{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:18:24Z","timestamp":1764937104445,"version":"3.46.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,5]]},"DOI":"10.7759\/cureus.98511","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:13:13Z","timestamp":1764936793000},"source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Efficacy of Methenamine Hippurate Across Different Patient Groups With Recurrent Urinary Tract Infections: Experience From a University Teaching Hospital in South Wales, United Kingdom"],"prefix":"10.7759","author":[{"given":"Philip","family":"Abolanle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Akintelure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maike","family":"Eylert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don S","family":"Wijayasuriya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan A","family":"Al-Ibraheem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coral","family":"Seymour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulette","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.03.035","article-title":"European Association of Urology guidelines on urological infections: summary of the 2024 guidelines","volume":"86","author":"Kranz J","year":"2024","unstructured":"Kranz J, Bartoletti R, Bruy\u00e8re F, et al.. European Association of Urology guidelines on urological infections: summary of the 2024 guidelines. Eur Urol. 2024, 86:27-41. 10.1016\/j.eururo.2024.03.035","journal-title":"Eur Urol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-007-6180-2","article-title":"Community-onset urinary tract infections: a population-based assessment","volume":"35","author":"Laupland KB","year":"2007","unstructured":"Laupland KB, Ross T, Pitout JD, Church DL, Gregson DB. Community-onset urinary tract infections: a population-based assessment. Infection. 2007, 35:150-3. 10.1007\/s15010-007-6180-2","journal-title":"Infection"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.12816\/0003256","article-title":"Recurrent urinary tract infections management in women: a review","volume":"13","author":"Al-Badr A","year":"2013","unstructured":"Al-Badr A, Al-Shaikh G. Recurrent urinary tract infections management in women: a review. Sultan Qaboos Univ Med J. 2013, 13:359-67. 10.12816\/0003256","journal-title":"Sultan Qaboos Univ Med J"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001209.pub2","article-title":"Antibiotics for preventing recurrent urinary tract infection in non-pregnant women","volume":"2004","author":"Albert X","year":"2004","unstructured":"Albert X, Huertas I, Pereir\u00f3 II, Sanf\u00e9lix J, Gosalbes V, Perrota C. Antibiotics for preventing recurrent urinary tract infection in non-pregnant women. Cochrane Database Syst Rev. 2004, 2004:CD001209. 10.1002\/14651858.CD001209.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.1.91","article-title":"Recurrence of urinary tract infection in a primary care setting: analysis of a 1-year follow-up of 179 women","volume":"22","author":"Ik\u00e4heimo R","year":"1996","unstructured":"Ik\u00e4heimo R, Siitonen A, Heiskanen T, K\u00e4rkk\u00e4inen U, Kuosmanen P, Lipponen P, M\u00e4kel\u00e4 PH. Recurrence of urinary tract infection in a primary care setting: analysis of a 1-year follow-up of 179 women. Clin Infect Dis. 1996, 22:91-9. 10.1093\/clinids\/22.1.91","journal-title":"Clin Infect Dis"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaf194","article-title":"The impact of inter-infection time on antimicrobial resistance profiles in women with multiple urinary tract infections over time","volume":"80","author":"Honda T","year":"2025","unstructured":"Honda T, Vazquez-Montes MD, Fanshawe TR, Stoesser N, Butler CC, Walker AS, Hayward G. The impact of inter-infection time on antimicrobial resistance profiles in women with multiple urinary tract infections over time. J Antimicrob Chemother. 2025, 80:2234-40. 10.1093\/jac\/dkaf194","journal-title":"J Antimicrob Chemother"},{"key":"ref7","unstructured":"UK antimicrobial resistance strategy and action plan. engagement exercise. (2012). Accessed: 9 November 2025: https:\/\/www.gov.uk\/government\/publications\/uk-antimicrobial-resistance-strategy-and-action-plan-engagement-exercise."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2024.2445621","article-title":"Methenamine hippurate in UTI management: a reemerging pharmacological strategy","volume":"17","author":"Nadeem M","year":"2024","unstructured":"Nadeem M, Hashim H. Methenamine hippurate in UTI management: a reemerging pharmacological strategy. Expert Rev Clin Pharmacol. 2024, 17:1095-8. 10.1080\/17512433.2024.2445621","journal-title":"Expert Rev Clin Pharmacol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3310\/QOIZ6538","article-title":"Methenamine hippurate compared with antibiotic prophylaxis to prevent recurrent urinary tract infections in women: the ALTAR non-inferiority RCT","volume":"26","author":"Harding C","year":"2022","unstructured":"Harding C, Chadwick T, Homer T, et al.. Methenamine hippurate compared with antibiotic prophylaxis to prevent recurrent urinary tract infections in women: the ALTAR non-inferiority RCT. Health Technol Assess. 2022, 26:1-172. 10.3310\/QOIZ6538","journal-title":"Health Technol Assess"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003265.pub2","article-title":"Methenamine hippurate for preventing urinary tract infections","author":"Lee BB","year":"2007","unstructured":"Lee BB, Simpson JM, Craig JC, Bhuta T. Methenamine hippurate for preventing urinary tract infections. Cochrane Database Syst Rev. 2007, CD003265. 10.1002\/14651858.CD003265.