{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T23:51:35Z","timestamp":1763337095507,"version":"3.45.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,16]]},"DOI":"10.7759\/cureus.96995","type":"journal-article","created":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T23:48:17Z","timestamp":1763336897000},"source":"Crossref","is-referenced-by-count":0,"title":["Radiotherapy for Hypopharyngeal Carcinoma: Analysis of Multi-institutional Data From Over 170 Patients"],"prefix":"10.7759","author":[{"given":"Hideya","family":"Yamazaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aibe","family":"Norihiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Kimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Masui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Nagasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akito","family":"Asato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiro","family":"Kodani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","unstructured":"Data visualization tools for exploring the global cancer burden in 2022. (2022). Accessed. August 14, 2025: https:\/\/gco.iarc.fr\/today\/ data\/factsheets\/cancers\/5-Hypopharynx-fact-sheet.pdf."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3205\/000339","article-title":"Evidence-based guideline diagnosis, treatment, prevention and aftercare of oropharyngeal and hypopharyngeal carcinoma","volume":"23","author":"Dietz A","year":"2025","unstructured":"Dietz A, Taylor K, Bayer O, et al.. Evidence-based guideline diagnosis, treatment, prevention and aftercare of oropharyngeal and hypopharyngeal carcinoma. Ger Med Sci. 2025, 23:Doc03. 10.3205\/000339","journal-title":"Ger Med Sci"},{"key":"ref3","unstructured":"National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology Head and Neck Cancers. Version 2.2025. (2025). Accessed. August 14, 2025: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): A phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting CM","year":"2011","unstructured":"Nutting CM, Morden JP, Harrington KJ, et al.. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): A phase 3 multicentre randomised controlled trial. Lancet Oncol. 2011, 12:127-36. 10.1016\/S1470-2045(10)70290-4","journal-title":"Lancet Oncol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23649","article-title":"Outcomes of intensity-modulated radiotherapy versus conventional radiotherapy for hypopharyngeal cancer","volume":"37","author":"Mok G","year":"2015","unstructured":"Mok G, Gauthier I, Jiang H, et al.. Outcomes of intensity-modulated radiotherapy versus conventional radiotherapy for hypopharyngeal cancer. Head Neck. 2015, 37:655-61. 10.1002\/hed.23649","journal-title":"Head Neck"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25509","article-title":"Hypopharyngeal squamous cell carcinoma: Three-dimensional or Intensity-modulated radiotherapy? A single institution's experience","volume":"126","author":"Katsoulakis E","year":"2016","unstructured":"Katsoulakis E, Riaz N, Hu M, Morris L, Sherman E, McBride S, Lee N. Hypopharyngeal squamous cell carcinoma: Three-dimensional or Intensity-modulated radiotherapy? A single institution's experience. Laryngoscope. 2016, 126:620-6. 10.1002\/lary.25509","journal-title":"Laryngoscope"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds065","article-title":"Laryngeal preservation with induction chemotherapy for hypopharyngeal squamous cell carcinoma: 10-year results of EORTC trial 24891","volume":"23","author":"Lefebvre JL","year":"2012","unstructured":"Lefebvre JL, Andry G, Chevalier D, et al.. Laryngeal preservation with induction chemotherapy for hypopharyngeal squamous cell carcinoma: 10-year results of EORTC trial 24891. Ann Oncol. 2012, 23:2708-14. 10.1093\/annonc\/mds065","journal-title":"Ann Oncol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.6097","article-title":"Long-term results of RTOG 91-11: A comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer","volume":"31","author":"Forastiere AA","year":"2013","unstructured":"Forastiere AA, Zhang Q, Weber RS, et al.. Long-term results of RTOG 91-11: A comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol. 2013, 31:845-52. 10.1200\/JCO.2012.43.6097","journal-title":"J Clin Oncol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053422","article-title":"Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck","volume":"354","author":"Bonner JA","year":"2006","unstructured":"Bonner JA, Harari PM, Giralt J, et al.. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006, 354:567-78. 10.1056\/NEJMoa053422","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.04.009","article-title":"Induction chemotherapy followed by cisplatin or cetuximab concomitant to radiotherapy for laryngeal\/hypopharyngeal cancer: Long-term results of the TREMPLIN randomised GORTEC trial","volume":"133","author":"Janoray G","year":"2020","unstructured":"Janoray G, Pointreau Y, Alfonsi M, et al.. Induction chemotherapy followed by cisplatin or cetuximab concomitant to radiotherapy for laryngeal\/hypopharyngeal cancer: Long-term results of the TREMPLIN randomised GORTEC trial. Eur J Cancer. 