{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:38:54Z","timestamp":1762529934692,"version":"build-2065373602"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,7]]},"DOI":"10.7759\/cureus.96306","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:34:42Z","timestamp":1762529682000},"source":"Crossref","is-referenced-by-count":0,"title":["Intratracheal Budesonide Combined With Surfactant for Pulmonary Hemorrhage in a Preterm Neonate: A Case Report"],"prefix":"10.7759","author":[{"given":"Saeka","family":"Matsubara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiko","family":"Tanimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16127","article-title":"Pulmonary haemorrhage in neonates: systematic review of management","volume":"111","author":"Barnes ME","year":"2022","unstructured":"Barnes ME, Feeney E, Duncan A, et al.. Pulmonary haemorrhage in neonates: systematic review of management. Acta Paediatr. 2022, 111:236-44. 10.1111\/apa.16127","journal-title":"Acta Paediatr"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-3084(88)90063-1","article-title":"A biophysical mechanism by which plasma proteins inhibit lung surfactant activity","volume":"49","author":"Holm BA","year":"1988","unstructured":"Holm BA, Enhorning G, Notter RH, et al.. A biophysical mechanism by which plasma proteins inhibit lung surfactant activity. Chem Phys Lipids. 1988, 49:49-55. 10.1016\/0009-3084(88)90063-1","journal-title":"Chem Phys Lipids"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.95.1.32","article-title":"Surfactant therapy in neonates with respiratory deterioration due to pulmonary hemorrhage","volume":"95","author":"Pandit PB","year":"1995","unstructured":"Pandit PB, Dunn MS, Colucci EA, et al.. Surfactant therapy in neonates with respiratory deterioration due to pulmonary hemorrhage. Pediatrics. 1995, 95:32-6. 10.1542\/peds.95.1.32","journal-title":"Pediatrics"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-003-1276-x","article-title":"Surfactant therapy in neonates with respiratory failure due to haemorrhagic pulmonary oedema","volume":"162","author":"Amizuka T","year":"2003","unstructured":"Amizuka T, Shimizu H, Niida Y, Ogawa Y. Surfactant therapy in neonates with respiratory failure due to haemorrhagic pulmonary oedema. Eur J Pediatr. 2003, 162:697-702. 10.1007\/s00431-003-1276-x","journal-title":"Eur J Pediatr"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2013.04.005","article-title":"Short-term outcome of pulmonary hemorrhage in very-low-birth-weight preterm infants","volume":"54","author":"Yen TA","year":"2013","unstructured":"Yen TA, Wang CC, Hsieh WS, Chou HC, Chen CY, Tsao PN. Short-term outcome of pulmonary hemorrhage in very-low-birth-weight preterm infants. Pediatr Neonatol. 2013, 54:330-4. 10.1016\/j.pedneo.2013.04.005","journal-title":"Pediatr Neonatol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.21037\/tp-22-8","article-title":"A systematic review and meta-analysis of pulmonary surfactant combined with budesonide in the treatment of neonatal respiratory distress syndrome","volume":"11","author":"Yi Z","year":"2022","unstructured":"Yi Z, Tan Y, Liu Y, et al.. A systematic review and meta-analysis of pulmonary surfactant combined with budesonide in the treatment of neonatal respiratory distress syndrome. Transl Pediatr. 2022, 11:526-36. 10.21037\/tp-22-8","journal-title":"Transl Pediatr"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201505-0861OC","article-title":"Intratracheal administration of budesonide\/surfactant to prevent bronchopulmonary dysplasia","volume":"193","author":"Yeh TF","year":"2016","unstructured":"Yeh TF, Chen CM, Wu SY, et al.. Intratracheal administration of budesonide\/surfactant to prevent bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2016, 193:86-95. 10.1164\/rccm.201505-0861OC","journal-title":"Am J Respir Crit Care Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00210","article-title":"Endotracheal surfactant combined with budesonide for neonatal ARDS","volume":"8","author":"Deliloglu B","year":"2020","unstructured":"Deliloglu B, Tuzun F, Cengiz MM, Ozkan H, Duman N. Endotracheal surfactant combined with budesonide for neonatal ARDS. Front Pediatr. 2020, 8:210. 10.3389\/fped.2020.00210","journal-title":"Front Pediatr"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000218117","article-title":"Inhibition of secretory phospholipase A2-induced cytokine production in human lung macrophages by budesonide","volume":"150","author":"Triggiani M","year":"2009","unstructured":"Triggiani M, Granata F, Petraroli A, et al.. Inhibition of secretory phospholipase A2-induced cytokine production in human lung macrophages by budesonide. Int Arch Allergy Immunol. 