{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T13:56:52Z","timestamp":1765375012447,"version":"3.46.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,10]]},"DOI":"10.7759\/cureus.98887","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T13:14:57Z","timestamp":1765372497000},"source":"Crossref","is-referenced-by-count":0,"title":["Panhypopituitarism Secondary to a Central Nervous System Germinoma"],"prefix":"10.7759","author":[{"given":"Somia","family":"Hassanes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eboh","family":"Cecil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betsy","family":"Francis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0037","article-title":"Pediatric central nervous system germ cell tumors: a review","volume":"13","author":"Echevarr\u00eda ME","year":"2008","unstructured":"Echevarr\u00eda ME, Fangusaro J, Goldman S. Pediatric central nervous system germ cell tumors: a review. Oncologist. 2008, 13:690-9. 10.1634\/theoncologist.2008-0037","journal-title":"Oncologist"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.06.016","article-title":"The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: renal, penile, and testicular tumours","volume":"82","author":"Moch H","year":"2022","unstructured":"Moch H, Amin MB, Berney DM, et al.. The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: renal, penile, and testicular tumours. Eur Urol. 2022, 82:458-68. 10.1016\/j.eururo.2022.06.016","journal-title":"Eur Urol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14040979","article-title":"Roles of tumor markers in central nervous system germ cell tumors revisited with histopathology-proven cases in a large international cohort","volume":"14","author":"Takami H","year":"2022","unstructured":"Takami H, Graffeo CS, Perry A, et al.. Roles of tumor markers in central nervous system germ cell tumors revisited with histopathology-proven cases in a large international cohort. Cancers (Basel). 2022, 14:979. 10.3390\/cancers14040979","journal-title":"Cancers (Basel)"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1568","article-title":"Testicular germ-cell tumours in a broader perspective","volume":"5","author":"Oosterhuis JW","year":"2005","unstructured":"Oosterhuis JW, Looijenga LH. Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer. 2005, 5:210-22. 10.1038\/nrc1568","journal-title":"Nat Rev Cancer"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2012.86","article-title":"Testicular cancer: a new generation of biomarkers for malignant germ cell tumours","volume":"9","author":"Murray MJ","year":"2012","unstructured":"Murray MJ, Coleman N. Testicular cancer: a new generation of biomarkers for malignant germ cell tumours. Nat Rev Urol. 2012, 9:298-300. 10.1038\/nrurol.2012.86","journal-title":"Nat Rev Urol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2020.05.009","article-title":"Molecular and epigenetic pathogenesis of germ cell tumors","volume":"8","author":"M\u00fcller MR","year":"2021","unstructured":"M\u00fcller MR, Skowron MA, Albers P, Nettersheim D. Molecular and epigenetic pathogenesis of germ cell tumors. Asian J Urol. 2021, 8:144-54. 10.1016\/j.ajur.2020.05.009","journal-title":"Asian J Urol"},{"key":"ref7","article-title":"Germ cell tumours","volume":"5","author":"Talerman A","year":"1985","unstructured":"Talerman A. Germ cell tumours. Ann Pathol. 1985, 5:145-57.","journal-title":"Ann Pathol"},{"key":"ref8","article-title":"Holland-Frei Cancer Medicine. 6th Edition","author":"Rodriguez-Galindo C","year":"2003","unstructured":"Rodriguez-Galindo C, Pappo AS., Kufe DW, et al.. Holland-Frei Cancer Medicine. 6th Edition. BC Decker, Hamilton, ON; 2003."},{"key":"ref9","unstructured":"Brain Tumour Research. Germ cell tumour (GCT). (2025). Accessed. October 18, 2025: https:\/\/braintumourresearch.org\/pages\/types-of-brain-tumours-germ-cell-tumour-gct."},{"key":"ref10","unstructured":"The Royal Marsden. Intracranial germ cell tumour. (2025). Accessed. October 18, 2025: https:\/\/www.royalmarsden.nhs.uk\/your-care\/cancer-types\/paediatric-cancers\/germ-cell-tumours\/intracranial-germ-cell-tu...."