{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T07:56:01Z","timestamp":1762934161891,"version":"3.45.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,11]]},"DOI":"10.7759\/cureus.96637","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T07:53:05Z","timestamp":1762933985000},"source":"Crossref","is-referenced-by-count":0,"title":["The Comparative Effectiveness of PDE5 Inhibitors and \u03b23 Agonists Versus \u03b1-Blockers in Medical Expulsive Therapy for Distal Ureteric Stones: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.7759","author":[{"given":"Maheshwara","family":"Ramanah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indrajit","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarvesh","family":"Nunkoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mooroogiah","family":"Krissheeven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indraneel","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Urolithiasis: history, epidemiology, aetiologic factors and management","volume":"45","author":"Kachkoul R","year":"2023","unstructured":"Kachkoul R, Touimi GB, El Mouhri G, El Habbani R, Mohim M, Lahrichi A. Urolithiasis: history, epidemiology, aetiologic factors and management. Malays J Pathol. 2023, 45:333-52.","journal-title":"Malays J Pathol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2010.51.3.193","article-title":"Tamsulosin versus alfuzosin in the treatment of patients with distal ureteral stones: prospective, randomized, comparative study","volume":"51","author":"Ahmed AF","year":"2010","unstructured":"Ahmed AF, Al-Sayed AY. Tamsulosin versus alfuzosin in the treatment of patients with distal ureteral stones: prospective, randomized, comparative study. Korean J Urol. 2010, 51:193-7. 10.4111\/kju.2010.51.3.193","journal-title":"Korean J Urol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.5217","article-title":"In vivo evaluation of the chemical composition of urinary stones using dual-energy CT","volume":"197","author":"Manglaviti G","year":"2011","unstructured":"Manglaviti G, Tresoldi S, Guerrer CS, Di Leo G, Montanari E, Sardanelli F, Cornalba G. In vivo evaluation of the chemical composition of urinary stones using dual-energy CT. AJR Am J Roentgenol. 2011, 197:W76-83. 10.2214\/AJR.10.5217","journal-title":"AJR Am J Roentgenol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(77)90097-8","article-title":"Relation of spontaneous passage of ureteral calculi to size","volume":"10","author":"Ueno A","year":"1977","unstructured":"Ueno A, Kawamura T, Ogawa A, Takayasu H. Relation of spontaneous passage of ureteral calculi to size. Urology. 1977, 10:544-6. 10.1016\/0090-4295(77)90097-8","journal-title":"Urology"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-5538.IBJU.2019.0550","article-title":"Efficacy and safety of various surgical treatments for proximal ureteral stone \u226510mm: a systematic review and network meta-analysis","volume":"46","author":"Wang Y","year":"2020","unstructured":"Wang Y, Chang X, Li J, Han Z. Efficacy and safety of various surgical treatments for proximal ureteral stone \u226510mm: a systematic review and network meta-analysis. Int Braz J Urol. 2020, 46:902-26. 10.1590\/S1677-5538.IBJU.2019.0550","journal-title":"Int Braz J Urol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp030813","article-title":"Acute renal colic from ureteral calculus","volume":"350","author":"Teichman JM","year":"2004","unstructured":"Teichman JM. Acute renal colic from ureteral calculus. N Engl J Med. 2004, 350:684-93. 10.1056\/NEJMcp030813","journal-title":"N Engl J Med"},{"key":"ref7","article-title":"Efficacy and safety of tamsulosin in the medical expulsion therapy for distal ureteral calculi: a systematic review and meta-analysis of placebo-controlled trials","volume":"16","author":"Tao RZ","year":"2019","unstructured":"Tao RZ, Qin ZQ, Liu FD, Lv JL. Efficacy and safety of tamsulosin in the medical expulsion therapy for distal ureteral calculi: a systematic review and meta-analysis of placebo-controlled trials. Urol J. 2019, 16:224-31.","journal-title":"Urol J"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-017-0974-1","article-title":"Role of silodosin as medical expulsive therapy in ureteral calculi: a meta-analysis of randomized controlled trials","volume":"46","author":"Liu XJ","year":"2018","unstructured":"Liu XJ, Wen JG, Wan YD, Hu BW, Wang QW, Wang Y. Role of silodosin as medical expulsive therapy in ureteral calculi: a meta-analysis of randomized controlled trials. Urolithiasis. 