2020, 133:86-93. 10.1016\/j.ejca.2020.04.009","journal-title":"Eur J Cancer"},{"key":"ref11","article-title":"Hypopharyngeal Cancer. Treatment Planning Guidelines 2024. Igaki H (ed): Japanese Society for Radiation Oncology (JASTRO)","volume":"133","author":"Yoshimura R","year":"2024","unstructured":"Yoshimura R. Hypopharyngeal Cancer. Treatment Planning Guidelines 2024. Igaki H (ed): Japanese Society for Radiation Oncology (JASTRO). Kanehara Inc., Tokyo, Japan. 2024, 133:137.","journal-title":"Kanehara Inc., Tokyo, Japan"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software 'EZR' for medical statistics","volume":"48","author":"Kanda Y","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplant. 2013, 48:452-8. 10.1038\/bmt.2012.244","journal-title":"Bone Marrow Transplant"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyv216","article-title":"Retrospective analysis of the clinical efficacy of definitive chemoradiotherapy for patients with hypopharyngeal cancer","volume":"46","author":"Takehana K","year":"2016","unstructured":"Takehana K, Kodaira T, Tachibana H, et al.. Retrospective analysis of the clinical efficacy of definitive chemoradiotherapy for patients with hypopharyngeal cancer. Jpn J Clin Oncol. 2016, 46:344-9. 10.1093\/jjco\/hyv216","journal-title":"Jpn J Clin Oncol"},{"key":"ref14","article-title":"Radiation and low dose adriamycin for the treatment of carcinoma of the hypopharynx","volume":"20","author":"Yamazaki H","year":"2000","unstructured":"Yamazaki H, Inoue T, Tanaka E, et al.. Radiation and low dose adriamycin for the treatment of carcinoma of the hypopharynx. Anticancer Res. 2000, 20:4713-20.","journal-title":"Anticancer Res"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14418","article-title":"A single institution's experience of definitive radiotherapy using volumetric-modulated Arc therapy for hypopharyngeal cancers","volume":"40","author":"Kubo K","year":"2020","unstructured":"Kubo K, Murakami Y, Imano N, et al.. A single institution's experience of definitive radiotherapy using volumetric-modulated Arc therapy for hypopharyngeal cancers. Anticancer Res. 2020, 40:4183-90. 10.21873\/anticanres.14418","journal-title":"Anticancer Res"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12626","article-title":"Definitive chemoradiation in locally advanced squamous cell carcinoma of the hypopharynx: Long-term outcomes and toxicity","volume":"38","author":"Juloori A","year":"2018","unstructured":"Juloori A, Koyfman SA, Geiger JL, et al.. Definitive chemoradiation in locally advanced squamous cell carcinoma of the hypopharynx: Long-term outcomes and toxicity. Anticancer Res. 2018, 38:3543-9. 10.21873\/anticanres.12626","journal-title":"Anticancer Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1177\/19160216241293633","article-title":"Upfront surgery versus upfront concurrent chemoradiotherapy as primary modality in hypopharyngeal squamous cell carcinoma: A systematic review and meta-analysis","volume":"53","author":"Tsai TY","year":"2024","unstructured":"Tsai TY, Yap WK, Wang TH, et al.. Upfront surgery versus upfront concurrent chemoradiotherapy as primary modality in hypopharyngeal squamous cell carcinoma: A systematic review and meta-analysis. J Otolaryngol Head Neck Surg. 2024, 53:10.1177\/19160216241293633","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0277460","article-title":"Treatment options for resectable hypopharyngeal squamous cell carcinoma: A systematic review and meta-analysis of randomized controlled trials","volume":"17","author":"Panda S","year":"2022","unstructured":"Panda S, Sakthivel P, Gurusamy KS, Sharma A, Thakar A. Treatment options for resectable hypopharyngeal squamous cell carcinoma: A systematic review and meta-analysis of randomized controlled trials. PLoS One. 2022, 17:e0277460. 10.1371\/journal.pone.0277460","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/hed.28162","article-title":"Survival outcomes of the patients with advanced hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy and total pharyngolaryngectomy based on reports of Head and Neck Cancer Registry of Japan","volume":"47","author":"Horichi Y","year":"2025","unstructured":"Horichi Y, Shinomiya H, Kitayama M, et al.. Survival outcomes of the patients with advanced hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy and total pharyngolaryngectomy based on reports of Head and Neck Cancer Registry of Japan. Head Neck. 2025, 47:2412-24. 10.1002\/hed.28162","journal-title":"Head Neck"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/430213-radiotherapy-for-hypopharyngeal-carcinoma-analysis-of-multi-institutional-data-from-over-170-patients","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T23:48:21Z","timestamp":1763336901000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/430213-radiotherapy-for-hypopharyngeal-carcinoma-analysis-of-multi-institutional-data-from-over-170-patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,16]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.96995","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,16]]}}}