{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T19:12:22Z","timestamp":1761333142403,"version":"build-2065373602"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,24]]},"DOI":"10.7759\/cureus.95343","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T19:08:12Z","timestamp":1761332892000},"source":"Crossref","is-referenced-by-count":0,"title":["Umbilicus Porocarcinoma: An Uncommon Neoplasm at a Unique Site"],"prefix":"10.7759","author":[{"given":"In\u00eas","family":"Sousa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Nobre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Clara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno G","family":"Rama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14215232","article-title":"Diagnosis and management of porocarcinoma","volume":"14","author":"Miyamoto K","year":"2022","unstructured":"Miyamoto K, Yanagi T, Maeda T, Ujiie H. Diagnosis and management of porocarcinoma. Cancers (Basel). 2022, 14:5232. 10.3390\/cancers14215232","journal-title":"Cancers (Basel)"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13081431","article-title":"Eccrine porocarcinoma: a review of the literature","volume":"13","author":"Tsiogka A","year":"2023","unstructured":"Tsiogka A, Koumaki D, Kyriazopoulou M, Liopyris K, Stratigos A, Gregoriou S. Eccrine porocarcinoma: a review of the literature. Diagnostics (Basel). 2023, 13:1431. 10.3390\/diagnostics13081431","journal-title":"Diagnostics (Basel)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590230105015","article-title":"Epidermotropic eccrine carcinoma. A case combining features of eccrine poroma and Paget's dermatosis","volume":"88","author":"Pinkus H","year":"1963","unstructured":"Pinkus H, Mehregan AH. Epidermotropic eccrine carcinoma. A case combining features of eccrine poroma and Paget's dermatosis. Archives of Dermatology. 1963, 88:597-606. 10.1001\/archderm.1963.01590230105015","journal-title":"Archives of Dermatology"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000253989","article-title":"Oncogenic differentiation of the intraepidermal eccrine sweat duct: eccrine poroma, poroepithelioma and porocarcinoma","volume":"138","author":"Mishima Y","year":"1969","unstructured":"Mishima Y, Morioka S. Oncogenic differentiation of the intraepidermal eccrine sweat duct: eccrine poroma, poroepithelioma and porocarcinoma. Dermatologica. 1969, 138:238-50. 10.1159\/000253989","journal-title":"Dermatologica"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/15278.7171","article-title":"Primary axillary porocarcinoma: a rare cutaneous tumour","volume":"10","author":"Devi NR","year":"2016","unstructured":"Devi NR, Valarmathi K, Lilly M, Satish S, Mishra N. Primary axillary porocarcinoma: a rare cutaneous tumour. J Clin Diagn Res. 2016, 10:ED04-6. 10.7860\/JCDR\/2016\/15278.7171","journal-title":"J Clin Diagn Res"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322010000700014","article-title":"Eccrine porocarcinoma (malignant eccrine poroma): a series of eight challenging cases","volume":"65","author":"de Almeida Luz M","year":"2010","unstructured":"de Almeida Luz M, Ogata DC, Montenegro MF, Biasi LJ, Ribeiro LC. Eccrine porocarcinoma (malignant eccrine poroma): a series of eight challenging cases. Clinics (Sao Paulo). 2010, 65:739-42. 10.1590\/S1807-59322010000700014","journal-title":"Clinics (Sao Paulo)"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200110000-00003","article-title":"P53 protein expression in eccrine poroma and porocarcinoma","volume":"23","author":"Akalin T","year":"2001","unstructured":"Akalin T, Sen S, Y\u00fccet\u00fcrk A, Kandilo\u011flu G. P53 protein expression in eccrine poroma and porocarcinoma. Am J Dermatopathol. 2001, 23:402-6. 