{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:02:11Z","timestamp":1783702931262,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,19]]},"DOI":"10.7759\/cureus.97297","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T07:41:22Z","timestamp":1763624482000},"source":"Crossref","is-referenced-by-count":1,"title":["Impact of Inflammatory Bowel Disease on Quality of Life and Work Productivity in Patients Under Treatment"],"prefix":"10.7759","author":[{"given":"Nikolaos","family":"Kafalis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionysios","family":"Kogias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios P","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Moschos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Skendros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Ritis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Kouklakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng SC","year":"2017","unstructured":"Ng SC, Shi HY, Hamidi N, et al.. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017, 390:2769-78. 10.1016\/S0140-6736(17)32448-0","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn's disease","volume":"389","author":"Torres J","year":"2017","unstructured":"Torres J, Mehandru S, Colombel JF, Peyrin-Biroulet L. Crohn's disease. Lancet. 2017, 389:1741-55. 10.1016\/S0140-6736(16)31711-1","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000278","article-title":"Self-reported disability in patients with inflammatory bowel disease largely determined by disease activity and illness perceptions","volume":"21","author":"van der Have M","year":"2015","unstructured":"van der Have M, Fidder HH, Leenders M, et al.. Self-reported disability in patients with inflammatory bowel disease largely determined by disease activity and illness perceptions. Inflamm Bowel Dis. 2015, 21:369-77. 10.1097\/MIB.0000000000000278","journal-title":"Inflamm Bowel Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1023\/a:1020841601110","article-title":"Factors affecting health related quality of life of patients with inflammatory bowel disease","volume":"11","author":"Casellas F","year":"2002","unstructured":"Casellas F, L\u00f3pez-Vivancos J, Casado A, Malagelada JR. Factors affecting health related quality of life of patients with inflammatory bowel disease. Qual Life Res. 2002, 11:775-81. 10.1023\/a:1020841601110","journal-title":"Qual Life Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9","article-title":"EuroQol--a new facility for the measurement of health-related quality of life","volume":"16","year":"1990","unstructured":"EuroQol--a new facility for the measurement of health-related quality of life. Health Policy. 1990, 16.199-208. 10.1016\/0168-8510(90)90421-9","journal-title":"Health Policy"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199304050-00006","article-title":"The validity and reproducibility of a work productivity and activity impairment instrument","volume":"4","author":"Reilly MC","year":"1993","unstructured":"Reilly MC, Zbrozek AS, Dukes EM. The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics. 1993, 4:353-65. 10.2165\/00019053-199304050-00006","journal-title":"Pharmacoeconomics"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.08.047","article-title":"Multidimensional patient-reported outcomes and quality of life at diagnosis of IBD: a population-based inception cohort study","volume":"23","author":"Attauabi M","year":"2025","unstructured":"Attauabi M, Madsen GR, Bendtsen F, Seidelin JB, Burisch J. Multidimensional patient-reported outcomes and quality of life at diagnosis of IBD: a population-based inception cohort study. Clin Gastroenterol Hepatol. 2025, 23:1418-27. 10.1016\/j.cgh.2024.08.047","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2024.05.019","article-title":"Qualitative and psychometric evaluation of 29-item Patient-Reported Outcomes Measurement Information System\u00ae to assess general health-related quality of life in patients with moderately to severely active inflammatory bowel disease","volume":"27","author":"Sands BE","year":"2024","unstructured":"Sands BE, Pan\u00e9s J, Feagan BG, et al.. Qualitative and psychometric evaluation of 29-item Patient-Reported Outcomes Measurement Information System\u00ae to assess general health-related quality of life in patients with moderately to severely active inflammatory bowel disease. Value Health. 2024, 27:1225-34. 10.1016\/j.jval.2024.05.019","journal-title":"Value Health"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad195","article-title":"A core outcome set for inflammatory bowel diseases: development and recommendations for implementation in clinical practice through an international multi-stakeholder consensus process","volume":"18","author":"Fierens L","year":"2024","unstructured":"Fierens L, Carney N, Novacek G, et al.. A core outcome set for inflammatory bowel diseases: development and recommendations for implementation in clinical practice through an international multi-stakeholder consensus process. J Crohns Colitis. 2024, 18:1583-95. 