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Oxf Med Case Reports. 2020, 2020:omaa057. 10.1093\/omcr\/omaa057","journal-title":"Oxf Med Case Reports"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.47370","article-title":"Clostridium bifermentans infection of a prosthetic knee joint in a patient with human immunodeficiency virus: a case report","volume":"15","author":"Moran M","year":"2023","unstructured":"Moran M, Patel SH, Kahlon G. Clostridium bifermentans infection of a prosthetic knee joint in a patient with human immunodeficiency virus: a case report. Cureus. 2023, 15:e47370. 10.7759\/cureus.47370","journal-title":"Cureus"},{"key":"ref53","unstructured":"EUCAST. Clinical breakpoint tables. (2025). Accessed: October 23, 2025: https:\/\/www.eucast.org\/clinical_breakpoints."},{"key":"ref54","unstructured":"Pocket guide to diagnosis & treatment of periprosthetic joint infection (PJI) - Pro implant. (2025). Accessed. 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