{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:13:30Z","timestamp":1763118810899,"version":"3.45.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,14]]},"DOI":"10.7759\/cureus.96819","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:09:43Z","timestamp":1763118583000},"source":"Crossref","is-referenced-by-count":0,"title":["A Case Series of Bacillary Layer Detachment (BALAD) in Neovascular Age-Related Macular Degeneration (nAMD): A Novel Optical Coherence Tomography (OCT) Biomarker"],"prefix":"10.7759","author":[{"given":"Konstantinos","family":"Flindris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantina","family":"Gorgoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Koumpoulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.64.13.12","article-title":"Pathophysiology of secondary macular hole in rhegmatogenous retinal detachment","volume":"64","author":"Martins Melo I","year":"2023","unstructured":"Martins Melo I, Jhaveri A, Bansal A, Lee WW, Oquendo PL, Curcio CA, Muni RH. Pathophysiology of secondary macular hole in rhegmatogenous retinal detachment. Invest Ophthalmol Vis Sci. 2023, 64:12. 10.1167\/iovs.64.13.12","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2022.101349","article-title":"Bilateral diffuse uveal melanocytic proliferation: report of a novel optical coherence tomography finding and clinical response to plasmapheresis","volume":"25","author":"Antaki F","year":"2022","unstructured":"Antaki F, Ferreira BG, Sahyoun JY, Hammamji K. Bilateral diffuse uveal melanocytic proliferation: report of a novel optical coherence tomography finding and clinical response to plasmapheresis. Am J Ophthalmol Case Rep. 2022, 25:101349. 10.1016\/j.ajoc.2022.101349","journal-title":"Am J Ophthalmol Case Rep"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.55369","article-title":"Bilateral acute posterior multifocal placoid pigment epitheliopathy with bacillary layer detachment following Sinopharm COVID-19 vaccination: a case report","volume":"16","author":"Mahar PS","year":"2024","unstructured":"Mahar PS, Monis MD, Memon AS, Azam M. Bilateral acute posterior multifocal placoid pigment epitheliopathy with bacillary layer detachment following Sinopharm COVID-19 vaccination: a case report. Cureus. 2024, 16:e55369. 10.7759\/cureus.55369","journal-title":"Cureus"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/cells11213453","article-title":"A linkage between angiogenesis and inflammation in neovascular age-related macular degeneration","volume":"11","author":"Heloter\u00e4 H","year":"2022","unstructured":"Heloter\u00e4 H, Kaarniranta K. A linkage between angiogenesis and inflammation in neovascular age-related macular degeneration. Cells. 2022, 11:10.3390\/cells11213453","journal-title":"Cells"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/biom12111629","article-title":"Current and novel therapeutic approaches for treatment of neovascular age-related macular degeneration","volume":"12","author":"ElSheikh RH","year":"2022","unstructured":"ElSheikh RH, Chauhan MZ, Sallam AB. Current and novel therapeutic approaches for treatment of neovascular age-related macular degeneration. Biomolecules. 2022, 12:10.3390\/biom12111629","journal-title":"Biomolecules"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-024-00612-x","article-title":"Clinical characteristics and risk factors of bacillary layer detachment in central serous chorioretinopathy: a comparative multicenter study","volume":"10","author":"Casella AM","year":"2024","unstructured":"Casella AM, Fuganti RM, Mansour AM, et al.. Clinical characteristics and risk factors of bacillary layer detachment in central serous chorioretinopathy: a comparative multicenter study. Int J Retina Vitreous. 2024, 10:96. 10.1186\/s40942-024-00612-x","journal-title":"Int J Retina Vitreous"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-023-02892-7","article-title":"Bacillary layer detachment with malignant choroidal tumors: a case series","volume":"23","author":"Fouad YA","year":"2023","unstructured":"Fouad YA, Salman AG, Ashour DM, Elkady MS, Abdel-Khalek N, Nowara M, Ebeid WM. Bacillary layer detachment with malignant choroidal tumors: a case series. BMC Ophthalmol. 2023, 23:142. 10.1186\/s12886-023-02892-7","journal-title":"BMC Ophthalmol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2022.101653","article-title":"Bacillary layer detachment in serpiginous-like choroiditis of presumed intraocular tuberculosis: report of two cases","volume":"27","author":"Socci da Costa D","year":"2022","unstructured":"Socci da Costa D, Gomes E Silva A, Melichar A, Neves DB, Correa PA, Moraes RT. Bacillary layer detachment in serpiginous-like choroiditis of presumed intraocular tuberculosis: report of two cases. Am J Ophthalmol Case Rep. 2022, 27:101653. 10.1016\/j.ajoc.2022.101653","journal-title":"Am J Ophthalmol Case Rep"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2021.09.010","article-title":"Long-term outcomes of bacillary layer detachment in neovascular age-related macular degeneration","volume":"6","author":"Ramtohul P","year":"2022","unstructured":"Ramtohul P, Malcl\u00e8s A, Gigon E, Freund KB, Introini U, Bandello F, Cicinelli MV. Long-term outcomes of bacillary layer detachment in neovascular age-related macular degeneration. Ophthalmol Retina. 2022, 6:185-95. 10.1016\/j.oret.2021.09.010","journal-title":"Ophthalmol Retina"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2025.01.005","article-title":"Bacillary layer detachment: updates on its clinical and prognostic significance in retinal disease","volume":"70","author":"Feo A","year":"2025","unstructured":"Feo A, Stradiotto E, Govetto A, et al.. Bacillary layer detachment: updates on its clinical and prognostic significance in retinal disease. Surv Ophthalmol. 2025, 70:401-11. 