2009, 150:144-55. 10.1159\/000218117","journal-title":"Int Arch Allergy Immunol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30214-X","article-title":"The Montreux definition of neonatal ARDS: biological and clinical background behind the description of a new entity","volume":"5","author":"Luca DD","year":"2017","unstructured":"Luca DD, van Kaam AH, Tingay DG, et al.. The Montreux definition of neonatal ARDS: biological and clinical background behind the description of a new entity. Lancet Respir Med. 2017, 5:657-66. 10.1016\/S2213-2600(17)30214-X","journal-title":"Lancet Respir Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002961","article-title":"Epidemiology of neonatal acute respiratory distress syndrome: prospective, multicenter, international cohort study","volume":"23","author":"De Luca D","year":"2022","unstructured":"De Luca D, Tingay DG, van Kaam AH, et al.. Epidemiology of neonatal acute respiratory distress syndrome: prospective, multicenter, international cohort study. Pediatr Crit Care Med. 2022, 23:524-34. 10.1097\/PCC.0000000000002961","journal-title":"Pediatr Crit Care Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2021.07.011","article-title":"Strategies to protect surfactant and enhance its activity","volume":"44","author":"De Luca D","year":"2021","unstructured":"De Luca D, Autilio C. Strategies to protect surfactant and enhance its activity. Biomed J. 2021, 44:654-62. 10.1016\/j.bj.2021.07.011","journal-title":"Biomed J"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-021-01003-x","article-title":"Secretory phospholipase A2 enzymes in acute lung injury","volume":"79","author":"Letsiou E","year":"2021","unstructured":"Letsiou E, Htwe YM, Dudek SM. Secretory phospholipase A2 enzymes in acute lung injury. Cell Biochem Biophys. 2021, 79:609-17. 10.1007\/s12013-021-01003-x","journal-title":"Cell Biochem Biophys"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.4.1434","article-title":"Effects of hemoglobin and cell membrane lipids on pulmonary surfactant activity","volume":"63","author":"Holm BA","year":"1987","unstructured":"Holm BA, Notter RH. Effects of hemoglobin and cell membrane lipids on pulmonary surfactant activity. J Appl Physiol (1985). 1987, 63:1434-42. 10.1152\/jappl.1987.63.4.1434","journal-title":"J Appl Physiol (1985)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2005.10.014","article-title":"Lysophospholipid and fatty acid inhibition of pulmonary surfactant: non-enzymatic models of phospholipase A2 surfactant hydrolysis","volume":"1720","author":"Hite RD","year":"2005","unstructured":"Hite RD, Seeds MC, Jacinto RB, Grier BL, Waite BM, Bass DA. Lysophospholipid and fatty acid inhibition of pulmonary surfactant: non-enzymatic models of phospholipase A2 surfactant hydrolysis. Biochim Biophys Acta. 2005, 1720:14-21. 10.1016\/j.bbamem.2005.10.014","journal-title":"Biochim Biophys Acta"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1021\/bi00488a032","article-title":"Pulmonary surfactant-associated protein A enhances the surface activity of lipid extract surfactant and reverses inhibition by blood proteins in vitro","volume":"29","author":"Cockshutt AM","year":"1990","unstructured":"Cockshutt AM, Weitz J, Possmayer F. Pulmonary surfactant-associated protein A enhances the surface activity of lipid extract surfactant and reverses inhibition by blood proteins in vitro. Biochemistry. 1990, 29:8424-9. 10.1021\/bi00488a032","journal-title":"Biochemistry"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2008.29.3155","article-title":"Effect of inhaled budesonide on surfactant protein expression in asthmatic mice","volume":"29","author":"Yu ZW","year":"2008","unstructured":"Yu ZW, Zhang JH. Effect of inhaled budesonide on surfactant protein expression in asthmatic mice. Allergy Asthma Proc. 2008, 29:486-92. 10.2500\/aap.2008.29.3155","journal-title":"Allergy Asthma Proc"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s0169-409x(01)00106-5","article-title":"Exogenous surfactant as a drug delivery agent","volume":"47","author":"Haitsma JJ","year":"2001","unstructured":"Haitsma JJ, Lachmann U, Lachmann B. Exogenous surfactant as a drug delivery agent. Adv Drug Deliv Rev. 2001, 47:197-207. 10.1016\/s0169-409x(01)00106-5","journal-title":"Adv Drug Deliv Rev"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005254.pub4","article-title":"Surfactant for pulmonary haemorrhage in neonates","volume":"2","author":"Aziz A","year":"2020","unstructured":"Aziz A, Ohlsson A. Surfactant for pulmonary haemorrhage in neonates. Cochrane Database Syst Rev. 2020, 2:CD005254. 