10.1097\/00000372-200110000-00003","journal-title":"Am J Dermatopathol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000365348","article-title":"Successful treatment of eccrine porocarcinoma metastasized to a cervical lymph node with CyberKnife radiosurgery","volume":"6","author":"Fujimura T","year":"2014","unstructured":"Fujimura T, Hashimoto A, Furudate S, Kambayashi Y, Haga T, Aiba S. Successful treatment of eccrine porocarcinoma metastasized to a cervical lymph node with CyberKnife radiosurgery. Case Rep Dermatol. 2014, 6:159-63. 10.1159\/000365348","journal-title":"Case Rep Dermatol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200106000-00002","article-title":"Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases","volume":"25","author":"Robson A","year":"2001","unstructured":"Robson A, Greene J, Ansari N, Kim B, Seed PT, McKee PH, Calonje E. Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. Am J Surg Pathol. 2001, 25:710-20. 10.1097\/00000478-200106000-00002","journal-title":"Am J Surg Pathol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2017.06.027","article-title":"Porocarcinoma; presentation and management, a meta-analysis of 453 cases","volume":"20","author":"Salih AM","year":"2017","unstructured":"Salih AM, Kakamad FH, Baba HO, et al.. Porocarcinoma; presentation and management, a meta-analysis of 453 cases. Ann Med Surg (Lond). 2017, 20:74-9. 10.1016\/j.amsu.2017.06.027","journal-title":"Ann Med Surg (Lond)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25115760","article-title":"Porocarcinoma: clinical and histological features, immunohistochemistry and outcomes: a systematic review","volume":"25","author":"Bienstman T","year":"2024","unstructured":"Bienstman T, G\u00fcven\u00e7 C, Garmyn M. Porocarcinoma: clinical and histological features, immunohistochemistry and outcomes: a systematic review. Int J Mol Sci. 2024, 25:5760. 10.3390\/ijms25115760","journal-title":"Int J Mol Sci"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2024.01.038","article-title":"Metastatic porocarcinoma: a case demonstrating objective response to pembrolizumab","volume":"50","author":"Benhayoun C","year":"2024","unstructured":"Benhayoun C, Duval Modeste AB, Tamarit C, Joly P, Janela-Lapert R. Metastatic porocarcinoma: a case demonstrating objective response to pembrolizumab. JAAD Case Rep. 2024, 50:44-6. 10.1016\/j.jdcr.2024.01.038","journal-title":"JAAD Case Rep"},{"key":"ref13","article-title":"Eccrine porocarcinoma: a case report and literature review","volume":"4","author":"Arslan D","year":"2013","unstructured":"Arslan D, Kaplan MA, Tatl\u0131 AM, Uysal M. Eccrine porocarcinoma: a case report and literature review. J Clin Exp Investig. 2013, 4:370-3.","journal-title":"J Clin Exp Investig"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2013.25.3.348","article-title":"A case of eccrine porocarcinoma: usefulness of immunostain for s-100 protein in the diagnoses of recurrent and metastatic dedifferentiated lesions","volume":"25","author":"Kurisu Y","year":"2013","unstructured":"Kurisu Y, Tsuji M, Yasuda E, Shibayama Y. A case of eccrine porocarcinoma: usefulness of immunostain for s-100 protein in the diagnoses of recurrent and metastatic dedifferentiated lesions. Ann Dermatol. 2013, 25:348-51. 10.5021\/ad.2013.25.3.348","journal-title":"Ann Dermatol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/16083.7149","article-title":"Eccrine porocarcinoma of the scalp: a rare case report with review of literature","volume":"10","author":"Masamatti SS","year":"2016","unstructured":"Masamatti SS, Narasimha A, Bhat A, Chowdappa V. Eccrine porocarcinoma of the scalp: a rare case report with review of literature. J Clin Diagn Res. 2016, 10:ED15-6. 