ Health Perspect. 1998, 106:1229-34. 10.1289\/ehp.98106s51229","journal-title":"Environ Health Perspect"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7163\/aa9856","article-title":"Lipid peroxidation in cardiac surgery: towards consensus on biomonitoring, diagnostic tools and therapeutic implementation","volume":"12","author":"Romano R","year":"2018","unstructured":"Romano R, Cristescu SM, Risby TH, Marczin N. Lipid peroxidation in cardiac surgery: towards consensus on biomonitoring, diagnostic tools and therapeutic implementation. J Breath Res. 2018, 12:027109. 10.1088\/1752-7163\/aa9856","journal-title":"J Breath Res"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2016.10.021","article-title":"Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges","volume":"524","author":"Tsikas D","year":"2017","unstructured":"Tsikas D. Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges. Anal Biochem. 2017, 524:13-30.","journal-title":"Anal Biochem"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2008.504","article-title":"Utility of the surgical Apgar score: validation in 4119 patients","volume":"144","author":"Regenbogen SE","year":"2009","unstructured":"Regenbogen SE, Ehrenfeld JM, Lipsitz SR, Greenberg CC, Hutter MM, Gawande AA. Utility of the surgical Apgar score: validation in 4119 patients. Arch Surg. 2009, 144:30-6. 10.1001\/archsurg.2008.504","journal-title":"Arch Surg"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318219d734","article-title":"Expansion of the surgical Apgar score across all surgical subspecialties as a means to predict postoperative mortality","volume":"114","author":"Reynolds PQ","year":"2011","unstructured":"Reynolds PQ, Sanders NW, Schildcrout JS, Mercaldo ND, St Jacques PJ. Expansion of the surgical Apgar score across all surgical subspecialties as a means to predict postoperative mortality. Anesthesiology. 2011, 114:1305-12. 10.1097\/ALN.0b013e318219d734","journal-title":"Anesthesiology"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.10.019","article-title":"Surgical outcome measurement for a global patient population: validation of the Surgical Apgar Score in 8 countries","volume":"149","author":"Haynes AB","year":"2011","unstructured":"Haynes AB, Regenbogen SE, Weiser TG, Lipsitz SR, Dziekan G, Berry WR, Gawande AA. Surgical outcome measurement for a global patient population: validation of the Surgical Apgar Score in 8 countries. Surgery. 2011, 149:519-24. 10.1016\/j.surg.2010.10.019","journal-title":"Surgery"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012845","article-title":"Reduction of oxidative stress a key for enhanced postoperative recovery with fewer complications in esophageal surgery patients: randomized control trial to investigate therapeutic impact of anesthesia management and usefulness of simple blood test for prediction of high-risk patients","volume":"97","author":"Tsuchiya M","year":"2018","unstructured":"Tsuchiya M, Shiomoto K, Mizutani K, et al.. Reduction of oxidative stress a key for enhanced postoperative recovery with fewer complications in esophageal surgery patients: randomized control trial to investigate therapeutic impact of anesthesia management and usefulness of simple blood test for prediction of high-risk patients. Medicine (Baltimore). 2018, 97:e12845. 10.1097\/MD.0000000000012845","journal-title":"Medicine (Baltimore)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-80739-x","article-title":"Association between oxidative stress and postoperative delirium in joint replacement using diacron-reactive oxygen metabolites and biological antioxidant potential tests","volume":"14","author":"Yuba T","year":"2024","unstructured":"Yuba T, Koyama Y, Takahashi A, Fujino Y, Shimada S. Association between oxidative stress and postoperative delirium in joint replacement using diacron-reactive oxygen metabolites and biological antioxidant potential tests. Sci Rep. 2024, 14:29854. 10.1038\/s41598-024-80739-x","journal-title":"Sci Rep"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0121OC","article-title":"Vitamin C prevents cigarette smoke-induced pulmonary emphysema in mice and provides pulmonary restoration","volume":"50","author":"Koike K","year":"2014","unstructured":"Koike K, Ishigami A, Sato Y, et al.. Vitamin C prevents cigarette smoke-induced pulmonary emphysema in mice and provides pulmonary restoration. Am J Respir Cell Mol Biol. 2014, 50:347-57. 