},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab252","article-title":"EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults","volume":"24","author":"Frappaz D","year":"2022","unstructured":"Frappaz D, Dhall G, Murray MJ, et al.. EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults. Neuro Oncol. 2022, 24:516-27. 10.1093\/neuonc\/noab252","journal-title":"Neuro Oncol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/his.14675","article-title":"An introduction to the WHO 5th edition 2022 classification of testicular tumours","volume":"81","author":"Berney DM","year":"2022","unstructured":"Berney DM, Cree I, Rao V, et al.. An introduction to the WHO 5th edition 2022 classification of testicular tumours. Histopathology. 2022, 81:459-66. 10.1111\/his.14675","journal-title":"Histopathology"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000302","article-title":"Testicular tumors: a contemporary update on morphologic, immunohistochemical and molecular features","volume":"28","author":"Al-Obaidy KI","year":"2021","unstructured":"Al-Obaidy KI, Idrees MT. Testicular tumors: a contemporary update on morphologic, immunohistochemical and molecular features. Adv Anat Pathol. 2021, 28:258-75. 10.1097\/PAP.0000000000000302","journal-title":"Adv Anat Pathol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-025-04023-7","article-title":"Germ cell tumors in children","volume":"486","author":"Bode PK","year":"2025","unstructured":"Bode PK, Blasco-Santana L, Colmenero I, Reyes-M\u00fagica M. Germ cell tumors in children. Virchows Arch. 2025, 486:65-79. 10.1007\/s00428-025-04023-7","journal-title":"Virchows Arch"},{"key":"ref15","unstructured":"Pathology Outlines. Testis & paratestis general WHO classification. (2023). Accessed. October 18, 2025: https:\/\/www.pathologyoutlines.com\/topic\/testistestclassif.html."},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1247-5","article-title":"Mutually exclusive mutations of KIT and RAS are associated with KIT mRNA expression and chromosomal instability in primary intracranial pure germinomas","volume":"127","author":"Fukushima S","year":"2014","unstructured":"Fukushima S, Otsuka A, Suzuki T, et al.. Mutually exclusive mutations of KIT and RAS are associated with KIT mRNA expression and chromosomal instability in primary intracranial pure germinomas. Acta Neuropathol. 2014, 127:911-25. 10.1007\/s00401-014-1247-5","journal-title":"Acta Neuropathol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2007.00855.x","article-title":"Testicular dysgenesis syndrome and the origin of carcinoma in situ testis","volume":"31","author":"Sonne SB","year":"2008","unstructured":"Sonne SB, Kristensen DM, Novotny GW, et al.. Testicular dysgenesis syndrome and the origin of carcinoma in situ testis. Int J Androl. 2008, 31:275-87. 10.1111\/j.1365-2605.2007.00855.x","journal-title":"Int J Androl"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0471","article-title":"Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults","volume":"65","author":"McIntyre A","year":"2005","unstructured":"McIntyre A, Summersgill B, Grygalewicz B, et al.. Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults. Cancer Res. 2005, 65:8085-9. 10.1158\/0008-5472.CAN-05-0471","journal-title":"Cancer Res"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10392","article-title":"CNS germinomas are characterized by global demethylation, chromosomal instability and mutational activation of the Kit-, Ras\/Raf\/Erk- and Akt-pathways","volume":"7","author":"Schulte SL","year":"2016","unstructured":"Schulte SL, Waha A, Steiger B, et al.. CNS germinomas are characterized by global demethylation, chromosomal instability and mutational activation of the Kit-, Ras\/Raf\/Erk- and Akt-pathways. Oncotarget. 2016, 7:55026-42. 10.18632\/oncotarget.10392","journal-title":"Oncotarget"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.148079","article-title":"Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis","volume":"17","author":"Elzinga-Tinke JE","year":"2015","unstructured":"Elzinga-Tinke JE, Dohle GR, Looijenga LH. Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis. Asian J Androl. 2015, 17:381-93. 