{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T09:03:11Z","timestamp":1763802191967,"version":"3.45.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,22]]},"DOI":"10.7759\/cureus.97482","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T09:01:54Z","timestamp":1763802114000},"source":"Crossref","is-referenced-by-count":0,"title":["Four-Week Hypofractionated Radiotherapy for Early Glottic Cancer: A Prospective Study of Toxicity and Tolerance With Historical Comparison"],"prefix":"10.7759","author":[{"given":"Georgios","family":"Moschos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia","family":"Theodoridou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Areti","family":"Gkantaifi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Giakoumettis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Capizzello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Styliani","family":"Stylianidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Plataniotis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung H","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021, 71:209-49. 10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000902","article-title":"Updated disease distributions, risk factors, and trends of laryngeal cancer: a global analysis of cancer registries","volume":"110","author":"Huang J","year":"2024","unstructured":"Huang J, Chan SC, Ko S, et al.. Updated disease distributions, risk factors, and trends of laryngeal cancer: a global analysis of cancer registries. Int J Surg. 2024, 110:810-9. 10.1097\/JS9.0000000000000902","journal-title":"Int J Surg"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1028-2","article-title":"Current trends in initial management of laryngeal cancer: the declining use of open surgery","volume":"266","author":"Silver CE","year":"2009","unstructured":"Silver CE, Beitler JJ, Shaha AR, Rinaldo A, Ferlito A. Current trends in initial management of laryngeal cancer: the declining use of open surgery. Eur Arch Otorhinolaryngol. 2009, 266:1333-52. 10.1007\/s00405-009-1028-2","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14361-9","article-title":"Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial","volume":"362","author":"Overgaard J","year":"2003","unstructured":"Overgaard J, Hansen HS, Specht L, et al.. Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial. Lancet. 2003, 362:933-40. 10.1016\/S0140-6736(03)14361-9","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00375-7","article-title":"Clinical radiobiology of glottic T1 squamous cell carcinoma","volume":"43","author":"Skladowski K","year":"1999","unstructured":"Skladowski K, Tarnawski R, Maciejewski B, et al.. Clinical radiobiology of glottic T1 squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 1999, 43:101-6. 10.1016\/S0360-3016(98)00375-7","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00284-8","article-title":"Influence of fraction size, total dose, and overall time on local control of T1-T2 glottic carcinoma","volume":"39","author":"Le QT","year":"1997","unstructured":"Le QT, Fu KK, Kroll S, et al.. Influence of fraction size, total dose, and overall time on local control of T1-T2 glottic carcinoma. Int J Radiat Oncol Biol Phys. 1997, 39:115-26. 10.1016\/S0360-3016(97)00284-8","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrx023","article-title":"Radiotherapy for laryngeal cancer - technical aspects and alternate fractionation","volume":"58","author":"Yamazaki H","year":"2017","unstructured":"Yamazaki H, Suzuki G, Nakamura S, Yoshida K, Konishi K, Teshima T, Ogawa K. Radiotherapy for laryngeal cancer - technical aspects and alternate fractionation. J Radiat Res. 2017, 58:495-508. 10.1093\/jrr\/rrx023","journal-title":"J Radiat Res"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.15660","article-title":"Limited toxicity of hypofractionated intensity modulated radiation therapy for head and neck cancer","volume":"42","author":"Mayo ZS","year":"2022","unstructured":"Mayo ZS, Ilori EO, Matia B, et al.. Limited toxicity of hypofractionated intensity modulated radiation therapy for head and neck cancer. Anticancer Res. 2022, 42:1845-9. 10.21873\/anticanres.15660","journal-title":"Anticancer Res"},{"key":"ref9","article-title":"Radiotherapy Dose Fractionation. Fourth Edition","year":"2024","unstructured":"Radiotherapy Dose Fractionation. Fourth Edition. The Royal College of Radiologists, London, UK; 2024."},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-014-0285-4","article-title":"Development of a standardized method for contouring the larynx and its substructures","volume":"9","author":"Choi M","year":"2014","unstructured":"Choi M, Refaat T, Lester MS, Bacchus I, Rademaker AW, Mittal BB. Development of a standardized method for contouring the larynx and its substructures. Radiat Oncol. 2014, 9:10.1186\/s13014-014-0285-4","journal-title":"Radiat Oncol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.07.1754","article-title":"Use of normal tissue complication probability models in the clinic","volume":"76","author":"Marks LB","year":"2010","unstructured":"Marks LB, Yorke ED, Jackson A, et al.. Use of normal tissue complication probability models in the clinic. Int J Radiat Oncol Biol Phys. 2010, 76:10-9. 10.1016\/j.ijrobp.2009.07.1754","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"Cox JD","year":"1995","unstructured":"Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys. 1995, 31:1341-6. 10.1016\/0360-3016(95)00060-C","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.26717\/BJSTR.2023.49.007772","article-title":"Radical radiotherapy for early-stage carcinoma of the glottis. Should we switch to hypofractionation?","volume":"49","author":"Moschos G","year":"2023","unstructured":"Moschos G, Theodoridou A, Stylianidou S, Capizzello A, Plataniotis G. Radical radiotherapy for early-stage carcinoma of the glottis. Should we switch to hypofractionation?. Biomed J Sci Tech Res. 2023, 49:39621-6. 