{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:09:12Z","timestamp":1785442152383,"version":"3.56.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,14]]},"DOI":"10.7759\/cureus.96813","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T08:02:30Z","timestamp":1763107350000},"source":"Crossref","is-referenced-by-count":1,"title":["Spontaneous Pregnancy After Isotretinoin Use in a Man After Unsuccessful Microdissection Testicular Sperm Extraction"],"prefix":"10.7759","author":[{"given":"Zaed","family":"Jaber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerat","family":"Hanspal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Jaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjith","family":"Ramasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.4103\/aja202472","article-title":"Nonobstructive azoospermia: an etiologic review","volume":"27","author":"Hubbard L","year":"2025","unstructured":"Hubbard L, Rambhatla A, Glina S. Nonobstructive azoospermia: an etiologic review. Asian J Androl. 2025, 27:279-87.","journal-title":"Asian J Androl"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del279","article-title":"Histological evaluation of the human testis-approaches to optimizing the clinical value of the assessment: mini review","volume":"22","author":"McLachlan RI","year":"2007","unstructured":"McLachlan RI, Rajpert-De Meyts E, Hoei-Hansen CE, de Kretser DM, Skakkebaek NE. Histological evaluation of the human testis-approaches to optimizing the clinical value of the assessment: mini review. Hum Reprod. 2007, 22:2-16. 10.1093\/humrep\/del279","journal-title":"Hum Reprod"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1202302","article-title":"Reproduction in men with Klinefelter syndrome: the past, the present, and the future","volume":"27","author":"Paduch DA","year":"2009","unstructured":"Paduch DA, Bolyakov A, Cohen P, Travis A. Reproduction in men with Klinefelter syndrome: the past, the present, and the future. Semin Reprod Med. 2009, 27:137-48. 10.1055\/s-0029-1202302","journal-title":"Semin Reprod Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41303","article-title":"The key role of vitamin A in spermatogenesis","volume":"120","author":"Hogarth CA","year":"2010","unstructured":"Hogarth CA, Griswold MD. The key role of vitamin A in spermatogenesis. J Clin Invest. 2010, 120:956-62. 10.1172\/JCI41303","journal-title":"J Clin Invest"},{"key":"ref5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005501","article-title":"Retinoic acid receptors control spermatogonia cell-fate and induce expression of the SALL4A transcription factor","volume":"11","author":"Gely-Pernot A","year":"2015","unstructured":"Gely-Pernot A, Raverdeau M, Teletin M, et al.. Retinoic acid receptors control spermatogonia cell-fate and induce expression of the SALL4A transcription factor. PLoS Genet. 2015, 11:e1005501.","journal-title":"PLoS Genet"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12420","article-title":"Isotretinoin administration improves sperm production in men with infertility from oligoasthenozoospermia: a pilot study","volume":"5","author":"Amory JK","year":"2017","unstructured":"Amory JK, Ostrowski KA, Gannon JR, et al.. Isotretinoin administration improves sperm production in men with infertility from oligoasthenozoospermia: a pilot study. Andrology. 2017, 5:1115-23. 10.1111\/andr.12420","journal-title":"Andrology"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9966","article-title":"Teratogenic effect of isotretinoin in both fertile females and males (review)","volume":"21","author":"Draghici CC","year":"2021","unstructured":"Draghici CC, Miulescu RG, Petca RC, Petca A, Dumitra\u0219cu MC, \u0218andru F. Teratogenic effect of isotretinoin in both fertile females and males (review). Exp Ther Med. 2021, 21:534. 10.3892\/etm.2021.9966","journal-title":"Exp Ther Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2015.1119839","article-title":"The effect of systemic isotretinoin on male fertility","volume":"35","author":"\u00c7inar L","year":"2016","unstructured":"\u00c7inar L, Kartal D, Ergin C, et al.. The effect of systemic isotretinoin on male fertility. Cutan Ocul Toxicol. 2016, 35:296-9. 10.3109\/15569527.2015.1119839","journal-title":"Cutan Ocul Toxicol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2023.2207038","article-title":"Effect of systemic isotretinoin therapy on semen parameters","volume":"55","author":"Gurel A","year":"2023","unstructured":"Gurel A, Gurel G, F\u0131rat F, et al.. Effect of systemic isotretinoin therapy on semen parameters. Ann Med. 2023, 55:2207038. 10.1080\/07853890.2023.2207038","journal-title":"Ann Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_18_21","article-title":"Isotretinoin for the treatment of nonobstructive azoospermia: a pilot study","volume":"23","author":"Amory JK","year":"2021","unstructured":"Amory JK, Muller CH, Walsh TJ. Isotretinoin for the treatment of nonobstructive azoospermia: a pilot study. Asian J Androl. 2021, 23:537-40. 