{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T22:24:38Z","timestamp":1761776678755,"version":"build-2065373602"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,29]]},"DOI":"10.7759\/cureus.95701","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T22:21:28Z","timestamp":1761776488000},"source":"Crossref","is-referenced-by-count":0,"title":["Rotational Thromboelastometry (ROTEM)-Assisted Anaesthetic Management of a Parturient With Paroxysmal Nocturnal Haemoglobinuria and Aplastic Anaemia for Caesarean Section: A Case Report"],"prefix":"10.7759","author":[{"given":"Despoina Fani","family":"Papadaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanouil","family":"Stamatakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giolanda","family":"Varvarousi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Valsamidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","unstructured":"Paroxysmal nocturnal hemoglobinuria. (2023). Accessed. July 7, 2025: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK562292\/."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.28","article-title":"Paroxysmal nocturnal haemoglobinuria","volume":"3","author":"Hill A","year":"2017","unstructured":"Hill A, DeZern AE, Kinoshita T, Brodsky RA. Paroxysmal nocturnal haemoglobinuria. Nat Rev Dis Primers. 2017, 3:17028. 10.1038\/nrdp.2017.28","journal-title":"Nat Rev Dis Primers"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.183046","article-title":"Concurrent treatment of aplastic anemia\/paroxysmal nocturnal hemoglobinuria syndrome with immunosuppressive therapy and eculizumab: a UK experience","volume":"103","author":"Griffin M","year":"2018","unstructured":"Griffin M, Kulasekararaj A, Gandhi S, et al.. Concurrent treatment of aplastic anemia\/paroxysmal nocturnal hemoglobinuria syndrome with immunosuppressive therapy and eculizumab: a UK experience. Haematologica. 2018, 103:e345-7. 10.3324\/haematol.2017.183046","journal-title":"Haematologica"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.14740\/jmc3478","article-title":"Two roads diverge: treatment choice in coexisting severe aplastic anemia and paroxysmal nocturnal hemoglobinuria","volume":"11","author":"Shakir A","year":"2020","unstructured":"Shakir A, Narula S, LaGrow A, Nusrat S. Two roads diverge: treatment choice in coexisting severe aplastic anemia and paroxysmal nocturnal hemoglobinuria. J Med Cases. 2020, 11:182-4. 10.14740\/jmc3478","journal-title":"J Med Cases"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.543372","article-title":"Pregnancy in classical paroxysmal nocturnal hemoglobinuria and aplastic anemia-paroxysmal nocturnal hemoglobinuria: a high-risk constellation","volume":"7","author":"Alashkar F","year":"2020","unstructured":"Alashkar F, Saner FH, Vance C, et al.. Pregnancy in classical paroxysmal nocturnal hemoglobinuria and aplastic anemia-paroxysmal nocturnal hemoglobinuria: a high-risk constellation. Front Med (Lausanne). 2020, 7:543372. 10.3389\/fmed.2020.543372","journal-title":"Front Med (Lausanne)"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-025-06353-7","article-title":"Paroxysmal nocturnal haemoglobinuria in pregnancy-a systematic review with meta analysis","volume":"104","author":"Manning JE","year":"2025","unstructured":"Manning JE, Ciantar E, Griffin M, Kelly RJ. Paroxysmal nocturnal haemoglobinuria in pregnancy-a systematic review with meta analysis. Ann Hematol. 2025, 104:2517-25. 10.1007\/s00277-025-06353-7","journal-title":"Ann Hematol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502950","article-title":"Eculizumab in pregnant patients withparoxysmal nocturnal hemoglobinuria","volume":"373","author":"Kelly RJ","year":"2015","unstructured":"Kelly RJ, H\u00f6chsmann B, Szer J, et al.. Eculizumab in pregnant patients withparoxysmal nocturnal hemoglobinuria. N Engl J Med. 2015, 373:1032-9. 10.1056\/NEJMoa1502950","journal-title":"N Engl J Med"},{"key":"ref8","article-title":"Cardiac surgery in a patient with paroxysmal nocturnal hemoglobinuria","volume":"87","author":"Knobloch K","year":"2002","unstructured":"Knobloch K, Zardo P, Gohrbandt B, et al.. Cardiac surgery in a patient with paroxysmal nocturnal hemoglobinuria. Haematologica. 2002, 87:ECR29.","journal-title":"Haematologica"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/BF03022959","article-title":"The management of cesarean delivery in a parturient with paroxysmal nocturnal hemoglobinuria complicated by severe preeclampsia","volume":"54","author":"Allen TK","year":"2007","unstructured":"Allen TK, George RB, Olufolabi AJ, James AH, Muir HA, Habib AS. The management of cesarean delivery in a parturient with paroxysmal nocturnal hemoglobinuria complicated by severe preeclampsia. Can J Anaesth. 2007, 54:646-51. 10.1007\/BF03022959","journal-title":"Can J Anaesth"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e328362a5e4","article-title":"Anaesthesia and orphan disease: laparoscopic cholecystectomy with paroxysmal nocturnal haemoglobinuria and human mAb therapy","volume":"30","author":"Vargas M","year":"2013","unstructured":"Vargas M, Lallo C, Marra A, Servillo G. Anaesthesia and orphan disease: laparoscopic cholecystectomy with paroxysmal nocturnal haemoglobinuria and human mAb therapy. Eur J Anaesthesiol. 