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Hum Reprod. 2000, 15:1163-9. 10.1093\/humrep\/15.5.1163","journal-title":"Hum Reprod"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.5.855","article-title":"Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology","volume":"16","author":"Ntrivalas EI","year":"2001","unstructured":"Ntrivalas EI, Kwak-Kim JY, Gilman-Sachs A, et al.. Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology. Hum Reprod. 2001, 16:855-61. 10.1093\/humrep\/16.5.855","journal-title":"Hum Reprod"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2012.705391","article-title":"Infertility and pregnancy loss in euthyroid women with thyroid autoimmunity","volume":"29","author":"Artini PG","year":"2013","unstructured":"Artini PG, Uccelli A, Papini F, Simi G, Di Berardino OM, Ruggiero M, Cela V. Infertility and pregnancy loss in euthyroid women with thyroid autoimmunity. Gynecol Endocrinol. 2013, 29:36-41. 10.3109\/09513590.2012.705391","journal-title":"Gynecol Endocrinol"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn013","article-title":"Bidirectional effects on autoimmunity and reproduction","volume":"14","author":"Cervera R","year":"2008","unstructured":"Cervera R, Balasch J. Bidirectional effects on autoimmunity and reproduction. Hum Reprod Update. 2008, 14:359-66. 10.1093\/humupd\/dmn013","journal-title":"Hum Reprod Update"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200001)43:1<140::AID-ANR18>3.0.CO;2-P","article-title":"Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2-glycoprotein I","volume":"43","author":"Di Simone N","year":"2000","unstructured":"Di Simone N, Meroni PL, de Papa N, et al.. Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2-glycoprotein I. Arthritis Rheum. 2000, 43:1-140. 10.1002\/1529-0131(200001)43:1&lt;140::AID-ANR18&gt;3.0.CO;2-P","journal-title":"Arthritis Rheum"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/19009.8403","article-title":"The effect of anti-thyroid peroxidase antibodies on pregnancy outcomes in euthyroid women","volume":"10","author":"Meena M","year":"2016","unstructured":"Meena M, Chopra S, Jain V, Aggarwal N. The effect of anti-thyroid peroxidase antibodies on pregnancy outcomes in euthyroid women. J Clin Diagn Res. 2016, 10:QC04-7. 10.7860\/JCDR\/2016\/19009.8403","journal-title":"J Clin Diagn Res"},{"key":"ref56","article-title":"Social environmental and genetic influences on obesity and obesity-promoting behaviors: fostering research integration","author":"Faith MS","year":"2006","unstructured":"Faith MS, Kral TVE. Social environmental and genetic influences on obesity and obesity-promoting behaviors: fostering research integration. Genes, Behavior, and the Social Environment: Moving Beyond the Nature\/Nurture Debate. Hernandez LM, Blazer DG (ed): National Academies Press (US), Washington (DC); 2006."},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.69332","article-title":"The impact of female obesity on the outcome of fertility treatment","volume":"3","author":"Pandey S","year":"2010","unstructured":"Pandey S, Pandey S, Maheshwari A, Bhattacharya S. The impact of female obesity on the outcome of fertility treatment. J Hum Reprod Sci. 2010, 3:62-7. 10.4103\/0974-1208.69332","journal-title":"J Hum Reprod Sci"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.4103\/0976-9668.160021","article-title":"Anti-thyroid peroxidase antibody positivity during early pregnancy is associated with pregnancy complications and maternal morbidity in later life","volume":"6","author":"Bhattacharyya R","year":"2015","unstructured":"Bhattacharyya R, Mukherjee K, Das A, Biswas MR, Basunia SR, Mukherjee A. Anti-thyroid peroxidase antibody positivity during early pregnancy is associated with pregnancy complications and maternal morbidity in later life. J Nat Sci Biol Med. 2015, 6:402-5. 10.4103\/0976-9668.160021","journal-title":"J Nat Sci Biol Med"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-714","article-title":"The relationship between polycystic ovary syndrome and infertility: a bibliometric analysis","volume":"10","author":"Zhuang S","year":"2022","unstructured":"Zhuang S, Jing C, Yu L, Ji L, Liu W, Hu X. The relationship between polycystic ovary syndrome and infertility: a bibliometric analysis. Ann Transl Med. 2022, 10:318. 