2018, 46:211-8. 10.1007\/s00240-017-0974-1","journal-title":"Urolithiasis"},{"key":"ref9","article-title":"Surgical management of stones: American Urological Association\/Endourological Society Guideline, part II","volume":"196","author":"Assimos D","year":"2016","unstructured":"Assimos D, Krambeck A, Miller NL, et al.. Surgical management of stones: American Urological Association\/Endourological Society Guideline, part II. J Urol. 2016, 196:1161.","journal-title":"J Urol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2007.01812.x","article-title":"Examination of alpha 1 adrenoceptor subtypes in the human ureter","volume":"14","author":"Itoh Y","year":"2007","unstructured":"Itoh Y, Kojima Y, Yasui T, Tozawa K, Sasaki S, Kohri K. Examination of alpha 1 adrenoceptor subtypes in the human ureter. Int J Urol. 2007, 14:749-53. 10.1111\/j.1442-2042.2007.01812.x","journal-title":"Int J Urol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.07.053","article-title":"Medical expulsive therapy for urinary stones: future trends and knowledge gaps","volume":"76","author":"De Coninck V","year":"2019","unstructured":"De Coninck V, Antonelli J, Chew B, Patterson JM, Skolarikos A, Bultitude M. Medical expulsive therapy for urinary stones: future trends and knowledge gaps. Eur Urol. 2019, 76:658-66. 10.1016\/j.eururo.2019.07.053","journal-title":"Eur Urol"},{"key":"ref12","article-title":"Efficacy and safety of PDE5-Is and a-1 blockers for treating distal ureteral calculi: a mixed treatment comparison network meta-analysis of randomized controlled clinical trials","volume":"12","author":"Liu Z","year":"2019","unstructured":"Liu Z, Su J, Yuan D, et al.. Efficacy and safety of PDE5-Is and a-1 blockers for treating distal ureteral calculi: a mixed treatment comparison network meta-analysis of randomized controlled clinical trials. Int J Clin Exp Med. 2019, 12:4623-37.","journal-title":"Int J Clin Exp Med"},{"key":"ref13","article-title":"Existence of a beta3-adrenoceptro and its functional role in the human ureter","volume":"164","author":"Park YC","year":"2000","unstructured":"Park YC, Tomiyama Y, Hayakawa K, et al.. Existence of a beta3-adrenoceptro and its functional role in the human ureter. J Urol. 2000, 164:1364-70.","journal-title":"J Urol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-018-1075-5","article-title":"Efficacy of mirabegron in medical expulsive therapy","volume":"47","author":"Solakhan M","year":"2019","unstructured":"Solakhan M, Bayrak O, Bulut E. Efficacy of mirabegron in medical expulsive therapy. Urolithiasis. 2019, 47:303-7. 10.1007\/s00240-018-1075-5","journal-title":"Urolithiasis"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14205","article-title":"PDE5 inhibitors - pharmacology and clinical applications 20\u00a0years after sildenafil discovery","volume":"175","author":"Andersson KE","year":"2018","unstructured":"Andersson KE. PDE5 inhibitors - pharmacology and clinical applications 20\u00a0years after sildenafil discovery. Br J Pharmacol. 2018, 175:2554-65. 10.1111\/bph.14205","journal-title":"Br J Pharmacol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher D","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009, 6:e1000097. 10.1371\/journal.pmed.1000097","journal-title":"PLoS Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne JA","year":"2019","unstructured":"Sterne JA, Savovi\u0107 J, Page MJ, et al.. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019, 366:l4898. 10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1411","article-title":"Risk-of-bias VISualization (robvis): an R package and Shiny web app for visualizing risk-of-bias assessments","volume":"12","author":"McGuinness LA","year":"2021","unstructured":"McGuinness LA, Higgins JP. Risk-of-bias VISualization (robvis): an R package and Shiny web app for visualizing risk-of-bias assessments. Res Synth Methods. 2021, 12:55-61. 10.1002\/jrsm.1411","journal-title":"Res Synth Methods"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins JP","year":"2002","unstructured":"Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002, 21:1539-58. 