{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T01:37:11Z","timestamp":1764207431591,"version":"3.46.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,26]]},"DOI":"10.7759\/cureus.97886","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T01:34:33Z","timestamp":1764207273000},"source":"Crossref","is-referenced-by-count":0,"title":["Rapidly Progressive Bilateral Syphilitic Optic Neuritis in an Elderly Patient: A Case Report"],"prefix":"10.7759","author":[{"given":"Masahiko","family":"Funatsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Wakuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayano","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waka","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junki","family":"Sunada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiaki","family":"Higashijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Wasai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","unstructured":"Syphilis medical guide. (2018). Accessed. June 30, 2025: https:\/\/jssti.jp\/pdf\/syphilis-medical_guide.pdf."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(08)70065-3","article-title":"Infectious syphilis in high-income settings in the 21st century","volume":"8","author":"Fenton KA","year":"2008","unstructured":"Fenton KA, Breban R, Vardavas R, et al.. Infectious syphilis in high-income settings in the 21st century. Lancet Infect Dis. 2008, 8:244-53. 10.1016\/s1473-3099(08)70065-3","journal-title":"Lancet Infect Dis"},{"key":"ref3","article-title":"Primary and secondary syphilis--United States, 2005-2013","volume":"63","author":"Patton ME","year":"2014","unstructured":"Patton ME, Su JR, Nelson R, Weinstock H. Primary and secondary syphilis--United States, 2005-2013. MMWR Morb Mort Wkly Rep. 2014, 63:402-6.","journal-title":"MMWR Morb Mort Wkly Rep"},{"key":"ref4","article-title":"Featured syphilis 2023 now","volume":"44","author":"Nakayama S","year":"2023","unstructured":"Nakayama S. Featured syphilis 2023 now. IASR Infectious Agents Surveillance Report. 2023, 44:1-5.","journal-title":"IASR Infectious Agents Surveillance Report"},{"key":"ref5","article-title":"A case of retinitis in a patient with syphilis","volume":"25","author":"Hara R","year":"2008","unstructured":"Hara R, Miwa E, Saji N, Azumi N. A case of retinitis in a patient with syphilis. Atarashii Ganka. 2008, 25:855-9.","journal-title":"Atarashii Ganka"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3109\/01658107.2015.1134586","article-title":"Syphilitic optic neuropathy: re-emerging cases over a 2-year period","volume":"40","author":"Apinyawasisuk S","year":"2016","unstructured":"Apinyawasisuk S, Poonyathalang A, Preechawat P, Vanikieti K. Syphilitic optic neuropathy: re-emerging cases over a 2-year period. Neuroophthalmology. 2016, 40:69-73. 10.3109\/01658107.2015.1134586","journal-title":"Neuroophthalmology"},{"key":"ref7","article-title":"A case of syphilitic optic neuritis and chorioretinitis associated with human immunodeficiency virus infection","volume":"21","author":"Yamamoto K","year":"2004","unstructured":"Yamamoto K, Kikuchi M, Kawamoto M, et al.. A case of syphilitic optic neuritis and chorioretinitis associated with human immunodeficiency virus infection. Atarashii Ganka. 2004, 21:1273-6.","journal-title":"Atarashii Ganka"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.5678","article-title":"Unilateral syphilitic optic neuritis without meningitis or uveitis","volume":"10","author":"Yamashita S","year":"2022","unstructured":"Yamashita S, Tago M, Nishi TM, Yamashita SI. Unilateral syphilitic optic neuritis without meningitis or uveitis. Clin Case Rep. 2022, 10:e05678. 10.1002\/ccr3.5678","journal-title":"Clin Case Rep"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.72534","article-title":"Ocular syphilis with unilateral optic papillitis and outer retinopathy complicated by diabetic retinopathy","volume":"16","author":"Nonaka K","year":"2024","unstructured":"Nonaka K, Takahashi Y, Hasegawa T, Iida T. Ocular syphilis with unilateral optic papillitis and outer retinopathy complicated by diabetic retinopathy. Cureus. 2024, 16:e72534. 10.7759\/cureus.72534","journal-title":"Cureus"},{"key":"ref10","article-title":"Treatment of sexually transmitted diseases and tips for medical interviews","author":"Kato Y","year":"2018","unstructured":"Kato Y. Treatment of sexually transmitted diseases and tips for medical interviews. Monthly Book Derma. Abe M (ed): All Japan Hospital Publishing Association, Tokyo; 2018. 275:99-102."},{"key":"ref11","article-title":"Sexually Transmitted Infections Treatment Guidelines, 2021","volume":"70","author":"Kimberly A","year":"2021","unstructured":"Kimberly A, Laura H, Philip A, et al..  Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Morb Mort Wkly Rep. 2021, 70:1-187.","journal-title":"MMWR Morb Mort Wkly Rep"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(90)32418-1","article-title":"Acute syphilitic posterior placoid chorioretinitis","volume":"97","author":"Gass JD","year":"1990","unstructured":"Gass JD, Braunstein RA, Chenoweth RG. Acute syphilitic posterior placoid chorioretinitis. Ophthalmology . 1990, 97:1288-97. 10.1016\/s0161-6420(90)32418-1","journal-title":"Ophthalmology"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4103\/JOCO.JOCO_184_20","article-title":"Choriocapillaris involvement in acute syphilis posterior placoid chorioretinitis is responsible for functional impairment and points towards an immunologic mechanism: a comprehensive clinicopathological approach","volume":"32","author":"Herbort CP Jr","year":"2020","unstructured":"Herbort CP Jr, Papasavvas I, Mantovani A. Choriocapillaris involvement in acute syphilis posterior placoid chorioretinitis is responsible for functional impairment and points towards an immunologic mechanism: a comprehensive clinicopathological approach. J Curr Ophthalmol. 2020, 32:381-9. 10.4103\/JOCO.JOCO_184_20","journal-title":"J Curr Ophthalmol"},{"key":"ref14","article-title":"Uveitis clinical practice guidelines","volume":"123","year":"2019","unstructured":"Uveitis clinical practice guidelines. J Jpn Ophthalmol Soc. 2019, 123.662-5.","journal-title":"J Jpn Ophthalmol Soc"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6594849","article-title":"Clinical features and treatments of syphilitic uveitis: a systematic review and meta-analysis","volume":"2017","author":"Zhang T","year":"2017","unstructured":"Zhang T, Zhu Y, Xu G. Clinical features and treatments of syphilitic uveitis: a systematic review and meta-analysis. J Ophthalmol. 2017, 2017:6594849. 10.1155\/2017\/6594849","journal-title":"J Ophthalmol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.800383","article-title":"An updated review of recent advances in neurosyphilis","volume":"9","author":"Zhou J","year":"2022","unstructured":"Zhou J, Zhang H, Tang K, Liu R, Li J. An updated review of recent advances in neurosyphilis. Front Med (Lausanne). 2022, 9:800383. 10.3389\/fmed.2022.800383","journal-title":"Front Med (Lausanne)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/393156-rapidly-progressive-bilateral-syphilitic-optic-neuritis-in-an-elderly-patient-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T01:34:35Z","timestamp":1764207275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/393156-rapidly-progressive-bilateral-syphilitic-optic-neuritis-in-an-elderly-patient-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.97886","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,26]]}}}