{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:20:37Z","timestamp":1790050837883,"version":"4.0.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,25]]},"DOI":"10.7759\/cureus.97817","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T07:17:21Z","timestamp":1764141441000},"source":"Crossref","is-referenced-by-count":1,"title":["Utilization of Hematological Markers to Distinguish Bile Reflux Gastritis From Helicobacter pylori-Associated Gastritis in Pediatric Patients"],"prefix":"10.7759","author":[{"given":"Shehanshah","family":"Muhammad Arqam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maliha","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Labiqa","family":"Khowaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Ul Haq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhan","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshy","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Tayyab","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raheel Ahmad","family":"Sohail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Hamza","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000517263","article-title":"The relationship between primary duodenogastric reflux and Helicobacter pylori gastritis in children","volume":"40","author":"Arslan M","year":"2022","unstructured":"Arslan M, Balamtekin N. The relationship between primary duodenogastric reflux and Helicobacter pylori gastritis in children. Dig Dis. 2022, 40:276-81. 10.1159\/000517263","journal-title":"Dig Dis"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11051312","article-title":"Helicobacter pylori and its role in gastric cancer","volume":"11","author":"Reyes VE","year":"2023","unstructured":"Reyes VE. Helicobacter pylori and its role in gastric cancer. Microorganisms. 2023, 11:10.3390\/microorganisms11051312","journal-title":"Microorganisms"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202302_31190","article-title":"Impact of chronic Helicobacter pylori infection on inflammatory markers and hematological parameters","volume":"27","author":"Sa\u011flam N\u00d6","year":"2023","unstructured":"Sa\u011flam N\u00d6, Civan HA. Impact of chronic Helicobacter pylori infection on inflammatory markers and hematological parameters. Eur Rev Med Pharmacol Sci. 2023, 27:969-79. 10.26355\/eurrev_202302_31190","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2642551","article-title":"Bile reflux gastritis: insights into pathogenesis, relevant factors, carcinomatous risk, diagnosis, and management","volume":"2022","author":"Shi X","year":"2022","unstructured":"Shi X, Chen Z, Yang Y, Yan S. Bile reflux gastritis: insights into pathogenesis, relevant factors, carcinomatous risk, diagnosis, and management. Gastroenterol Res Pract. 2022, 2022:2642551. 10.1155\/2022\/2642551","journal-title":"Gastroenterol Res Pract"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S474925","article-title":"Immune cell crisis and excess histopathological features during the development and progression of H. pylori infection in the gastric mucosa","volume":"18","author":"Wang SN","year":"2025","unstructured":"Wang SN, Wang YK, Li P, Kong LC, Deng WY, Jiang B, Li YY. Immune cell crisis and excess histopathological features during the development and progression of H. pylori infection in the gastric mucosa. Int J Gen Med. 2025, 18:1345-57. 10.2147\/IJGM.S474925","journal-title":"Int J Gen Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12020508","article-title":"Evolution of diagnostic methods for Helicobacter pylori infections: from traditional tests to high technology, advanced sensitivity and discrimination tools","volume":"12","author":"Cardos AI","year":"2022","unstructured":"Cardos AI, Maghiar A, Zaha DC, Pop O, Fritea L, Miere Groza F, Cavalu S. Evolution of diagnostic methods for Helicobacter pylori infections: from traditional tests to high technology, advanced sensitivity and discrimination tools. Diagnostics (Basel). 