10.7860\/JCDR\/2016\/16083.7149","journal-title":"J Clin Diagn Res"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1177\/229255030301100304","article-title":"Eccrine porocarcinoma: a case report and review of the literature","volume":"11","author":"Lloyd MS","year":"2003","unstructured":"Lloyd MS, El-Muttardi N, Robson A. Eccrine porocarcinoma: a case report and review of the literature. Can J Plast Surg. 2003, 11:153-6. 10.1177\/229255030301100304","journal-title":"Can J Plast Surg"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2007.00324.x","article-title":"Eccrine porocarcinoma: clinical and pathological studies of 12 cases","volume":"34","author":"Shiohara J","year":"2007","unstructured":"Shiohara J, Koga H, Uhara H, Takata M, Saida T. Eccrine porocarcinoma: clinical and pathological studies of 12 cases. J Dermatol. 2007, 34:516-22. 10.1111\/j.1346-8138.2007.00324.x","journal-title":"J Dermatol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000355606","article-title":"Eccrine porocarcinoma: clinical and pathological report of eight cases","volume":"5","author":"Kurashige Y","year":"2013","unstructured":"Kurashige Y, Minemura T, Nagatani T. Eccrine porocarcinoma: clinical and pathological report of eight cases. Case Rep Dermatol. 2013, 5:259-66. 10.1159\/000355606","journal-title":"Case Rep Dermatol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2005.00201.x","article-title":"Eccrine porocarcinoma of the upper eyelid","volume":"46","author":"Kim Y","year":"2005","unstructured":"Kim Y, Scolyer RA, Chia EM, Steven D, Ghabrial R. Eccrine porocarcinoma of the upper eyelid. Australas J Dermatol. 2005, 46:278-81. 10.1111\/j.1440-0960.2005.00201.x","journal-title":"Australas J Dermatol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2007.049213","article-title":"The squamous variant of eccrine porocarcinoma: a clinicopathological study of 21 cases","volume":"61","author":"Mahomed F","year":"2008","unstructured":"Mahomed F, Blok J, Grayson W. The squamous variant of eccrine porocarcinoma: a clinicopathological study of 21 cases. J Clin Pathol. 2008, 61:361-5. 10.1136\/jcp.2007.049213","journal-title":"J Clin Pathol"},{"key":"ref21","article-title":"Presentation and management of porocarcinoma: a systematic review with meta-analysis of more than one thousand patients","volume":"2","author":"Abdullah AS","year":"2024","unstructured":"Abdullah AS, Kakamad SH, Adbullah F, et al.. Presentation and management of porocarcinoma: a systematic review with meta-analysis of more than one thousand patients. Barw Medical Journal. 2024, 2:38-46.","journal-title":"Barw Medical Journal"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1023\/a:1011196615177","article-title":"Metastatic eccrine porocarcinoma: response to docetaxel (Taxotere) chemotherapy","volume":"12","author":"Plunkett TA","year":"2001","unstructured":"Plunkett TA, Hanby AM, Miles DW, Rubens RD. Metastatic eccrine porocarcinoma: response to docetaxel (Taxotere) chemotherapy. Ann Oncol. 2001, 12:411-4. 10.1023\/a:1011196615177","journal-title":"Ann Oncol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3173","article-title":"Evaluation of sentinel lymph node biopsy for eccrine porocarcinoma","volume":"99(7)","author":"Tsunoda K","year":"2019","unstructured":"Tsunoda K, Onishi M, Maeda F, Akasaka T, Sugai T, Amano H. Evaluation of sentinel lymph node biopsy for eccrine porocarcinoma. Acta Dermato-Venereologica. 2019, 99(7):691-692. 10.2340\/00015555-3173","journal-title":"Acta Dermato-Venereologica"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/343993-umbilicus-porocarcinoma-an-uncommon-neoplasm-at-a-unique-site","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T19:08:13Z","timestamp":1761332893000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/343993-umbilicus-porocarcinoma-an-uncommon-neoplasm-at-a-unique-site"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":23,"URL":"https:\/\/doi.org\/10.7759\/cureus.95343","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2025,10,24]]}}}