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Eur Heart J. 2015, 36:3075-128. 10.1093\/eurheartj\/ehv319","journal-title":"Eur Heart J"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/416222-therapeutic-dilemmas-in-the-management-of-stroke-among-patients-with-infective-endocarditis-ie-a-literature-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:41:53Z","timestamp":1763116913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/416222-therapeutic-dilemmas-in-the-management-of-stroke-among-patients-with-infective-endocarditis-ie-a-literature-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":50,"URL":"https:\/\/doi.org\/10.7759\/cureus.96817","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,14]]}}}