{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:16:39Z","timestamp":1761977799464,"version":"build-2065373602"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,31]]},"DOI":"10.7759\/cureus.95866","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:12:00Z","timestamp":1761977520000},"source":"Crossref","is-referenced-by-count":0,"title":["Bilateral Carpal Tunnel Syndrome Induced by Nivolumab Immunotherapy"],"prefix":"10.7759","author":[{"given":"Amjed  A","family":"Alhilfi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Hilman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008091","article-title":"Varied phenotypes and management of immune checkpoint inhibitor-associated neuropathies","volume":"93","author":"Dubey D","year":"2019","unstructured":"Dubey D, David WS, Amato AA, et al.. Varied phenotypes and management of immune checkpoint inhibitor-associated neuropathies. Neurology. 2019, 93:e1093-103. 10.1212\/WNL.0000000000008091","journal-title":"Neurology"},{"key":"ref2","article-title":"Carpal tunnel syndrome","volume":"83","author":"LeBlanc KE","year":"2011","unstructured":"LeBlanc KE, Cestia W. Carpal tunnel syndrome. Am Fam Physician. 2011, 83:952-8.","journal-title":"Am Fam Physician"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2011.01.014","article-title":"Carpal tunnel syndrome: the role of occupational factors","volume":"25","author":"Palmer KT","year":"2011","unstructured":"Palmer KT. Carpal tunnel syndrome: the role of occupational factors. Best Pract Res Clin Rheumatol. 2011, 25:15-29. 10.1016\/j.berh.2011.01.014","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1177\/1756286418799864","article-title":"Neurological complications of immune checkpoint inhibitors: what happens when you 'take the brakes off' the immune system","volume":"11","author":"Dalakas MC","year":"2018","unstructured":"Dalakas MC. Neurological complications of immune checkpoint inhibitors: what happens when you 'take the brakes off' the immune system. Ther Adv Neurol Disord. 2018, 11:1756286418799864. 10.1177\/1756286418799864","journal-title":"Ther Adv Neurol Disord"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw558","article-title":"Neurotoxicity from immune-checkpoint inhibition in the treatment of melanoma: a single centre experience and review of the literature","volume":"28","author":"Spain L","year":"2017","unstructured":"Spain L, Walls G, Julve M, et al.. Neurotoxicity from immune-checkpoint inhibition in the treatment of melanoma: a single centre experience and review of the literature. Ann Oncol. 2017, 28:377-85. 10.1093\/annonc\/mdw558","journal-title":"Ann Oncol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.12.001","article-title":"Neurological adverse events associated with immune checkpoint inhibitors: review of the literature","volume":"73","author":"Cuzzubbo S","year":"2017","unstructured":"Cuzzubbo S, Javeri F, Tissier M, et al.. Neurological adverse events associated with immune checkpoint inhibitors: review of the literature. Eur J Cancer. 2017, 73:1-8. 10.1016\/j.ejca.2016.12.001","journal-title":"Eur J Cancer"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.7333","article-title":"Carpal tunnel syndrome: a review of literature","volume":"12","author":"Genova A","year":"2020","unstructured":"Genova A, Dix O, Saefan A, Thakur M, Hassan A. Carpal tunnel syndrome: a review of literature. Cureus. 2020, 12:e7333. 10.7759\/cureus.7333","journal-title":"Cureus"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-017-0300-z","article-title":"Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group","volume":"5","author":"Puzanov I","year":"2017","unstructured":"Puzanov I, Diab A, Abdallah K, et al.. Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group. J Immunother Cancer. 2017, 5:95. 10.1186\/s40425-017-0300-z","journal-title":"J Immunother Cancer"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000344","article-title":"Carpal tunnel syndrome: a new adverse effect of immune checkpoint inhibitors, 11 cases","volume":"44","author":"Lechevalier D","year":"2021","unstructured":"Lechevalier D, Denis D, Le Corre Y, et al.. Carpal tunnel syndrome: a new adverse effect of immune checkpoint inhibitors, 11 cases. J Immunother. 2021, 44:122-6. 