2022, 12:10.3390\/diagnostics12020508","journal-title":"Diagnostics (Basel)"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcvp.2025.100229","article-title":"Prognostic value of inflammatory markers including neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume, platelet distribution width, and red blood cell distribution width in viral hepatitis: a systematic review and meta-analysis","author":"Roudsari PP","year":"2025","unstructured":"Roudsari PP, Shojaei S, Firoozbakhsh P, et al.. Prognostic value of inflammatory markers including neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume, platelet distribution width, and red blood cell distribution width in viral hepatitis: a systematic review and meta-analysis. J Clin Virol Plus. 2025, 10.1016\/j.jcvp.2025.100229","journal-title":"J Clin Virol Plus"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-23191-z","article-title":"Searching for serum biomarkers linking coronary heart disease and Helicobacter pylori infection using infrared spectroscopy and artificial neural networks","volume":"12","author":"Gonciarz W","year":"2022","unstructured":"Gonciarz W, Lechowicz \u0141, Urbaniak M, et al.. Searching for serum biomarkers linking coronary heart disease and Helicobacter pylori infection using infrared spectroscopy and artificial neural networks. Sci Rep. 2022, 12:18284. 10.1038\/s41598-022-23191-z","journal-title":"Sci Rep"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.5114\/pg.2023.132461","article-title":"Helicobacter pylori gastritis in Jordanian children: persistence versus resolution","volume":"19","author":"Altamimi E","year":"2024","unstructured":"Altamimi E, Salameh L, AlNsour H, Rawabdeh N. Helicobacter pylori gastritis in Jordanian children: persistence versus resolution. Prz Gastroenterol. 2024, 19:311-20. 10.5114\/pg.2023.132461","journal-title":"Prz Gastroenterol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2021.1950898","article-title":"Hematological and biochemical parameters as diagnostic and prognostic markers in SARS-COV-2 infected patients of Pakistan: a retrospective comparative analysis","volume":"26","author":"Khalid A","year":"2021","unstructured":"Khalid A, Ali Jaffar M, Khan T, et al.. Hematological and biochemical parameters as diagnostic and prognostic markers in SARS-COV-2 infected patients of Pakistan: a retrospective comparative analysis. Hematology. 2021, 26:529-42. 10.1080\/16078454.2021.1950898","journal-title":"Hematology"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-025-07148-9","article-title":"Diagnostic value of neutrophil to lymphocyte ratio in identifying gastritis in children with chronic abdominal pain in northern Iran","volume":"18","author":"Erfanipour M","year":"2025","unstructured":"Erfanipour M, Dooki ME, Nikbakht HA, Nesheli HM, Pornasrolah M, Nikpour M, Mehrabani S. Diagnostic value of neutrophil to lymphocyte ratio in identifying gastritis in children with chronic abdominal pain in northern Iran. BMC Res Notes. 2025, 18:68. 10.1186\/s13104-025-07148-9","journal-title":"BMC Res Notes"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12652","article-title":"Endoscopic findings of Helicobacter pylori gastritis in children and young adults based on the Kyoto classification of gastritis and age-associated changes","volume":"5","author":"Hojo M","year":"2021","unstructured":"Hojo M, Nagahara A, Kudo T, et al.. Endoscopic findings of Helicobacter pylori gastritis in children and young adults based on the Kyoto classification of gastritis and age-associated changes. JGH Open. 2021, 5:1197-202. 10.1002\/jgh3.12652","journal-title":"JGH Open"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/children9091359","article-title":"Worldwide prevalence and risk factors of Helicobacter pylori infection in children","volume":"9","author":"Borka Balas R","year":"2022","unstructured":"Borka Balas R, Meli\u021b LE, M\u0103rginean CO. Worldwide prevalence and risk factors of Helicobacter pylori infection in children. Children (Basel). 2022, 9:10.3390\/children9091359","journal-title":"Children (Basel)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003414","article-title":"Helicobacter pylori\u2010negative chronic gastritis in children: a systematic review","volume":"74","author":"Assa A","year":"2022","unstructured":"Assa A, Borrelli O, Broekaert I, et al.. Helicobacter pylori\u2010negative chronic gastritis in children: a systematic review. J Pediatr Gastroenterol Nutr. 2022, 74:956-67. 10.1097\/MPG.0000000000003414","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1743502","article-title":"The association between Helicobacter pylori infection and iron deficiency anemia in children: a systematic review and meta-analysis","volume":"17","author":"Hamdan SZ","year":"2022","unstructured":"Hamdan SZ, Hamdan HZ. The association between Helicobacter pylori infection and iron deficiency anemia in children: a systematic review and meta-analysis. J Pediatr Infect Dis. 2022, 17:59-70. 