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StatPearls Publishing, Treasure Island (FL); 2025."},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v6.i7.446","article-title":"Nuclear medicine and the failed joint replacement: past, present, and future","volume":"6","author":"Palestro CJ","year":"2014","unstructured":"Palestro CJ. Nuclear medicine and the failed joint replacement: past, present, and future. World J Radiol. 2014, 6:446-58. 10.4329\/wjr.v6.i7.446","journal-title":"World J Radiol"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-025-02003-6","article-title":"[18F]NaF PET\/CT Imaging of iliac bones to assess bone turnover","volume":"27","author":"Singh SB","year":"2025","unstructured":"Singh SB, Gandhi OH, Shrestha BB, et al.. [18F]NaF PET\/CT Imaging of iliac bones to assess bone turnover. 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J Vet Sci. 2020, 21:10. 10.4142\/jvs.2020.21.e10","journal-title":"J Vet Sci"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.3390\/ani11020284","article-title":"Evaluation of bone healing using contrast-enhanced ultrasonography in non-operative treatment of tibial fracture in a puppy dog","volume":"11","author":"Macr\u00ec F","year":"2021","unstructured":"Macr\u00ec F, Angileri V, Russo T, Russo MT, Tabb\u00ec M, Di Pietro S. Evaluation of bone healing using contrast-enhanced ultrasonography in non-operative treatment of tibial fracture in a puppy dog. Animals (Basel). 2021, 11:10.3390\/ani11020284","journal-title":"Animals (Basel)"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.3390\/s19040955","article-title":"Ultrasound radiation force for the assessment of bone fracture healing in children: an in vivo pilot study","volume":"19","author":"Ghavami S","year":"2019","unstructured":"Ghavami S, Gregory A, Webb J, et al.. 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Photoacoustics. 2022, 28:10.1016\/j.pacs.2022.100409","journal-title":"Photoacoustics"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.211785","article-title":"Artificial intelligence in fracture detection: a systematic review and meta-analysis","volume":"304","author":"Kuo RY","year":"2022","unstructured":"Kuo RY, Harrison C, Curran TA, et al.. Artificial intelligence in fracture detection: a systematic review and meta-analysis. Radiology. 2022, 304:50-62. 10.1148\/radiol.211785","journal-title":"Radiology"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.210937","article-title":"Improving radiographic fracture recognition performance and efficiency using artificial intelligence","volume":"302","author":"Guermazi A","year":"2022","unstructured":"Guermazi A, Tannoury C, Kompel AJ, et al.. Improving radiographic fracture recognition performance and efficiency using artificial intelligence. 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Global Spine J. 2025, 10.1177\/21925682251391687","journal-title":"Global Spine J"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1007\/s13246-019-00795-w","article-title":"Anatomical reduction and precise internal fixation of intra-articular fractures of the distal radius with virtual X-ray and 3D printing","volume":"43","author":"Xu J","year":"2019","unstructured":"Xu J, Zhang G, He Z, et al.. Anatomical reduction and precise internal fixation of intra-articular fractures of the distal radius with virtual X-ray and 3D printing. Australas Phys Eng Sci Med. 2019, 43:35-47. 10.1007\/s13246-019-00795-w","journal-title":"Australas Phys Eng Sci Med"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-025-08632-w","article-title":"Clinical study of 3D printing template in the treatment of pediatric distal tibial epiphyseal fracture","volume":"26","author":"Hui T","year":"2025","unstructured":"Hui T, Wang J, Yu Y, Qiang L, Dong H, Lin W. 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