{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T06:50:21Z","timestamp":1765695021214,"version":"3.48.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,13]]},"DOI":"10.7759\/cureus.99171","type":"journal-article","created":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T06:45:42Z","timestamp":1765694742000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Prognostic Implications of Isocitrate Dehydrogenase Mutation in Gliomas Within a Latin American Public Oncology System: Insights From a Retrospective Panamanian Cohort"],"prefix":"10.7759","author":[{"given":"Francisco","family":"Palma-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Abrego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allyson","family":"O\u00b4Neill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul","family":"Lorenzo-Luaces","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Salgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Chong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael E","family":"Arauz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-12048-5_1","article-title":"Epidemiology of gliomas","author":"Ostrom QT","year":"2015","unstructured":"Ostrom QT, Gittleman H, Stetson L, Virk SM, Barnholtz-Sloan JS. Epidemiology of gliomas. Current Understanding and Treatment of Gliomas. Raizer J, Parsa A (ed): Springer, Cham, Switzerland; 2015. 163:1-14. 10.1007\/978-3-319-12048-5_1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO Classification of Tumors of the Central Nervous System: a summary","volume":"23","author":"Louis DN","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P, et al.. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021, 23:1231-51. 10.1093\/neuonc\/noab106","journal-title":"Neuro Oncol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-0814-x","article-title":"IDH mutation in glioma: molecular mechanisms and potential therapeutic targets","volume":"122","author":"Han S","year":"2020","unstructured":"Han S, Liu Y, Cai SJ, et al.. IDH mutation in glioma: molecular mechanisms and potential therapeutic targets. Br J Cancer. 2020, 122:1580-9. 10.1038\/s41416-020-0814-x","journal-title":"Br J Cancer"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-013-0345-4","article-title":"IDH1 and IDH2 mutations in gliomas","volume":"13","author":"Cohen AL","year":"2013","unstructured":"Cohen AL, Holmen SL, Colman H. IDH1 and IDH2 mutations in gliomas. Curr Neurol Neurosci Rep. 2013, 13:345. 10.1007\/s11910-013-0345-4","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068782","article-title":"IDH1\/IDH2 mutations define the prognosis and molecular profiles of patients with gliomas: a meta-analysis","volume":"8","author":"Zou P","year":"2013","unstructured":"Zou P, Xu H, Chen P, Yan Q, Zhao L, Zhao P, Gu A. IDH1\/IDH2 mutations define the prognosis and molecular profiles of patients with gliomas: a meta-analysis. PLoS One. 2013, 8:e68782. 10.1371\/journal.pone.0068782","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac198","article-title":"National-level overall survival patterns for molecularly-defined diffuse glioma types in the United States","volume":"25","author":"Ostrom QT","year":"2023","unstructured":"Ostrom QT, Shoaf ML, Cioffi G, et al.. National-level overall survival patterns for molecularly-defined diffuse glioma types in the United States. Neuro Oncol. 2023, 25:799-807. 10.1093\/neuonc\/noac198","journal-title":"Neuro Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14072518","article-title":"Potential biomarkers for IDH-mutant and IDH-wild-type glioblastomas: a single-center retrospective study","volume":"14","author":"Sarac ME","year":"2025","unstructured":"Sarac ME, Boga Z, Kara \u00dc, Akb\u0131y\u0131k T, \u00c7\u0131nk\u0131 AH, Olguner SK. Potential biomarkers for IDH-mutant and IDH-wild-type glioblastomas: a single-center retrospective study. J Clin Med. 2025, 14:10.3390\/jcm14072518","journal-title":"J Clin Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3171\/2024.5.JNS24393","article-title":"Long-term survivors in 976 supratentorial glioblastoma, IDH-wildtype patients","volume":"142","author":"Aboubakr O","year":"2025","unstructured":"Aboubakr O, Moiraghi A, Elia A, et al.. Long-term survivors in 976 supratentorial glioblastoma, IDH-wildtype patients. J Neurosurg. 2025, 142:174-86. 10.3171\/2024.5.JNS24393","journal-title":"J Neurosurg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4008","article-title":"Prognostic role of IDH mutations in gliomas: a meta-analysis of 55 observational studies","volume":"6","author":"Xia L","year":"2015","unstructured":"Xia L, Wu B, Fu Z, et al.. Prognostic role of IDH mutations in gliomas: a meta-analysis of 55 observational studies. Oncotarget. 2015, 6:17354-65. 10.18632\/oncotarget.4008","journal-title":"Oncotarget"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02424-0","article-title":"Prognostic value of tumour volume in patients with a poor Karnofsky performance status scale - a bicentric retrospective study","volume":"21","author":"Barz M","year":"2021","unstructured":"Barz M, Gerhardt J, Bette S, et al.. Prognostic value of tumour volume in patients with a poor Karnofsky performance status scale - a bicentric retrospective study. BMC Neurol. 2021, 21:446. 10.1186\/s12883-021-02424-0","journal-title":"BMC Neurol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac003","article-title":"IDH-mutated gliomas promote epileptogenesis through d-2-hydroxyglutarate-dependent mTOR hyperactivation","volume":"24","author":"Mortazavi A","year":"2022","unstructured":"Mortazavi A, Fayed I, Bachani M, et al.. IDH-mutated gliomas promote epileptogenesis through d-2-hydroxyglutarate-dependent mTOR hyperactivation. Neuro Oncol. 2022, 24:1423-35. 10.1093\/neuonc\/noac003","journal-title":"Neuro Oncol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007415.pub2","article-title":"Temozolomide for high grade glioma","volume":"2013","author":"Hart MG","year":"2013","unstructured":"Hart MG, Garside R, Rogers G, Stein K, Grant R. Temozolomide for high grade glioma. Cochrane Database Syst Rev. 2013, 2013:CD007415. 10.1002\/14651858.CD007415.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.101099","article-title":"Surgery of IDH-mutated grade 2 glioma: continually setting the bar higher","volume":"46","author":"Mandonnet E","year":"2024","unstructured":"Mandonnet E. Surgery of IDH-mutated grade 2 glioma: continually setting the bar higher. Lancet Reg Health Eur. 2024, 46:101099. 10.1016\/j.lanepe.2024.101099","journal-title":"Lancet Reg Health Eur"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/438417-clinical-and-prognostic-implications-of-isocitrate-dehydrogenase-mutation-in-gliomas-within-a-latin-american-public-oncology-system-insights-from-a-retrospective-panamanian-cohort","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T06:45:43Z","timestamp":1765694743000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/438417-clinical-and-prognostic-implications-of-isocitrate-dehydrogenase-mutation-in-gliomas-within-a-latin-american-public-oncology-system-insights-from-a-retrospective-panamanian-cohort"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,13]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.99171","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,13]]}}}