10.4103\/1008-682X.148079","journal-title":"Asian J Androl"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1673-2","article-title":"Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas","volume":"133","author":"Fukushima S","year":"2017","unstructured":"Fukushima S, Yamashita S, Kobayashi H, et al.. Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas. Acta Neuropathol. 2017, 133:445-62. 10.1007\/s00401-017-1673-2","journal-title":"Acta Neuropathol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-023-01416-2","article-title":"Intracranial germinomas: diagnosis, pathogenesis, clinical presentation, and management","volume":"25","author":"Kremenevski N","year":"2023","unstructured":"Kremenevski N, Buchfelder M, Hore N. Intracranial germinomas: diagnosis, pathogenesis, clinical presentation, and management. Curr Oncol Rep. 2023, 25:765-75. 10.1007\/s11912-023-01416-2","journal-title":"Curr Oncol Rep"},{"key":"ref23","unstructured":"European Reference Network. Childhood intracranial germ cell tumours. (2021). Accessed. October 18, 2025: https:\/\/siope.eu\/media\/documents\/escp-childhood-intracranial-germ-cell-tumours.pdf."},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2217\/cns.15.13","article-title":"Management of CNS germinoma","volume":"4","author":"Osorio DS","year":"2015","unstructured":"Osorio DS, Allen JC. Management of CNS germinoma. CNS Oncol. 2015, 4:273-9. 10.2217\/cns.15.13","journal-title":"CNS Oncol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000261908.36803.ac","article-title":"CNS germ cell tumor (CNSGCT) of childhood: presentation and delayed diagnosis","volume":"68","author":"Crawford JR","year":"2007","unstructured":"Crawford JR, Santi MR, Vezina G, et al.. CNS germ cell tumor (CNSGCT) of childhood: presentation and delayed diagnosis. Neurology. 2007, 68:1668-73. 10.1212\/01.wnl.0000261908.36803.ac","journal-title":"Neurology"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2024.02.047","article-title":"Germinoma of basal ganglia","volume":"19","author":"Tuan HX","year":"2024","unstructured":"Tuan HX, Huyen NT, Son ND, Trung NV, Anh NH, Hung ND, Duc NM. Germinoma of basal ganglia. Radiol Case Rep. 2024, 19:2072-80. 10.1016\/j.radcr.2024.02.047","journal-title":"Radiol Case Rep"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2011.586000","article-title":"Intracranial germ cell tumours. A review with special reference to endocrine manifestations","volume":"51","author":"Jorsal T","year":"2012","unstructured":"Jorsal T, R\u00f8rth M. Intracranial germ cell tumours. A review with special reference to endocrine manifestations. Acta Oncol. 2012, 51:3-9. 10.3109\/0284186X.2011.586000","journal-title":"Acta Oncol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-015-2616-7","article-title":"Germinoma in the bilateral basal ganglia presented with cognitive deterioration","volume":"31","author":"Wataya T","year":"2015","unstructured":"Wataya T, Ishizaki R, Kitagawa M, Tashiro Y. Germinoma in the bilateral basal ganglia presented with cognitive deterioration. Childs Nerv Syst. 2015, 31:953-8. 10.1007\/s00381-015-2616-7","journal-title":"Childs Nerv Syst"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.32098","article-title":"Evaluating diagnostic delays and late endocrine sequelae in children with intracranial germ cell tumors: a territory-wide population-based study","author":"Poon SW","year":"2025","unstructured":"Poon SW, Tung JY, Pang GS, et al.. Evaluating diagnostic delays and late endocrine sequelae in children with intracranial germ cell tumors: a territory-wide population-based study. Pediatr Blood Cancer. 2025, e32098. 10.1002\/pbc.32098","journal-title":"Pediatr Blood Cancer"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-52-1-9","article-title":"Hormonal and metabolic abnormalities associated with central nervous system germinoma in children and adolescents and the effect of therapy: report of 10 patients","volume":"52","author":"Sklar CA","year":"1981","unstructured":"Sklar CA, Grumbach MM, Kaplan SL, Conte FA. Hormonal and metabolic abnormalities associated with central nervous system germinoma in children and adolescents and the effect of therapy: report of 10 patients. J Clin Endocrinol Metab. 1981, 52:9-16. 