10.21037\/atm-22-714","journal-title":"Ann Transl Med"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59091551","article-title":"Adenomyosis and infertility: a literature review","volume":"59","author":"Pados G","year":"2023","unstructured":"Pados G, Gordts S, Sorrentino F, Nisolle M, Nappi L, Daniilidis A. Adenomyosis and infertility: a literature review. Medicina (Kaunas). 2023, 59:1551. 10.3390\/medicina59091551","journal-title":"Medicina (Kaunas)"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv044","article-title":"Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome","volume":"22","author":"Vannuccini S","year":"2016","unstructured":"Vannuccini S, Clifton VL, Fraser IS, Taylor HS, Critchley H, Giudice LC, Petraglia F. Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome. Hum Reprod Update. 2016, 22:104-15. 10.1093\/humupd\/dmv044","journal-title":"Hum Reprod Update"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00734-y","article-title":"A global view of hypertensive disorders and diabetes mellitus during pregnancy","volume":"18","author":"Jiang L","year":"2022","unstructured":"Jiang L, Tang K, Magee LA, et al.. A global view of hypertensive disorders and diabetes mellitus during pregnancy. Nat Rev Endocrinol. 2022, 18:760-75. 10.1038\/s41574-022-00734-y","journal-title":"Nat Rev Endocrinol"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812537","article-title":"Levothyroxine in women with thyroid peroxidase antibodies before conception","volume":"380","author":"Dhillon-Smith RK","year":"2019","unstructured":"Dhillon-Smith RK, Middleton LJ, Sunner KK, et al.. Levothyroxine in women with thyroid peroxidase antibodies before conception. N Engl J Med. 2019, 380:1316-25. 10.1056\/NEJMoa1812537","journal-title":"N Engl J Med"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00045-6","article-title":"Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial","volume":"10","author":"van Dijk MM","year":"2022","unstructured":"van Dijk MM, Vissenberg R, Fliers E, et al.. Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Diabetes Endocrinol. 2022, 10:322-9. 10.1016\/S2213-8587(22)00045-6","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.03.048","article-title":"Effects of enoxaparin on late pregnancy complications and neonatal outcome in women with recurrent pregnancy loss and thrombophilia: results from the Live-Enox study","volume":"84","author":"Brenner B","year":"2005","unstructured":"Brenner B, Bar J, Ellis M, Yarom I, Yohai D, Samueloff A. Effects of enoxaparin on late pregnancy complications and neonatal outcome in women with recurrent pregnancy loss and thrombophilia: results from the Live-Enox study. Fertil Steril. 2005, 84:770-3. 10.1016\/j.fertnstert.2005.03.048","journal-title":"Fertil Steril"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13590","article-title":"Thyroid autoantibodies in pregnancy are associated with hypertensive disorders of pregnancy: Ma'anshan birth cohort study","volume":"88","author":"Han Y","year":"2018","unstructured":"Han Y, Mao LJ, Ge X, et al.. Thyroid autoantibodies in pregnancy are associated with hypertensive disorders of pregnancy: Ma'anshan birth cohort study. Clin Endocrinol (Oxf). 2018, 88:928-35. 10.1111\/cen.13590","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00109.2020","article-title":"Low molecular weight heparin promotes transcription and release of placental growth factor from endothelial cells","volume":"318","author":"McLaughlin K","year":"2020","unstructured":"McLaughlin K, Nadeem L, Wat J, Baczyk D, Lye SJ, Kingdom JC. Low molecular weight heparin promotes transcription and release of placental growth factor from endothelial cells. Am J Physiol Heart Circ Physiol. 2020, 318:H1008-17. 10.1152\/ajpheart.00109.2020","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.3109\/07435800.2014.966384","article-title":"Thyroid autoimmunity in pregnancy and its influences on maternal and fetal outcome in Iran (a prospective study)","volume":"40","author":"Saki F","year":"2015","unstructured":"Saki F, Dabbaghmanesh MH, Ghaemi SZ, Forouhari S, Omrani GR, Bakhshayeshkaram M. Thyroid autoimmunity in pregnancy and its influences on maternal and fetal outcome in Iran (a prospective study). Endocr Res. 2015, 40:139-45. 