2013, 30:770-2. 10.1097\/EJA.0b013e328362a5e4","journal-title":"Eur J Anaesthesiol"},{"key":"ref11","article-title":"Anesthetic and perioperative management of a patient with paroxysmal nocturnal hemoglobinuria","volume":"37","author":"Choi EK","year":"2018","unstructured":"Choi EK, Kim KB, Park SJ, Park KB. Anesthetic and perioperative management of a patient with paroxysmal nocturnal hemoglobinuria. Keimyung Med J. 2018, 37:92-6.","journal-title":"Keimyung Med J"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.1707","article-title":"Preoperative administration of eculizumab to prevent surgery-triggered hemolysis during cesarean section with paroxysmal nocturnal hemoglobinuria","volume":"6","author":"Li D","year":"2018","unstructured":"Li D, Wang L, Horiuchi I, et al.. Preoperative administration of eculizumab to prevent surgery-triggered hemolysis during cesarean section with paroxysmal nocturnal hemoglobinuria. Clin Case Rep. 2018, 6:1807-9. 10.1002\/ccr3.1707","journal-title":"Clin Case Rep"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S149683","article-title":"Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations","volume":"10","author":"Riveros-Perez E","year":"2018","unstructured":"Riveros-Perez E, Hermesch AC, Barbour LA, Hawkins JL. Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations. Int J Womens Health. 2018, 10:117-25. 10.2147\/IJWH.S149683","journal-title":"Int J Womens Health"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001195","article-title":"Immune modulation by volatile anesthetics","volume":"125","author":"Stollings LM","year":"2016","unstructured":"Stollings LM, Jia LJ, Tang P, Dou H, Lu B, Xu Y. Immune modulation by volatile anesthetics. Anesthesiology. 2016, 125:399-411. 10.1097\/ALN.0000000000001195","journal-title":"Anesthesiology"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-130291","article-title":"Platelet function in paroxysmal nocturnal haemoglobinuria","volume":"134","author":"Ayyalil FM","year":"2019","unstructured":"Ayyalil FM, Montague SJ, Hicks S, et al.. Platelet function in paroxysmal nocturnal haemoglobinuria. Blood. 2019, 134:4884. 10.1182\/blood-2019-130291","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-016-1946-x","article-title":"Pregnancy outcomes of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: a Japanese experience and updated review","volume":"103","author":"Miyasaka N","year":"2016","unstructured":"Miyasaka N, Miura O, Kawaguchi T, et al.. Pregnancy outcomes of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: a Japanese experience and updated review. Int J Hematol. 2016, 103:703-12. 10.1007\/s12185-016-1946-x","journal-title":"Int J Hematol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.01.021","article-title":"Activation of the complement system in normal pregnancy and preeclampsia","volume":"47","author":"Derzsy Z","year":"2010","unstructured":"Derzsy Z, Proh\u00e1szka Z, Rig\u00f3 J Jr, F\u00fcst G, Molvarec A. Activation of the complement system in normal pregnancy and preeclampsia. Mol Immunol. 2010, 47:1500-6. 10.1016\/j.molimm.2010.01.021","journal-title":"Mol Immunol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2014.11.003","article-title":"Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn","volume":"220","author":"Hallstensen RF","year":"2015","unstructured":"Hallstensen RF, Bergseth G, Foss S, et al.. Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn. Immunobiology. 2015, 220:452-9. 10.1016\/j.imbio.2014.11.003","journal-title":"Immunobiology"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14565","article-title":"Placental disposition of eculizumab, C5 and C5-eculizumab in two pregnancies of a woman with paroxysmal nocturnal haemoglobinuria","volume":"87","author":"Eliesen GA","year":"2021","unstructured":"Eliesen GA, van Drongelen J, van den Broek PH, et al.. Placental disposition of eculizumab, C5 and C5-eculizumab in two pregnancies of a woman with paroxysmal nocturnal haemoglobinuria. Br J Clin Pharmacol. 2021, 87:2128-31. 10.1111\/bcp.14565","journal-title":"Br J Clin Pharmacol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.01.012","article-title":"Placental passage of eculizumab and complement blockade in a newborn","volume":"95","author":"Duineveld C","year":"2019","unstructured":"Duineveld C, Wijnsma KL, Volokhina EB, van den Heuvel LP, van de Kar NC, Wetzels JF. Placental passage of eculizumab and complement blockade in a newborn. Kidney Int. 2019, 95:996. 10.1016\/j.kint.2019.01.012","journal-title":"Kidney Int"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/391994-rotational-thromboelastometry-rotem-assisted-anaesthetic-management-of-a-parturient-with-paroxysmal-nocturnal-haemoglobinuria-and-aplastic-anaemia-for-caesarean-section-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T22:21:29Z","timestamp":1761776489000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/391994-rotational-thromboelastometry-rotem-assisted-anaesthetic-management-of-a-parturient-with-paroxysmal-nocturnal-haemoglobinuria-and-aplastic-anaemia-for-caesarean-section-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,29]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.95701","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,29]]}}}