{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:09:01Z","timestamp":1792030141303,"version":"4.4.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,25]]},"DOI":"10.7759\/cureus.97732","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T11:21:19Z","timestamp":1764069679000},"source":"Crossref","is-referenced-by-count":1,"title":["Maternal Interleukin-6 as a Predictor of Preterm Birth: A Prospective Observational Study at the County Clinical Emergency Hospital of Sibiu"],"prefix":"10.7759","author":[{"given":"Sandra","family":"Neamtu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca","family":"Badila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu","family":"Chicea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60820-4","article-title":"National, regional, and worldwide estimates of preterm birth rates in the year 2010: a systematic analysis and implications for policy and programs","volume":"379","author":"Blencowe H","year":"2012","unstructured":"Blencowe H, Cousens S, Oestergaard MZ, et al.. National, regional, and worldwide estimates of preterm birth rates in the year 2010: a systematic analysis and implications for policy and programs. Lancet. 2012, 379:2162-72. 10.1016\/S0140-6736(12)60820-4","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-956773","article-title":"The role of inflammation and infection in preterm birth","volume":"25","author":"Romero R","year":"2007","unstructured":"Romero R, Espinoza J, Gon\u00e7alves LF, Kusanovic JP, Friel L, Hassan S. The role of inflammation and infection in preterm birth. Semin Reprod Med. 2007, 25:21-39. 10.1055\/s-2006-956773","journal-title":"Semin Reprod Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00574","article-title":"Preterm birth, intrauterine infection, and fetal inflammation","volume":"5","author":"Kemp MW","year":"2014","unstructured":"Kemp MW. Preterm birth, intrauterine infection, and fetal inflammation. Front Immunol. 2014, 5:574. 10.3389\/fimmu.2014.00574","journal-title":"Front Immunol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2006.089","article-title":"Normal and abnormal transformation of the spiral arteries during pregnancy","volume":"34","author":"Espinoza J","year":"2006","unstructured":"Espinoza J, Romero R, Mee Kim Y, et al.. Normal and abnormal transformation of the spiral arteries during pregnancy. J Perinat Med. 2006, 34:447-58. 10.1515\/JPM.2006.089","journal-title":"J Perinat Med"},{"key":"ref5","article-title":"Cytokines and parturition: IL-6 as a signal for uterine activation","volume":"68","author":"Keelan JA","year":"2003","unstructured":"Keelan JA, Blumenstein M, Helliwell RJ, Sato TA, Marvin KW, Mitchell MD. Cytokines and parturition: IL-6 as a signal for uterine activation. Biol Reprod. 2003, 68:566-571.","journal-title":"Biol Reprod"},{"key":"ref6","article-title":"Amniotic fluid interleukin-6 as a marker of infection and preterm labor","volume":"162","author":"Romero R","year":"1990","unstructured":"Romero R, Mazor M, Brandt F, et al.. Amniotic fluid interleukin-6 as a marker of infection and preterm labor. Am J Obstet Gynecol. 1990, 162:813-20.","journal-title":"Am J Obstet Gynecol"},{"key":"ref7","article-title":"The diagnostic and prognostic value of amniotic fluid white blood cell count, glucose, interleukin-6, and gram stain in patients with preterm labor and intact membranes","volume":"169","author":"Romero R","year":"1993","unstructured":"Romero R, Yoon BH, Mazor M, et al.. The diagnostic and prognostic value of amniotic fluid white blood cell count, glucose, interleukin-6, and gram stain in patients with preterm labor and intact membranes. Am J Obstet Gynecol. 1993, 169:805-16.","journal-title":"Am J Obstet Gynecol"},{"key":"ref8","doi-asserted-by":"crossref","DOI":"10.3109\/14767058.2014.954243","article-title":"Sterile intra-amniotic inflammation in asymptomatic women with a sonographic short cervix: prevalence and clinical significance","volume":"28","author":"Romero R","year":"2015","unstructured":"Romero R, Miranda J, Chaiworapongsa T, et al.. Sterile intra-amniotic inflammation in asymptomatic women with a sonographic short cervix: prevalence and clinical significance. J Matern Fetal Neonatal Med. 2015, 28:1343-59.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.02.003","article-title":"A history of preeclampsia is associated with a risk for coronary artery calcification 3 decades later","volume":"214","author":"White WM","year":"2016","unstructured":"White WM, Mielke MM, Araoz PA, et al.. A history of preeclampsia is associated with a risk for coronary artery calcification 3 decades later. Am J Obstet Gynecol. 2016, 214:519.e1-8. 10.1016\/j.ajog.2016.02.003","journal-title":"Am J Obstet Gynecol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.958463","article-title":"Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes","volume":"28","author":"Romero R","year":"2015","unstructured":"Romero R, Miranda J, Chaemsaithong P, et al.. Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2015, 28:1394-409. 