10.1097\/CJI.0000000000000344","journal-title":"J Immunother"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13091340","article-title":"Carpal tunnel syndrome associated with immune checkpoint inhibitors","volume":"13","author":"Yakobson A","year":"2023","unstructured":"Yakobson A, Rouvinov K, Cohen AY, et al.. Carpal tunnel syndrome associated with immune checkpoint inhibitors. J Pers Med. 2023, 13:1340. 10.3390\/jpm13091340","journal-title":"J Pers Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.23958\/ijirms\/vol05-i11\/981","article-title":"Carpal tunnel syndrome as an unusual immune checkpoint inhibitor adverse effect: a case series and review of the literature","volume":"5","author":"Shalata W","year":"2020","unstructured":"Shalata W, Yakobson A, Massalha I, et al.. Carpal tunnel syndrome as an unusual immune checkpoint inhibitor adverse effect: a case series and review of the literature. Int J Inn Res Med Sci. 2020, 5:550-3. 10.23958\/ijirms\/vol05-i11\/981","journal-title":"Int J Inn Res Med Sci"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/1078155220950430","article-title":"Development of carpal tunnel syndrome in association with checkpoint inhibitors","volume":"27","author":"Eisenbud L","year":"2021","unstructured":"Eisenbud L, Ejadi S, Mar N. Development of carpal tunnel syndrome in association with checkpoint inhibitors. J Oncol Pharm Pract. 2021, 27:764-5. 10.1177\/1078155220950430","journal-title":"J Oncol Pharm Pract"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5603\/ocp.100043","article-title":"Complications of immunotherapy in the course of long-term response in a patient with non-small cell lung cancer","volume":"20","author":"Gorzelak-Magiera AS","year":"2024","unstructured":"Gorzelak-Magiera AS, Domaga\u0142a-Haduch M, Gisterek-Grocholska I. Complications of immunotherapy in the course of long-term response in a patient with non-small cell lung cancer. Oncol Clin Pract. 2024, 20:325-6. 10.5603\/ocp.100043","journal-title":"Oncol Clin Pract"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.2.153","article-title":"Prevalence of carpal tunnel syndrome in a general population","volume":"282","author":"Atroshi I","year":"1999","unstructured":"Atroshi I, Gummesson C, Johnsson R, Ornstein E, Ranstam J, Ros\u00e9n I. Prevalence of carpal tunnel syndrome in a general population. JAMA. 1999, 282:153-8. 10.1001\/jama.282.2.153","journal-title":"JAMA"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.56.11.1459","article-title":"Multiperspective follow-up of untreated carpal tunnel syndrome: a multicenter study","volume":"56","author":"Padua L","year":"2001","unstructured":"Padua L, Padua R, Aprile I, Pasqualetti P, Tonali P. Multiperspective follow-up of untreated carpal tunnel syndrome: a multicenter study. Neurology. 2001, 56:1459-66. 10.1212\/wnl.56.11.1459","journal-title":"Neurology"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.3351","article-title":"Prevalence and incidence of carpal tunnel syndrome in US working populations: pooled analysis of six prospective studies","volume":"39","author":"Dale AM","year":"2013","unstructured":"Dale AM, Harris-Adamson C, Rempel D, et al.. Prevalence and incidence of carpal tunnel syndrome in US working populations: pooled analysis of six prospective studies. Scand J Work Environ Health. 2013, 39:495-505. 10.5271\/sjweh.3351","journal-title":"Scand J Work Environ Health"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.shaw.2014.01.003","article-title":"Meta-analysis: association between wrist posture and carpal tunnel syndrome among workers","volume":"5","author":"You D","year":"2014","unstructured":"You D, Smith AH, Rempel D. Meta-analysis: association between wrist posture and carpal tunnel syndrome among workers. Saf Health Work. 2014, 5:27-31. 10.1016\/j.shaw.2014.01.003","journal-title":"Saf Health Work"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/426913-bilateral-carpal-tunnel-syndrome-induced-by-nivolumab-immunotherapy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:12:01Z","timestamp":1761977521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/426913-bilateral-carpal-tunnel-syndrome-induced-by-nivolumab-immunotherapy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":17,"URL":"https:\/\/doi.org\/10.7759\/cureus.95866","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,31]]}}}