{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T18:41:28Z","timestamp":1763318488067,"version":"3.45.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,16]]},"DOI":"10.7759\/cureus.96986","type":"journal-article","created":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T18:36:25Z","timestamp":1763318185000},"source":"Crossref","is-referenced-by-count":0,"title":["The Effectiveness of Clear Aligners Versus Fixed Aligners in Malocclusion Patients Undergoing Orthodontic Treatment: A Systematic Review and Meta-Analysis"],"prefix":"10.7759","author":[{"given":"Abdulaziz","family":"Owayed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhari M","family":"Alshammari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayed  A","family":"Alsaleh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulwa","family":"Al Terkait","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulwahab N","family":"Alenezi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa M","family":"Alajmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulaziz H","family":"Alajmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Bourkhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousef","family":"Alajmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad S","family":"Shanat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Abdelaziz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01993-3","article-title":"Relationship between dental caries, oral hygiene and malocclusion among Syrian refugee children and adolescents: a cross-sectional study","volume":"21","author":"Salim NA","year":"2021","unstructured":"Salim NA, Alamoush RA, Al-Abdallah MM, Al-Asmar AA, Satterthwaite JD. Relationship between dental caries, oral hygiene and malocclusion among Syrian refugee children and adolescents: a cross-sectional study. BMC Oral Health. 2021, 21:629. 10.1186\/s12903-021-01993-3","journal-title":"BMC Oral Health"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2017.05.028","article-title":"Psychological well-being, dental esthetics, and psychosocial impacts in\u00a0adolescent orthodontic patients: a\u00a0prospective longitudinal study","volume":"153","author":"Deng X","year":"2018","unstructured":"Deng X, Wang YJ, Deng F, Liu PL, Wu Y. Psychological well-being, dental esthetics, and psychosocial impacts in\u00a0adolescent orthodontic patients: a\u00a0prospective longitudinal study. Am J Orthod Dentofacial Orthop. 2018, 153:87-96.e2. 10.1016\/j.ajodo.2017.05.028","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20237110","article-title":"Oral health-related quality of life among adolescents in the first 6 months of fixed orthodontic therapy","volume":"20","author":"Fahd CG","year":"2023","unstructured":"Fahd CG, Castro GG, Costa AC, Costa CP, Carvalho CN, Pinzan-Vercelino CR, Ferreira MC. Oral health-related quality of life among adolescents in the first 6 months of fixed orthodontic therapy. Int J Environ Res Public Health. 2023, 20:7110. 10.3390\/ijerph20237110","journal-title":"Int J Environ Res Public Health"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-015-0060-4","article-title":"Braces versus Invisalign\u00ae: gingival parameters and patients' satisfaction during treatment: a cross-sectional study","volume":"15","author":"Azaripour A","year":"2015","unstructured":"Azaripour A, Weusmann J, Mahmoodi B, Peppas D, Gerhold-Ay A, Van Noorden CJ, Willershausen B. Braces versus Invisalign\u00ae: gingival parameters and patients' satisfaction during treatment: a cross-sectional study. BMC Oral Health. 2015, 15:69. 10.1186\/s12903-015-0060-4","journal-title":"BMC Oral Health"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2024.102081","article-title":"Effectiveness of clear orthodontic aligners in correcting malocclusions: a systematic review and meta-analysis","volume":"25","author":"Baneshi M","year":"2025","unstructured":"Baneshi M, O'Malley L, El-Angbawi A, Thiruvenkatachari B. Effectiveness of clear orthodontic aligners in correcting malocclusions: a systematic review and meta-analysis. J Evid Based Dent Pract. 2025, 25:102081. 10.1016\/j.jebdp.2024.102081","journal-title":"J Evid Based Dent Pract"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"year":"2019","unstructured":"Cochrane Handbook for Systematic Reviews of Interventions. Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (ed). John Wiley & Sons, Chichester (UK); 2019. https:\/\/www.cochrane.org\/authors\/handbooks-and-manuals\/handbook.","article-title":"Cochrane Handbook for Systematic Reviews of Interventions. Accessed February 1, 2025","key":"ref7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1997.tb00941.x","article-title":"Derivation and validation of a short-form oral health impact profile","volume":"25","author":"Slade GD","year":"1997","unstructured":"Slade GD. Derivation and validation of a short-form oral health impact profile. Community Dent Oral Epidemiol. 1997, 25:284-90. 10.1111\/j.1600-0528.1997.tb00941.x","journal-title":"Community Dent Oral Epidemiol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0889-5406(98)70179-9","article-title":"Objective grading system for dental casts and panoramic radiographs","volume":"114","author":"Casko JS","year":"1998","unstructured":"Casko JS, Vaden JL, Kokich VG, et al.. Objective grading system for dental casts and panoramic radiographs. Am J Orthod Dentofacial Orthop. 1998, 114:589-99. 10.1016\/s0889-5406(98)70179-9","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne JA","year":"2019","unstructured":"Sterne JA, Savovi\u0107 J, Page MJ, et al.. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019, 366:l4898. 10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2025.vol39.012","article-title":"Impact of orthodontic treatment with aligners and fixed appliances on OHRQoL: a randomized clinical trial","volume":"39","author":"Borsato TT","year":"2025","unstructured":"Borsato TT, Bittencourt JM, Paiva SM, et al.. Impact of orthodontic treatment with aligners and fixed appliances on OHRQoL: a randomized clinical trial. Braz Oral Res. 2025, 39:e12. 10.1590\/1807-3107bor-2025.vol39.012","journal-title":"Braz Oral Res"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ortho.2023.100817","article-title":"Treatment effectiveness of young adults using clear aligners versus buccal fixed appliances in class I malocclusion with first premolar extraction using the ABO-objective grading system: a randomized controlled clinical trial","volume":"21","author":"Jaber ST","year":"2023","unstructured":"Jaber ST, Hajeer MY, Burhan AS, Alam MK, Al-Ibrahim HM. Treatment effectiveness of young adults using clear aligners versus buccal fixed appliances in class I malocclusion with first premolar extraction using the ABO-objective grading system: a randomized controlled clinical trial. Int Orthod. 2023, 21:100817. 10.1016\/j.ortho.2023.100817","journal-title":"Int Orthod"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.25555","article-title":"Orthognathic surgery and aligners. A comparative assessment of periodontal health and quality of life in postsurgical orthodontic treatment with aligners versus traditional fixed appliances: a randomized controlled trial","volume":"28","author":"de Leyva P","year":"2023","unstructured":"de Leyva P, Eslava JM, Hern\u00e1ndez-Alfaro F, Acero J. Orthognathic surgery and aligners. A comparative assessment of periodontal health and quality of life in postsurgical orthodontic treatment with aligners versus traditional fixed appliances: a randomized controlled trial. Med Oral Patol Oral Cir Bucal. 2023, 28:e208-16. 10.4317\/medoral.25555","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"ref14","article-title":"The effectiveness of the Invisalign appliance in extraction cases using the the ABO model grading system: a multicenter randomized controlled trial","volume":"8","author":"Li W","year":"2015","unstructured":"Li W, Wang S, Zhang Y. The effectiveness of the Invisalign appliance in extraction cases using the the ABO model grading system: a multicenter randomized controlled trial. Int J Clin Exp Med. 2015, 8:8276-82.","journal-title":"Int J Clin Exp Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2319\/110620-917.1","article-title":"Effects of orthodontic treatment with aligners and fixed appliances on speech","volume":"91","author":"Damasceno Melo PE","year":"2021","unstructured":"Damasceno Melo PE, Bocato JR, de Castro Ferreira Conti AC, Siqueira de Souza KR, Freire Fernandes TM, de Almeida MR, Pedron Oltramari PV. Effects of orthodontic treatment with aligners and fixed appliances on speech. Angle Orthod. 2021, 91:711-7. 