{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:08:07Z","timestamp":1790082487723,"version":"4.0.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,24]]},"DOI":"10.7759\/cureus.97692","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:05:53Z","timestamp":1764029153000},"source":"Crossref","is-referenced-by-count":2,"title":["Impact of Periodontal Interventions on Glycemic Indices and Periodontal Status Among Adults With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis"],"prefix":"10.7759","author":[{"given":"Heliette  Emperatriz E","family":"Delgado Castromonte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo  P","family":"Jaramillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellinger","family":"Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misael","family":"Martinez Becerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan  S","family":"Hernandez Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Alcala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maritza  R","family":"Martinez Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188171","article-title":"The effects of non-surgical periodontal treatment on glycemic control, oxidative stress balance and quality of life in patients with type 2 diabetes: a randomized clinical trial","volume":"12","author":"Mizuno H","year":"2017","unstructured":"Mizuno H, Ekuni D, Maruyama T, et al.. The effects of non-surgical periodontal treatment on glycemic control, oxidative stress balance and quality of life in patients with type 2 diabetes: a randomized clinical trial. PLoS One. 2017, 12:e0188171. 10.1371\/journal.pone.0188171","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-018-0479-5","article-title":"Effects of nonsurgical periodontal treatment on glycated haemoglobin on type 2 diabetes patients (PARODIA 1 study): a randomized controlled trial in a sub-Saharan Africa population","volume":"18","author":"Tsobgny-Tsague NF","year":"2018","unstructured":"Tsobgny-Tsague NF, Lontchi-Yimagou E, Nana AR, et al.. Effects of nonsurgical periodontal treatment on glycated haemoglobin on type 2 diabetes patients (PARODIA 1 study): a randomized controlled trial in a sub-Saharan Africa population. BMC Oral Health. 2018, 18:28. 10.1186\/s12903-018-0479-5","journal-title":"BMC Oral Health"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2019-000665","article-title":"Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial","volume":"8","author":"G\u00f3mez-Sandoval JR","year":"2020","unstructured":"G\u00f3mez-Sandoval JR, Robles-Cervantes JA, Hern\u00e1ndez-Gonz\u00e1lez SO, et al.. Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial. BMJ Open Diabetes Res Care. 2020, 8:10.1136\/bmjdrc-2019-000665","journal-title":"BMJ Open Diabetes Res Care"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13005-020-00253-z","article-title":"Application value of combination therapy of periodontal curettage and root planing on moderate-to-severe chronic periodontitis in patients with type 2 diabetes","volume":"17","author":"Bian Y","year":"2021","unstructured":"Bian Y, Liu C, Fu Z. Application value of combination therapy of periodontal curettage and root planing on moderate-to-severe chronic periodontitis in patients with type 2 diabetes. Head Face Med. 2021, 17:12. 10.1186\/s13005-020-00253-z","journal-title":"Head Face Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01620-1","article-title":"Clinical efficacy of scaling and root planing with and without metronidazole on glycemic control: three-arm randomized controlled trial","volume":"21","author":"Qureshi A","year":"2021","unstructured":"Qureshi A, Bokhari SA, Haque Z, Baloch AA, Zaheer S. Clinical efficacy of scaling and root planing with and without metronidazole on glycemic control: three-arm randomized controlled trial. BMC Oral Health. 2021, 21:253. 10.1186\/s12903-021-01620-1","journal-title":"BMC Oral Health"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18063018","article-title":"Inflammatory status and glycemic control level of patients with type 2 diabetes and periodontitis: a randomized clinical trial","volume":"18","author":"Rapone B","year":"2021","unstructured":"Rapone B, Ferrara E, Corsalini M, et al.. Inflammatory status and glycemic control level of patients with type 2 diabetes and periodontitis: a randomized clinical trial. Int J Environ Res Public Health. 2021, 18:10.3390\/ijerph18063018","journal-title":"Int J Environ Res Public Health"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-03908-6","article-title":"Influence of physical activity on periodontal health in patients with type 2 diabetes mellitus. A blinded, randomized, controlled trial","volume":"25","author":"Wernicke K","year":"2021","unstructured":"Wernicke K, Grischke J, Stiesch M, et al.. Influence of physical activity on periodontal health in patients with type 2 diabetes mellitus. A blinded, randomized, controlled trial. Clin Oral Investig. 2021, 25:6101-7. 10.1007\/s00784-021-03908-6","journal-title":"Clin Oral Investig"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-05239-0","article-title":"The effect of antimicrobial photodynamic therapy on periodontal disease and glycemic control in patients with type 2 diabetes mellitus","volume":"27","author":"Brinar S","year":"2023","unstructured":"Brinar S, Skvar\u010da A, Ga\u0161pirc B, Schara R. The effect of antimicrobial photodynamic therapy on periodontal disease and glycemic control in patients with type 2 diabetes mellitus. Clin Oral Investig. 2023, 27:6235-44. 10.1007\/s00784-023-05239-0","journal-title":"Clin Oral Investig"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-025-06485-2","article-title":"Non-surgical periodontal therapy with and without hyaluronic acid gel in type 2 diabetic stage-II periodontitis patients: a randomized clinical trial","volume":"25","author":"Al-Abbadi R","year":"2025","unstructured":"Al-Abbadi R, Shemais N, Nawwar A, Fawzy El-Sayed KM. Non-surgical periodontal therapy with and without hyaluronic acid gel in type 2 diabetic stage-II periodontitis patients: a randomized clinical trial. BMC Oral Health. 