10.1093\/ecco-jcc\/jjad195","journal-title":"J Crohns Colitis"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142481","article-title":"Evolution of costs of inflammatory bowel disease over two years of follow-up","volume":"11","author":"van der Valk ME","year":"2016","unstructured":"van der Valk ME, Mangen MJ, Severs M, et al.. Evolution of costs of inflammatory bowel disease over two years of follow-up. PLoS One. 2016, 11:e0142481. 10.1371\/journal.pone.0142481","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/17562848251333989","article-title":"IBD-related disability among patients with ulcerative colitis in China: a cross-sectional study","volume":"18","author":"Zhang M","year":"2025","unstructured":"Zhang M, Liu X, Min S, Shen H, Zhu L. IBD-related disability among patients with ulcerative colitis in China: a cross-sectional study. Therap Adv Gastroenterol. 2025, 18:17562848251333989. 10.1177\/17562848251333989","journal-title":"Therap Adv Gastroenterol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.082909","article-title":"The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications","volume":"55","author":"Satsangi J","year":"2006","unstructured":"Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006, 55:749-53. 10.1136\/gut.2005.082909","journal-title":"Gut"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(80)92767-1","article-title":"A simple index of Crohn's-disease activity","volume":"1","author":"Harvey RF","year":"1980","unstructured":"Harvey RF, Bradshaw JM. A simple index of Crohn's-disease activity. Lancet. 1980, 1:514. 10.1016\/s0140-6736(80)92767-1","journal-title":"Lancet"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20520","article-title":"Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis","volume":"14","author":"Lewis JD","year":"2008","unstructured":"Lewis JD, Chuai S, Nessel L, Lichtenstein GR, Aberra FN, Ellenberg JH. Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis. Inflamm Bowel Dis. 2008, 14:1660-6. 10.1002\/ibd.20520","journal-title":"Inflamm Bowel Dis"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5107(04)01878-4","article-title":"Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD","volume":"60","author":"Daperno M","year":"2004","unstructured":"Daperno M, D'Haens G, Van Assche G, et al.. Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD. Gastrointest Endosc. 2004, 60:505-12. 10.1016\/s0016-5107(04)01878-4","journal-title":"Gastrointest Endosc"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90613-6","article-title":"Predictability of the postoperative course of Crohn's disease","volume":"99","author":"Rutgeerts P","year":"1990","unstructured":"Rutgeerts P, Geboes K, Vantrappen G, Beyls J, Kerremans R, Hiele M. Predictability of the postoperative course of Crohn's disease. Gastroenterology. 1990, 99:956-63. 10.1016\/0016-5085(90)90613-6","journal-title":"Gastroenterology"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712243172603","article-title":"Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study","volume":"317","author":"Schroeder KW","year":"1987","unstructured":"Schroeder KW, Tremaine WJ, Ilstrup DM. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N Engl J Med. 1987, 317:1625-9. 10.1056\/NEJM198712243172603","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2008.02.016","article-title":"Validity, reliability, and responsiveness of the work productivity and activity impairment questionnaire in Crohn's disease","volume":"30","author":"Reilly MC","year":"2008","unstructured":"Reilly MC, Gerlier L, Brabant Y, Brown M. Validity, reliability, and responsiveness of the work productivity and activity impairment questionnaire in Crohn's disease. Clin Ther. 2008, 30:393-404. 10.1016\/j.clinthera.2008.02.016","journal-title":"Clin Ther"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izx100","article-title":"Quality of life in inflammatory bowel disease: a systematic review and meta-analyses-part I","volume":"24","author":"Knowles SR","year":"2018","unstructured":"Knowles SR, Graff LA, Wilding H, Hewitt C, Keefer L, Mikocka-Walus A. Quality of life in inflammatory bowel disease: a systematic review and meta-analyses-part I. Inflamm Bowel Dis. 2018, 24:742-51. 10.1093\/ibd\/izx100","journal-title":"Inflamm Bowel Dis"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303376","article-title":"Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNF\u03b1 therapy: results from the COIN study","volume":"63","author":"van der Valk ME","year":"2014","unstructured":"van der Valk ME, Mangen MJ, Leenders M, et al.. Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNF\u03b1 therapy: results from the COIN study. Gut. 2014, 63:72-9. 10.1136\/gutjnl-2012-303376","journal-title":"Gut"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X17732720","article-title":"Preventing disability in inflammatory bowel disease","volume":"10","author":"Allen PB","year":"2017","unstructured":"Allen PB, Gower-Rousseau C, Danese S, Peyrin-Biroulet L. Preventing disability in inflammatory bowel disease. Therap Adv Gastroenterol. 2017, 10:865-76. 