{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T12:25:37Z","timestamp":1765110337814,"version":"3.46.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,7]]},"DOI":"10.7759\/cureus.98628","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T12:21:19Z","timestamp":1765110079000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical Significance of Lactate Dehydrogenase A Expression in Colorectal Cancer"],"prefix":"10.7759","author":[{"given":"Jarunya","family":"Ngamkham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hathaiwan","family":"Moungthard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiwaporn","family":"Thesawadwomg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maneerut","family":"Mus-U-Dee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thainsang","family":"Phansri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krittika","family":"Boonmark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thitaporn","family":"Phukhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray F","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024, 74:229-63. 10.3322\/caac.21834","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327736","article-title":"Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN","volume":"72","author":"Morgan E","year":"2023","unstructured":"Morgan E, Arnold M, Gini A, et al.. Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut. 2023, 72:338-44. 10.1136\/gutjnl-2022-327736","journal-title":"Gut"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.07.055","article-title":"Epidemiology and mechanisms of the increasing incidence of colon and rectal cancers in young adults","volume":"158","author":"Stoffel EM","year":"2020","unstructured":"Stoffel EM, Murphy CC. Epidemiology and mechanisms of the increasing incidence of colon and rectal cancers in young adults. Gastroenterology. 2020, 158:341-53. 10.1053\/j.gastro.2019.07.055","journal-title":"Gastroenterology"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16081530","article-title":"Colorectal cancer: epidemiology, risk factors, and prevention","volume":"16","author":"Roshandel G","year":"2024","unstructured":"Roshandel G, Ghasemi-Kebria F, Malekzadeh R. Colorectal cancer: epidemiology, risk factors, and prevention. Cancers (Basel). 2024, 16:1530. 10.3390\/cancers16081530","journal-title":"Cancers (Basel)"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130235","article-title":"Molecular genetics of colorectal cancer","volume":"6","author":"Fearon ER","year":"2011","unstructured":"Fearon ER. Molecular genetics of colorectal cancer. Annu Rev Pathol. 2011, 6:479-507. 10.1146\/annurev-pathol-011110-130235","journal-title":"Annu Rev Pathol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2019.05.018","article-title":"Metabolic pathways regulating colorectal cancer initiation and progression","volume":"98","author":"La Vecchia S","year":"2020","unstructured":"La Vecchia S, Sebasti\u00e1n C. Metabolic pathways regulating colorectal cancer initiation and progression. Semin Cell Dev Biol. 2020, 98:63-70. 10.1016\/j.semcdb.2019.05.018","journal-title":"Semin Cell Dev Biol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-092910-154237","article-title":"Aerobic glycolysis: meeting the metabolic requirements of cell proliferation","volume":"27","author":"Lunt SY","year":"2011","unstructured":"Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol. 2011, 27:441-64. 10.1146\/annurev-cellbio-092910-154237","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.04.002","article-title":"Metabolic hallmarks of metastasis formation","volume":"28","author":"Elia I","year":"2018","unstructured":"Elia I, Doglioni G, Fendt SM. Metabolic hallmarks of metastasis formation. Trends Cell Biol. 2018, 28:673-84. 10.1016\/j.tcb.2018.04.002","journal-title":"Trends Cell Biol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.12.006","article-title":"The emerging hallmarks of cancer metabolism","volume":"23","author":"Pavlova NN","year":"2016","unstructured":"Pavlova NN, Thompson CB. The emerging hallmarks of cancer metabolism. Cell Metab. 2016, 23:27-47. 10.1016\/j.cmet.2015.12.006","journal-title":"Cell Metab"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.039","article-title":"Understanding the intersections between metabolism and cancer biology","volume":"168","author":"Vander Heiden MG","year":"2017","unstructured":"Vander Heiden MG, DeBerardinis RJ. Understanding the intersections between metabolism and cancer biology. Cell. 2017, 168:657-69. 