10.1210\/jcem-52-1-9","journal-title":"J Clin Endocrinol Metab"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.47.83","article-title":"Long-term outcome of endocrine function in patients with neurohypophyseal germinomas","volume":"47","author":"Sa ki N","year":"2000","unstructured":"Sa ki N, Tamaki K, Murai H, et al.. Long-term outcome of endocrine function in patients with neurohypophyseal germinomas. Endocr J. 2000, 47:83-9. 10.1507\/endocrj.47.83","journal-title":"Endocr J"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1200337","article-title":"Endocrine disturbances in suprasellar germinomas","volume":"120","author":"Buchfelder M","year":"1989","unstructured":"Buchfelder M, Fahlbusch R, Walther M, Mann K. Endocrine disturbances in suprasellar germinomas. Acta Endocrinol (Copenh). 1989, 120:337-42. 10.1530\/acta.0.1200337","journal-title":"Acta Endocrinol (Copenh)"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-022-03121-9","article-title":"Endocrine manifestations of paediatric intracranial germ cell tumours: from diagnosis to long-term follow-up","volume":"77","author":"Partenope C","year":"2022","unstructured":"Partenope C, Pozzobon G, Weber G, Arya VB, Carceller F, Albanese A. Endocrine manifestations of paediatric intracranial germ cell tumours: from diagnosis to long-term follow-up. Endocrine. 2022, 77:546-55. 10.1007\/s12020-022-03121-9","journal-title":"Endocrine"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvaa046.401","article-title":"MON-085 The clinical and endocrinologic manifestations of germinoma in Taiwanese pediatric population: one medical center experience","volume":"4","author":"Chang HY","year":"2020","unstructured":"Chang HY, Lo FS. MON-085 The clinical and endocrinologic manifestations of germinoma in Taiwanese pediatric population: one medical center experience. J Endocr Soc. 2020, 4:MON-085. 10.1210\/jendso\/bvaa046.401","journal-title":"J Endocr Soc"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.15844\/pedneurbriefs-20-3-4","article-title":"Suprasellar germinoma and growth retardation","volume":"20","author":"Millichap JG","year":"2006","unstructured":"Millichap JG. Suprasellar germinoma and growth retardation. Pediatr Neurol Briefs. 2006, 20:19-20. 10.15844\/pedneurbriefs-20-3-4","journal-title":"Pediatr Neurol Briefs"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1080\/08035250500430262","article-title":"Intracranial germinoma: a rare but important differential diagnosis in children with growth retardation","volume":"95","author":"Gottschling S","year":"2006","unstructured":"Gottschling S, Graf N, Meyer S, Reinhard H, Krenn T, Rohrer T. Intracranial germinoma: a rare but important differential diagnosis in children with growth retardation. Acta Paediatr. 2006, 95:302-5. 10.1080\/08035250500430262","journal-title":"Acta Paediatr"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.83337","article-title":"Central hypothyroidism","volume":"15","author":"Gupta V","year":"2011","unstructured":"Gupta V, Lee M. Central hypothyroidism. Indian J Endocrinol Metab. 2011, 15:S99-S106. 10.4103\/2230-8210.83337","journal-title":"Indian J Endocrinol Metab"},{"key":"ref38","doi-asserted-by":"crossref","DOI":"10.1097\/00019616-200205000-00009","article-title":"Central hypothyroidism","volume":"12","author":"Gudmundsdottir A","year":"2002","unstructured":"Gudmundsdottir A, Schlechte JA. Central hypothyroidism. Endocrinologist. 2002, 12:218-23.","journal-title":"Endocrinologist"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.20945\/2359-3997000000493","article-title":"Central adrenal insufficiency: who, when, and how? From the evidence to the controversies - an exploratory review","volume":"66","author":"Bitencourt MR","year":"2022","unstructured":"Bitencourt MR, Batista RL, Biscotto I, Carvalho LR. Central adrenal insufficiency: who, when, and how? From the evidence to the controversies - an exploratory review. Arch Endocrinol Metab. 2022, 66:541-50. 