10.1016\/j.survophthal.2025.01.005","journal-title":"Surv Ophthalmol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003217","article-title":"Bacillary layer detachment: multimodal imaging and histologic evidence of a novel optical coherence tomography terminology: literature review and proposed theory","volume":"41","author":"Ramtohul P","year":"2021","unstructured":"Ramtohul P, Engelbert M, Malcl\u00e8s A, et al.. Bacillary layer detachment: multimodal imaging and histologic evidence of a novel optical coherence tomography terminology: literature review and proposed theory. Retina. 2021, 41:2193-207. 10.1097\/IAE.0000000000003217","journal-title":"Retina"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.11.011","article-title":"Risk of inflammation, retinal vasculitis, and retinal occlusion-related events with brolucizumab: post hoc review of HAWK and HARRIER","volume":"128","author":"Mon\u00e9s J","year":"2021","unstructured":"Mon\u00e9s J, Srivastava SK, Jaffe GJ, et al.. Risk of inflammation, retinal vasculitis, and retinal occlusion-related events with brolucizumab: post hoc review of HAWK and HARRIER. Ophthalmology. 2021, 128:1050-9. 10.1016\/j.ophtha.2020.11.011","journal-title":"Ophthalmology"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003858","article-title":"Clinical features and prognostic value of bacillary layer detachment in acute Vogt-Koyanagi-Harada disease","volume":"43","author":"Kwak JJ","year":"2023","unstructured":"Kwak JJ, Lee J, Byeon SH. Clinical features and prognostic value of bacillary layer detachment in acute Vogt-Koyanagi-Harada disease. Retina. 2023, 43:1700-7. 10.1097\/IAE.0000000000003858","journal-title":"Retina"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/11206721241300204","article-title":"Characteristics of submacular hemorrhage with bacillary layer detachment and intrabacillary hemorrhage","volume":"35","author":"Choudhary A","year":"2025","unstructured":"Choudhary A, Kapoor S, Sehgal G, et al.. Characteristics of submacular hemorrhage with bacillary layer detachment and intrabacillary hemorrhage. Eur J Ophthalmol. 2025, 35:1349-57. 10.1177\/11206721241300204","journal-title":"Eur J Ophthalmol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2023-256629","article-title":"Bacillary layer detachment as an inflammatory biomarker in toxoplasmosis retinochoroiditis: serial evolution on optical coherence tomography","volume":"16","author":"Desai A","year":"2023","unstructured":"Desai A, Tyagi M. Bacillary layer detachment as an inflammatory biomarker in toxoplasmosis retinochoroiditis: serial evolution on optical coherence tomography. BMJ Case Rep. 2023, 16:10.1136\/bcr-2023-256629","journal-title":"BMJ Case Rep"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20231207-01","article-title":"Multilayered exudative bacillary layer detachment in active choroidal neovascularization: a new optical coherence tomography sign","volume":"55","author":"Fern\u00e1ndez-Vigo JI","year":"2024","unstructured":"Fern\u00e1ndez-Vigo JI, L\u00f3pez-Guajardo L, Dolz-Marco R, Donate-L\u00f3pez J. Multilayered exudative bacillary layer detachment in active choroidal neovascularization: a new optical coherence tomography sign. Ophthalmic Surg Lasers Imaging Retina. 2024, 55:92-4. 10.3928\/23258160-20231207-01","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20231023-02","article-title":"Bacillary layer detachment as a presenting feature of ocular sarcoidosis","volume":"54","author":"Serels CM","year":"2023","unstructured":"Serels CM, Bhatter P, Srivastava SK, Lowder CY, Mammo DA. Bacillary layer detachment as a presenting feature of ocular sarcoidosis. Ophthalmic Surg Lasers Imaging Retina. 2023, 54:686-90. 10.3928\/23258160-20231023-02","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000001371","article-title":"Ruptured retinal arterial macroaneurysms associated with hemorrhagic bacillary layer detachments","volume":"18","author":"Doobin D","year":"2024","unstructured":"Doobin D, Sharma T, Horowitz J. Ruptured retinal arterial macroaneurysms associated with hemorrhagic bacillary layer detachments. Retin Cases Brief Rep. 2024, 18:269-73. 10.1097\/ICB.0000000000001371","journal-title":"Retin Cases Brief Rep"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-025-00673-6","article-title":"Bacillary layer detachment in acute Vogt-Koyanagi-Harada disease: an early predictor of long-term complications in a Brazilian cohort","volume":"11","author":"Missaka RF","year":"2025","unstructured":"Missaka RF, Goldbaum M, Machado CG, et al.. Bacillary layer detachment in acute Vogt-Koyanagi-Harada disease: an early predictor of long-term complications in a Brazilian cohort. Int J Retina Vitreous. 2025, 11:50. 10.1186\/s40942-025-00673-6","journal-title":"Int J Retina Vitreous"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000035576","article-title":"Prevalence of bacillary layer detachment in diabetic macular edema and response to 3 anti-vascular endothelial growth factor treatment","volume":"102","author":"Chen YG","year":"2023","unstructured":"Chen YG, Chang YH, Shen HC, Pao SI, Hou YC, Liang IC. Prevalence of bacillary layer detachment in diabetic macular edema and response to 3 anti-vascular endothelial growth factor treatment. Medicine (Baltimore). 2023, 102:e35576. 10.1097\/MD.0000000000035576","journal-title":"Medicine (Baltimore)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/434977-a-case-series-of-bacillary-layer-detachment-balad-in-neovascular-age-related-macular-degeneration-namd-a-novel-optical-coherence-tomography-oct-biomarker","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:09:44Z","timestamp":1763118584000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/434977-a-case-series-of-bacillary-layer-detachment-balad-in-neovascular-age-related-macular-degeneration-namd-a-novel-optical-coherence-tomography-oct-biomarker"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.96819","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,14]]}}}