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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol. 2004, 166:213-23. 10.1083\/jcb.200403069","journal-title":"J Cell Biol"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.024","article-title":"Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids","volume":"141","author":"Sancak Y","year":"2010","unstructured":"Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010, 141:290-303. 10.1016\/j.cell.2010.02.024","journal-title":"Cell"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.09.026","article-title":"Intersubunit crosstalk in the Rag GTPase heterodimer enables mTORC1 to respond rapidly to amino acid availability","volume":"68","author":"Shen K","year":"2017","unstructured":"Shen K. 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A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013, 340:1100-6. 10.1126\/science.1232044","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab2674","article-title":"Sestrin2 is a leucine sensor for the mTORC1 pathway","volume":"351","author":"Wolfson RL","year":"2016","unstructured":"Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM. Sestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016, 351:43-8. 10.1126\/science.aab2674","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.035","article-title":"The CASTOR proteins are arginine sensors for the mTORC1 pathway","volume":"165","author":"Chantranupong L","year":"2016","unstructured":"Chantranupong L, Scaria SM, Saxton RA, et al.. The CASTOR proteins are arginine sensors for the mTORC1 pathway. 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Mol Cell. 2019, 73:971-84. 10.1016\/j.molcel.2018.12.001","journal-title":"Mol Cell"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1126\/science.1199498","article-title":"The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling","volume":"332","author":"Hsu PP","year":"2011","unstructured":"Hsu PP, Kang SA, Rameseder J, et al.. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science. 2011, 332:1317-22. 10.1126\/science.1199498","journal-title":"Science"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1126\/science.1199484","article-title":"Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling","volume":"332","author":"Yu Y","year":"2011","unstructured":"Yu Y, Yoon SO, Poulogiannis G, et al.. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science. 2011, 332:1322-6. 10.1126\/science.1199484","journal-title":"Science"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308061100","article-title":"The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress","volume":"101","author":"Shaw RJ","year":"2004","unstructured":"Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A. 2004, 101:3329-35. 10.1073\/pnas.0308061100","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00788","article-title":"mTOR as a key regulator in maintaining skeletal muscle mass","volume":"8","author":"Yoon MS","year":"2017","unstructured":"Yoon MS. mTOR as a key regulator in maintaining skeletal muscle mass. Front Physiol. 2017, 8:788. 10.3389\/fphys.2017.00788","journal-title":"Front Physiol"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05483-x","article-title":"Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle","volume":"7","author":"Song Z","year":"2017","unstructured":"Song Z, Moore DR, Hodson N, et al.. Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle. Sci Rep. 2017, 7:5028. 10.1038\/s41598-017-05483-x","journal-title":"Sci Rep"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000189","article-title":"Resistance exercise-induced hypertrophy: a potential role for rapamycin-insensitive mTOR","volume":"47","author":"Ogasawara R","year":"2019","unstructured":"Ogasawara R. Resistance exercise-induced hypertrophy: a potential role for rapamycin-insensitive mTOR. Exerc Sport Sci Rev. 2019, 47:129-41. 10.1249\/JES.0000000000000189","journal-title":"Exerc Sport Sci Rev"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1999.276.1.C120","article-title":"Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise","volume":"276","author":"Baar K","year":"1999","unstructured":"Baar K, Esser K. Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise. 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J Physiol. 2005, 568:665-76. 10.1113\/jphysiol.2005.089839","journal-title":"J Physiol"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1038\/nature02866","article-title":"Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity","volume":"431","author":"Um SH","year":"2004","unstructured":"Um SH, Frigerio F, Watanabe M, et al.. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature. 2004, 431:200-5. 10.1038\/nature02866","journal-title":"Nature"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914798107","article-title":"Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis","volume":"107","author":"Li S","year":"2010","unstructured":"Li S, Brown MS, Goldstein JL. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci U S A. 2010, 107:3441-6. 