10.1002\/sim.1186","journal-title":"Stat Med"},{"key":"ref20","unstructured":"Review Manager (RevMan). Version (8.1.1). The Cochrane Collaboration. (2024). Accessed. July 10, 2025: http:\/\/revman.cochrane.org."},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/03915603231204081","article-title":"Does mirabegron have a potential role as a medical expulsive therapy in the treatment of distal ureteral stones? A prospective randomized controlled study","volume":"91","author":"Samir M","year":"2024","unstructured":"Samir M, Awad AF, Maged WA. Does mirabegron have a potential role as a medical expulsive therapy in the treatment of distal ureteral stones? A prospective randomized controlled study. Urologia. 2024, 91:136-40. 10.1177\/03915603231204081","journal-title":"Urologia"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-023-03880-y","article-title":"Evaluation of the efficacy and safety of either or both mirabegron and silodosin, as a medical expulsive therapy for distal ureteric stones","volume":"56","author":"Abdel-Kader MS","year":"2024","unstructured":"Abdel-Kader MS, Sayed AM, Sayed SM, AbdelRazek M. Evaluation of the efficacy and safety of either or both mirabegron and silodosin, as a medical expulsive therapy for distal ureteric stones. Int Urol Nephrol. 2024, 56:1605-10. 10.1007\/s11255-023-03880-y","journal-title":"Int Urol Nephrol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2023.10849","article-title":"Comparative study between tamsulosin, silodosin and tadala\ufb01l as a medical expulsive therapy for lower ureteral stones","volume":"95","author":"Abdelaal MA","year":"2023","unstructured":"Abdelaal MA, El-Dydamony EM. Comparative study between tamsulosin, silodosin and tadala\ufb01l as a medical expulsive therapy for lower ureteral stones. Arch Ital Urol Androl. 2023, 95:10849. 10.4081\/aiua.2023.10849","journal-title":"Arch Ital Urol Androl"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-5538.IBJU.2020.1007","article-title":"Efficacy of tamsulosin versus tadalafil as medical expulsive therapy on stone expulsion in patients with distal ureteral stones: a randomized double-blind clinical trial","volume":"47","author":"Falahatkar S","year":"2021","unstructured":"Falahatkar S, Akhavan A, Esmaeili S, Amin A, Kazemnezhad E, Jafari A. Efficacy of tamsulosin versus tadalafil as medical expulsive therapy on stone expulsion in patients with distal ureteral stones: a randomized double-blind clinical trial. Int Braz J Urol. 2021, 47:982-8. 10.1590\/S1677-5538.IBJU.2020.1007","journal-title":"Int Braz J Urol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-021-03772-9","article-title":"Mirabegron in medical expulsive therapy for distal ureteral stones: a prospective, randomized, controlled study","volume":"39","author":"Tang QL","year":"2021","unstructured":"Tang QL, Wang DJ, Zhou S, Tao RZ. Mirabegron in medical expulsive therapy for distal ureteral stones: a prospective, randomized, controlled study. World J Urol. 2021, 39:4465-70. 10.1007\/s00345-021-03772-9","journal-title":"World J Urol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.4111\/icu.2016.57.5.351","article-title":"Tamsulosin versus tadalafil as a medical expulsive therapy for distal ureteral stones: a prospective randomized study","volume":"57","author":"Kc HB","year":"2016","unstructured":"Kc HB, Shrestha A, Acharya GB, Basnet RB, Shah AK, Shrestha PM. Tamsulosin versus tadalafil as a medical expulsive therapy for distal ureteral stones: a prospective randomized study. Investig Clin Urol. 2016, 57:351-6. 10.4111\/icu.2016.57.5.351","journal-title":"Investig Clin Urol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1177\/1756287218801282","article-title":"Mirabegron, alone and in combination, in the treatment of overactive bladder: real-world evidence and experience","volume":"10","author":"Allison SJ","year":"2018","unstructured":"Allison SJ, Gibson W. Mirabegron, alone and in combination, in the treatment of overactive bladder: real-world evidence and experience. Ther Adv Urol. 2018, 10:411-9. 10.1177\/1756287218801282","journal-title":"Ther Adv Urol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2004.04819.x","article-title":"The efficacy and safety of tadalafil: an update","volume":"93","author":"Carson CC","year":"2004","unstructured":"Carson CC, Rajfer J, Eardley I, et al.. The efficacy and safety of tadalafil: an update. BJU Int. 2004, 93:1276-81. 