{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:35:31Z","timestamp":1770359731011,"version":"3.49.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,28]]},"DOI":"10.7759\/cureus.95634","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:24:52Z","timestamp":1761715492000},"source":"Crossref","is-referenced-by-count":1,"title":["Antibiotic Prophylaxis in Maxillofacial Surgery and Evidence-Based Practice: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Gayatri","family":"Moharana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajat","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spandita","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2020.09.020","article-title":"Antibiotic prophylaxis in oral and maxillofacial surgery: a systematic review","volume":"59","author":"Milic T","year":"2021","unstructured":"Milic T, Raidoo P, Gebauer D. Antibiotic prophylaxis in oral and maxillofacial surgery: a systematic review. Br J Oral Maxillofac Surg. 2021, 59:633-42. 10.1016\/j.bjoms.2020.09.020","journal-title":"Br J Oral Maxillofac Surg"},{"key":"ref2","article-title":"Antibiotic prophylaxis in oral and maxillofacial surgery","volume":"11","author":"Salmer\u00f3n-Escobar JI","year":"2006","unstructured":"Salmer\u00f3n-Escobar JI, del Amo-Fern\u00e1ndez de Velasco A. Antibiotic prophylaxis in oral and maxillofacial surgery. Med Oral Patol Oral Cir Bucal. 2006, 11:E292-6.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2022.03.003","article-title":"Comparison of three antibiotic protocols for prevention of infection in dental implant surgery: a randomized clinical trial","volume":"50","author":"Tabrizi R","year":"2022","unstructured":"Tabrizi R, Mobin F, Dehghanpour M, Torabi ZS. Comparison of three antibiotic protocols for prevention of infection in dental implant surgery: a randomized clinical trial. J Craniomaxillofac Surg. 2022, 50:293-7. 10.1016\/j.jcms.2022.03.003","journal-title":"J Craniomaxillofac Surg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12098","article-title":"Effect of systemic antibiotics on clinical and patient-reported outcomes of implant therapy - a multicenter randomized controlled clinical trial","volume":"25","author":"Tan WC","year":"2014","unstructured":"Tan WC, Ong M, Han J, et al.. Effect of systemic antibiotics on clinical and patient-reported outcomes of implant therapy - a multicenter randomized controlled clinical trial. Clin Oral Implants Res. 2014, 25:185-93. 10.1111\/clr.12098","journal-title":"Clin Oral Implants Res"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12124","article-title":"The influence of prophylactic antibiotic administration on post-operative morbidity in dental implant surgery. A prospective double blind randomized controlled clinical trial","volume":"25","author":"Nolan R","year":"2014","unstructured":"Nolan R, Kemmoona M, Polyzois I, Claffey N. The influence of prophylactic antibiotic administration on post-operative morbidity in dental implant surgery. A prospective double blind randomized controlled clinical trial. Clin Oral Implants Res. 2014, 25:252-9. 10.1111\/clr.12124","journal-title":"Clin Oral Implants Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.24274","article-title":"Effect of antibiotic prophylaxis for preventing infectious complications following impacted mandibular third molar surgery. A randomized controlled trial","volume":"26","author":"Yanine N","year":"2021","unstructured":"Yanine N, Sabelle N, Vergara-G\u00e1rate V, et al.. Effect of antibiotic prophylaxis for preventing infectious complications following impacted mandibular third molar surgery. A randomized controlled trial. Med Oral Patol Oral Cir Bucal. 2021, 26:e703-10. 10.4317\/medoral.24274","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2020.08.034","article-title":"Do perioperative antibiotics reduce complications of mandibular third molar removal? A double-blind randomized controlled clinical trial","volume":"131","author":"Mariscal-Cazalla MD","year":"2021","unstructured":"Mariscal-Cazalla MD, Manzano-Moreno FJ, Garc\u00eda-V\u00e1zquez M, Vallecillo-Capilla MF, Olmedo-Gaya MV. Do perioperative antibiotics reduce complications of mandibular third molar removal? A double-blind randomized controlled clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol. 2021, 131:286-94. 10.1016\/j.oooo.2020.08.034","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2015.02.018","article-title":"Incidence of bisphosphonate-related osteonecrosis of the jaw in high-risk patients undergoing surgical tooth extraction","volume":"43","author":"Bodem JP","year":"2015","unstructured":"Bodem JP, Kargus S, Eckstein S, Saure D, Engel M, Hoffmann J, Freudlsperger C. Incidence of bisphosphonate-related osteonecrosis of the jaw in high-risk patients undergoing surgical tooth extraction. J Craniomaxillofac Surg. 2015, 43:510-4. 