10.20945\/2359-3997000000493","journal-title":"Arch Endocrinol Metab"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2018-0824","article-title":"Central adrenal insufficiency: open issues regarding diagnosis and glucocorticoid treatment","volume":"57","author":"Ceccato F","year":"2019","unstructured":"Ceccato F, Scaroni C. Central adrenal insufficiency: open issues regarding diagnosis and glucocorticoid treatment. Clin Chem Lab Med. 2019, 57:1125-35. 10.1515\/cclm-2018-0824","journal-title":"Clin Chem Lab Med"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.4997\/JRCPE.2017.307","article-title":"Central diabetes insipidus unmasked by corticosteroid therapy for cerebral metastases: beware the case with pituitary involvement and hypopituitarism","volume":"47","author":"Chin HX","year":"2017","unstructured":"Chin HX, Quek TP, Leow MK. Central diabetes insipidus unmasked by corticosteroid therapy for cerebral metastases: beware the case with pituitary involvement and hypopituitarism. J R Coll Physicians Edinb. 2017, 47:247-9. 10.4997\/JRCPE.2017.307","journal-title":"J R Coll Physicians Edinb"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/649154","article-title":"Central hypogonadotropic hypogonadism: genetic complexity of a complex disease","volume":"2014","author":"Marino M","year":"2014","unstructured":"Marino M, Moriondo V, Vighi E, Pignatti E, Simoni M. Central hypogonadotropic hypogonadism: genetic complexity of a complex disease. Int J Endocrinol. 2014, 2014:649154. 10.1155\/2014\/649154","journal-title":"Int J Endocrinol"},{"key":"ref43","unstructured":"University of Florida Health. Hypogonadotropic hypogonadism. (2025). Accessed. October 20, 2025: https:\/\/ufhealth.org\/conditions-and-treatments\/hypogonadotropic-hypogonadism."},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13382","article-title":"Growth hormone deficiency in adults with hypopituitarism-what are the risks and can they be eliminated by therapy?","volume":"290","author":"Johannsson G","year":"2021","unstructured":"Johannsson G, Ragnarsson O. Growth hormone deficiency in adults with hypopituitarism-what are the risks and can they be eliminated by therapy?. J Intern Med. 2021, 290:1180-93. 10.1111\/joim.13382","journal-title":"J Intern Med"},{"key":"ref45","unstructured":"Growth hormone deficiency. (2016). Accessed. October 20, 2025: https:\/\/rarediseases.org\/rare-diseases\/growth-hormone-deficiency\/."},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-025-04596-7","article-title":"A comprehensive dataset of germinoma on MRI\/CT with clinical and radiomic data","volume":"12","author":"Huang L","year":"2025","unstructured":"Huang L, Gong J, Feng D, et al.. A comprehensive dataset of germinoma on MRI\/CT with clinical and radiomic data. Sci Data. 2025, 12:312. 10.1038\/s41597-025-04596-7","journal-title":"Sci Data"},{"key":"ref47","unstructured":"Radiopaedia. Central nervous system germinoma. (2025). Accessed. November 7, 2025: https:\/\/radiopaedia.org\/articles\/central-nervous-system-germinoma?lang=us."},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11111980","article-title":"Cerebrospinal fluid levels of AFP and hCG: validation of the analytical method and application in the diagnosis of central nervous system germ cell tumors","volume":"11","author":"D'Alessandro A","year":"2021","unstructured":"D'Alessandro A, Ciavardelli D, Pastore A, et al.. Cerebrospinal fluid levels of AFP and hCG: validation of the analytical method and application in the diagnosis of central nervous system germ cell tumors. Diagnostics (Basel). 2021, 11:1980. 10.3390\/diagnostics11111980","journal-title":"Diagnostics (Basel)"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Radiopaedia. Intracranial germ cell tumours. (2025). Accessed. November 7, 2025: https:\/\/doi.org\/10.53347\/rID-5956.","DOI":"10.53347\/rID-5956"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcped.2024.100146","article-title":"Overview of current European practice for the management of patients with intracranial germ cell tumours","volume":"3","author":"Diezi M","year":"2024","unstructured":"Diezi M, Pizer B, Murray MJ. Overview of current European practice for the management of patients with intracranial germ cell tumours. EJC Paediatr Oncol. 2024, 3:100146. 