10.1111\/j.1464-410X.2004.04819.x","journal-title":"BJU Int"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-019-02368-y","article-title":"Efficacy of silodosin or mirabegron in medical expulsive therapy for ureteral stones: a prospective, randomized-controlled study","volume":"52","author":"Bayar G","year":"2020","unstructured":"Bayar G, Yavuz A, Cakmak S, Ofluoglu Y, Kilinc MF, Kucuk E, Ayd\u0131n M. Efficacy of silodosin or mirabegron in medical expulsive therapy for ureteral stones: a prospective, randomized-controlled study. Int Urol Nephrol. 2020, 52:835-40. 10.1007\/s11255-019-02368-y","journal-title":"Int Urol Nephrol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.18203\/2319-2003.ijbcp20243837","article-title":"Comparison of safety and efficacy of silodosin versus mirabegron in medical expulsive therapy for lower ureteric stone: a prospective, open label and randomized controlled trial","volume":"14","author":"Sharma I","year":"2025","unstructured":"Sharma I, Sood A, Sharma K, Sawaraj S, Patiyal N. Comparison of safety and efficacy of silodosin versus mirabegron in medical expulsive therapy for lower ureteric stone: a prospective, open label and randomized controlled trial. Int J Basic Clin Pharmacol. 2025, 14:62-8. 10.18203\/2319-2003.ijbcp20243837","journal-title":"Int J Basic Clin Pharmacol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.aju.2017.11.012","article-title":"Comparing tamsulosin, silodosin versus silodosin plus tadalafil as medical expulsive therapy for lower ureteric stones: a randomised trial","volume":"16","author":"Rahman MJ","year":"2018","unstructured":"Rahman MJ, Faridi MS, Mibang N, Singh RS. Comparing tamsulosin, silodosin versus silodosin plus tadalafil as medical expulsive therapy for lower ureteric stones: a randomised trial. Arab J Urol. 2018, 16:245-9. 10.1016\/j.aju.2017.11.012","journal-title":"Arab J Urol"},{"key":"ref32","article-title":"Comparison of tadalafil and tamsulosin in medical expulsive therapy for ureteric calculus: prospective, randomized, placebo-controlled study","volume":"2","author":"Laddha A","year":"2019","unstructured":"Laddha A, Mishra S, Ganpule A, Sabnis R, Desai M. Comparison of tadalafil and tamsulosin in medical expulsive therapy for ureteric calculus: prospective, randomized, placebo-controlled study. Innov J Med Health Sci. 2019, 2:294-8.","journal-title":"Innov J Med Health Sci"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0315328","article-title":"Evaluating the safety and effectiveness of \u03b1-blockers versus mirabegron for medical expulsive therapy in ureteral calculi: a systematic review and meta-analysis","volume":"19","author":"Yan H","year":"2024","unstructured":"Yan H, Li X, Zheng X, Cui Y, Huang J, Cheng Y. Evaluating the safety and effectiveness of \u03b1-blockers versus mirabegron for medical expulsive therapy in ureteral calculi: a systematic review and meta-analysis. PLoS One. 2024, 19:e0315328. 10.1371\/journal.pone.0315328","journal-title":"PLoS One"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-018-0345-4","article-title":"Efficacy and safety of PDE5-Is and \u03b1-1 blockers for treating lower ureteric stones or LUTS: a meta-analysis of RCTs","volume":"18","author":"Sun X","year":"2018","unstructured":"Sun X, Guan W, Liu H, et al.. Efficacy and safety of PDE5-Is and \u03b1-1 blockers for treating lower ureteric stones or LUTS: a meta-analysis of RCTs. BMC Urol. 2018, 18:30. 10.1186\/s12894-018-0345-4","journal-title":"BMC Urol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/418421-the-comparative-effectiveness-of-pde5-inhibitors-and-3-agonists-versus--blockers-in-medical-expulsive-therapy-for-distal-ureteric-stones-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T07:53:08Z","timestamp":1762933988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/418421-the-comparative-effectiveness-of-pde5-inhibitors-and-3-agonists-versus--blockers-in-medical-expulsive-therapy-for-distal-ureteric-stones-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,11]]},"references-count":34,"URL":"https:\/\/doi.org\/10.7759\/cureus.96637","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,11]]}}}