10.2319\/110620-917.1","journal-title":"Angle Orthod"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-04335-1","article-title":"Comparison of anxiety, pain, and quality of life in individuals with mild or moderate malocclusion between conventional fixed orthodontic treatment versus Invisalign: a randomised clinical trial","volume":"24","author":"Tunca Y","year":"2024","unstructured":"Tunca Y, Kaya Y, Tunca M, Keskin S. Comparison of anxiety, pain, and quality of life in individuals with mild or moderate malocclusion between conventional fixed orthodontic treatment versus Invisalign: a randomised clinical trial. BMC Oral Health. 2024, 24:576. 10.1186\/s12903-024-04335-1","journal-title":"BMC Oral Health"},{"key":"ref17","article-title":"Treatment and Post-treatment Posterior Occlusal Changes in Invisalign\u00ae and Traditional Braces: A Randomized Controlled [Thesis]","author":"Preston KA","year":"2019","unstructured":"Preston KA. Treatment and Post-treatment Posterior Occlusal Changes in Invisalign\u00ae and Traditional Braces: A Randomized Controlled [Thesis]. Texas A & M University, College Station, TX; 2019."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.5152\/TurkJOrthod.2019.18083","article-title":"Orthodontic treatment with clear aligners and the scientific reality behind their marketing: a literature review","volume":"32","author":"Tamer \u0130","year":"2019","unstructured":"Tamer \u0130, \u00d6zta\u015f E, Mar\u015fan G. Orthodontic treatment with clear aligners and the scientific reality behind their marketing: a literature review. Turk J Orthod. 2019, 32:241-6. 10.5152\/TurkJOrthod.2019.18083","journal-title":"Turk J Orthod"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13066","article-title":"Four-dimensional oral health-related quality of life impact in children: a systematic review","volume":"48","author":"Omara M","year":"2021","unstructured":"Omara M, Stamm T, Bekes K. Four-dimensional oral health-related quality of life impact in children: a systematic review. J Oral Rehabil. 2021, 48:293-304. 10.1111\/joor.13066","journal-title":"J Oral Rehabil"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-016-0389-9","article-title":"Health, health-related quality of life, and quality of life: what is the difference?","volume":"34","author":"Karimi M","year":"2016","unstructured":"Karimi M, Brazier J. Health, health-related quality of life, and quality of life: what is the difference?. Pharmacoeconomics. 2016, 34:645-9. 10.1007\/s40273-016-0389-9","journal-title":"Pharmacoeconomics"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/725913","article-title":"The correlations between health-related quality of life changes and pain and anxiety in orthodontic patients in the initial stage of treatment","volume":"2015","author":"Wang J","year":"2015","unstructured":"Wang J, Tang X, Shen Y, Shang G, Fang L, Wang R, Xu Y. The correlations between health-related quality of life changes and pain and anxiety in orthodontic patients in the initial stage of treatment. Biomed Res Int. 2015, 2015:725913. 10.1155\/2015\/725913","journal-title":"Biomed Res Int"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-020-01191-7","article-title":"Low-level laser therapy effectiveness in reducing initial orthodontic archwire placement pain in premolars extraction cases: a single-blind, placebo-controlled, randomized clinical trial","volume":"20","author":"AlSayed Hasan MM","year":"2020","unstructured":"AlSayed Hasan MM, Sultan K, Ajaj M, Voborn\u00e1 I, Hamadah O. Low-level laser therapy effectiveness in reducing initial orthodontic archwire placement pain in premolars extraction cases: a single-blind, placebo-controlled, randomized clinical trial. BMC Oral Health. 2020, 20:209. 10.1186\/s12903-020-01191-7","journal-title":"BMC Oral Health"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512444446","article-title":"Cognitive behavioral therapy for orthodontic pain control: a randomized trial","volume":"91","author":"Wang J","year":"2012","unstructured":"Wang J, Jian F, Chen J, et al.. Cognitive behavioral therapy for orthodontic pain control: a randomized trial. J Dent Res. 2012, 91:580-5. 10.1177\/0022034512444446","journal-title":"J Dent Res"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s40510-014-0064-7","article-title":"Analysis of pain level in cases treated with Invisalign aligner: comparison with fixed edgewise appliance therapy","volume":"15","author":"Fujiyama K","year":"2014","unstructured":"Fujiyama K, Honjo T, Suzuki M, Matsuoka S, Deguchi T. Analysis of pain level in cases treated with Invisalign aligner: comparison with fixed edgewise appliance therapy. Prog Orthod. 