{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:31:18Z","timestamp":1773081078036,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,16]]},"DOI":"10.7759\/cureus.96948","type":"journal-article","created":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T09:57:36Z","timestamp":1763287056000},"source":"Crossref","is-referenced-by-count":1,"title":["A Rare Side Effect of Vaccine-Induced Thyrotoxicosis: A Case Report"],"prefix":"10.7759","author":[{"given":"Muhammad","family":"Munir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon","family":"Mlawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balaji","family":"Murakonda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahid","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510030","article-title":"Graves' disease","volume":"375","author":"Smith TJ","year":"2016","unstructured":"Smith TJ, Heged\u00fcs L. Graves' disease. N Engl J Med. 2016, 375:1552-65. 10.1056\/NEJMra1510030","journal-title":"N Engl J Med"},{"key":"ref2","unstructured":"WHO COVID-19 dashboard. (2025). Accessed. November 16, 2025: https:\/\/data.who.int\/dashboards\/covid19\/cases?n=c."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01316-3","article-title":"A case of subacute thyroiditis associated with Covid-19 infection","volume":"43","author":"Asfuroglu Kalkan E","year":"2020","unstructured":"Asfuroglu Kalkan E, Ates I. A case of subacute thyroiditis associated with Covid-19 infection. J Endocrinol Invest. 2020, 43:1173-4. 10.1007\/s40618-020-01316-3","journal-title":"J Endocrinol Invest"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01312-7","article-title":"SARS-CoV-2: a potential trigger for subacute thyroiditis? Insights from a case report","volume":"43","author":"Ippolito S","year":"2020","unstructured":"Ippolito S, Dentali F, Tanda ML. SARS-CoV-2: a potential trigger for subacute thyroiditis? Insights from a case report. J Endocrinol Invest. 2020, 43:1171-2. 10.1007\/s40618-020-01312-7","journal-title":"J Endocrinol Invest"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa276","article-title":"Subacute thyroiditis after SARS-CoV-2 infection","volume":"105","author":"Brancatella A","year":"2020","unstructured":"Brancatella A, Ricci D, Viola N, Sgr\u00f2 D, Santini F, Latrofa F. Subacute thyroiditis after SARS-CoV-2 infection. J Clin Endocrinol Metab. 2020, 105:dgaa276. 10.1210\/clinem\/dgaa276","journal-title":"J Clin Endocrinol Metab"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-021-01707-0","article-title":"Thyroid as a target of adjuvant autoimmunity\/inflammatory syndrome due to mRNA-based SARS-CoV2 vaccination: from Graves' disease to silent thyroiditis","volume":"45","author":"Pujol A","year":"2022","unstructured":"Pujol A, G\u00f3mez LA, Gallegos C, et al.. Thyroid as a target of adjuvant autoimmunity\/inflammatory syndrome due to mRNA-based SARS-CoV2 vaccination: from Graves' disease to silent thyroiditis. J Endocrinol Invest. 2022, 45:875-82. 10.1007\/s40618-021-01707-0","journal-title":"J Endocrinol Invest"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2023.103287","article-title":"Autoimmune\/inflammatory syndrome induced by adjuvants (ASIA) in 2023","volume":"22","author":"Cohen Tervaert JW","year":"2023","unstructured":"Cohen Tervaert JW, Martinez-Lavin M, Jara LJ, Halpert G, Watad A, Amital H, Shoenfeld Y. Autoimmune\/inflammatory syndrome induced by adjuvants (ASIA) in 2023. Autoimmun Rev. 2023, 22:103287. 10.1016\/j.autrev.2023.103287","journal-title":"Autoimmun Rev"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.778964","article-title":"Development of Graves\u2019 disease after SARS-CoV-2 mRNA vaccination: a case report and literature review","volume":"9","author":"Lui DT","year":"2021","unstructured":"Lui DT, Lee KK, Lee CH, Lee AC, Hung IF, Tan KC. Development of Graves\u2019 disease after SARS-CoV-2 mRNA vaccination: a case report and literature review. Front Public Health. 2021, 9:778964. 10.3389\/fpubh.2021.778964","journal-title":"Front Public Health"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9101108","article-title":"A case of exacerbation of subclinical hyperthyroidism after first administration of BNT162b2 mRNA COVID-19 vaccine","volume":"9","author":"Yamamoto K","year":"2021","unstructured":"Yamamoto K, Mashiba T, Takano K, et al.. A case of exacerbation of subclinical hyperthyroidism after first administration of BNT162b2 mRNA COVID-19 vaccine. Vaccines (Basel). 2021, 9:1108. 10.3390\/vaccines9101108","journal-title":"Vaccines (Basel)"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.617089","article-title":"Reaction of human monoclonal antibodies to SARS-CoV-2 proteins with tissue antigens: implications for autoimmune diseases","volume":"11","author":"Vojdani A","year":"2021","unstructured":"Vojdani A, Vojdani E, Kharrazian D. Reaction of human monoclonal antibodies to SARS-CoV-2 proteins with tissue antigens: implications for autoimmune diseases. Front Immunol. 