10.3109\/14767058.2014.958463","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03328.x","article-title":"Prediction of spontaneous preterm delivery in women with threatened preterm labour: a prospective cohort study of multiple proteins in maternal serum","volume":"119","author":"Tsiartas P","year":"2012","unstructured":"Tsiartas P, Holst RM, Wennerholm UB, et al.. Prediction of spontaneous preterm delivery in women with threatened preterm labour: a prospective cohort study of multiple proteins in maternal serum. BJOG. 2012, 119:866-78. 10.1111\/j.1471-0528.2012.03328.x","journal-title":"BJOG"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1006621","article-title":"A point of care test for interleukin-6 in amniotic fluid in preterm prelabor rupture of membranes: a step toward the early treatment of acute intra-amniotic inflammation\/infection","volume":"29","author":"Chaemsaithong P","year":"2016","unstructured":"Chaemsaithong P, Romero R, Korzeniewski SJ, et al.. A point of care test for interleukin-6 in amniotic fluid in preterm prelabor rupture of membranes: a step toward the early treatment of acute intra-amniotic inflammation\/infection. J Matern Fetal Neonatal Med. 2016, 29:360-7. 10.3109\/14767058.2015.1006621","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsgi.2004.04.001","article-title":"The role of matrix degrading enzymes and apoptosis in rupture of membranes","volume":"11","author":"Menon R","year":"2004","unstructured":"Menon R, Fortunato SJ. The role of matrix degrading enzymes and apoptosis in rupture of membranes. J Soc Gynecol Investig. 2004, 11:427-37. 10.1016\/j.jsgi.2004.04.001","journal-title":"J Soc Gynecol Investig"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005183422007","article-title":"Intrauterine infection and preterm delivery","volume":"342","author":"Goldenberg RL","year":"2000","unstructured":"Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med. 2000, 342:1500-7. 10.1056\/NEJM200005183422007","journal-title":"N Engl J Med"},{"key":"ref15","article-title":"Biomarkers for spontaneous preterm birth: interleukin-6 and beyond","volume":"49","author":"Kacerovsky M","year":"2021","unstructured":"Kacerovsky M, Jacobsson B. Biomarkers for spontaneous preterm birth: interleukin-6 and beyond. J Perinat Med. 2021, 49:673-81.","journal-title":"J Perinat Med"},{"key":"ref16","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddn049","article-title":"Interleukin-6 (IL6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth","volume":"17","author":"Velez DR","year":"2008","unstructured":"Velez DR, Fortunato SJ, Thorsen P, Williams SM, Menon R. Interleukin-6 (IL6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth. Hum Mol Genet. 2008, 17:1619-30.","journal-title":"Hum Mol Genet"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.07.009","article-title":"Femur-sparing pattern of fetal growth after maternal\u00a0Zika virus infection","volume":"219","author":"Yasri S","year":"2018","unstructured":"Yasri S, Wiwanitkit V. Femur-sparing pattern of fetal growth after maternal\u00a0Zika virus infection. Am J Obstet Gynecol. 2018, 219:514. 10.1016\/j.ajog.2018.07.009","journal-title":"Am J Obstet Gynecol"},{"key":"ref18","article-title":"Inflammatory markers and adverse pregnancy outcomes: a systematic review","volume":"27","author":"Nguyen DP","year":"2014","unstructured":"Nguyen DP, Gerber S, Hohlfeld P, et al.. Inflammatory markers and adverse pregnancy outcomes: a systematic review. J Matern Fetal Neonatal Med. 2014, 27:857-67.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.10.693","article-title":"Medroxyprogesterone acetate, but not progesterone, protects against inflammation-induced parturition and intrauterine fetal demise","volume":"190","author":"Elovitz M","year":"2004","unstructured":"Elovitz M, Wang Z. Medroxyprogesterone acetate, but not progesterone, protects against inflammation-induced parturition and intrauterine fetal demise. Am J Obstet Gynecol. 2004, 190:693-701. 10.1016\/j.ajog.2003.10.693","journal-title":"Am J Obstet Gynecol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2020.101146","article-title":"The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications","volume":"25","author":"Jung E","year":"2020","unstructured":"Jung E, Romero R, Yeo L, et al.. The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications. Semin Fetal Neonatal Med. 2020, 25:101146. 10.1016\/j.siny.2020.101146","journal-title":"Semin Fetal Neonatal Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/432577-maternal-interleukin-6-as-a-predictor-of-preterm-birth-a-prospective-observational-study-at-the-county-clinical-emergency-hospital-of-sibiu","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T11:21:20Z","timestamp":1764069680000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/432577-maternal-interleukin-6-as-a-predictor-of-preterm-birth-a-prospective-observational-study-at-the-county-clinical-emergency-hospital-of-sibiu"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.97732","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,25]]}}}