2014, 15:64. 10.1186\/s40510-014-0064-7","journal-title":"Prog Orthod"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjaa037","article-title":"Comparison of pain perception, anxiety, and impacts on oral health-related quality of life between patients receiving clear aligners and fixed appliances during the initial stage of orthodontic treatment","volume":"43","author":"Gao M","year":"2021","unstructured":"Gao M, Yan X, Zhao R, et al.. Comparison of pain perception, anxiety, and impacts on oral health-related quality of life between patients receiving clear aligners and fixed appliances during the initial stage of orthodontic treatment. Eur J Orthod. 2021, 43:353-9. 10.1093\/ejo\/cjaa037","journal-title":"Eur J Orthod"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s40510-019-0303-z","article-title":"Pain level between clear aligners and fixed appliances: a systematic review","volume":"21","author":"Cardoso PC","year":"2020","unstructured":"Cardoso PC, Espinosa DG, Mecenas P, Flores-Mir C, Normando D. Pain level between clear aligners and fixed appliances: a systematic review. Prog Orthod. 2020, 21:3. 10.1186\/s40510-019-0303-z","journal-title":"Prog Orthod"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/s41432-020-0140-4","article-title":"Limited evidence on differences between fixed appliances and clear aligners regarding pain level","volume":"21","author":"Mheissen S","year":"2020","unstructured":"Mheissen S, Khan H, Aldandan M. Limited evidence on differences between fixed appliances and clear aligners regarding pain level. Evid Based Dent. 2020, 21:144-5. 10.1038\/s41432-020-0140-4","journal-title":"Evid Based Dent"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072088","article-title":"Pain and oral-health-related quality of life in orthodontic patients during initial therapy with conventional, low-friction, and lingual brackets and aligners (invisalign): a prospective clinical study","volume":"9","author":"Antonio-Zancajo L","year":"2020","unstructured":"Antonio-Zancajo L, Montero J, Albaladejo A, Oteo-Calatayud MD, Alvarado-Lorenzo A. Pain and oral-health-related quality of life in orthodontic patients during initial therapy with conventional, low-friction, and lingual brackets and aligners (invisalign): a prospective clinical study. J Clin Med. 2020, 9:2088. 10.3390\/jcm9072088","journal-title":"J Clin Med"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjac012","article-title":"The impact of non-extraction orthodontic treatment on oral health-related quality of life: clear aligners versus fixed appliances-a randomized controlled trial","volume":"44","author":"Alfawal AM","year":"2022","unstructured":"Alfawal AM, Burhan AS, Mahmoud G, Ajaj MA, Nawaya FR, Hanafi I. The impact of non-extraction orthodontic treatment on oral health-related quality of life: clear aligners versus fixed appliances-a randomized controlled trial. Eur J Orthod. 2022, 44:595-602. 10.1093\/ejo\/cjac012","journal-title":"Eur J Orthod"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.2319\/062820-592.1","article-title":"Quality of life in an adolescent orthodontic population","volume":"91","author":"Sharma R","year":"2021","unstructured":"Sharma R, Drummond R, Wiltshire W, Schroth R, Lekic M, Bertone M, Tate R. Quality of life in an adolescent orthodontic population. Angle Orthod. 2021, 91:718-24. 10.2319\/062820-592.1","journal-title":"Angle Orthod"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/431941-the-effectiveness-of-clear-aligners-versus-fixed-aligners-in-malocclusion-patients-undergoing-orthodontic-treatment-a-systematic-review-and-meta-analysis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T18:36:26Z","timestamp":1763318186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/431941-the-effectiveness-of-clear-aligners-versus-fixed-aligners-in-malocclusion-patients-undergoing-orthodontic-treatment-a-systematic-review-and-meta-analysis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,16]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.96986","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2025,11,16]]}}}