10.26717\/BJSTR.2023.49.007772","journal-title":"Biomed J Sci Tech Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/cancers4020566","article-title":"An estimation of radiobiological parameters for head-and-neck cancer cells and the clinical implications","volume":"4","author":"Qi XS","year":"2012","unstructured":"Qi XS, Yang Q, Lee SP, Li XA, Wang D. An estimation of radiobiological parameters for head-and-neck cancer cells and the clinical implications. Cancers (Basel). 2012, 4:566-80. 10.3390\/cancers4020566","journal-title":"Cancers (Basel)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.06.014","article-title":"Radiotherapy for early glottic carcinoma (T1N0M0): results of prospective randomized study of radiation fraction size and overall treatment time","volume":"64","author":"Yamazaki H","year":"2006","unstructured":"Yamazaki H, Nishiyama K, Tanaka E, Koizumi M, Chatani M. Radiotherapy for early glottic carcinoma (T1N0M0): results of prospective randomized study of radiation fraction size and overall treatment time. Int J Radiat Oncol Biol Phys. 2006, 64:77-82. 10.1016\/j.ijrobp.2005.06.014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.09.016","article-title":"A prospective randomized trial comparing hypofractionation with conventional fractionation radiotherapy for T1-2 glottic squamous cell carcinomas: results of a Korean Radiation Oncology Group (KROG-0201) study","volume":"110","author":"Moon SH","year":"2014","unstructured":"Moon SH, Cho KH, Chung EJ, et al.. A prospective randomized trial comparing hypofractionation with conventional fractionation radiotherapy for T1-2 glottic squamous cell carcinomas: results of a Korean Radiation Oncology Group (KROG-0201) study. Radiother Oncol. 2014, 110:98-103. 10.1016\/j.radonc.2013.09.016","journal-title":"Radiother Oncol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2012.5.2.94","article-title":"Definitive radiation therapy for early glottic cancer: experience of two fractionation schedules","volume":"5","author":"Kim TG","year":"2012","unstructured":"Kim TG, Ahn YC, Nam HR, Chung MK, Jeong HS, Son YI, Baek CH. Definitive radiation therapy for early glottic cancer: experience of two fractionation schedules. Clin Exp Otorhinolaryngol. 2012, 5:94-100. 10.3342\/ceo.2012.5.2.94","journal-title":"Clin Exp Otorhinolaryngol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.20.4029","article-title":"T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy","volume":"19","author":"Mendenhall WM","year":"2001","unstructured":"Mendenhall WM, Amdur RJ, Morris CG, Hinerman RW. T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy. J Clin Oncol. 2001, 19:4029-36. 10.1200\/JCO.2001.19.20.4029","journal-title":"J Clin Oncol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(03)00059-8","article-title":"Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital Experience","volume":"68","author":"Gowda RV","year":"2003","unstructured":"Gowda RV, Henk JM, Mais KL, Sykes AJ, Swindell R, Slevin NJ. Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital Experience. Radiother Oncol. 2003, 68:105-11. 10.1016\/S0167-8140(03)00059-8","journal-title":"Radiother Oncol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2009.02.008","article-title":"Outcome of T1N0M0 squamous cell carcinoma of the larynx treated with short-course radiotherapy to a total dose of 50 Gy in 16 fractions: the Birmingham experience","volume":"21","author":"Cheah NL","year":"2009","unstructured":"Cheah NL, Lupton S, Marshall A, Hartley A, Glaholm J. Outcome of T1N0M0 squamous cell carcinoma of the larynx treated with short-course radiotherapy to a total dose of 50 Gy in 16 fractions: the Birmingham experience. Clin Oncol (R Coll Radiol). 2009, 21:494-501. 10.1016\/j.clon.2009.02.008","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2012.07.001","article-title":"Hypofractionated radiotherapy for T1N0M0 glottic cancer: retrospective analysis of two different cohorts of dose-fractionation schedules from a single institution","volume":"24","author":"Laskar SG","year":"2012","unstructured":"Laskar SG, Baijal G, Murthy V, Chilukuri S, Budrukkar A, Gupta T, Agarwal JP. Hypofractionated radiotherapy for T1N0M0 glottic cancer: retrospective analysis of two different cohorts of dose-fractionation schedules from a single institution. Clin Oncol (R Coll Radiol). 2012, 24:180-6. 10.1016\/j.clon.2012.07.001","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.2006.01559.x","article-title":"T1N0\/T2N0 glottic carcinoma: a comparison of two fractionation schedules","volume":"50","author":"Short S","year":"2006","unstructured":"Short S, Krawitz H, Macann A, et al.. T1N0\/T2N0 glottic carcinoma: a comparison of two fractionation schedules. Australas Radiol. 2006, 50:152-7. 10.1111\/j.1440-1673.2006.01559.x","journal-title":"Australas Radiol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/428102-four-week-hypofractionated-radiotherapy-for-early-glottic-cancer-a-prospective-study-of-toxicity-and-tolerance-with-historical-comparison","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T09:01:55Z","timestamp":1763802115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/428102-four-week-hypofractionated-radiotherapy-for-early-glottic-cancer-a-prospective-study-of-toxicity-and-tolerance-with-historical-comparison"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,22]]},"references-count":22,"URL":"https:\/\/doi.org\/10.7759\/cureus.97482","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,22]]}}}