10.1016\/j.ejcped.2024.100146","journal-title":"EJC Paediatr Oncol"},{"key":"ref51","article-title":"Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience","volume":"7","author":"Gao Y","year":"2014","unstructured":"Gao Y, Jiang J, Liu Q. Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience. Int J Clin Exp Pathol. 2014, 7:6965-72.","journal-title":"Int J Clin Exp Pathol"},{"key":"ref52","article-title":"Hypothyroidism","author":"Patil N","year":"2025","unstructured":"Patil N, Rehman A, Anastasopoulou C, et al.. Hypothyroidism. StatPearls Publishing, Treasure Island, FL; 2025."},{"key":"ref53","unstructured":"Imperial Centre for Endocrinology. Endocrinology handbook. (2025). Accessed. October 20, 2025: https:\/\/www.impendo.co.uk\/endocrine-bible."},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13866","article-title":"Diagnosis and management of central diabetes insipidus in adults","volume":"90","author":"Garrahy A","year":"2019","unstructured":"Garrahy A, Moran C, Thompson CJ. Diagnosis and management of central diabetes insipidus in adults. Clin Endocrinol (Oxf). 2019, 90:23-30. 10.1111\/cen.13866","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.13523","article-title":"Diabetes insipidus: pathogenesis, diagnosis, and clinical management","volume":"13","author":"Mutter CM","year":"2021","unstructured":"Mutter CM, Smith T, Menze O, Zakharia M, Nguyen H. Diabetes insipidus: pathogenesis, diagnosis, and clinical management. Cureus. 2021, 13:e13523. 10.7759\/cureus.13523","journal-title":"Cureus"},{"key":"ref56","unstructured":"Water deprivation and desmopressin test. (2024). Accessed. October 20, 2025: https:\/\/gpnotebook.com\/en-GB\/pages\/diabetes-and-endocrinology\/water-deprivation-and-desmopressin-test."},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.902364","article-title":"Growth hormone stimulation testing: to test or not to test? That is one of the questions","volume":"13","author":"Yau M","year":"2022","unstructured":"Yau M, Rapaport R. Growth hormone stimulation testing: to test or not to test? That is one of the questions. Front Endocrinol (Lausanne). 2022, 13:902364. 10.3389\/fendo.2022.902364","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307228","article-title":"Controversies in the diagnosis and management of growth hormone deficiency in childhood and adolescence","volume":"101","author":"Murray PG","year":"2016","unstructured":"Murray PG, Dattani MT, Clayton PE. Controversies in the diagnosis and management of growth hormone deficiency in childhood and adolescence. Arch Dis Child. 2016, 101:96-100. 10.1136\/archdischild-2014-307228","journal-title":"Arch Dis Child"},{"key":"ref59","unstructured":"Human growth hormone (somatropin) in adults with growth hormone deficiency. (2023). Accessed. October 20, 2025: https:\/\/www.nice.org.uk\/guidance\/ta64\/chapter\/1-Recommendations."},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-13323-1","article-title":"Optimal treatment approach for intracranial germinoma: a systematic review and meta-analysis","volume":"25","author":"Zhou Z","year":"2025","unstructured":"Zhou Z, Liu J, Yue Q, et al.. Optimal treatment approach for intracranial germinoma: a systematic review and meta-analysis. BMC Cancer. 2025, 25:26. 10.1186\/s12885-024-13323-1","journal-title":"BMC Cancer"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2018.01.009","article-title":"Current management of intracranial germ cell tumours","volume":"30","author":"Bowzyk Al-Naeeb A","year":"2018","unstructured":"Bowzyk Al-Naeeb A, Murray M, Horan G, Harris F, Kortmann RD, Nicholson J, Ajithkumar T. Current management of intracranial germ cell tumours. Clin Oncol (R Coll Radiol). 2018, 30:204-14. 10.1016\/j.clon.2018.01.009","journal-title":"Clin Oncol (R Coll Radiol)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/436643-panhypopituitarism-secondary-to-a-central-nervous-system-germinoma","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T13:15:00Z","timestamp":1765372500000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/436643-panhypopituitarism-secondary-to-a-central-nervous-system-germinoma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":61,"URL":"https:\/\/doi.org\/10.7759\/cureus.98887","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,10]]}}}