10.3109\/07435800.2014.966384","journal-title":"Endocr Res"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3441","article-title":"A longitudinal study of thyroid markers during pregnancy and the risk of gestational diabetes mellitus and post-partum glucose metabolism","volume":"37","author":"Tang L","year":"2021","unstructured":"Tang L, Li P, Zhou H, Li L. A longitudinal study of thyroid markers during pregnancy and the risk of gestational diabetes mellitus and post-partum glucose metabolism. Diabetes Metab Res Rev. 2021, 37:e3441. 10.1002\/dmrr.3441","journal-title":"Diabetes Metab Res Rev"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-1022-6","article-title":"Maternal TSH level and TPOAb status in early pregnancy and their relationship to the risk of gestational diabetes mellitus","volume":"54","author":"Ying H","year":"2016","unstructured":"Ying H, Tang YP, Bao YR, Su XJ, Cai X, Li YH, Wang DF. Maternal TSH level and TPOAb status in early pregnancy and their relationship to the risk of gestational diabetes mellitus. Endocrine. 2016, 54:742-50. 10.1007\/s12020-016-1022-6","journal-title":"Endocrine"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011895","article-title":"LMWH prevents thromboinflammation in the placenta via\u00a0HBEGF-AKT signaling","volume":"8","author":"Singh KK","year":"2024","unstructured":"Singh KK, Gupta A, Forstner D, et al.. LMWH prevents thromboinflammation in the placenta via\u00a0HBEGF-AKT signaling. Blood Adv. 2024, 8:4756-66. 10.1182\/bloodadvances.2023011895","journal-title":"Blood Adv"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500751","article-title":"Thyroid autoimmunity and miscarriage","volume":"150","author":"Prummel MF","year":"2004","unstructured":"Prummel MF, Wiersinga WM. Thyroid autoimmunity and miscarriage. Eur J Endocrinol. 2004, 150:751-5. 10.1530\/eje.0.1500751","journal-title":"Eur J Endocrinol"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmw019","article-title":"The impact of thyroid autoimmunity on IVF\/ICSI outcome: a systematic review and meta-analysis","volume":"22","author":"Busnelli A","year":"2016","unstructured":"Busnelli A, Paffoni A, Fedele L, Somigliana E. The impact of thyroid autoimmunity on IVF\/ICSI outcome: a systematic review and meta-analysis. Hum Reprod Update. 2016, 22:775-90. 10.1093\/humupd\/dmw019","journal-title":"Hum Reprod Update"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d2616","article-title":"Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence","volume":"342","author":"Thangaratinam S","year":"2011","unstructured":"Thangaratinam S, Tan A, Knox E, Kilby MD, Franklyn J, Coomarasamy A. Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence. BMJ. 2011, 342:d2616. 10.1136\/bmj.d2616","journal-title":"BMJ"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1285504","article-title":"Maternal thyroid peroxidase antibody positivity and its association with incidence of low birth weight in infants","volume":"14","author":"Chen L","year":"2023","unstructured":"Chen L, Lin D, Lin Z, Ye E, Sun M, Lu X. Maternal thyroid peroxidase antibody positivity and its association with incidence of low birth weight in infants. Front Endocrinol (Lausanne). 2023, 14:1285504. 10.3389\/fendo.2023.1285504","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1520","article-title":"Perinatal outcome of children born to mothers with thyroid dysfunction or antibodies: a prospective population-based cohort study","volume":"94","author":"M\u00e4nnist\u00f6 T","year":"2009","unstructured":"M\u00e4nnist\u00f6 T, V\u00e4\u00e4r\u00e4sm\u00e4ki M, Pouta A, et al.. Perinatal outcome of children born to mothers with thyroid dysfunction or antibodies: a prospective population-based cohort study. J Clin Endocrinol Metab. 2009, 94:772-9. 10.1210\/jc.2008-1520","journal-title":"J Clin Endocrinol Metab"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.2217\/17455057.3.1.9","article-title":"Enoxaparin use in pregnancy: state of the art","volume":"3","author":"Brenner B","year":"2007","unstructured":"Brenner B. Enoxaparin use in pregnancy: state of the art. 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