10.1055\/s-0042-1743502","journal-title":"J Pediatr Infect Dis"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/frhem.2024.1423494","article-title":"The nexus between Helicobacter pylori infection and anemia\u2014a systematic review","volume":"3","author":"Motupalli SK","year":"2024","unstructured":"Motupalli SK. The nexus between Helicobacter pylori infection and anemia\u2014a systematic review. Front Hematol. 2024, 3:1423494. 10.3389\/frhem.2024.1423494","journal-title":"Front Hematol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.5056\/jnm22186","article-title":"Roles of cytokines in pathological and physiological gastroesophageal reflux exposure","volume":"30","author":"Ergun P","year":"2024","unstructured":"Ergun P, Kipcak S, Gunel NS, Bor S, Sozmen EY. Roles of cytokines in pathological and physiological gastroesophageal reflux exposure. J Neurogastroenterol Motil. 2024, 30:290-302. 10.5056\/jnm22186","journal-title":"J Neurogastroenterol Motil"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.18502\/acta.v58i1.3701","article-title":"Changes in hemoglobin level and mean corpuscular volume during the convalescent phase of acute febrile illness in children: a study of the possible role of hemolysis","volume":"9","author":"Fekri K","year":"2020","unstructured":"Fekri K, Kianpour F. Changes in hemoglobin level and mean corpuscular volume during the convalescent phase of acute febrile illness in children: a study of the possible role of hemolysis. Acta Medica. 2020, 9:14. 10.18502\/acta.v58i1.3701","journal-title":"Acta Medica"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12787","article-title":"Relationship between active Helicobacter pylori infection and anemia, iron deficiency, iron deficiency anemia: a cross-sectional study in a sub-Saharan setting","volume":"6","author":"Eyoum Bille BB","year":"2022","unstructured":"Eyoum Bille BB, Kouitcheu Mabeku LB. Relationship between active Helicobacter pylori infection and anemia, iron deficiency, iron deficiency anemia: a cross-sectional study in a sub-Saharan setting. JGH Open. 2022, 6:554-68. 10.1002\/jgh3.12787","journal-title":"JGH Open"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-024-10427-8","article-title":"The association of Helicobacter pylori infection with the risk of anemia in children: systematic review and meta-analysis","volume":"25","author":"Walle M","year":"2025","unstructured":"Walle M, Tesfaye A, Agidew MM, Semaw M, Mekuria S, Getu F. The association of Helicobacter pylori infection with the risk of anemia in children: systematic review and meta-analysis. BMC Infect Dis. 2025, 25:23. 10.1186\/s12879-024-10427-8","journal-title":"BMC Infect Dis"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021985","article-title":"Pediatric gastritis and its impact on hematologic parameters","volume":"99","author":"S\u0103s\u0103ran MO","year":"2020","unstructured":"S\u0103s\u0103ran MO, Meli\u0163 LE, Mocan S, Ghiga DV, Dobru ED. Pediatric gastritis and its impact on hematologic parameters. Medicine (Baltimore). 2020, 99:e21985. 10.1097\/MD.0000000000021985","journal-title":"Medicine (Baltimore)"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.7197\/cmj.1084756","article-title":"The role of neutrophil-lymphocyte ratio and platelet-lymphocyte ratios in predicting H pylori positivity and severity in patients with chronic gastritis","volume":"44","author":"Koc S","year":"2022","unstructured":"Koc S, Gedikli MA. The role of neutrophil-lymphocyte ratio and platelet-lymphocyte ratios in predicting H pylori positivity and severity in patients with chronic gastritis. Cumhur Med J. 2022, 44:87-91. 10.7197\/cmj.1084756","journal-title":"Cumhur Med J"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/428914-utilization-of-hematological-markers-to-distinguish-bile-reflux-gastritis-from-helicobacter-pylori-associated-gastritis-in-pediatric-patients","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T07:17:22Z","timestamp":1764141442000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/428914-utilization-of-hematological-markers-to-distinguish-bile-reflux-gastritis-from-helicobacter-pylori-associated-gastritis-in-pediatric-patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":22,"URL":"https:\/\/doi.org\/10.7759\/cureus.97817","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,25]]}}}