10.1073\/pnas.0914798107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.06.002","article-title":"Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways","volume":"14","author":"Yecies JL","year":"2011","unstructured":"Yecies JL, Zhang HH, Menon S, et al.. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. 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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab. 2009, 9:311-26. 10.1016\/j.cmet.2009.02.002","journal-title":"Cell Metab"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44774","article-title":"Role of mTOR in podocyte function and diabetic nephropathy in humans and mice","volume":"121","author":"G\u00f6del M","year":"2011","unstructured":"G\u00f6del M, Hartleben B, Herbach N, et al.. Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest. 2011, 121:2197-209. 10.1172\/JCI44774","journal-title":"J Clin Invest"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.12.009","article-title":"Metformin inhibits hepatic mTORC1 signaling via dose-dependent mechanisms involving AMPK and the TSC complex","volume":"25","author":"Howell JJ","year":"2017","unstructured":"Howell JJ, Hellberg K, Turner M, et al.. 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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 2012, 335:1638-43. 10.1126\/science.1215135","journal-title":"Science"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2009.11.003","article-title":"mTOR signaling: at the crossroads of plasticity, memory and disease","volume":"33","author":"Hoeffer CA","year":"2010","unstructured":"Hoeffer CA, Klann E. mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci. 2010, 33:67-75. 10.1016\/j.tins.2009.11.003","journal-title":"Trends Neurosci"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2423-05.2005","article-title":"The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus","volume":"25","author":"Banko JL","year":"2005","unstructured":"Banko JL, Poulin F, Hou L, DeMaria CT, Sonenberg N, Klann E. 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Neurobiol Dis. 2009, 34:113-20. 10.1242\/dmm.002386","journal-title":"Neurobiol Dis"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2008.07.005","article-title":"Oncogenes on my mind: ERK and mTOR signaling in cognitive diseases","volume":"24","author":"Krab LC","year":"2008","unstructured":"Krab LC. Oncogenes on my mind: ERK and mTOR signaling in cognitive diseases. Trends Genet. 2008, 24:489-97. 10.1016\/j.tig.2008.07.005","journal-title":"Trends Genet"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq491","article-title":"Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex","volume":"17","author":"Zeng LH","year":"2008","unstructured":"Zeng LH. Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex. Hum Mol Genet. 2008, 17:2118-31. 10.1093\/hmg\/ddq491","journal-title":"Hum Mol Genet"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.1038\/nm1788","article-title":"Reversal of learning deficits in a Tsc2+\/- mouse model of tuberous sclerosis","volume":"14","author":"Ehninger D","year":"2008","unstructured":"Ehninger D, Han S, Shilyansky C, et al.. Reversal of learning deficits in a Tsc2+\/- mouse model of tuberous sclerosis. Nat Med. 2008, 14:843-8. 10.1038\/nm1788","journal-title":"Nat Med"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park KK","year":"2008","unstructured":"Park KK, Liu K, Hu Y, et al.. Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway. 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Endocr Relat Cancer. 2003, 10:203-8. 10.1677\/erc.0.0100203","journal-title":"Endocr Relat Cancer"},{"key":"ref143","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200212000-00006","article-title":"PTEN inactivation is rare in melanoma tumours but occurs frequently in melanoma cell lines","volume":"12","author":"Pollock PM","year":"2002","unstructured":"Pollock PM, Walker GJ, Glendening JM, Que Noy T, Bloch NC, Fountain JW, Hayward NK. PTEN inactivation is rare in melanoma tumours but occurs frequently in melanoma cell lines. Melanoma Res. 2002, 12:565-75. 10.1097\/00008390-200212000-00006","journal-title":"Melanoma Res"},{"key":"ref144","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.19.9267","article-title":"AKT2, a putative oncogene encoding a member of a subfamily of protein-serine\/threonine kinases, is amplified in human ovarian carcinomas","volume":"89","author":"Cheng JQ","year":"1992","unstructured":"Cheng JQ, Godwin AK, Bellacosa A, et al.. 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Cancer Res. 1989, 49:4682-9.","journal-title":"Cancer Res"},{"key":"ref147","article-title":"Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin","volume":"63","author":"Ly C","year":"2003","unstructured":"Ly C, Arechiga AF, Melo JV, Walsh CM, Ong ST. Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. Cancer Res. 2003, 63:5716-22.","journal-title":"Cancer Res"},{"key":"ref148","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04362.x","article-title":"Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukemia","volume":"121","author":"Care RS","year":"2003","unstructured":"Care RS.  Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukemia. 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