{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:36:25Z","timestamp":1762266985481,"version":"build-2065373602"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,4]]},"DOI":"10.7759\/cureus.96079","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:31:41Z","timestamp":1762266701000},"source":"Crossref","is-referenced-by-count":0,"title":["Could Methotrexate Be an Option for Managing Ectopic Pregnancies in Women With an Initial High \u03b2-Human Chorionic Gonadotropin Level?"],"prefix":"10.7759","author":[{"given":"Sherin","family":"Hassaballa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Abdelmohsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayantara","family":"Bijral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14189","article-title":"Diagnosis and management of ectopic pregnancy: Green-top guideline No. 21","volume":"123","author":"RCOG Green-top Guideline","year":"2016","unstructured":"RCOG Green-top Guideline. Diagnosis and management of ectopic pregnancy: Green-top guideline No. 21. BJOG. 2016, 123:e15-55. 10.1111\/1471-0528.14189","journal-title":"BJOG"},{"key":"ref2","article-title":"Lessons for the care of women with ectopic pregnancies","author":"Felker A","year":"2024","unstructured":"Felker A, Kelly T, Vause S, et al.. Lessons for the care of women with ectopic pregnancies. Saving Lives, Improving Mothers\u2019 Care Compiled Report - Lessons Learned to Inform Maternity Care From the UK and Ireland Confidential Enquiries Into Maternal Deaths and Morbidity 2020-22. Felker A, Patel R, Kotnis R, Kenyon S, Knight M (ed): National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK; 2024. 51-9."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002560","article-title":"ACOG practice bulletin No. 193: tubal ectopic pregnancy","volume":"131","author":"Committee on Practice Bulletins\u2014Gynecology","year":"2018","unstructured":"Committee on Practice Bulletins\u2014Gynecology. ACOG practice bulletin No. 193: tubal ectopic pregnancy. Obstet Gynecol. 2018, 131:e91-e103. 10.1097\/AOG.0000000000002560","journal-title":"Obstet Gynecol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2011.09.023","article-title":"The optimal cutoff serum level of human chorionic gonadotropin for efficacy of methotrexate treatment in women with extrauterine pregnancy","volume":"116","author":"Sagiv R","year":"2012","unstructured":"Sagiv R, Debby A, Feit H, Cohen-Sacher B, Keidar R, Golan A. The optimal cutoff serum level of human chorionic gonadotropin for efficacy of methotrexate treatment in women with extrauterine pregnancy. Int J Gynaecol Obstet. 2012, 116:101-4. 10.1016\/j.ijgo.2011.09.023","journal-title":"Int J Gynaecol Obstet"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S421956","article-title":"Evaluation of guidelines and consensus on ectopic pregnancy based by AGREE II method","volume":"15","author":"Fu Y","year":"2023","unstructured":"Fu Y, Zhang W, Wang Q, Hu C, Li Q, Huang J. Evaluation of guidelines and consensus on ectopic pregnancy based by AGREE II method. Int J Womens Health. 2023, 15:1367-74. 10.2147\/IJWH.S421956","journal-title":"Int J Womens Health"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a135774","article-title":"Identification of hormonal parameters for successful systemic single-dose methotrexate therapy in ectopic pregnancy","volume":"10","author":"Corsan GH","year":"1995","unstructured":"Corsan GH, Karacan M, Qasim S, Bohrer MK, Ransom MX, Kemmann E. Identification of hormonal parameters for successful systemic single-dose methotrexate therapy in ectopic pregnancy. Hum Reprod. 1995, 10:2719-22. 10.1093\/oxfordjournals.humrep.a135774","journal-title":"Hum Reprod"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9","article-title":"Predictors of success in methotrexate treatment of women with unruptured tubal pregnancies","volume":"21","author":"Nazac A","year":"2003","unstructured":"Nazac A, Gervaise A, Bouyer J, de Tayrac R, Capella-Allouc S, Fernandez H. Predictors of success in methotrexate treatment of women with unruptured tubal pregnancies. Ultrasound Obstet Gynecol. 2003, 21:181-5. 10.1002\/uog.9","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.06.013","article-title":"Medical treatment of ectopic pregnancy: a committee opinion","volume":"100","author":"The Practice Committee of the American Society for Reproductive Medicine","year":"2013","unstructured":"The Practice Committee of the American Society for Reproductive Medicine. Medical treatment of ectopic pregnancy: a committee opinion. Fertil Steril. 2013, 100:638-44. 10.1016\/j.fertnstert.2013.06.013","journal-title":"Fertil Steril"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2001.00038.x","article-title":"A randomised trial comparing single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured tubal pregnancy","volume":"108","author":"Sowter MC","year":"2001","unstructured":"Sowter MC, Farquhar CM, Petrie KJ, Gudex G. A randomised trial comparing single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured tubal pregnancy. BJOG. 2001, 108:192-203. 