10.1177\/1756283X17732720","journal-title":"Therap Adv Gastroenterol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.07.042","article-title":"Extraintestinal manifestations of inflammatory bowel disease: current concepts, treatment, and implications for disease management","volume":"161","author":"Rogler G","year":"2021","unstructured":"Rogler G, Singh A, Kavanaugh A, Rubin DT. Extraintestinal manifestations of inflammatory bowel disease: current concepts, treatment, and implications for disease management. Gastroenterology. 2021, 161:1118-32. 10.1053\/j.gastro.2021.07.042","journal-title":"Gastroenterology"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1574569","article-title":"Extraintestinal manifestations in inflammatory bowel disease - epidemiology, genetics, and pathogenesis","volume":"13","author":"Greuter T","year":"2019","unstructured":"Greuter T, Vavricka SR. Extraintestinal manifestations in inflammatory bowel disease - epidemiology, genetics, and pathogenesis. Expert Rev Gastroenterol Hepatol. 2019, 13:307-17. 10.1080\/17474124.2019.1574569","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-334395","article-title":"British Society of Gastroenterology guidelines on inflammatory bowel disease in adults: 2025","volume":"74","author":"Moran GW","year":"2025","unstructured":"Moran GW, Gordon M, Sinopolou V, et al.. British Society of Gastroenterology guidelines on inflammatory bowel disease in adults: 2025. Gut. 2025, 74:s1-s101. 10.1136\/gutjnl-2024-334395","journal-title":"Gut"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.031","article-title":"STRIDE-II: an update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD","volume":"160","author":"Turner D","year":"2021","unstructured":"Turner D, Ricciuto A, Lewis A, et al.. STRIDE-II: an update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD. Gastroenterology. 2021, 160:1570-83. 10.1053\/j.gastro.2020.12.031","journal-title":"Gastroenterology"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S32690","article-title":"Patient perspectives on the impact of Crohn's disease: results from group interviews","volume":"6","author":"Norton BA","year":"2012","unstructured":"Norton BA, Thomas R, Lomax KG, Dudley-Brown S. Patient perspectives on the impact of Crohn's disease: results from group interviews. Patient Prefer Adherence. 2012, 6:509-20. 10.2147\/PPA.S32690","journal-title":"Patient Prefer Adherence"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14134733","article-title":"Objective treatment targets and their correlation with patient-reported outcomes in inflammatory bowel disease: a real-world study","volume":"14","author":"Wetwittayakhlang P","year":"2025","unstructured":"Wetwittayakhlang P, Ngampech S, Pattarakulniyom S, Lakatos PL. Objective treatment targets and their correlation with patient-reported outcomes in inflammatory bowel disease: a real-world study. J Clin Med. 2025, 14:4733. 10.3390\/jcm14134733","journal-title":"J Clin Med"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093\/crocol\/otad006","article-title":"The real-world global use of patient-reported outcomes for the care of patients with inflammatory bowel disease","volume":"5","author":"Horrigan JM","year":"2023","unstructured":"Horrigan JM, Louis E, Spinelli A, et al.. The real-world global use of patient-reported outcomes for the care of patients with inflammatory bowel disease. Crohns Colitis 360. 2023, 5:otad006. 10.1093\/crocol\/otad006","journal-title":"Crohns Colitis 360"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06647-y","article-title":"Impaired quality of working life in inflammatory bowel disease patients","volume":"66","author":"van Gennep S","year":"2021","unstructured":"van Gennep S, de Boer NK, Gielen ME, et al.. Impaired quality of working life in inflammatory bowel disease patients. Dig Dis Sci. 2021, 66:2916-24. 10.1007\/s10620-020-06647-y","journal-title":"Dig Dis Sci"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2024.00104","article-title":"Health-related quality of life, work productivity, and persisting challenges in treated ulcerative colitis patients: a Japanese National Health and Wellness Survey","volume":"23","author":"Hiraoka S","year":"2025","unstructured":"Hiraoka S, Huang Z, Qin F, Nathan Arokianathan FM, Dav\u00e9 K, Shah S, Kim H. Health-related quality of life, work productivity, and persisting challenges in treated ulcerative colitis patients: a Japanese National Health and Wellness Survey. Intest Res. 2025, 23:524-40. 10.5217\/ir.2024.00104","journal-title":"Intest Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/429987-impact-of-inflammatory-bowel-disease-on-quality-of-life-and-work-productivity-in-patients-under-treatment","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T07:41:22Z","timestamp":1763624482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/429987-impact-of-inflammatory-bowel-disease-on-quality-of-life-and-work-productivity-in-patients-under-treatment"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.97297","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,19]]}}}