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2025.07.006","article-title":"Methenamine hippurate as prophylaxis for recurrent urinary tract infections in older women-a triple-blind, randomised, placebo-controlled, phase IV trial (ImpresU)","volume":"31","author":"Heltveit-Olsen SR","year":"2025","unstructured":"Heltveit-Olsen SR, Arnljots ES, Sundvall PD, et al.. Methenamine hippurate as prophylaxis for recurrent urinary tract infections in older women-a triple-blind, randomised, placebo-controlled, phase IV trial (ImpresU). Clin Microbiol Infect. 2025, 31:1873-9. 10.1016\/j.cmi.2025.07.006","journal-title":"Clin Microbiol Infect"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-074445","article-title":"Cost-effectiveness of methenamine hippurate compared with antibiotic prophylaxis for the management of recurrent urinary tract infections in secondary care: a multicentre, open-label, randomised, non-inferiority trial","volume":"14","author":"King W","year":"2024","unstructured":"King W, Homer T, Harding C, Mossop H, Chadwick T, Abouhajar A, Vale L. Cost-effectiveness of methenamine hippurate compared with antibiotic prophylaxis for the management of recurrent urinary tract infections in secondary care: a multicentre, open-label, randomised, non-inferiority trial. BMJ Open. 2024, 14:e074445. 10.1136\/bmjopen-2023-074445","journal-title":"BMJ Open"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177\/00369330251355285","article-title":"Cost of non-antimicrobials for prophylaxis in the management of recurrent UTIs","volume":"70","author":"Joshi A","year":"2025","unstructured":"Joshi A, Tzelves L, Julieb\u00f8-Jones P, Kamal W, Shrestha A, Somani B. Cost of non-antimicrobials for prophylaxis in the management of recurrent UTIs. Scott Med J. 2025, 70:46-53. 10.1177\/00369330251355285","journal-title":"Scott Med J"},{"key":"ref14","article-title":"Evidence Review for the Effectiveness of Methenamine Hippurate in the Prevention of Recurrent Urinary Tract Infections (UTIs): Urinary Tract Infection (Recurrent): Antimicrobial Prescribing","author":"National Institute for Health and Care Excellence (NICE)","year":"2024","unstructured":"National Institute for Health and Care Excellence (NICE). Evidence Review for the Effectiveness of Methenamine Hippurate in the Prevention of Recurrent Urinary Tract Infections (UTIs): Urinary Tract Infection (Recurrent): Antimicrobial Prescribing. National Institute for Health and Care Excellence (NICE), London; 2024."},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-021-04849-0","article-title":"Methenamine hippurate compared with trimethoprim for the prevention of recurrent urinary tract infections: a randomized clinical trial","volume":"33","author":"Botros C","year":"2022","unstructured":"Botros C, Lozo S, Iyer S, et al.. Methenamine hippurate compared with trimethoprim for the prevention of recurrent urinary tract infections: a randomized clinical trial. Int Urogynecol J. 2022, 33:571-80. 10.1007\/s00192-021-04849-0","journal-title":"Int Urogynecol J"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/UPJ.0000000000000259","article-title":"Methenamine prophylaxis for recurrent urinary tract infections in a tertiary referral center","volume":"8","author":"Wade C","year":"2021","unstructured":"Wade C, Lacy ME, Harris L, Goldwag J, Erickson DR. Methenamine prophylaxis for recurrent urinary tract infections in a tertiary referral center. Urol Pract. 2021, 8:699-704. 10.1097\/UPJ.0000000000000259","journal-title":"Urol Pract"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-024-05726-2","article-title":"Use of methenamine for urinary tract infection prophylaxis: systematic review of recent evidence","volume":"35","author":"Davidson SM","year":"2024","unstructured":"Davidson SM, Brown JN, Nance CB, Townsend ML. Use of methenamine for urinary tract infection prophylaxis: systematic review of recent evidence. Int Urogynecol J. 2024, 35:483-9. 10.1007\/s00192-024-05726-2","journal-title":"Int Urogynecol J"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2012.777","article-title":"Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women","volume":"172","author":"Beerepoot MA","year":"2012","unstructured":"Beerepoot MA, ter Riet G, Nys S, et al.. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Arch Intern Med. 2012, 172:704-12. 10.1001\/archinternmed.2012.777","journal-title":"Arch Intern Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000001108","article-title":"The resurgence of methenamine hippurate in the prevention of recurrent UTIs in women - a systematic review","volume":"33","author":"Kale S","year":"2023","unstructured":"Kale S, Somani BK. The resurgence of methenamine hippurate in the prevention of recurrent UTIs in women - a systematic review. Curr Opin Urol. 2023, 33:488-96. 10.1097\/MOU.0000000000001108","journal-title":"Curr Opin Urol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5193","article-title":"Non-antibiotic options for recurrent urinary tract infections in women","volume":"359","author":"Barclay J","year":"2017","unstructured":"Barclay J, Veeratterapillay R, Harding C. Non-antibiotic options for recurrent urinary tract infections in women. BMJ. 2017, 359:j5193. 10.1136\/bmj.j5193","journal-title":"BMJ"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/441113-exploring-the-efficacy-of-methenamine-hippurate-across-different-patient-groups-with-recurrent-urinary-tract-infections-experience-from-a-university-teaching-hospital-in-south-wales-united-kingdom","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:13:17Z","timestamp":1764936797000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/441113-exploring-the-efficacy-of-methenamine-hippurate-across-different-patient-groups-with-recurrent-urinary-tract-infections-experience-from-a-university-teaching-hospital-in-south-wales-united-kingdom"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,5]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.98511","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,5]]}}}