10.1165\/rcmb.2013-0121OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.06.042","article-title":"Ascorbic acid prolongs the viability and stability of isolated perfused lungs: A mechanistic study using 31P and hyperpolarized 13C nuclear magnetic resonance","volume":"89","author":"Shaghaghi H","year":"2015","unstructured":"Shaghaghi H, Kadlecek S, Siddiqui S, et al.. Ascorbic acid prolongs the viability and stability of isolated perfused lungs: A mechanistic study using 31P and hyperpolarized 13C nuclear magnetic resonance. Free Radic Biol Med. 2015, 89:62-71. 10.1016\/j.freeradbiomed.2015.06.042","journal-title":"Free Radic Biol Med"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200212000-00014","article-title":"Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients","volume":"236","author":"Nathens AB","year":"2002","unstructured":"Nathens AB, Neff MJ, Jurkovich GJ, et al.. Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann Surg. 2002, 236:814-22. 10.1097\/00000658-200212000-00014","journal-title":"Ann Surg"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000133144.60584.F6","article-title":"The beneficial effects of antioxidant supplementation in enteral feeding in critically ill patients: a prospective, randomized, double-blind, placebo-controlled trial","volume":"99","author":"Crimi E","year":"2004","unstructured":"Crimi E, Liguori A, Condorelli M, et al.. The beneficial effects of antioxidant supplementation in enteral feeding in critically ill patients: a prospective, randomized, double-blind, placebo-controlled trial. Anesth Analg. 2004, 99:857-63. 10.1213\/01.ANE.0000133144.60584.F6","journal-title":"Anesth Analg"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2021.11.039","article-title":"Efficacy and safety of perioperative vitamin C in patients undergoing noncardiac surgery: a systematic review and meta-analysis of randomised trials","volume":"128","author":"Suter M","year":"2022","unstructured":"Suter M, Bollen Pinto B, Belletti A, Putzu A. Efficacy and safety of perioperative vitamin C in patients undergoing noncardiac surgery: a systematic review and meta-analysis of randomised trials. Br J Anaesth. 2022, 128:664-78. 10.1016\/j.bja.2021.11.039","journal-title":"Br J Anaesth"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.4055\/cios.2017.9.3.317","article-title":"The efficacy of vitamin C on postoperative outcomes after posterior lumbar interbody fusion: a randomized, placebo-controlled trial","volume":"9","author":"Lee GW","year":"2017","unstructured":"Lee GW, Yang HS, Yeom JS, Ahn MW. The efficacy of vitamin C on postoperative outcomes after posterior lumbar interbody fusion: a randomized, placebo-controlled trial. Clin Orthop Surg. 2017, 9:317-24. 10.4055\/cios.2017.9.3.317","journal-title":"Clin Orthop Surg"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1997.sp004024","article-title":"Oxidative stress: oxidants and antioxidants","volume":"82","author":"Sies H","year":"1997","unstructured":"Sies H. Oxidative stress: oxidants and antioxidants. Exp Physiol. 1997, 82:291-5. 10.1113\/expphysiol.1997.sp004024","journal-title":"Exp Physiol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/33308","article-title":"Vitamin C exhibits pro-oxidant properties","volume":"392","author":"Podmore ID","year":"1998","unstructured":"Podmore ID, Griffiths HR, Herbert KE, Mistry N, Mistry P, Lunec J. Vitamin C exhibits pro-oxidant properties. Nature. 1998, 392:559. 10.1038\/33308","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000201445.77125.26","article-title":"Chronic antioxidant supplementation impairs coronary endothelial function and myocardial perfusion in normal pigs","volume":"47","author":"Versari D","year":"2006","unstructured":"Versari D, Daghini E, Rodriguez-Porcel M, et al.. Chronic antioxidant supplementation impairs coronary endothelial function and myocardial perfusion in normal pigs. Hypertension. 2006, 47:475-81. 10.1161\/01.HYP.0000201445.77125.26","journal-title":"Hypertension"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.8.842","article-title":"Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis","volume":"297","author":"Bjelakovic G","year":"2007","unstructured":"Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA. 2007, 297:842-57. 10.1001\/jama.297.8.842","journal-title":"JAMA"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/425938-association-between-postoperative-complications-and-real-time-oxidative-stress-measurements-using-electron-spin-resonance-an-observational-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:14:34Z","timestamp":1761196474000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/425938-association-between-postoperative-complications-and-real-time-oxidative-stress-measurements-using-electron-spin-resonance-an-observational-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":28,"URL":"https:\/\/doi.org\/10.7759\/cureus.95199","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,22]]}}}