10.1111\/j.1471-0528.2001.00038.x","journal-title":"BJOG"},{"key":"ref10","article-title":"Ectopic Pregnancy and Miscarriage: Diagnosis and Initial Management in Early Pregnancy of Ectopic Pregnancy and Miscarriage","author":"National Collaborating Centre for Women's and Children's Health (UK)","year":"2012","unstructured":"National Collaborating Centre for Women's and Children's Health (UK). Ectopic Pregnancy and Miscarriage: Diagnosis and Initial Management in Early Pregnancy of Ectopic Pregnancy and Miscarriage. RCOG Press, London, UK; 2012."},{"key":"ref11","unstructured":"National Institute for Health and Care Excellence. Ectopic pregnancy and miscarriage. diagnosis and initial management. (2023). https:\/\/www.nice.org.uk\/guidance\/ng126."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912233412604","article-title":"Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies","volume":"341","author":"Lipscomb GH","year":"1999","unstructured":"Lipscomb GH, McCord ML, Stovall TG, Huff G, Portera SG, Ling FW. Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies. N Engl J Med. 1999, 341:1974-8. 10.1056\/NEJM199912233412604","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(99)00114-9","article-title":"Predictive score for the systemic treatment of unruptured ectopic pregnancy with a single dose of methotrexate","volume":"67","author":"Elito J Jr","year":"1999","unstructured":"Elito J Jr, Reichmann AP, Uchiyama MN, Camano L. Predictive score for the systemic treatment of unruptured ectopic pregnancy with a single dose of methotrexate. Int J Gynaecol Obstet. 1999, 67:75-9. 10.1016\/S0020-7292(99)00114-9","journal-title":"Int J Gynaecol Obstet"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.310","article-title":"Predictors of success with methotrexate treatment of tubal ectopic pregnancy at Grady Memorial Hospital","volume":"188","author":"Potter MB","year":"2003","unstructured":"Potter MB, Lepine LA, Jamieson DJ. Predictors of success with methotrexate treatment of tubal ectopic pregnancy at Grady Memorial Hospital. Am J Obstet Gynecol. 2003, 188:1192-4. 10.1067\/mob.2003.310","journal-title":"Am J Obstet Gynecol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurox.2024.100286","article-title":"Methotrexate as the first-line treatment of unruptured tubular ectopic pregnancies with high initial human chorionic gonadotropin levels: a retrospective cohort","volume":"21","author":"Keikha F","year":"2024","unstructured":"Keikha F, Ardekani SS, Parsaei M, Zargarzadeh N, Hadizadeh A, Tarafdari A. Methotrexate as the first-line treatment of unruptured tubular ectopic pregnancies with high initial human chorionic gonadotropin levels: a retrospective cohort. Eur J Obstet Gynecol Reprod Biol X. 2024, 21:100286. 10.1016\/j.eurox.2024.100286","journal-title":"Eur J Obstet Gynecol Reprod Biol X"},{"key":"ref16","article-title":"Diagnosis and management of ectopic pregnancy","volume":"90","author":"Barash JH","year":"2014","unstructured":"Barash JH, Buchanan EM, Hillson C. Diagnosis and management of ectopic pregnancy. Am Fam Physician. 2014, 90:34-40.","journal-title":"Am Fam Physician"},{"key":"ref17","unstructured":"NHS England. Choice and personalised care in maternity services. (2024). https.\/\/www.england.nhs.uk\/mat-transformation\/choice-and-personalisation."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/birt.12827","article-title":"Birth \"outside of guidance\"\u2014An exploration of a Birth Choices Clinic in the United Kingdom","volume":"52","author":"McAllister S","year":"2025","unstructured":"McAllister S, Litchfield C. Birth \"outside of guidance\"\u2014An exploration of a Birth Choices Clinic in the United Kingdom. Birth. 2025, 52:46-54. 10.1111\/birt.12827","journal-title":"Birth"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.83252","article-title":"Chronic pelvic pain due to residual ectopic tissue after treatment with methotrexate","volume":"17","author":"Hillebrand AM","year":"2025","unstructured":"Hillebrand AM, To J. Chronic pelvic pain due to residual ectopic tissue after treatment with methotrexate. Cureus. 2025, 17:e83252. 10.7759\/cureus.83252","journal-title":"Cureus"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/426336-could-methotrexate-be-an-option-for-managing-ectopic-pregnancies-in-women-with-an-initial-high--human-chorionic-gonadotropin-level","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:31:42Z","timestamp":1762266702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/426336-could-methotrexate-be-an-option-for-managing-ectopic-pregnancies-in-women-with-an-initial-high--human-chorionic-gonadotropin-level"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.96079","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2025,11,4]]}}}