{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:03:26Z","timestamp":1765811006788,"version":"3.48.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,15]]},"DOI":"10.7759\/cureus.99283","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:59:02Z","timestamp":1765810742000},"source":"Crossref","is-referenced-by-count":0,"title":["A Potential Case of Acamprosate-Induced Syncope in an Elderly Patient: A Case Report and Literature Review"],"prefix":"10.7759","author":[{"given":"Khaled","family":"Al Khodari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Hieu","family":"Troung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Keratishvili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laith","family":"Sorour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasneem","family":"Anagreh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouaz","family":"Al Khodari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.7.11.1465","article-title":"Acamprosate in the treatment of alcohol dependence: clinical and economic considerations","volume":"7","author":"Mason BJ","year":"2007","unstructured":"Mason BJ, Crean R. Acamprosate in the treatment of alcohol dependence: clinical and economic considerations. Expert Rev Neurother. 2007, 7:1465-77. 10.1586\/14737175.7.11.1465","journal-title":"Expert Rev Neurother"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000108656.81563.05","article-title":"The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis","volume":"28","author":"Mann K","year":"2004","unstructured":"Mann K, Lehert P, Morgan MY. The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis. Alcohol Clin Exp Res. 2004, 28:51-63. 10.1097\/01.ALC.0000108656.81563.05","journal-title":"Alcohol Clin Exp Res"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1097\/ADM.0b013e31816319fd","article-title":"Acamprosate: safety and tolerability in the treatment of alcohol dependence","volume":"2","author":"Rosenthal RN","year":"2008","unstructured":"Rosenthal RN, Gage A, Perhach JL, Goodman AM. Acamprosate: safety and tolerability in the treatment of alcohol dependence. J Addict Med. 2008, 2:40-50.","journal-title":"J Addict Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2014.12.2.166","article-title":"Acamprosate-induced extrapyramidal symptoms in an elderly patient with alcohol dependence","volume":"12","author":"Woo J","year":"2014","unstructured":"Woo J, Rim HD. Acamprosate-induced extrapyramidal symptoms in an elderly patient with alcohol dependence. Clin Psychopharmacol Neurosci. 2014, 12:166-8. 10.9758\/cpn.2014.12.2.166","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.33266","article-title":"Unusual side effects with acamprosate","volume":"49","author":"Sidana AK","year":"2007","unstructured":"Sidana AK, Mangla D. Unusual side effects with acamprosate. Indian J Psychiatry. 2007, 49:143. 10.4103\/0019-5545.33266","journal-title":"Indian J Psychiatry"},{"key":"ref6","article-title":"Acamprosate-induced myoclonic jerks: a rare side effect","volume":"53","author":"Soni PK","year":"2021","unstructured":"Soni PK, Singh LK, Das S, Nandan NK. Acamprosate-induced myoclonic jerks: a rare side effect. Indian J Pharmacol. 2021, 53:511-2.","journal-title":"Indian J Pharmacol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00471","article-title":"Syncope: epidemiology, etiology, and prognosis","volume":"5","author":"da Silva RM","year":"2014","unstructured":"da Silva RM. Syncope: epidemiology, etiology, and prognosis. Front Physiol. 2014, 5:471. 10.3389\/fphys.2014.00471","journal-title":"Front Physiol"},{"key":"ref8","article-title":"Syncope","author":"Grossman SA","year":"2025","unstructured":"Grossman SA, Badireddy M. Syncope. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2025."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad163","article-title":"Twenty-five years of research on syncope","volume":"25","author":"Fedorowski A","year":"2023","unstructured":"Fedorowski A, Kulakowski P, Brignole M, et al.. Twenty-five years of research on syncope. Europace. 2023, 25:euad163. 10.1093\/europace\/euad163","journal-title":"Europace"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.1750101","article-title":"The American Psychiatric Association practice guideline for the pharmacological treatment of patients with alcohol use disorder","volume":"175","author":"Reus VI","year":"2018","unstructured":"Reus VI, Fochtmann LJ, Bukstein O, et al.. The American Psychiatric Association practice guideline for the pharmacological treatment of patients with alcohol use disorder. Am J Psychiatry. 2018, 175:86-90. 10.1176\/appi.ajp.2017.1750101","journal-title":"Am J Psychiatry"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12070","article-title":"The clinical pharmacology of acamprosate","volume":"77","author":"Kalk NJ","year":"2014","unstructured":"Kalk NJ, Lingford-Hughes AR. The clinical pharmacology of acamprosate. Br J Clin Pharmacol. 2014, 77:315-23. 10.1111\/bcp.12070","journal-title":"Br J Clin Pharmacol"},{"key":"ref12","unstructured":"Acamprosate side effects. (2025). Accessed. September 21, 2025: https:\/\/www.drugs.com\/sfx\/acamprosate-side-effects.html."},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.1177\/0269881120944154","article-title":"Hypertension and orthostatic hypotension with venlafaxine treatment in depressed older adults","volume":"34","author":"Wathra R","year":"2020","unstructured":"Wathra R, Mulsant BH, Thomson L, et al.. Hypertension and orthostatic hypotension with venlafaxine treatment in depressed older adults. J Psychopharmacol. 2020, 34:1112-8.","journal-title":"J Psychopharmacol"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.1097\/01.JGP.0000204328.50105.b3","article-title":"Cardiovascular changes associated with venlafaxine in the treatment of late-life depression","volume":"14","author":"Johnson EM","year":"2006","unstructured":"Johnson EM, Whyte E, Mulsant BH, Pollock BG, Weber E, Begley AE, Reynolds CF. Cardiovascular changes associated with venlafaxine in the treatment of late-life depression. Am J Geriatr Psychiatry. 2006, 14:796-802.","journal-title":"Am J Geriatr Psychiatry"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.482018","article-title":"Neurocardiogenic syncope and related disorders of orthostatic intolerance","volume":"111","author":"Grubb BP","year":"2005","unstructured":"Grubb BP. Neurocardiogenic syncope and related disorders of orthostatic intolerance. Circulation. 2005, 111:2997-3006. 10.1161\/CIRCULATIONAHA.104.482018","journal-title":"Circulation"},{"key":"ref16","article-title":"Alcohol hangover: mechanisms and mediators","volume":"22","author":"Swift R","year":"1998","unstructured":"Swift R, Davidson D. Alcohol hangover: mechanisms and mediators. Alcohol Health Res World. 1998, 22:54-60.","journal-title":"Alcohol Health Res World"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/422553-a-potential-case-of-acamprosate-induced-syncope-in-an-elderly-patient-a-case-report-and-literature-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:59:05Z","timestamp":1765810745000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/422553-a-potential-case-of-acamprosate-induced-syncope-in-an-elderly-patient-a-case-report-and-literature-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.99283","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,15]]}}}