{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T12:19:10Z","timestamp":1764764350690,"version":"3.46.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,3]]},"DOI":"10.7759\/cureus.98366","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T12:15:18Z","timestamp":1764764118000},"source":"Crossref","is-referenced-by-count":0,"title":["Late-Onset Gastrointestinal Manifestations of Multiple Endocrine Neoplasia Type 2B (MEN2B): Diffuse Ganglioneuromatosis Causing Megacolon"],"prefix":"10.7759","author":[{"given":"Maheen","family":"Rana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saddam","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Osman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Anant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-17-0209","article-title":"A comprehensive review on MEN2B","volume":"25","author":"Castinetti F","year":"2018","unstructured":"Castinetti F, Moley J, Mulligan L, Waguespack SG. A comprehensive review on MEN2B. Endocr Relat Cancer. 2018, 25:T29-39. 10.1530\/ERC-17-0209","journal-title":"Endocr Relat Cancer"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-27302008000800031","article-title":"Early diagnosis of multiple endocrine neoplasia type 2B: a challenge for physicians","volume":"52","author":"Camacho CP","year":"2008","unstructured":"Camacho CP, Hoff AO, Lindsey SC, et al.. Early diagnosis of multiple endocrine neoplasia type 2B: a challenge for physicians. Arq Bras Endocrinol Metabol. 2008, 52:1393-8. 10.1590\/s0004-27302008000800031","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/2050640615611630","article-title":"Characteristics of chronic megacolon among patients diagnosed with multiple endocrine neoplasia type 2B","volume":"4","author":"Gibbons D","year":"2016","unstructured":"Gibbons D, Camilleri M, Nelson AD, Eckert D. Characteristics of chronic megacolon among patients diagnosed with multiple endocrine neoplasia type 2B. United European Gastroenterol J. 2016, 4:449-54. 10.1177\/2050640615611630","journal-title":"United European Gastroenterol J"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200205000-00006","article-title":"Gastrointestinal manifestations of multiple endocrine neoplasia type 2","volume":"235","author":"Cohen MS","year":"2002","unstructured":"Cohen MS, Phay JE, Albinson C, et al.. Gastrointestinal manifestations of multiple endocrine neoplasia type 2. Ann Surg. 2002, 235:648-54; discussion 654-5. 10.1097\/00000658-200205000-00006","journal-title":"Ann Surg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0039-6060(05)80097-2","article-title":"Multiple endocrine neoplasia type 2B: more than an endocrine disorder","volume":"118","author":"O\u2019Riordain D","year":"1995","unstructured":"O\u2019Riordain D, O\u2019Brien T, Crotty T, Gharib H, Grant C, van Heerden J. Multiple endocrine neoplasia type 2B: more than an endocrine disorder. Surgery. 1995, 118:936-42. 10.1016\/s0039-6060(05)80097-2","journal-title":"Surgery"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182a6f43a","article-title":"Surgical curability of medullary thyroid cancer in multiple endocrine neoplasia 2B: a changing perspective","volume":"259","author":"Brauckhoff M","year":"2014","unstructured":"Brauckhoff M, Machens A, Lorenz K, Bj\u00f8ro T, Varhaug JE, Dralle H. Surgical curability of medullary thyroid cancer in multiple endocrine neoplasia 2B: a changing perspective. Ann Surg. 2014, 259:800-6. 10.1097\/SLA.0b013e3182a6f43a","journal-title":"Ann Surg"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.140.1.73","article-title":"Multiple endocrine neoplasia (MEN) syndrome type IIB: gastrointestinal manifestations","volume":"140","author":"Demos TC","year":"1983","unstructured":"Demos TC, Blonder J, Schey WL, Braithwaite SS, Goldstein PL. Multiple endocrine neoplasia (MEN) syndrome type IIB: gastrointestinal manifestations. AJR Am J Roentgenol. 1983, 140:73-8. 10.2214\/ajr.140.1.73","journal-title":"AJR Am J Roentgenol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jcemcr\/luaf004","article-title":"3 in 1: manifestations of multiple endocrine neoplasia type 2B on imaging","volume":"3","author":"Belcher V","year":"2025","unstructured":"Belcher V, Hinshaw T, Field J, Haider A. 3 in 1: manifestations of multiple endocrine neoplasia type 2B on imaging. JCEM Case Rep. 2025, 3:luaf004. 10.1210\/jcemcr\/luaf004","journal-title":"JCEM Case Rep"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/413711-late-onset-gastrointestinal-manifestations-of-multiple-endocrine-neoplasia-type-2b-men2b-diffuse-ganglioneuromatosis-causing-megacolon","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T12:15:19Z","timestamp":1764764119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/413711-late-onset-gastrointestinal-manifestations-of-multiple-endocrine-neoplasia-type-2b-men2b-diffuse-ganglioneuromatosis-causing-megacolon"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":8,"URL":"https:\/\/doi.org\/10.7759\/cureus.98366","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,3]]}}}