10.4103\/aja.aja_18_21","journal-title":"Asian J Androl"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-025-03567-6","article-title":"Treatment with isotretinoin can improve de novo sperm production in nonobstructive azoospermia or cryptozoospermia","volume":"42","author":"Jessup CM","year":"2025","unstructured":"Jessup CM, Amory JK, Turek PJ. Treatment with isotretinoin can improve de novo sperm production in nonobstructive azoospermia or cryptozoospermia. J Assist Reprod Genet. 2025, 42:2793-9. 10.1007\/s10815-025-03567-6","journal-title":"J Assist Reprod Genet"},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2015.05.037","article-title":"Outcomes of microdissection testicular sperm extraction in men with nonobstructive azoospermia due to maturation arrest","volume":"104","author":"Bernie AM","year":"2015","unstructured":"Bernie AM, Shah K, Halpern JA, Scovell J, Ramasamy R, Robinson B, Schlegel PN. Outcomes of microdissection testicular sperm extraction in men with nonobstructive azoospermia due to maturation arrest. Fertil Steril. 2015, 104:569-73.e1.","journal-title":"Fertil Steril"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.1038\/aja.2010.178","article-title":"The value of testicular 'mapping' in men with non-obstructive azoospermia","volume":"13","author":"Beliveau ME","year":"2011","unstructured":"Beliveau ME, Turek PJ. The value of testicular 'mapping' in men with non-obstructive azoospermia. Asian J Androl. 2011, 13:225-30.","journal-title":"Asian J Androl"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2017.07.07","article-title":"Microdissection testicular sperm extraction","volume":"6","author":"Flannigan R","year":"2017","unstructured":"Flannigan R, Bach PV, Schlegel PN. Microdissection testicular sperm extraction. Transl Androl Urol. 2017, 6:745-52. 10.21037\/tau.2017.07.07","journal-title":"Transl Androl Urol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2011.61","article-title":"Surgical recovery of sperm in non-obstructive azoospermia","volume":"14","author":"Ishikawa T","year":"2012","unstructured":"Ishikawa T. Surgical recovery of sperm in non-obstructive azoospermia. Asian J Androl. 2012, 14:109-15. 10.1038\/aja.2011.61","journal-title":"Asian J Androl"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.21037\/tau-2025-319","article-title":"Natural pregnancy following kidney transplantation in an azoospermic male: a case report","volume":"14","author":"Nguyen NT","year":"2025","unstructured":"Nguyen NT, Nguyen HH, Takeshima T, Kuroda S, Yumura Y, Atmoko W, Nguyen HD. Natural pregnancy following kidney transplantation in an azoospermic male: a case report. Transl Androl Urol. 2025, 14:2118-23. 10.21037\/tau-2025-319","journal-title":"Transl Androl Urol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-021-02979-4","article-title":"Microdissection testicular sperm extraction (micro-TESE) in men with infertility due to nonobstructive azoospermia: summary of current literature","volume":"53","author":"Achermann AP","year":"2021","unstructured":"Achermann AP, Pereira TA, Esteves SC. Microdissection testicular sperm extraction (micro-TESE) in men with infertility due to nonobstructive azoospermia: summary of current literature. Int Urol Nephrol. 2021, 53:2193-210. 10.1007\/s11255-021-02979-4","journal-title":"Int Urol Nephrol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.20373","article-title":"The rates of major malformations after gestational exposure to isotretinoin: a systematic review and meta-analysis","volume":"64","author":"Choi EJ","year":"2021","unstructured":"Choi EJ, Kim N, Kwak HS, et al.. The rates of major malformations after gestational exposure to isotretinoin: a systematic review and meta-analysis. Obstet Gynecol Sci. 2021, 64:364-73. 10.5468\/ogs.20373","journal-title":"Obstet Gynecol Sci"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.09.031","article-title":"Infertility and teratogenicity after paternal exposure to systemic dermatologic medications: a systematic review","volume":"80","author":"Zakhem GA","year":"2019","unstructured":"Zakhem GA, Motosko CC, Mu EW, Ho RS. Infertility and teratogenicity after paternal exposure to systemic dermatologic medications: a systematic review. J Am Acad Dermatol. 2019, 80:957-69. 10.1016\/j.jaad.2018.09.031","journal-title":"J Am Acad Dermatol"},{"key":"ref20","unstructured":"Label. ACCUTANE-isotretinoin capsule, gelatin coated. (2023). Accessed: September 28, 2025: https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=5b524a51-a16b-496e-b764-11c98c479c36."}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/432526-spontaneous-pregnancy-after-isotretinoin-use-in-a-man-after-unsuccessful-microdissection-testicular-sperm-extraction","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T08:02:31Z","timestamp":1763107351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/432526-spontaneous-pregnancy-after-isotretinoin-use-in-a-man-after-unsuccessful-microdissection-testicular-sperm-extraction"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.96813","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,14]]}}}