10.1016\/j.cell.2016.12.039","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03342","article-title":"Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step","volume":"3","author":"Shestov AA","year":"2014","unstructured":"Shestov AA, Liu X, Ser Z, et al.. Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. Elife. 2014, 3:e03342. 10.7554\/eLife.03342","journal-title":"Elife"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden MG","year":"2009","unstructured":"Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009, 324:1029-33. 10.1126\/science.1160809","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3038","article-title":"Otto Warburg's contributions to current concepts of cancer metabolism","volume":"11","author":"Koppenol WH","year":"2011","unstructured":"Koppenol WH, Bounds PL, Dang CV. Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer. 2011, 11:325-37. 10.1038\/nrc3038","journal-title":"Nat Rev Cancer"},{"key":"ref14","article-title":"Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies","volume":"11","author":"Phan LM","year":"2014","unstructured":"Phan LM, Yeung SC, Lee MH. Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies. Cancer Biol Med. 2014, 11:1-19.","journal-title":"Cancer Biol Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.13.206","article-title":"Inhibition of lactate dehydrogenase activity as an approach to cancer therapy","volume":"6","author":"Fiume L","year":"2014","unstructured":"Fiume L, Manerba M, Vettraino M, Di Stefano G. Inhibition of lactate dehydrogenase activity as an approach to cancer therapy. Future Med Chem. 2014, 6:429-45. 10.4155\/fmc.13.206","journal-title":"Future Med Chem"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-06773-z","article-title":"Lactate dehydrogenase A: a potential new target for tumor drug resistance intervention","volume":"23","author":"Wang M","year":"2025","unstructured":"Wang M, Zhou Q, Cao T, Li F, Li X, Zhang M, Zhou Y. Lactate dehydrogenase A: a potential new target for tumor drug resistance intervention. J Transl Med. 2025, 23:713. 10.1186\/s12967-025-06773-z","journal-title":"J Transl Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-101","article-title":"Lactate dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma","volume":"13","author":"Girgis H","year":"2014","unstructured":"Girgis H, Masui O, White NM, et al.. Lactate dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma. Mol Cancer. 2014, 13:101. 10.1186\/1476-4598-13-101","journal-title":"Mol Cancer"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.04.023","article-title":"Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance","volume":"9","author":"Fantin VR","year":"2006","unstructured":"Fantin VR, St-Pierre J, Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell. 2006, 9:425-34. 10.1016\/j.ccr.2006.04.023","journal-title":"Cancer Cell"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.60","article-title":"Targeting cellular metabolism to improve cancer therapeutics","volume":"4","author":"Zhao Y","year":"2013","unstructured":"Zhao Y, Butler EB, Tan M. Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis. 2013, 4:e532. 10.1038\/cddis.2013.60","journal-title":"Cell Death Dis"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.03.003","article-title":"Targeting lactate dehydrogenase-a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells","volume":"19","author":"Xie H","year":"2014","unstructured":"Xie H, Hanai J, Ren JG, et al.. Targeting lactate dehydrogenase-a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells. Cell Metab. 2014, 19:795-809. 10.1016\/j.cmet.2014.03.003","journal-title":"Cell Metab"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.21037\/jgo-24-560","article-title":"LDHA as a predictive biomarker and its association with the infiltration of immune cells in pancreatic adenocarcinoma","volume":"15","author":"Zheng Q","year":"2024","unstructured":"Zheng Q, Xie Y, Xu L, et al.. LDHA as a predictive biomarker and its association with the infiltration of immune cells in pancreatic adenocarcinoma. J Gastrointest Oncol. 2024, 15:1746-59. 10.21037\/jgo-24-560","journal-title":"J Gastrointest Oncol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.467","article-title":"Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression","volume":"11","author":"Cheng CS","year":"2021","unstructured":"Cheng CS, Tan HY, Wang N, Chen L, Meng Z, Chen Z, Feng Y. Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression. Clin Transl Med. 2021, 11:e467. 10.1002\/ctm2.467","journal-title":"Clin Transl Med"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-015-1307-x","article-title":"Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate\/H+ symporters","volume":"94","author":"Marchiq I","year":"2016","unstructured":"Marchiq I, Pouyss\u00e9gur J. Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate\/H+ symporters. J Mol Med (Berl). 2016, 94:155-71. 10.1007\/s00109-015-1307-x","journal-title":"J Mol Med (Berl)"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01143","article-title":"Lactate in the regulation of tumor microenvironment and therapeutic approaches","volume":"9","author":"de la Cruz-L\u00f3pez KG","year":"2019","unstructured":"de la Cruz-L\u00f3pez KG, Castro-Mu\u00f1oz LJ, Reyes-Hern\u00e1ndez DO, Garc\u00eda-Carranc\u00e1 A, Manzo-Merino J. Lactate in the regulation of tumor microenvironment and therapeutic approaches. Front Oncol. 2019, 9:1143. 10.3389\/fonc.2019.01143","journal-title":"Front Oncol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126262","article-title":"Metabolic reprogramming of colorectal cancer cells and the microenvironment: implication for therapy","volume":"22","author":"Nenkov M","year":"2021","unstructured":"Nenkov M, Ma Y, Ga\u00dfler N, Chen Y. Metabolic reprogramming of colorectal cancer cells and the microenvironment: implication for therapy. Int J Mol Sci. 2021, 22:10.3390\/ijms22126262","journal-title":"Int J Mol Sci"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11893","article-title":"Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential","volume":"7","author":"Knudsen ES","year":"2016","unstructured":"Knudsen ES, Balaji U, Freinkman E, McCue P, Witkiewicz AK. Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential. Oncotarget. 2016, 7:78396-411. 10.18632\/oncotarget.11893","journal-title":"Oncotarget"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16129","article-title":"Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis","volume":"8","author":"Cruz MD","year":"2017","unstructured":"Cruz MD, Ledbetter S, Chowdhury S, et al.. Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis. Oncotarget. 2017, 8:20543-57. 10.18632\/oncotarget.16129","journal-title":"Oncotarget"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-025-02623-5","article-title":"Metabolic reprogramming in colorectal cancer: a review of aerobic glycolysis and its therapeutic implications for targeted treatment strategies","volume":"11","author":"Pang B","year":"2025","unstructured":"Pang B, Wu H. Metabolic reprogramming in colorectal cancer: a review of aerobic glycolysis and its therapeutic implications for targeted treatment strategies. Cell Death Discov. 2025, 11:321. 10.1038\/s41420-025-02623-5","journal-title":"Cell Death Discov"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010268","article-title":"Expression and prognostic value of lactate dehydrogenase-A and -D subunits in human uterine myoma and uterine sarcoma","volume":"97","author":"Song KJ","year":"2018","unstructured":"Song KJ, Yu XN, Lv T, et al.. Expression and prognostic value of lactate dehydrogenase-A and -D subunits in human uterine myoma and uterine sarcoma. Medicine (Baltimore). 2018, 97:e0268. 10.1097\/MD.0000000000010268","journal-title":"Medicine (Baltimore)"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24536","article-title":"Relevance of CEA and LDH in relation to KRAS status in patients with unresectable colorectal liver metastases","volume":"115","author":"Connell LC","year":"2017","unstructured":"Connell LC, Boucher TM, Chou JF, Capanu M, Maldonado S, Kemeny NE. Relevance of CEA and LDH in relation to KRAS status in patients with unresectable colorectal liver metastases. J Surg Oncol. 2017, 115:480-7. 10.1002\/jso.24536","journal-title":"J Surg Oncol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/441667-clinical-significance-of-lactate-dehydrogenase-a-expression-in-colorectal-cancer","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T12:21:20Z","timestamp":1765110080000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/441667-clinical-significance-of-lactate-dehydrogenase-a-expression-in-colorectal-cancer"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,7]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.98628","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,7]]}}}