{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:59:30Z","timestamp":1787500770776,"version":"build-2736575974"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,20]]},"DOI":"10.7759\/cureus.99714","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T17:04:36Z","timestamp":1766250276000},"source":"Crossref","is-referenced-by-count":1,"title":["A Complex Diagnostic Challenge of Dual Antibiotic-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome With Multiorgan Involvement"],"prefix":"10.7759","author":[{"given":"Bola","family":"Habeb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Motakhaveri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica S","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.01.017","article-title":"The DRESS syndrome: a literature review","volume":"124","author":"Cacoub P","year":"2011","unstructured":"Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, Roujeau JC. The DRESS syndrome: a literature review. Am J Med. 2011, 124:588-97. 10.1016\/j.amjmed.2011.01.017","journal-title":"Am J Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12501","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study","volume":"169","author":"Kardaun SH","year":"2013","unstructured":"Kardaun SH, Sekula P, Valeyrie-Allanore L, et al.. Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study. Br J Dermatol. 2013, 169:1071-80. 10.1111\/bjd.12501","journal-title":"Br J Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2022.100673","article-title":"DRESS syndrome: a literature review and treatment algorithm","volume":"16","author":"Calle AM","year":"2023","unstructured":"Calle AM, Aguirre N, Ardila JC, Cardona Villa R. DRESS syndrome: a literature review and treatment algorithm. World Allergy Organ J. 2023, 16:100673. 10.1016\/j.waojou.2022.100673","journal-title":"World Allergy Organ J"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.02.002","article-title":"Vancomycin-associated drug-induced hypersensitivity syndrome","volume":"81","author":"Madigan LM","year":"2019","unstructured":"Madigan LM, Fox LP. Vancomycin-associated drug-induced hypersensitivity syndrome. J Am Acad Dermatol. 2019, 81:123-8. 10.1016\/j.jaad.2019.02.002","journal-title":"J Am Acad Dermatol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1355774","article-title":"Case report: minocycline-induced drug reaction with eosinophilia and systemic symptoms syndrome: a case report and literature review","volume":"15","author":"Zhao Z","year":"2024","unstructured":"Zhao Z, Lu M, Ying Y. Case report: minocycline-induced drug reaction with eosinophilia and systemic symptoms syndrome: a case report and literature review. Front Pharmacol. 2024, 15:1355774. 10.3389\/fphar.2024.1355774","journal-title":"Front Pharmacol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1108345","article-title":"Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in childhood: a narrative review","volume":"10","author":"Manieri E","year":"2023","unstructured":"Manieri E, Dondi A, Neri I, Lanari M. Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in childhood: a narrative review. Front Med (Lausanne). 2023, 10:1108345. 10.3389\/fmed.2023.1108345","journal-title":"Front Med (Lausanne)"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2025.03.007","article-title":"Recent advances in the diagnosis and treatment of DIHS\/DRESS in 2025","volume":"74","author":"Mizukawa Y","year":"2025","unstructured":"Mizukawa Y, Shiohara T. Recent advances in the diagnosis and treatment of DIHS\/DRESS in 2025. Allergol Int. 2025, 74:372-9. 10.1016\/j.alit.2025.03.007","journal-title":"Allergol Int"},{"key":"ref8","unstructured":"RegiSCAR score for drug reaction with eosinophilia and systemic symptoms (DRESS). (2025). https.\/\/www.mdcalc.com\/calc\/10084\/regiscar-score-drug-reaction-eosinophilia-systemic-symptoms-dress."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.02.1130","article-title":"Liver injury in patients with DRESS: a clinical study of 72 cases","volume":"72","author":"Lin IC","year":"2015","unstructured":"Lin IC, Yang HC, Strong C, Yang CW, Cho YT, Chen KL, Chu CY. Liver injury in patients with DRESS: a clinical study of 72 cases. J Am Acad Dermatol. 2015, 72:984-91. 10.1016\/j.jaad.2015.02.1130","journal-title":"J Am Acad Dermatol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.01.032","article-title":"DRESS syndrome: part II. Management and therapeutics","volume":"68","author":"Husain Z","year":"2013","unstructured":"Husain Z, Reddy BY, Schwartz RA. DRESS syndrome: part II. Management and therapeutics. J Am Acad Dermatol. 2013, 68:709.1-9. 10.1016\/j.jaad.2013.01.032","journal-title":"J Am Acad Dermatol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/CLD.0000000000000198","article-title":"A review of drug-induced liver injury with rash, eosinophilia, and systemic symptoms (DRESS) syndrome: cutaneous manifestations, clinical features, and management","volume":"23","author":"Arora N","year":"2024","unstructured":"Arora N, Chalasani N, Rahnama-Moghadam S. A review of drug-induced liver injury with rash, eosinophilia, and systemic symptoms (DRESS) syndrome: cutaneous manifestations, clinical features, and management. Clin Liver Dis (Hoboken). 2024, 23:0198. 10.1097\/CLD.0000000000000198","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12144576","article-title":"Renal manifestations of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a systematic review of 71 cases","volume":"12","author":"Dagnon da Silva M","year":"2023","unstructured":"Dagnon da Silva M, Domingues SM, Oluic S, et al.. Renal manifestations of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a systematic review of 71 cases. J Clin Med. 2023, 12:4576. 10.3390\/jcm12144576","journal-title":"J Clin Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/443931-a-complex-diagnostic-challenge-of-dual-antibiotic-induced-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-with-multiorgan-involvement","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T17:04:37Z","timestamp":1766250277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/443931-a-complex-diagnostic-challenge-of-dual-antibiotic-induced-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-with-multiorgan-involvement"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,20]]},"references-count":12,"URL":"https:\/\/doi.org\/10.7759\/cureus.99714","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,20]]}}}