2021, 11:617089. 10.3389\/fimmu.2020.617089","journal-title":"Front Immunol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13443","article-title":"New-onset autoimmune phenomena post-COVID-19 vaccination","volume":"165","author":"Chen Y","year":"2022","unstructured":"Chen Y, Xu Z, Wang P, Li XM, Shuai ZW, Ye DQ, Pan HF. New-onset autoimmune phenomena post-COVID-19 vaccination. Immunology. 2022, 165:386-401. 10.1111\/imm.13443","journal-title":"Immunology"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14860","article-title":"Increased incidence of Graves' disease during the SARS-CoV2 pandemic","volume":"98","author":"Barajas Galindo DE","year":"2023","unstructured":"Barajas Galindo DE, Ramos Bachiller B, Gonz\u00e1lez Roza L, et al.. Increased incidence of Graves' disease during the SARS-CoV2 pandemic. Clin Endocrinol (Oxf). 2023, 98:730-7. 10.1111\/cen.14860","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac550","article-title":"Distinct clinical features of post-COVID-19 vaccination early-onset Graves\u2019 disease","volume":"108","author":"di Filippo L","year":"2022","unstructured":"di Filippo L, Castellino L, Allora A, et al.. Distinct clinical features of post-COVID-19 vaccination early-onset Graves\u2019 disease. J Clin Endocrinol Metab. 2022, 108:107-13. 10.1210\/clinem\/dgac550","journal-title":"J Clin Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2023.101759","article-title":"COVID-19 vaccination and thyroiditis","volume":"37","author":"\u015eendur SN","year":"2023","unstructured":"\u015eendur SN, O\u011fuz SH, \u00dcnl\u00fct\u00fcrk U. COVID-19 vaccination and thyroiditis. Best Pract Res Clin Endocrinol Metab. 2023, 37:101759. 10.1016\/j.beem.2023.101759","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0017","article-title":"Thyrotropin receptor antibody levels at diagnosis and after thionamide course predict Graves\u2019 disease relapse","volume":"26","author":"Tun NN","year":"2016","unstructured":"Tun NN, Beckett G, Zammitt NN, Strachan MW, Seckl JR, Gibb FW. Thyrotropin receptor antibody levels at diagnosis and after thionamide course predict Graves\u2019 disease relapse. Thyroid. 2016, 26:1004-9. 10.1089\/thy.2016.0017","journal-title":"Thyroid"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmac008","article-title":"Consistency between thyrotropin receptor antibody (TRAb) and thyroid-stimulating antibody (TSAb) levels in patients with Graves disease","volume":"53","author":"Huang Y","year":"2022","unstructured":"Huang Y, Jin B, Huang Y, Dong A. Consistency between thyrotropin receptor antibody (TRAb) and thyroid-stimulating antibody (TSAb) levels in patients with Graves disease. Lab Med. 2022, 53:412-6. 10.1093\/labmed\/lmac008","journal-title":"Lab Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1058007","article-title":"Effect of SARS-CoV-2 BNT162b2 mRNA vaccine on thyroid autoimmunity: a twelve-month follow-up study","volume":"14","author":"Morita S","year":"2023","unstructured":"Morita S, Takagi T, Inaba H, et al.. Effect of SARS-CoV-2 BNT162b2 mRNA vaccine on thyroid autoimmunity: a twelve-month follow-up study. Front Endocrinol (Lausanne). 2023, 14:1058007. 10.3389\/fendo.2023.1058007","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.08.002","article-title":"Predicting post-vaccination autoimmunity: who might be at risk?","volume":"92","author":"Soriano A","year":"2015","unstructured":"Soriano A, Nesher G, Shoenfeld Y. Predicting post-vaccination autoimmunity: who might be at risk?. Pharmacol Res. 2015, 92:18-22. 10.1016\/j.phrs.2014.08.002","journal-title":"Pharmacol Res"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.11.001","article-title":"Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses","volume":"54","author":"Alameh MG","year":"2021","unstructured":"Alameh MG, Tomb\u00e1cz I, Bettini E, et al.. Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses. Immunity. 2021, 54:2877-92.e7. 10.1016\/j.immuni.2021.11.001","journal-title":"Immunity"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103479","article-title":"The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory","volume":"24","author":"Ndeupen S","year":"2021","unstructured":"Ndeupen S, Qin Z, Jacobsen S, Bouteau A, Estanbouli H, Igy\u00e1rt\u00f3 BZ. The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory. iScience. 2021, 24:103479. 10.1016\/j.isci.2021.103479","journal-title":"iScience"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/430753-a-rare-side-effect-of-vaccine-induced-thyrotoxicosis-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T09:57:36Z","timestamp":1763287056000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/430753-a-rare-side-effect-of-vaccine-induced-thyrotoxicosis-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,16]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.96948","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,16]]}}}