2025, 25:1166. 10.1186\/s12903-025-06485-2","journal-title":"BMC Oral Health"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-09034-7","article-title":"Community interventions improve diabetes management and oral health in type 2 diabetes patients with chronic periodontitis","volume":"15","author":"Zhang Y","year":"2025","unstructured":"Zhang Y, Chen Y, Wang C, Xu H, Zhou N, Hong X. Community interventions improve diabetes management and oral health in type 2 diabetes patients with chronic periodontitis. Sci Rep. 2025, 15:24395. 10.1038\/s41598-025-09034-7","journal-title":"Sci Rep"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/nri2925","article-title":"Type 2 diabetes as an inflammatory disease","volume":"11","author":"Donath MY","year":"2011","unstructured":"Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011, 11:98-107. 10.1038\/nri2925","journal-title":"Nat Rev Immunol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12002","article-title":"Inflammatory and immune pathways in the pathogenesis of periodontal disease","volume":"64","author":"Cekici A","year":"2014","unstructured":"Cekici A, Kantarci A, Hasturk H, Van Dyke TE. Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000. 2014, 64:57-80. 10.1111\/prd.12002","journal-title":"Periodontol 2000"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat0797","article-title":"A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans","volume":"10","author":"Dutzan N","year":"2018","unstructured":"Dutzan N, Kajikawa T, Abusleme L, et al.. A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans. Sci Transl Med. 2018, 10:10.1126\/scitranslmed.aat0797","journal-title":"Sci Transl Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12942","article-title":"Classification and diagnosis of aggressive periodontitis","volume":"45 Suppl 20","author":"Fine DH","year":"2018","unstructured":"Fine DH, Patil AG, Loos BG. Classification and diagnosis of aggressive periodontitis. J Clin Periodontol. 2018, 45 Suppl 20:S95-S111. 10.1111\/jcpe.12942","journal-title":"J Clin Periodontol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00384","article-title":"Fatty acid-induced lipotoxicity in pancreatic beta-cells during development of type 2 diabetes","volume":"9","author":"Oh YS","year":"2018","unstructured":"Oh YS, Bae GD, Baek DJ, Park EY, Jun HS. Fatty acid-induced lipotoxicity in pancreatic beta-cells during development of type 2 diabetes. Front Endocrinol (Lausanne). 2018, 9:384. 10.3389\/fendo.2018.00384","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12946","article-title":"Periodontitis: consensus report of Workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"45 Suppl 20","author":"Papapanou PN","year":"2018","unstructured":"Papapanou PN, Sanz M, Buduneli N, et al.. Periodontitis: consensus report of Workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol. 2018, 45 Suppl 20:S162-70. 10.1111\/jcpe.12946","journal-title":"J Clin Periodontol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12945","article-title":"Staging and grading of periodontitis: framework and proposal of a new classification and case definition","volume":"45 Suppl 20","author":"Tonetti MS","year":"2018","unstructured":"Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Clin Periodontol. 2018, 45 Suppl 20:S149-61. 10.1111\/jcpe.12945","journal-title":"J Clin Periodontol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2991\/jegh.k.191028.001","article-title":"Epidemiology of type 2 diabetes - global burden of disease and forecasted trends","volume":"10","author":"Khan MA","year":"2020","unstructured":"Khan MA, Hashim MJ, King JK, Govender RD, Mustafa H, Al Kaabi J. Epidemiology of type 2 diabetes - global burden of disease and forecasted trends. J Epidemiol Glob Health. 2020, 10:107-11. 10.2991\/jegh.k.191028.001","journal-title":"J Epidemiol Glob Health"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/08959374940080022001","article-title":"Microbial ecology of dental plaque and its significance in health and disease","volume":"8","author":"Marsh PD","year":"1994","unstructured":"Marsh PD. Microbial ecology of dental plaque and its significance in health and disease. Adv Dent Res. 1994, 8:263-71. 10.1177\/08959374940080022001","journal-title":"Adv Dent Res"},{"key":"ref20","article-title":"The relationship between diabetes mellitus and destructive periodontal disease: a meta-analysis","volume":"7","author":"Ch\u00e1varry NG","year":"2009","unstructured":"Ch\u00e1varry NG, Vettore MV, Sansone C, Sheiham A. The relationship between diabetes mellitus and destructive periodontal disease: a meta-analysis. Oral Health Prev Dent. 2009, 7:107-27.","journal-title":"Oral Health Prev Dent"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0254-6450.2017.10.028","article-title":"[Bias risk assessment: (3) Revised Cochrane bias risk assessment tool for individual randomized, cross-over trials (RoB2.0)]","volume":"38","author":"Wu SS","year":"2017","unstructured":"Wu SS, Sun F, Zhan SY. [Bias risk assessment: (3) Revised Cochrane bias risk assessment tool for individual randomized, cross-over trials (RoB2.0)]. Zhonghua Liu Xing Bing Xue Za Zhi. 2017, 38:1436-40. 10.3760\/cma.j.issn.0254-6450.2017.10.028","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/435189-impact-of-periodontal-interventions-on-glycemic-indices-and-periodontal-status-among-adults-with-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:05:56Z","timestamp":1764029156000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/435189-impact-of-periodontal-interventions-on-glycemic-indices-and-periodontal-status-among-adults-with-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":22,"URL":"https:\/\/doi.org\/10.7759\/cureus.97692","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,24]]}}}