10.1016\/j.jcms.2015.02.018","journal-title":"J Craniomaxillofac Surg"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.08.014","article-title":"Amoxicillin\/clavulanic acid 2000\/125\u00a0mg to prevent complications due to infection following completely bone-impacted lower third molar removal: a clinical trial","volume":"119","author":"Arteagoitia I","year":"2015","unstructured":"Arteagoitia I, Ramos E, Santamaria G, Barbier L, Alvarez J, Santamaria J. Amoxicillin\/clavulanic acid 2000\/125\u00a0mg to prevent complications due to infection following completely bone-impacted lower third molar removal: a clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015, 119:8-16. 10.1016\/j.oooo.2014.08.014","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2016.05.019","article-title":"Limiting antibiotics when managing mandible fractures may not increase infection risk","volume":"74","author":"Gaal A","year":"2016","unstructured":"Gaal A, Bailey B, Patel Y, Smiley N, Dodson T, Kim D, Dillon J. Limiting antibiotics when managing mandible fractures may not increase infection risk. J Oral Maxillofac Surg. 2016, 74:2008-18. 10.1016\/j.joms.2016.05.019","journal-title":"J Oral Maxillofac Surg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.11.017","article-title":"The efficiency of extended postoperative antibiotic prophylaxis in orthognathic surgery: a prospective, randomized, double-blind, placebo-controlled clinical trial","volume":"47","author":"Ghantous Y","year":"2019","unstructured":"Ghantous Y, Araidy S, Yaffe V, Mirochnik R, El-Raziq MA, El-Naaj IA. The efficiency of extended postoperative antibiotic prophylaxis in orthognathic surgery: a prospective, randomized, double-blind, placebo-controlled clinical trial. J Craniomaxillofac Surg. 2019, 47:228-32. 10.1016\/j.jcms.2018.11.017","journal-title":"J Craniomaxillofac Surg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2016.01.040","article-title":"Prevalence of surgical site infections following orthognathic surgery: a retrospective cohort analysis","volume":"74","author":"Davis CM","year":"2016","unstructured":"Davis CM, Gregoire CE, Steeves TW, Demsey A. Prevalence of surgical site infections following orthognathic surgery: a retrospective cohort analysis. J Oral Maxillofac Surg. 2016, 74:1199-206. 10.1016\/j.joms.2016.01.040","journal-title":"J Oral Maxillofac Surg"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2021.08.147","article-title":"Is penicillin allergy a risk factor for surgical site infection after oral and maxillofacial surgery?","volume":"80","author":"Roistacher DM","year":"2022","unstructured":"Roistacher DM, Heller JA, Ferraro NF, August M. Is penicillin allergy a risk factor for surgical site infection after oral and maxillofacial surgery?. J Oral Maxillofac Surg. 2022, 80:93-100. 10.1016\/j.joms.2021.08.147","journal-title":"J Oral Maxillofac Surg"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2021.11.001","article-title":"Intraoperative removal of third molars does not affect the postoperative infections after BSSO - randomized controlled trial","volume":"50","author":"Marimuthu M","year":"2022","unstructured":"Marimuthu M, Wahab PU, Mathew N, Abhinav RP. Intraoperative removal of third molars does not affect the postoperative infections after BSSO - randomized controlled trial. J Craniomaxillofac Surg. 2022, 50:103-6. 10.1016\/j.jcms.2021.11.001","journal-title":"J Craniomaxillofac Surg"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2012.10.036","article-title":"Antibiotic prophylaxis for bilateral sagittal split osteotomies: a randomized, double-blind clinical study","volume":"42","author":"Wahab PU","year":"2013","unstructured":"Wahab PU, Narayanan V, Nathan S, Madhulaxmi. Antibiotic prophylaxis for bilateral sagittal split osteotomies: a randomized, double-blind clinical study. Int J Oral Maxillofac Surg. 2013, 42:352-5. 10.1016\/j.ijom.2012.10.036","journal-title":"Int J Oral Maxillofac Surg"},{"key":"ref17","article-title":"The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses","author":"Wells G","year":"2000","unstructured":"Wells G, Shea B, O\u2019Connell D, et al.. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Ottawa Hospital Research Institute, Ottawa, Canada; 2000."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2009.50.1.55","article-title":"The efficacy of postoperative prophylactic antibiotics in orthognathic surgery: a prospective study in Le Fort I osteotomy and bilateral intraoral vertical ramus osteotomy","volume":"50","author":"Kang SH","year":"2009","unstructured":"Kang SH, Yoo JH, Yi CK. The efficacy of postoperative prophylactic antibiotics in orthognathic surgery: a prospective study in Le Fort I osteotomy and bilateral intraoral vertical ramus osteotomy. Yonsei Med J. 2009, 50:55-9. 10.3349\/ymj.2009.50.1.55","journal-title":"Yonsei Med J"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/421251-antibiotic-prophylaxis-in-maxillofacial-surgery-and-evidence-based-practice-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:24:53Z","timestamp":1761715493000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/421251-antibiotic-prophylaxis-in-maxillofacial-surgery-and-evidence-based-practice-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,28]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.95634","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,28]]}}}