10.1002\/14651858.CD005254.pub4","journal-title":"Cochrane Database Syst Rev"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1389090","article-title":"Comparison of two natural surfactants for pulmonary hemorrhage in very low-birth-weight infants: a randomized controlled trial","volume":"32","author":"Bozda\u011f \u015e","year":"2015","unstructured":"Bozda\u011f \u015e, Dilli D, G\u00f6kmen T, Dilmen U. Comparison of two natural surfactants for pulmonary hemorrhage in very low-birth-weight infants: a randomized controlled trial. Am J Perinatol. 2015, 32:211-8. 10.1055\/s-0034-1389090","journal-title":"Am J Perinatol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3236","article-title":"Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction","volume":"102","author":"Arbibe L","year":"1998","unstructured":"Arbibe L, Koumanov K, Vial D, et al.. Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction. J Clin Invest. 1998, 102:1152-60. 10.1172\/JCI3236","journal-title":"J Clin Invest"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03821-2","article-title":"Bovine surfactant in the treatment of pneumonia-induced-neonatal acute respiratory distress syndrome (NARDS) in neonates beyond 34 weeks of gestation: a multicentre, randomized, assessor-blinded, placebo-controlled trial","volume":"180","author":"Rong Z","year":"2021","unstructured":"Rong Z, Mo L, Pan R, et al.. Bovine surfactant in the treatment of pneumonia-induced-neonatal acute respiratory distress syndrome (NARDS) in neonates beyond 34 weeks of gestation: a multicentre, randomized, assessor-blinded, placebo-controlled trial. Eur J Pediatr. 2021, 180:1107-15. 10.1007\/s00431-020-03821-2","journal-title":"Eur J Pediatr"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.17380","article-title":"Intratracheal budesonide mixed with surfactant for extremely preterm infants: the PLUSS randomized clinical trial","volume":"332","author":"Manley BJ","year":"2024","unstructured":"Manley BJ, Kamlin CO, Donath SM, et al.. Intratracheal budesonide mixed with surfactant for extremely preterm infants: the PLUSS randomized clinical trial. JAMA. 2024, 332:1889-99. 10.1001\/jama.2024.17380","journal-title":"JAMA"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.16450","article-title":"Early intratracheal budesonide to reduce bronchopulmonary dysplasia in extremely preterm infants: the Budesonide in Babies (BiB) randomized clinical trial","volume":"334","author":"Ambalavanan N","year":"2025","unstructured":"Ambalavanan N, Carlo WA, Nowak KJ, et al.. Early intratracheal budesonide to reduce bronchopulmonary dysplasia in extremely preterm infants: the Budesonide in Babies (BiB) randomized clinical trial. JAMA. 2025, 334:1452-62. 10.1001\/jama.2025.16450","journal-title":"JAMA"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.34172\/aim.31725","article-title":"Endotracheal surfactant and budesonide combination therapy in neonatal acute respiratory distress syndrome due to late-onset sepsis","volume":"27","author":"Gunes AO","year":"2024","unstructured":"Gunes AO, Bozkaya A. Endotracheal surfactant and budesonide combination therapy in neonatal acute respiratory distress syndrome due to late-onset sepsis. Arch Iran Med. 2024, 27:573-9. 10.34172\/aim.31725","journal-title":"Arch Iran Med"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2174\/1574884710666150929100210","article-title":"Pharmacokinetics of budesonide administered with surfactant in premature lambs: implications for neonatal clinical trials","volume":"11","author":"Roberts JK","year":"2016","unstructured":"Roberts JK, Stockmann C, Dahl MJ, et al.. Pharmacokinetics of budesonide administered with surfactant in premature lambs: implications for neonatal clinical trials. Curr Clin Pharmacol. 2016, 11:53-61. 10.2174\/1574884710666150929100210","journal-title":"Curr Clin Pharmacol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/233600-intratracheal-budesonide-combined-with-surfactant-for-pulmonary-hemorrhage-in-a-preterm-neonate-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:34:43Z","timestamp":1762529683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/233600-intratracheal-budesonide-combined-with-surfactant-for-pulmonary-hemorrhage-in-a-preterm-neonate-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,7]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.96306","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,7]]}}}