{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:39:17Z","timestamp":1783463957286,"version":"3.55.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,23]]},"DOI":"10.7759\/cureus.97567","type":"journal-article","created":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T17:04:08Z","timestamp":1763917448000},"source":"Crossref","is-referenced-by-count":1,"title":["Huntington's Disease Research Over Six Decades: Global Insights, Gaps, and Future Directions"],"prefix":"10.7759","author":[{"given":"Hasini","family":"Masna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghana","family":"Konda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latha","family":"Ganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(07)60111-1\u00a0","article-title":"Huntington\u2019s disease","volume":"369","author":"Walker FO","year":"2007","unstructured":"Walker FO. Huntington\u2019s disease. Lancet. 2007, 369:218-28. 10.1016\/s0140-6736(07)60111-1\u00a0","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29228","article-title":"Prevalence and incidence of Huntington's disease: an updated systematic review and meta-analysis","volume":"37","author":"Medina A","year":"2022","unstructured":"Medina A, Mahjoub Y, Shaver L, Pringsheim T. Prevalence and incidence of Huntington's disease: an updated systematic review and meta-analysis. Mov Disord. 2022, 37:2327-35. 10.1002\/mds.29228","journal-title":"Mov Disord"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.28484\u00a0","article-title":"Huntington's disease: a clinical review","volume":"14","author":"Andhale R","year":"2022","unstructured":"Andhale R, Shrivastava D. Huntington's disease: a clinical review. Cureus. 2022, 14:e28484. 10.7759\/cureus.28484\u00a0","journal-title":"Cureus"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a024240","article-title":"Huntington's disease: mechanisms of pathogenesis and therapeutic strategies","volume":"7","author":"Jimenez-Sanchez M","year":"2017","unstructured":"Jimenez-Sanchez M, Licitra F, Underwood BR, Rubinsztein DC. Huntington's disease: mechanisms of pathogenesis and therapeutic strategies. Cold Spring Harb Perspect Med. 2017, 7:10.1101\/cshperspect.a024240","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref5","article-title":"Huntington Disease","author":"Ajitkumar A","year":"2025","unstructured":"Ajitkumar A, De Jesus O. Huntington Disease. StatPearls Publishing, Treasure Island, FL; 2025."},{"key":"ref6","unstructured":"Huntington disease. (2018). Accessed. November 21, 2025: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1305\/."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/11795735221092517","article-title":"Current and possible future therapeutic options for Huntington's disease","volume":"14","author":"Ferguson MW","year":"2022","unstructured":"Ferguson MW, Kennedy CJ, Palpagama TH, Waldvogel HJ, Faull RL, Kwakowsky A. Current and possible future therapeutic options for Huntington's disease. J Cent Nerv Syst Dis. 2022, 14:10.1177\/11795735221092517","journal-title":"J Cent Nerv Syst Dis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1594","article-title":"The powerful world of antisense oligonucleotides: from bench to bedside","volume":"11","author":"Quemener AM","year":"2020","unstructured":"Quemener AM, Bachelot L, Forestier A, Donnou-Fournet E, Gilot D, Galibert MD. The powerful world of antisense oligonucleotides: from bench to bedside. Wiley Interdiscip Rev RNA. 2020, 11:e1594. 10.1002\/wrna.1594","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.62186\/001c.129134","article-title":"Bibliometric analysis methods for the medical literature","author":"Ganti L","year":"2025","unstructured":"Ganti L, Persaud NA, Stead TS. Bibliometric analysis methods for the medical literature. Acad Med Surg. 2025, 10.62186\/001c.129134","journal-title":"Acad Med Surg"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"van Eck NJ","year":"2010","unstructured":"van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010, 84:523-38. 10.1007\/s11192-009-0146-3","journal-title":"Scientometrics"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-000-0007-0","article-title":"Huntington's disease","volume":"2","author":"Haskins BA","year":"2000","unstructured":"Haskins BA, Harrison MB. Huntington's disease. Curr Treat Options Neurol. 2000, 2:243-62. 10.1007\/s11940-000-0007-0","journal-title":"Curr Treat Options Neurol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-140115","article-title":"Understanding the outcomes measures used in Huntington disease pharmacological trials: a systematic review","volume":"3","author":"Carlozzi NE","year":"2014","unstructured":"Carlozzi NE, Miciura A, Migliore N, Dayalu P. Understanding the outcomes measures used in Huntington disease pharmacological trials: a systematic review. J Huntingtons Dis. 2014, 3:233-52. 10.3233\/JHD-140115","journal-title":"J Huntingtons Dis"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.03.009","article-title":"Huntingtin protein: a new option for fixing the Huntington's disease countdown clock","volume":"135","author":"Caterino M","year":"2018","unstructured":"Caterino M, Squillaro T, Montesarchio D, Giordano A, Giancola C, Melone MA. Huntingtin protein: a new option for fixing the Huntington's disease countdown clock. Neuropharmacology. 2018, 135:126-38. 10.1016\/j.neuropharm.2018.03.009","journal-title":"Neuropharmacology"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0263001","article-title":"The impact of the COVID-19 pandemic on scientific research in the life sciences","volume":"17","author":"Riccaboni M","year":"2022","unstructured":"Riccaboni M, Verginer L. The impact of the COVID-19 pandemic on scientific research in the life sciences. PLoS One. 2022, 17:e0263001. 10.1371\/journal.pone.0263001","journal-title":"PLoS One"},{"key":"ref15","unstructured":"Alzheimer\u2019s, Parkinson\u2019s, and Huntington\u2019s diseases share a common crucial feature. finding suggests that treatment for one disease could work for the other two. (2017). Accessed: July 27, 2024: https:\/\/www.sciencedaily.com\/releases\/2017\/05\/170523144123.htm."},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1722-x\u00a0","article-title":"Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins","volume":"134","author":"Flavin WP","year":"2017","unstructured":"Flavin WP, Bousset L, Green ZC, et al.. Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins. Acta Neuropathologica. 2017, 134:629-53. 10.1007\/s00401-017-1722-x\u00a0","journal-title":"Acta Neuropathologica"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.24473\u00a0","article-title":"The effect of Huntington's disease on the basal nuclei: a review","volume":"14","author":"Matz OC","year":"2022","unstructured":"Matz OC, Spocter M. The effect of Huntington's disease on the basal nuclei: a review. Cureus. 2022, 14:4. 10.7759\/cureus.24473\u00a0","journal-title":"Cureus"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.12703\/r\/10-77\u00a0","article-title":"Huntington's disease mouse models: unraveling the pathology caused by CAG repeat expansion","volume":"10","author":"Kaye J","year":"2021","unstructured":"Kaye J, Reisine T, Finkbeiner S. Huntington's disease mouse models: unraveling the pathology caused by CAG repeat expansion. Fac Rev. 2021, 10:77. 10.12703\/r\/10-77\u00a0","journal-title":"Fac Rev"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32453","article-title":"Genetic counseling and testing for Huntington's disease: a historical review","volume":"174","author":"Nance MA","year":"2017","unstructured":"Nance MA. Genetic counseling and testing for Huntington's disease: a historical review. Am J Med Genet B Neuropsychiatr Genet. 2017, 174:75-92. 10.1002\/ajmg.b.32453","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07549-8","article-title":"Consensus guidelines on genetic' testing for hereditary breast cancer from the American Society of Breast Surgeons","volume":"26","author":"Manahan ER","year":"2019","unstructured":"Manahan ER, Kuerer HM, Sebastian M, et al.. Consensus guidelines on genetic' testing for hereditary breast cancer from the American Society of Breast Surgeons. Ann Surg Oncol. 2019, 26:3025-31. 10.1245\/s10434-019-07549-8","journal-title":"Ann Surg Oncol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.1.2.255","article-title":"Huntington's disease genetics","volume":"1","author":"Myers RH","year":"2004","unstructured":"Myers RH. Huntington's disease genetics. NeuroRx. 2004, 1:255-62. 10.1602\/neurorx.1.2.255","journal-title":"NeuroRx"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-024-00655-0","article-title":"Huntington disease health related quality of life, function and well being: the patient's perspective","volume":"14","author":"P\u00e9rez-P\u00e9rez J","year":"2025","unstructured":"P\u00e9rez-P\u00e9rez J, Garc\u00eda-L\u00f3pez S, Valle TF, et al.. Huntington disease health related quality of life, function and well being: the patient's perspective. Neurol Ther. 2025, 14:99-115. 10.1007\/s40120-024-00655-0","journal-title":"Neurol Ther"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1177\/13591053251328934","article-title":"Huntington's disease caregivers: a qualitative exploration of caregivers experience","author":"Carney S","year":"2025","unstructured":"Carney S, Pender N, Rogers E. Huntington's disease caregivers: a qualitative exploration of caregivers experience. J Health Psychol. 2025, 2025. 10.1177\/13591053251328934","journal-title":"J Health Psychol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/412245-huntingtons-disease-research-over-six-decades-global-insights-gaps-and-future-directions","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T17:04:10Z","timestamp":1763917450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/412245-huntingtons-disease-research-over-six-decades-global-insights-gaps-and-future-directions"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,23]]},"references-count":23,"URL":"https:\/\/doi.org\/10.7759\/cureus.97567","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,23]]}}}